Suchergebnis: Katalogdaten im Frühjahrssemester 2018

Biologie Master Information
Wahlvertiefungen
Wahlvertiefung: Molekulare Gesundheitswissenschaften
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
551-0140-00LEpigeneticsW4 KP2VR. Paro, U. Grossniklaus, R. Santoro, A. Wutz
KurzbeschreibungEpigenetik untersucht die Vererbung von Merkmalen, die nicht auf eine Veränderung der DNA Sequenz zurückgeführt werden kann. Die Vorlesung gibt einen Überblick über epigenetische Phänomene und erklärt die zugrundeliegenden molekularen Mechanismen. Die Rolle von epigenetischen Prozessen bei der Krebsentstehung und anderen Krankheiten wird diskutiert.
LernzielDas Ziel des Kurses ist das Verständnis von epigenetischen Mechanismen und deren Funktion in der Entwicklung von Organismen, bei Regenerationsprozessen oder bei der Entstehung von Krankheiten.
InhaltThemen
- Historischer Überblick, Konzepte und Vergleich Genetik vs. Epigenetik
- Biologie von Chromatin: Struktur und Funktion, Organisation im Kern und die Rolle von Histon Modifikationen bei Prozessen wie Transkription und Replikation.
- DNA-Methylierung als epigenetische Modifikation
- Weitergabe epigenetischer Modifikationen während der Zellteilung: das Zellgedächtnis
- Stabilität/Revertierbarkeit epigenetischer Modifikationen: zelluläre Plastizität und Stammzellen.
- Genomisches Imprinting in Pflanzen und in Säugern
- X Chromosom Inaktivierung und Dosiskompensation
- Positionseffekte, Paramutationen und Transvektion
- RNA-induziertes Gensilencing
- die Rolle von epigenetischen Prozessen bei der Krebsentstehung oder der Zellalterung.
701-1350-00LCase Studies in Environment and HealthW4 KP2VK. McNeill, N. Borduas-Dedekind, T. Julian
KurzbeschreibungThis course will focus on a few individual chemicals and pathogens from different standpoints: their basic chemistry or biology, their environmental behavior, (eco)toxicology, and human health impacts. The course will draw out the common points in each chemical or pathogen's history.
LernzielThis course aims to illustrate how the individual properties of chemicals and pathogens along with societal pressures lead to environmental and human health crises. The ultimate goal of the course is to identify common aspects that will improve prediction of environmental crises before they occur. Students are expected to participate actively in the course, which includes the critical reading of the pertinent literature and class presentations.
InhaltEach semester will feature case studies of chemicals and pathogens that have had a profound effect on human health and the environment. The instructors will present eight of these and the students will present approx. six in groups of three or four. Students will be expected to contribute to the discussion and, on selected topics, to lead the discussion.
SkriptHandouts will be provided as needed.
LiteraturHandouts will be provided as needed.
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.
Requires application; selected applicants will be notified before the first week of lectures.
W4 KP2SW.‑D. Hardt, L. Eberl, U. F. Greber, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander
KurzbeschreibungLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
LernzielWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Inhaltfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
SkriptTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteraturTeachers will provide the research papers to be discussed.
Voraussetzungen / BesonderesRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to Link and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
227-0396-00LEXCITE Interdisciplinary Summer School on Bio-Medical Imaging Information Belegung eingeschränkt - Details anzeigen
The school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process.

