Suchergebnis: Katalogdaten im Frühjahrssemester 2021

Biologie Bachelor Information
Bachelor-Studium (Studienreglement 2013)
3. Studienjahr, 6. Semester
Blockkurse
Anmeldung zu Blockkursen muss zwingend über die website Link
Anmeldung möglich von 19.12.2020 bis 09.01.2021

Bitte die ETH Aufnahmekriterien für die Aufnahme von Studierenden der ETH in ETH Blockkurse auf der Blockkurs-Anmeldeseite unter "Zuteilung" beachten.
Blockkurse im 2. Semesterviertel
Von 18.03.2021 bis 16.04.2021
NummerTitelTypECTSUmfangDozierende
551-1554-00LMultigene Expression in Mammalian Cells Belegung eingeschränkt - Details anzeigen
Number of participants limited to 5.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PP. Berger, G. Schertler
KurzbeschreibungGenetic engineering of mammalian cells with multiple expression cassettes is an essential need in contemporary cell biology. It is useful for protein expression for structural studies, the reprogramming of somatic cells, or for the expression of several fluorescently-tagged sensors. In this course, we use MultiLabel (Kriz et al., Nat. Commun., 2010) to create multigene expression plasmids.
LernzielStudents will learn to design and clone multigene expression constructs for mammalian cells. The functionality of the constructs will be tested by immunofluorescence microscopy or Western blotting.
InhaltWe will clone fluorescently-tagged markers for subcellular compartments, assemble them to a multigene expression construct and transfect them into mammalian cells. These markers of subcellular compartments will be used to study the trafficking of activated receptors (e.g. serotonin receptor). Pictures will be taken on our microscopes and then we will quantify colocalization.
Skriptnone
551-0436-00LCryo-Electron Microscopic Studies of Ribosomal Complexes with Biomedically Important Viral Proteins Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PN. Ban, D. Böhringer, M. A. Leibundgut, T. Lenarcic
KurzbeschreibungMany viruses have evolved specialized mechanisms to hijack the host gene expression machinery and employ cellular resources to regulate viral life cycle. They accomplish this through producing non-structural proteins that can, among other things, inhibit host protein synthesis. Participants of this course will visualize ribosomes in complex with a non-structural viral protein at high resolution.
LernzielThe goal of the course is to acquire the most important techniques and methods for the purification and structural characterisation of macromolecular complexes by transmission electron microscopy. The emphasis of the course is on the special practical requirements for the application of these techniques on macromolecular structures in the MDa range.
InhaltProtein synthesis is a very energy intensive process that can consume over half the total metabolism of a cell. In eukaryotes, translation is therefore tightly regulated at the stage of initiation. Regulatory processes are much more complex at this step than in prokaryotes and a large number of RNA modification processes and translation initiation factors are required to ensure faithful initiation, elongation and termination of translation. However, several viruses may interfere with host translation by affecting the initiation step or by modifying the activity of key initiation factors to ensure an efficient translation of viral mRNA. Amongst such viruses is also SARS-CoV-2, which infects a large variety of vertebrate species. On entering host cells, the viral genomic RNA is translated by the cellular protein synthesis machinery to produce a set of non-structural proteins, which by inhibiting host translation render cell conditions favorable for viral production. Within the Ban lab, we have studied, and continue to investigate, medically relevant viral proteins. This course will involve producing and attempting to determine the structure of a non-structural viral protein in a ribosome-bound form.

