Search result: Catalogue data in Spring Semester 2018

MAS in Medical Physics Information
Specialization: General Medical Physics and Biomedical Engineering
Major in Biocompatible Materials
Core Courses
376-1622-00L Practical Methods in Tissue Engineering (offered in the Autumn Semester) and 376-1624-00L Practical Methods in Biofabrication (offered in the Spring Semester) are mutually exclusive to be eligible for credits.
NumberTitleTypeECTSHoursLecturers
151-0980-00LBiofluiddynamicsW4 credits2V + 1UD. Obrist, P. Jenny
AbstractIntroduction to the fluid dynamics of the human body and the modeling of physiological flow processes (biomedical fluid dynamics).
Learning objectiveA basic understanding of fluid dynamical processes in the human body. Knowledge of the basic concepts of fluid dynamics and the ability to apply these concepts appropriately.
ContentThis lecture is an introduction to the fluid dynamics of the human body (biomedical fluid dynamics). For selected topics of human physiology, we introduce fundamental concepts of fluid dynamics (e.g., creeping flow, incompressible flow, flow in porous media, flow with particles, fluid-structure interaction) and use them to model physiological flow processes. The list of studied topics includes the cardiovascular system and related diseases, blood rheology, microcirculation, respiratory fluid dynamics and fluid dynamics of the inner ear.
Lecture notesLecture notes are provided electronically.
LiteratureA list of books on selected topics of biofluiddynamics can be found on the course web page.
376-1308-00LDevelopment Strategies for Medical Implants Restricted registration - show details
Number of participants limited to 25 until 30.
Assignments will be considered chronological.
W3 credits2V + 1UJ. Mayer-Spetzler, M. Rubert
AbstractIntroduction to development strategies for implantable devices considering the interdependecies of biocompatibility, clinical and economical requirements ; discussion of the state of the art and actual trends in in orthopedics, sports medicine, traumatology and cardio-vascular surgery as well as regenerative medicine (tissue engineering).
Learning objectiveBasic considerations in implant development
Concept of structural and surface biocompatiblity and its relevance for the design of implant and surgical technique
Understanding of conflicting factors, e.g. clinical need, economics and regulatory requirements
Concepts of tissue engineering, its strengths and weaknesses as current and future clinical solution
ContentBiocompatibility as bionic guide line for the development of medical implants; implant and implantation related tissue reactions, biocompatible materials and material processing technologies; implant testing and regulatory procedures; discussion of the state of the art and actual trends in implant development in orthopedics, sports medicine, traumatology, spinal and cardio-vascular surgery; introduction to tissue engineering. Selected topics will be further illustrated by commented movies from surgeries.

Seminar:
Group seminars on selected controversial topics in implant development. Participation is mandatory

Planned excursions (limited availability, not mandatory, to be confirmed):
1. Participation (as visitor) on a life surgery (travel at own expense)
Lecture notesScribt (electronically available):
- presented slides
- selected scientific papers for further reading
LiteratureTextbooks on selected topics will be introduced during the lectures
Prerequisites / NoticeAchieved Bachelor degree is mandatory

The number of participants in the course is limited to 25-30 students in total.

Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is on the student's own responsability.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 credits2GA. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
AbstractThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
Learning objectiveThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
ContentTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Lecture notesn/a
LiteratureTopical Scientific Manuscripts
376-1614-00LPrinciples in Tissue EngineeringW3 credits2VK. Maniura, J. Möller, M. Zenobi-Wong
AbstractFundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
Learning objectiveUnderstanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed.
ContentThis class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
Lecture notesHandouts provided during the classes and references therin.
LiteratureThe molecular Biology of the Cell, Alberts et al., 5th Edition, 2009.
Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002
376-1624-00LPractical Methods in Biofabrication Restricted registration - show details
Number of participants limited to 12.
W5 credits4PM. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak
AbstractBiofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft.
Learning objectiveThe objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project.
Prerequisites / NoticeNot recommended if passed 376-1622-00 Practical Methods in Tissue Engineering
Practical Work
NumberTitleTypeECTSHoursLecturers
465-0800-00LPractical Work Restricted registration - show details
Only for MAS in Medical Physics
O4 creditsexternal organisers
AbstractThe practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution.
Learning objectiveThe practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem.
Electives
NumberTitleTypeECTSHoursLecturers
151-0622-00LMeasuring on the Nanometer ScaleW2 credits2GA. Stemmer, T. Wagner
AbstractIntroduction to theory and practical application of measuring techniques suitable for the nano domain.
Learning objectiveIntroduction to theory and practical application of measuring techniques suitable for the nano domain.
ContentConventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters.
Lecture notesClass notes and special papers will be distributed.
Major in Molecular Biology and Biophysics
Core Courses
NumberTitleTypeECTSHoursLecturers
551-1402-00LMolecular and Structural Biology VI: Biophysical Analysis of Macromolecular Mechanisms
This course is strongly recommended for the Masters Major "Biology and Biophysics".
W4 credits2VR. Glockshuber, T. Ishikawa, S. Jonas, B. Schuler, E. Weber-Ban
AbstractThe course is focussed on biophysical methods for characterising conformational transitions and reaction mechanisms of proteins and biological mecromolecules, with focus on methods that have not been covered in the Biology Bachelor Curriculum.
Learning objectiveThe goal of the course is to give the students a broad overview on biopyhsical techniques available for studying conformational transitions and complex reaction mechanisms of biological macromolecules. The course is particularly suited for students enrolled in the Majors "Structural Biology and Biophysics", "Biochemistry" and "Chemical Biology" of the Biology MSc curriculum, as well as for MSc students of Chemistry and Interdisciplinary Natural Sciences".
ContentThe biophysical methods covered in the course include advanced reaction kinetics, methods for the thermodynamic and kinetic analysis of protein-ligand interactions, classical and dynamic light scattering, analytical ultracentrifugation, spectroscopic techniques such as fluorescence anisotropy, fluorescence resonance energy transfer (FRET) and single molecule fluorescence spectrosopy, modern electron microscopy techniques, atomic force microscopy, and isothermal and differential scanning calorimetry.
Lecture notesCourse material from the individual lecturers wil be made available at the sharepoint website

https://team.biol.ethz.ch/e-learn/551-1402-00L
Prerequisites / NoticeFinished BSc curriculum in Biology, Chemistry or Interdisciplinary Natural Sciences. The course is also adequate for doctoral students with research projects in structural biology, biophysics, biochemistry and chemical biology.
Practical Work
NumberTitleTypeECTSHoursLecturers
465-0800-00LPractical Work Restricted registration - show details
Only for MAS in Medical Physics
O4 creditsexternal organisers
AbstractThe practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution.
Learning objectiveThe practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem.
Electives
NumberTitleTypeECTSHoursLecturers
151-0622-00LMeasuring on the Nanometer ScaleW2 credits2GA. Stemmer, T. Wagner
AbstractIntroduction to theory and practical application of measuring techniques suitable for the nano domain.
Learning objectiveIntroduction to theory and practical application of measuring techniques suitable for the nano domain.
ContentConventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters.
Lecture notesClass notes and special papers will be distributed.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 credits2GA. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
AbstractThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
Learning objectiveThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
ContentTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Lecture notesn/a
LiteratureTopical Scientific Manuscripts
Master's Thesis (for both Directions)
NumberTitleTypeECTSHoursLecturers
465-0900-00LMaster's Thesis
Only for MAS in Medical Physics
O15 credits32DSupervisors
AbstractThe master's thesis concludes the study program. The master thesis should prove the students' ability to independently, structurally and scientifically work on a topic in the field of the selected specialization.
Learning objectiveThe thesis is aimed at enhancing the student's capability to apply and connect methods and procedures of imparted content during the MAS program in the field of the selected specialization towards the solution of a problem.
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