Students have to apply for acceptance by April 23, 2018. To apply a curriculum vitae and an application letter need to be submitted. The notification of acceptance will be given by May 25, 2018. Further information can be found at: Link.
W4 KP6GS. Kozerke, G. Csúcs, J. Klohs-Füchtemeier, S. F. Noerrelykke, M. P. Wolf
KurzbeschreibungTwo-week summer school organized by EXCITE (Center for EXperimental & Clinical Imaging TEchnologies Zurich) on biological and medical imaging. The course covers X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, infrared and optical microscopy, electron microscopy, image processing and analysis.
LernzielStudents understand basic concepts and implementations of biological and medical imaging. Based on relative advantages and limitations of each method they can identify preferred procedures and applications. Common foundations and conceptual differences of the methods can be explained.
InhaltTwo-week summer school on biological and medical imaging. The course covers concepts and implementations of X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, infrared and optical microscopy and electron microscopy. Multi-modal and multi-scale imaging and supporting technologies such as image analysis and modeling are discussed. Dedicated modules for physical and life scientists taking into account the various backgrounds are offered.
SkriptHand-outs, Web links
Voraussetzungen / BesonderesThe school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process. To apply a curriculum vitae, a statement of purpose and applicants references need to be submitted. Further information can be found at: Link
227-0946-00LMolecular Imaging - Basic Principles and Biomedical ApplicationsW2 KP2VM. Rudin
KurzbeschreibungConcept: What is molecular imaging.
Discussion/comparison of the various imaging modalities used in molecular imaging.
Design of target specific probes: specificity, delivery, amplification strategies.
Biomedical Applications.
LernzielMolecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research.
InhaltConcept: What is molecular imaging.
Discussion/comparison of the various imaging modalities used in molecular imaging.
Design of target specific probes: specificity, delivery, amplification strategies.
Biomedical Applications.
551-1132-00LAllgemeine Virologie Information W2 KP1VK. Tobler, C. Fraefel
KurzbeschreibungEinführung in die Grundlagen der Virologie, welche die Charakterisierung von Viren, die Interaktionen der Viren mit infizierten Zellen, Wirten und Populationen, die Grundlagen des Schutzes vor Infektion und die Virusdiagnostik beinhaltet.
LernzielEinführung in die Grundlagen der Virologie.
InhaltGrundlagen der Virologie. Charakterisierung von Viren. Virus-Zell-Interaktionen. Virus-Wirt-Interaktionen. Virus-Population-Interaktionen. Schutz vor Virusinfektion. Virusdiagnostik.
SkriptDie Vorlesung ist auf dem Lehrbuch "Allgemeine Virologie" von Kurt Tobler, Mathias Ackermann und Cornel Fraefel aufgebaut.

Die Präsentationsfolien und ausgewählte Primärliteratur werden 24 bis 48 Stunden vor den Lektionen als .pdf-Dateien bereitgestellt.
LiteraturKurt Tobler, Mathias Ackermann und Cornel Fraefel,
Allgemeine Virologie, 2016,
1. Auflage UTB-Band-Nr.:4516 Haupt Verlag Bern
ISBN: 978-3-8252-4516-0
Voraussetzungen / BesonderesGrundkenntnisse in Molekularbiologie, Zellbiologie und Immunologie
376-1306-00LClinical Neuroscience Information W3 KP3GG. Schratt, Uni-Dozierende
KurzbeschreibungThe lecture series "Clinical Neuroscience" presents a comprehensive, condensed overview of the most important neurological diseases, their clinical presentation, diagnosis, therapy options and possible causes. Patient demonstrations (Übungen) follow every lecture that is dedicated to a particular disease.
LernzielBy the end of this module students should be able to:
- demonstrate their understanding and deep knowledge concerning the main neurological diseases
- identify and explain the different clinical presentation of these diseases, the methodology of diagnosis and the current therapies available
- summarize and critically review scientific literature efficiently and effectively
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 KP2GA. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
InhaltTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Skriptn/a
LiteraturTopical Scientific Manuscripts
551-0364-00LFunctional Genomics
Information for UZH students:
Enrolment to this course unit only possible at ETH. No enrolment to module BIO 254 at UZH.
Please mind the ETH enrolment deadlines for UZH students: Link
W3 KP2VC. von Mering, C. Beyer, B. Bodenmiller, M. Gstaiger, H. Rehrauer, R. Schlapbach, K. Shimizu, N. Zamboni, weitere Dozierende
KurzbeschreibungFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data.
LernzielFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data. Such data provide the basis for systems biology efforts to elucidate the structure, dynamics and regulation of cellular networks.
InhaltThe curriculum of the Functional Genomics course emphasizes an in depth understanding of new technology platforms for modern genomics and advanced genetics, including the application of functional genomics approaches such as advanced microarrays, proteomics, metabolomics, clustering and classification. Students will learn quality controls and standards (benchmarking) that apply to the generation of quantitative data and will be able to analyze and interpret these data. The training obtained in the Functional Genomics course will be immediately applicable to experimental research and design of systems biology projects.
Voraussetzungen / BesonderesThe Functional Genomics course will be taught in English.
551-0338-00LCurrent Approaches in Single Cell Analysis (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BIO256