A variety of purification techniques, including affinity chromatography and ultracentrifugation, will be used during the purification of macromolecular complexes. Purified assemblies will be then investigated functionally. Students will then characterise their samples structurally through transmission electron cryo-microscopy (cryo-EM), including sample preparation, microscopy, data evaluation and the calculation of densities. Finally, students will learn how to build and refine molecular models into parts of the calculated cryo-EM density. The participants will be working on a closed project related to current research within the laboratory and throughout the course the practical work will be accompanied by brief theoretical introductions. The principal aim of the course is to strengthen the skills required to independently conduct meaningful biophysical and biochemical experiments and to provide an early introduction into the structural characterisation of cellular macromolecular assemblies.
SkriptA script will be distributed at the beginning of the course that will cover the experiments to be performed, provide references to the relevant literature and suggest points for further consideration for interested students.
LiteraturLiterature
A basic overview is provided within the references below. Further reading and citations shall be detailed in the course script.
- A. Fersht, Structure and mechanism in protein science, Freeman, 1999 (Chapters 1 and 6).
- M. van Heel et al., Single-particle electron cryo microscopy: towards atomic resolution, Quart. Rev. Biophys. (33), 307-369 (2000).
Voraussetzungen / BesonderesThe course will be held in English. Students should have either completed courses:
551-0307-00L Biomolecular Structure and Mechanism I: Protein Structure and Function
551-0307-01L Biomolecular Structure and Mechanism II: Large Cellular Machines
or equivalent courses covering the structure and function of biological macromolecules.
Blockkurse im 3. Semesterviertel
Von 20.04.2021 bis 12.05.2021
NummerTitelTypECTSUmfangDozierende
551-0362-00LMolecular Health: Biomedical Analysis of the Extracellular Interactome Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PB. Wollscheid, E. Tschudy-Milani
KurzbeschreibungIn this course you will learn to measure, integrate, analyze and validate the cellular surfaceome as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to establish the surfaceome proteotype and its signaling interaction networks.
Lernziel"If a cell surface molecule such as the B cell receptor would have the size of a human being, then the cell surface of a B cell would have roughly the size of three times NYC Central Park." How many people/proteins/proteoforms reside in this space ("Surfaceome")? Similar to humans, proteins don't act alone. Function is encoded in dynamic protein-protein interactions. How are these proteoforms organized in signaling islands/networks in order to fulfill specific cellular functions ("Interactome")? What are the ligands interacting with the surfaceome to communicate information from other cells & tissues in the body? What goes wrong in these signaling islands if we get sick?

In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome and its signaling islands as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to generate unprecedented data to establish the surfaceome proteotype and its signaling interaction networks. This digital proteotype data layer provides the basis for generating qualitative and quantitative surfaceome models explaining how molecular nanoscale organization influences cellular signaling and biological function.
Inhalt"If a cell surface molecule such as the B cell receptor would have the size of a human being, then the cell surface of a B cell would have roughly the size of three times NYC Central Park." How many people/proteins/proteoforms reside in this space ("Surfaceome")? Similar to humans, proteins don't act alone. Function is encoded in dynamic protein-protein interactions. How are these proteoforms organized in signaling islands/networks in order to fulfill specific cellular functions ("Interactome")? What are the ligands interacting with the surfaceome to communicate information from other cells & tissues in the body? What goes wrong in these signaling islands if we get sick?

In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome and its signaling islands as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to generate unprecedented data to establish the surfaceome proteotype and its signaling interaction networks. This digital proteotype data layer provides the basis for generating qualitative and quantitative surfaceome models explaining how molecular nanoscale organization influences cellular signaling and biological function.
LiteraturD. Bausch-Fluck, E. S. Milani, B. Wollscheid, Surfaceome nanoscale organization and extracellular interaction networks, Curr. Opin. Chem. Biol. 48, 26–33 (2019).

Link
Voraussetzungen / BesonderesThis course requires a basic knowledge in mass spectrometry based proteomics and experience in computational data processing using R or MatLab. Ideally this course should be combined with course 551-0352-00L "Introduction to Mass Spectrometry-based Proteomics".
529-0810-01LOrganische Chemie II (für D-BIOL) Belegung eingeschränkt - Details anzeigen
-Wo immer möglich müssen die Distanzregeln eingehalten werden.
-Alle Studierende müssen während des gesamten Kurses Masken tragen. Bitte Reserve-Masken bereithalten. Zugelassen sind Hygienemasken (IIR) oder Schutzmasken (FFP2) ohne Ventil. Community Masken (Stoffmasken) sind nicht erlaubt.
-Die Installation und Aktivierung der Schweizer Covid-App ist sehr zu empfehlen.
-Alle zusätzlichen Regeln für einzelne Kurse müssen eingehalten werden -Studierende, die COVID-19-Symptome aufweisen, dürfen die ETH-Gebäude nicht betreten und müssen den verantwortlichen Kursleiter informieren.
W12 KP4PC. Thilgen
KurzbeschreibungBearbeiten eines organisch-synthetischen Teilprojekts aus der aktuellen Forschung einer Gruppe des Laboratoriums für Organische Chemie unter der Anleitung von Doktorierenden.
LernzielErlernen von Planung und Durchführung anspruchsvoller Mehrstufensynthesen unter Einbezug moderner Methoden; vertieftes Verständnis organisch-chemischer Reaktionen durch Experimente; Entwickeln eines organisch-synthetischen Forschungsprojekts; akkurates Protokollieren, Verfassen eines Berichts im Stil einer Veröffentlichung und Präsentieren der Ergebnisse in Form eines Kurzvortrags.
InhaltBearbeiten eines organisch-synthetischen Teilprojekts aus der aktuellen Forschung einer Gruppe des Laboratoriums für Organische Chemie unter der Anleitung von Doktorierenden.
SkriptKein Skript.
LiteraturKeine Pflichtliteratur. Literatur wird von den betreuenden Doktorierenden angegeben bzw. zur Verfügung gestellt.
Voraussetzungen / BesonderesVoraussetzungen: bestandenes Praktikum Organische Chemie I (529-0229-00); bestandene Sessionsprüfung Organische Chemie I (529-0221-00 bzw. 529-1011-00) / Organische Chemie II (529-0222-00 bzw. 529-1012-00). Die Zahl der Teilnehmenden ist auf 12 beschränkt.
551-0344-00LPlant Microbiomes Belegung eingeschränkt - Details anzeigen
Number of participants limited to 8.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PJ. Vorholt-Zambelli
KurzbeschreibungLaboratory course. Research projects in the field of plant microbiomes are conducted in small groups. They address open questions related to plant microbiomes and include microbial community assembly, microbial interactions, plant protection and plant immunity.
LernzielIntroduction to relevant subjects of the biology of plant-associated microorganisms. Training in practical work in a research laboratory. Exposure to current research topics in the field of plant microbiomes. Scientific writing in form of a research report.
InhaltResearch project in plant microbiomes. The techniques used will depend on the project, e.g. PCR, cloning, microbial community analysis via next-generation sequencing, plant inoculation experiments, phenotypic analyses, fluorescence microscopy, gene expression, metabolomics, bioinformatics
Skriptnone
LiteraturWill be provided for each of the projects at the beginning of the course.
551-1556-00LMacromolecular Structure Determination Using Modern Methods Belegung eingeschränkt - Details anzeigen
Number of participants limited to 11 in the 3rd semester quarter of the spring semester

Number of participants limited to 12 in the 4th semester quarter of the spring semester

The block course will only take place with a minimum of 4 participants.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PK. Locher, R. Irobalieva, J. Kowal, G. Schertler
KurzbeschreibungThis course will expose the students to two prominent techniques for high-resolution structural characterization of biological macromolecules. The students will have the opportunity to get hands-on experience in either cryo-electron microscopy (ETH) or X-ray crystallography (PSI).
LernzielThe goal of this course is to introduce the students to the principles of high-resolution structure determination. Students will conduct hands-on experiments and use computational techniques for data processing.
InhaltAt the ETH the students will prepare and vitrify a protein and then image it on a cryo-TEM. Next, the students will process the data and build an atomic model into the EM map.

At the PSI the students will purify and crystallize a membrane protein, collect X-ray diffraction data using synchrotron X-ray source or with cryo-EM, analyze and build an atomic model into a density map. They will refine this model and interpret and illustrate the determined structure. The course work is trying to present insights in the use of structural information. The course also includes a demonstration of the Synchrotron capabilities at the Paul Scherrer Institute (SLS).
Voraussetzungen / BesonderesThe students will be split into two groups for the practical part of the work: One group will work at ETH Hönggerberg, the other at the Paul Scherrer Institute (PSI) at Villigen. All students will spend one full day at the PSI for a tour of the facilities, including a visit of the synchrotron beam lines of the Swiss Light Source SLS.