Beachten Sie die Einschreibungstermine an der UZH: Link
W2 KP1VUni-Dozierende
KurzbeschreibungIn this lecture, we will discuss the most important single cell
approaches, the questions they can address and current developments. We will cover single cell: genomics, transcriptomics, proteomics (CyTOF mass cytometry), metabolomics and highly multiplexed imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data.
LernzielOn completion of this module the students should be able to:
- explain the basic principles of single cell analysis techniques
- identify and justify the limitations of the current single cell
technologies and suggest reasonable improvements
- know the basic challenges in data analysis imposed by the complex
multi parameter data.
Key skills:
On completion of this module the students should be able to:
- summarize and discuss the impact these technologies have on biology
and medicine
- design biological and biomedical experiments for which single cell
analysis is essential
InhaltCurrently single cell analysis approaches revolutionize the way we study and understand biological systems. In all biological and biomedical settings, cell populations and tissues are highly heterogeneous; this heterogeneity plays a critical role in basic biological processes such as cell cycle, development and organismic function, but is also a major player in disease, e.g. for cancer development, diagnosis and treatment.
Currently, single cell analysis techniques are rapidly developing and
find broad application, as the single cell measurements not only enable
to study cell specific functions, but often reveal unexpected biological
mechanisms in so far (assumed) well understood biological processes.
In this lecture, we will discuss the most important single cell approaches, the questions they can address and current developments. We will cover single cell genomics, single cell transcriptomics, single cell proteomics (CyTOF mass cytometry), single cell metabolomics and highly multiplexed single cell imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data.
551-1404-00LRNA and Proteins: Post-Transcriptional Regulation of Gene Expression (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BCH252

Beachten Sie die Einschreibungstermine an der UZH: Link
W3 KP2VUni-Dozierende
KurzbeschreibungThe course introduces the cellular processes and molecular mechanisms involved in regulating genome expression at the post-transcriptional level.
Topics will include :
-RNA processing, and transport;
-protein synthesis and translational control, trafficking and degradation;
-RNA-guided regulation (RNA interference, microRNAs);
-molecular surveillance and quality control mechanisms
Lernziel-Outline the cellular processes
used by eukaryotic and prokaryotic cells
to control gene expression at the post-
transcriptional level.
-Describe the molecular mechanisms
underlying post-transcriptional gene
regulation
-Identify experimental approaches
used to study post-transcriptional gene
regulation and describe their strengths
and weaknesses.
636-0111-00LSynthetic Biology I
Attention: This course was offered in previous semesters with the number: 636-0002-00L "Synthetic Biology I". Students that already passed course 636-0002-00L cannot receive credits for course 636-0111-00L.
W4 KP3GS. Panke, J. Stelling
KurzbeschreibungTheoretical & practical introduction into the design of dynamic biological systems at different levels of abstraction, ranging from biological fundamentals of systems design (introduction to bacterial gene regulation, elements of transcriptional & translational control, advanced genetic engineering) to engineering design principles (standards, abstractions) mathematical modelling & systems desig
LernzielAfter the course, students will be able to theoretically master the biological and engineering fundamentals required for biological design to be able to participate in the international iGEM competition (see Link).
InhaltThe overall goal of the course is to familiarize the students with the potential, the requirements and the problems of designing dynamic biological elements that are of central importance for manipulating biological systems, primarily (but not exclusively) prokaryotic systems. Next, the students will be taken through a number of successful examples of biological design, such as toggle switches, pulse generators, and oscillating systems, and apply the biological and engineering fundamentals to these examples, so that they get hands-on experience on how to integrate the various disciplines on their way to designing biological systems.
SkriptHandouts during classes.
LiteraturMark Ptashne, A Genetic Switch (3rd ed), Cold Spring Haror Laboratory Press
Uri Alon, An Introduction to Systems Biology, Chapman & Hall
Voraussetzungen / Besonderes1) Though we do not place a formal requirement for previous participation in particular courses, we expect all participants to be familiar with a certain level of biology and of mathematics. Specifically, there will be material for self study available on Link as of mid January, and everybody is expected to be fully familiar with this material BEFORE THE CLASS BEGINS to be able to follow the different lectures. Please contact Link for access to material
2) The course is also thought as a preparation for the participation in the international iGEM synthetic biology summer competition (Link, Link). This competition is also the contents of the course Synthetic Biology II. Link
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