The students joining the ETH Hönggerberg group will spend the majority of the time on data processing and are therefore expected to have some basic knowledge of bash terminal commands. Basic physics, optics and linear algebra knowledge is also helpful. By the end of the course, the students will be expected to understand concepts such as the difference between Fourier and real space, image formation, contrast transfer, fast Fourier transfer and Fourier shell correlation.
551-1312-00LRNA-Biology II Belegung eingeschränkt - Details anzeigen
Number of participants limited to 14.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PS. Jonas, F. Allain, J. Corn, U. Kutay, O. Voinnet
KurzbeschreibungIntroduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells.
LernzielThe students will obtain an overview about the diversity of current RNA-research. They will learn to design experiments and use techniques necessary to analyze different aspects of RNA biology. Through lectures and literature seminars, they will learn about the burning questions of RNA research and discuss approaches to address these questions experimentally. In practical lab projects the students will work in one of the participating laboratories. Finally, they will learn how to present and discuss their data in an appropriate manner. Student assessment is a graded semester performance based on individual performance in the laboratory, the written exam and the project presentation.
SkriptRelevant material from the lectures will be made available during the course via the corresponding Moodle page.
LiteraturDocumentation and recommended literature will be provided at the beginning and during the course.
551-1300-00LCause and Consequences of Unstable Genomes Belegung eingeschränkt - Details anzeigen
Number of participants limited to 14.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PM. Jagannathan, Y. Barral, C. Beyer, K. Bomblies, R. Kroschewski, G. Neurohr
KurzbeschreibungThe course will introduce students to key concepts and laboratory research within the broad field of "Genome stability".
LernzielStudents will learn to design, apply and evaluate current research strategies in a wide range of modern research areas encompassing the broad field of "Genome stability".
InhaltThe course will consist of lectures, practical laboratory work in small groups, informal progress report sessions, and the presentation of laboratory work. Lectures will expose students to key concepts and techniques in the field. Students will team into small groups and work in one laboratory for the duration of the course. Students will meet regularly for informal "progress report" discussions of their projects. Student performance will be assessed based on the quality of their practical work, a written exam on frontal lecture material, and a presentation of their practical work.
LiteraturDocumentation and recommended literature in the form of review articles and selected primary literature will be provided during the course.
Voraussetzungen / BesonderesThis course will be taught in English.
Blockkurse im 4. Semesterviertel
Von 14.05.2021 bis 04.06.2021
NummerTitelTypECTSUmfangDozierende
551-0376-00LExperimentelle Pflanzenökologie Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 20
Wird nur bei mindestens 4 Teilnehmenden durchgeführt.

Die Belegung erfolgt durch das D-BIOL Studiensekretariat.

Allgemeine Sicherheitsbestimmungen für alle Blockkurse:
-Wo immer möglich müssen die Distanzregeln eingehalten werden
-Alle Studierende müssen während des gesamten Kurses Masken tragen. Bitte Reserve-Masken bereithalten. Zugelassen sind Hygienemasken (IIR) oder Schutzmasken (FFP2) ohne Ventil. Community Masken (Stoffmasken) sind nicht erlaubt.
-Die Installation und Aktivierung der Schweizer Covid-App ist sehr zu empfehlen.
-Alle zusätzlichen Regeln für einzelne Kurse müssen eingehalten werden
-Studierende, die COVID-19-Symptome aufweisen, dürfen die ETH-Gebäude nicht betreten und müssen den verantwortlichen Kursleiter informieren.
W6 KP7PD. Ramseier, H. G. M. Olde Venterink
KurzbeschreibungDer Blockkurs gibt eine Einführung in die experimentelle Pflanzenökologie. Dabei wird mittels Vorlesungen, Demonstrationen, Exkursionen und eigenen Experimenten ein weites Spektrum von praxisnahen (für die Naturschutzpraxis) Experimenten über Einfluss von "global change"-Faktoren auf Ökosysteme bis zu Grundlagenforschung zur Koexistenz von Pflanzen in Ökosystemen abgedeckt.
Lernziel- Kennen lernen und evaluieren verschiedener experimenteller Ansätze, der Messmethoden und der benötigten Instrumente in der experimentellen Pflanzenökologie.
- Erlangung praktischer Fähigkeiten zur Durchführung und Auswertung pflanzenökologischer Experimente
InhaltExperimente in der Pflanzenökologie gewinnen zunehmend an Bedeutung zur Abschätzung des Einflusses von "Global Change" und invasiven Arten auf Ökosysteme und deren Funktionen und "ecosystem Services". Ausserdem gibt es viele Renaturierungsprojekte, wo man vom "trial - error"-Prinzip wegkommen möchte und aufgrund gezielter Experimente den Erfolg von Renaturierungsmassnahmen antizipieren möchte um die Planung entsprechend anpassen zu können.
In diesem Blockkurs wird ein Einblick in dieses Fachgebiet mittels Vorlesungen, Demonstrationen, Exkursionen, Literaturstudium und allem voran Experimenten in Gruppen vermittelt. In einem theoretischen Teil werden unter anderem Vor- und Nachteile verschiedener experimenteller Ansätze, Messmethoden und Geräten diskutiert.
Im praktischen Teil werde die Studierenden gruppenweise Experimente von A bis Z durchführen; dies beinhaltet klare Fragestellungen erarbeiten, Literatursuche, Anlage und Unterhalt der Experimente, Messungen, allenfalls chemische Analysen, Auswertungen und Vorträge. Beispiele von Experimenten: a) Einfluss funktioneller Gruppen auf die kühlende Wirkung von Flachdachbegrünungen; b) Einfluss der Mobilität von Nährstoffen im Boden auf die Konkurrenz und die Koexistenz von Pflanzen; c) Verhindert P-Mangel die weitere Ausbreitung von Amorpha fruticosa, einer invasiven Fabaceae am Tagliamento (N-Italien)? Wie optimieren Samen ihr Keimungsverhalten? Wie kann die Keimung für Renaturierungsprojekte oder Flachdachbegrünungen verbessert werden?
Auf einer der Exkursionen werden wir das Renaturierungsprojekt Seebachtalseen (Link), an welchem einer der Dozenten für die Wieder-etablierung von Flachmoorgesellschaften seit vielen Jahren beteiligt ist, besuchen. Auf einer andern Exkursionen werden wir einen langjährigen Flachdachversuch betreffs Einfluss verschiedener Substrate und unterschiedlicher Substratdicke auf die Entwicklung der Vegetation beleuchten.
SkriptUnterlagen werden im Kurs verteilt
Voraussetzungen / BesonderesDie Art von pflanzenökologischen Versuchen, wie sie innerhalb dieses Kurses angelegt werden, dauern typischerweise 6-8 Wochen. Daher werden sie vor dem eigentlichen Block durch die Studierenden eingerichtet und im Block (letztes Semesterquartal) geerntet. Wir geben zu Beginn des Semesters eine 45 minütige Einführung (Termin nach Absprache), bei welcher die Themenwahl und die Gruppeneinteilung stattfinden wird. Die Experimente werden danach gruppenweise angelegt. Die vor dem eigentlichen Block aufgewendete Zeit kann kompensiert werden.
376-1398-00LCellular and Behavioural Neuroscience Belegung eingeschränkt - Details anzeigen
Number of participants limited to 10.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected.
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged.
-Any additional rules for individual courses have to be respected.
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible.
W6 KP7PG. Schratt, J. Bohacek
KurzbeschreibungEinführung in unsere Forschung und Mitarbeit bei aktuellen Forschungsprojekten mit dem Ziel, selbstständiges wissenschaftliches Denken zu fördern und theoretisches Wissen in praktische Experimente umzusetzen. Der Kurs beinhaltet zudem das Lesen von Originalliteratur und die Präsentation der eigenen Arbeit.
LernzielMitarbeit bei aktuellen Forschungsprojekten mit dem Ziel, selbstständiges wissenschaftliches Denken zu fördern und theoretisches Wissen in praktische Experimente umzusetzen. Weitere Ziele sind das Lesen und die Interpretation von Originalliteratur und die Präsentation der eigenen Arbeit.
InhaltEinführung in unsere Forschung und Mitarbeit bei aktuellen Forschungsprojekten mit dem Ziel, selbstständiges wissenschaftliches Denken zu fördern und theoretisches Wissen in praktische Experimente umzusetzen. Die experimentellen Ansätze schliessen in vivo Experimente mit Ratten und/oder Mäusen ein. Neben den Verhaltensexperimenten werden auch histologisch-anatomische Auswertungen gemacht. Der Kurs beinhaltet zudem das Lesen von Originalliteratur und die Präsentation der eigenen Arbeit.
SkriptOriginalartikel werden während des Kurses ausgehändigt und diskutiert.
LiteraturOriginalartikel werden während des Kurses ausgehändigt und diskutiert.
551-1556-00LMacromolecular Structure Determination Using Modern Methods Belegung eingeschränkt - Details anzeigen
Number of participants limited to 11 in the 3rd semester quarter of the spring semester

Number of participants limited to 12 in the 4th semester quarter of the spring semester

The block course will only take place with a minimum of 4 participants.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PK. Locher, R. Irobalieva, J. Kowal, G. Schertler
KurzbeschreibungThis course will expose the students to two prominent techniques for high-resolution structural characterization of biological macromolecules. The students will have the opportunity to get hands-on experience in either cryo-electron microscopy (ETH) or X-ray crystallography (PSI).
LernzielThe goal of this course is to introduce the students to the principles of high-resolution structure determination. Students will conduct hands-on experiments and use computational techniques for data processing.
InhaltAt the ETH the students will prepare and vitrify a protein and then image it on a cryo-TEM. Next, the students will process the data and build an atomic model into the EM map.

At the PSI the students will purify and crystallize a membrane protein, collect X-ray diffraction data using synchrotron X-ray source or with cryo-EM, analyze and build an atomic model into a density map. They will refine this model and interpret and illustrate the determined structure. The course work is trying to present insights in the use of structural information. The course also includes a demonstration of the Synchrotron capabilities at the Paul Scherrer Institute (SLS).
Voraussetzungen / BesonderesThe students will be split into two groups for the practical part of the work: One group will work at ETH Hönggerberg, the other at the Paul Scherrer Institute (PSI) at Villigen. All students will spend one full day at the PSI for a tour of the facilities, including a visit of the synchrotron beam lines of the Swiss Light Source SLS.

The students joining the ETH Hönggerberg group will spend the majority of the time on data processing and are therefore expected to have some basic knowledge of bash terminal commands. Basic physics, optics and linear algebra knowledge is also helpful. By the end of the course, the students will be expected to understand concepts such as the difference between Fourier and real space, image formation, contrast transfer, fast Fourier transfer and Fourier shell correlation.
551-0334-00LMolecular Defense Mechanisms of Fungi Belegung eingeschränkt - Details anzeigen
Number of participants limited to 6.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PM. Künzler
KurzbeschreibungThe course offers an introduction into the molecular biology of fungi by participation in a current research project on Molecular Defense Mechanisms of Fungi. The performed experiments, in conjunction with accompanying seminars should enable the students to answer questions regarding central aspects of innate defense mechanisms and the life style of multicellular fungi.
LernzielThe course should enable the students to answer questions regarding central aspects of innate defense mechanisms and the life style of multicellular fungi, and their experimental accessibility.
InhaltExperiments include the isolation, identification and characterization of defense effector molecules from multicellular fungi. Methods include molecular genetics, biochemistry, mass spectrometry and biotoxicity assays towards different model organisms including fungi, bacteria, insects and nematodes. Experiments are supported by seminars giving an overview over Fungal Defense Mechanisms and Fungal Lifestyle.
LiteraturLink
Voraussetzungen / BesonderesThe "Leistungskontrolle" is composed of:
-Oral presentation of results
-Short oral exam (20') at the end of the course
-Written report
-Performance in the laboratory
Blockkurse in den Semesterferien
NummerTitelTypECTSUmfangDozierende
551-0396-01LImmunology I Belegung eingeschränkt - Details anzeigen
Number of participants limited to 30.

Prerequisites: Attendance of the concept courses Immunology I (551-0317-00L) and Immunology II (551-0318-00L)

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PA. Oxenius, B. Becher, M. Groettrup, M. Kopf, B. Ludewig, C. Münz, R. Spörri, M. van den Broek
KurzbeschreibungDieser Blockkurs in Immunologie vermittelt einen breiten Einblick und eine Einführung in praktisches Immunologisches Arbeiten sowie theoretische Vertiefungen in ausgewählten Gebieten der Immunologie.
LernzielDas Ziel des Blockkurses ist das Erlernen verschiedener immunologischer Techniken und umfasst die experimentelle Durchführung als auch Analyse und Interpretation der experimentellen Daten. Begleitet wird der praktische Teil von vertiefenden Vorlesungen in ausgewählten Gebieten der Immunologie, welche auf dem Inhalt des Immunologie-Konzeptkurses basieren. Selbständiges Erarbeiten und Präsentieren von Publikationen durch die Studenten bietet Grundlage für wissenschafltiche Diskussionen.
InhaltPraktische Arbeiten: Zellkultur, Isolation hämatopoietische Stammzellen und Differenzierung von Makrophagen und dendritischen Zellen, Aktivierung und Zytokinproduktion durch Makrophagen und dendritische Zellen, 51Cr release assay, VSV Neutralisationsassay, Durchflusszytometrie, Proliferationsexperimente, SEREX, Intrazelluläres Zytokinstaining, Immunhistologie und Fluoreszenzmikroskopie, MACS, Zytokin-Bioassays, Phagozytose, Proteosomale Prozessierung
Vertiefende Vorlesungen: Immune responses to pathogens, Vaccination and B cells, Tolerance & Autoimmunity, Antigen processing & presentation, Pattern recognition, NK cells, Generation of (TCR) tg or ko mice, Antigen screening and definition
SkriptEin Skript wird vor Kursbeginn online abrufbar sein (link wird im Immunologie-konzeptkurs bekannt gegeben, 551-0318-00L).
Voraussetzungen / BesonderesVoraussetzung für die Anmeldung zum Kurs ist der Besuch der Immunologie-Konzeptvorlesungen 551-0317-00L und 551-0318-00L.
Leistungskontrolle erfolgt individuell durch die beteiligten Dozenten.
701-2314-00LPflanzendiversität Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 4 (D-BIOL)

Voraussetzung: Teilnahme und bestandene Prüfung an der LV 701-0360-00L (Systematische Biologie: Pflanzen).

Belegung durch primäre Zielgruppe bis 19.02.2021.
Führung einer Warteliste bis 31.3.2021

Das Anmeldeformular muss bis 05.03.2021 eingereicht werden. Nicht bestätigte Plätze werden an Studierende auf der Warteliste vergeben.

Allgemeine Sicherheitsbestimmungen für alle Blockkurse:
-Wo immer möglich müssen die Distanzregeln eingehalten werden.
-Alle Studierende müssen während des gesamten Kurses Masken tragen. Bitte Reserve-Masken bereithalten. Zugelassen sind Hygienemasken (IIR) oder Schutzmasken (FFP2) ohne Ventil. Community Masken (Stoffmasken) sind nicht erlaubt.
-Die Installation und Aktivierung der Schweizer Covid-App ist sehr zu empfehlen.
-Alle zusätzlichen Regeln für einzelne Kurse müssen eingehalten werden -Studierende, die COVID-19-Symptome aufweisen, dürfen die ETH-Gebäude nicht betreten und müssen den verantwortlichen
W6 KP12PR. Berndt, A. Guggisberg
KurzbeschreibungIm Praktikum beschäftigen wir uns mit der Flora und Vegetation ausgewählter Gebiete von der kollinen bis in die alpine Stufe. Während zweier Geländepraktika vertiefen die Studierenden ihre Artenkenntnis und lernen wichtige Vegetationseinheiten und deren standörtliche Besonderheiten kennen.
LernzielKennenlernen der wichtigsten Vegetationstypen, deren Pflanzenarten und ökologischen Bedingungen von der kollinen bis in die alpine Stufe. Vertiefung taxonomischer und pflanzenmorphologischer Kenntnisse und Erwerb von Bestimmungspraxis mit einer wissenschaftlichen Bestimmungsflora. Erlernen der Grundlagen des wissenschaftlichen Sammelns und Herbarisierens von Pflanzen (Kursteil I kollin/montan).
InhaltIn diesem Kurs erweitern die Studierenden ihre Artenkenntnis und ihre Kenntnis der Pflanzenfamilien und Pflanzenmorphologie. Während der Exkursionen studieren wir ausserdem die Pflanzen in ihren charakteristischen Vegetationseinheiten und besprechen deren ökologische Bedingungen sowie eventuelle Anpassungen. Siehe weitere Details unter den jeweiligen Kursteilen.
Literatur- Baltisberger M., Nyffeler R. & Widmer A. 2013: Systematische Botanik. 4., vollständig überarbeitete und erweiterte Aufl. v/d/f Hochschulverlag AG an der ETH Zürich.
- Stützel T. 2015. Botanische Bestimmungsübungen (3. Aufl.). UTB, Ulmer Verlag.
- Hess H.E., Landolt E., Hirzel R. & Baltisberger M. 2015: Bestimmungsschlüssel zur Flora der Schweiz. 7., aktualisierte und überarbeitete Aufl., Birkhäuser Verlag, Basel/Boston/Berlin.
Voraussetzungen / BesonderesAm Praktikum können nur Studierende teilnehmen, die die einführenden Vorlesungen zur Systematischen Botanik sowie die zugehörigen Exkursionen und Übungen erfolgreich absolviert haben (siehe LV 701-0360-00L Systematische Biologie: Pflanzen). Es wird erwartet, dass die Teilnehmerinnen und Teilnehmer den grundlegenden Umgang mit einer Bestimmungsflora beherrschen (Bestimmungsschlüssel zur Flora der Schweiz) und mit der notwendigen pflanzenmorphologischen Terminologie vertraut sind.

Studierende anderer Universitäten nehmen bitte Kontakt mit den Dozierenden auf.

Programm:
Kursteil I kollin/montan: Je nach aktueller CoVid-Situation sind Programmänderungen möglich!
15.-19.6.: Tagesexkursionen (gesonderte Ankündigung)
22.6.: Prüfung (9-11 Uhr, HIL E1)

Kursteil II subalpin/alpin:
27.6.-1.7.: individuelle Aktivitäten oder geführte Tagesexkursionen (gesonderte Ankündigung)
3.7.: Prüfung im ETH Zentrum

Die Exkursion finden bei jedem Wetter statt. Sie erfordern deshalb Geländegängigkeit und angepasste Ausrüstung der Teilnehmerinnen und Teilnehmer. Feste Bergschuhe sind Pflicht!

Kosten:
Es fallen keine Kosten an.
551-0438-00LProtein Folding, Assembly and Degradation Belegung eingeschränkt - Details anzeigen
Number of participants limited to 6.

The enrolment is done by the D-BIOL study administration.

General safety regulations for all block courses:
-Whenever possible the distance rules have to be respected
-All students have to wear masks throughout the course. Please keep reserve masks ready. Surgical masks (IIR) or medical grade masks (FFP2) without a valve are permitted. Community masks (fabric masks) are not allowed.
-The installation and activation of the Swiss Covid-App is highly encouraged
-Any additional rules for individual courses have to be respected
-Students showing any COVID-19 symptoms are not allowed to enter ETH buildings and have to inform the course responsible
W6 KP7PR. Glockshuber, E. Weber-Ban
KurzbeschreibungStudents will carry out defined research projects related to the current research topics of the groups of Prof. Glockshuber and Prof. Weber-Ban. The topics include mechanistic studies on the assembly of adhesive pili from pathogenic bacteria, disulfide bond formation in the bacterial periplasm, ATP-dependent chaperone-protease complexes and formation of amyloid deposits in Alzheimer's disese.
LernzielThe course should enable the students to understand and apply biophysical methods, in particular kinetic and spectroscopic methods, to unravel the mechanism of complex reactions of biological macromolecules and assemblies in a quantitative manner.
InhaltThe students will be tutored in their experimental work by doctoral or postdoctoral students from the Glockshuber or Weber-Ban group. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as excercises on the numeric evaluation of biophysical data, and literature work.

Participation in one of the following projects will be possible:

Projects of the Glockshuber group:
- Purification, biophysical characterization and structure determiation of enzymes required for disulfide bond formation in the periplasm of Gram-negative bacteria.
- Mechanistic studies on the assembly of type 1 pili from pathogenic Escherichia coli strains. In vitro reconstitution of pilus assembly from all purified components. Characterization of folding, stability and assembly behaviour of individual pilus subunits.
- Identification of intermediates in the aggregation of the human Abeta peptide

Experimental work on these projects involves
- Molecular cloning, recombinant protein production in E. coli and protein purification
- Protein crystallization
- Thermodynamic and kinetic characterization of conformational changes in proteins and protein-ligand interactions by fluorescence and circular dischoism spectroscopy
- Analysis of rapid reactions by stopped-flow fluorescence
- Negative-stain electron microscopy
- Light scattering



Projects of the Weber-Ban group:

- Generation and purification of site-directed variants of the E. coli ClpA/P protease and chaperone-proteasome complexes from other organisms, their biophysical characterization, including rapid kinetics by stopped-flow methods, ATPase activity measurtements, negative-stain electron microscopy and light scattering
Voraussetzungen / BesonderesMarks will be given according to the following criteria:

- Planning, execution and documentation of experimental work
- Final report, including introduction with short overview on the relevant literature, results with figures and brief discussion (maximum: 5 pages)
- Performance in the exercises
GESS Wissenschaft im Kontext
Wissenschaft im Kontext
» Empfehlungen aus dem Bereich Wissenschaft im Kontext (Typ B) für das D-BIOL
» siehe Studiengang Wissenschaft im Kontext: Typ A: Förderung allgemeiner Reflexionsfähigkeiten
Sprachkurse
» siehe Studiengang Wissenschaft im Kontext: Sprachkurse ETH/UZH
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