Search result: Catalogue data in Autumn Semester 2022
Chemical and Bioengineering Master  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Biochemical Engineering | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0837-01L | Biomicrofluidic Engineering  Number of participants limited to 25. | W+ | 6 credits | 3G | A. de Mello | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Microfluidics describes the behaviour, control and manipulation of fluids geometrically constrained within sub-uL environments. Microfluidic devices enable physical and chemical processes to be controlled with exquisite precision and in an fast and efficient manner. This course introduces the underlying concepts, features and applications of microfluidic systems in the chemical and life sciences. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | We will investigate the theoretical concepts behind microfluidic device operation, the methods of microfluidic device manufacture and the application of microfluidic architectures to important problems faced in modern day chemical and biological analysis. A central component of this course is a research project. This will allow students to develop a practical understanding of the benefits of miniaturization in chemical and biological experimentation. Projects will be performed in groups of between four and six students and will include both experimental and simulation aspects. Each group, under the guidance of a mentor, will plan and execute a novel research project. The results of this activity will be disseminated through an 'academic-style" research article and a "conference-style" oral presentation. Course grades will be evaluated through both a written exam and the project grade. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Specific topics covered in the course include, but are not limited to: 1. Theoretical Concepts Scaling laws, features of thermal/mass transport, diffusion, basic description of fluid flow in small volumes, microfluidic mixing strategies. 2. Microfluidic Device Manufacture Basic principles of conventional lithography of rigid materials, ‘soft’ lithography, polymer machining (injection molding, hot embossing, and 3D-printing). 3. Electrokinetics Principles of electrophoresis, electroosmosis, high performance capillary electrophoresis, electrokinetic scaling laws, chip-based electrophoresis and isoelectric focusing. 4. Mass Transfer Phenomena Key features of mass transport in microfluidic systems, diffusive transport, diffusion-convection, Péclet number, Taylor-Aris diffusion, chaotic mixing and Damköhler numbers. 5. Heat Transfer Phenomena Key features of thermal transport in microfluidic systems, conduction, convection, heat transfer by convection in internal flows, heat transfer processes in microfluidic devices. 6. Microfluidic Systems for Materials Synthesis Microfluidic reactors for the controlled synthesis of colloidal nanomaterials, advanced automation for bespoke materials discovery & characterization. 7. Point-of-Care Diagnostics Microscale tools for diagnostics, challenges associated with point-of-care (PoC) diagnostic testing, requirements for PoC devices, common PoC device formats, applications of PoC diagnostics in the developing world. 8. Microscale DNA Amplification Amplification and analysis of nucleic acids using batch, continuous flow and droplet-based microfluidic reactors. 9. Small volume Molecular Detection Spectroscopic approaches for analyte detection in small volumes with a particular focus on single molecule detection. 10. Droplets and Segmented Flows Formation, manipulation and use of liquid/liquid segmented flows in chemical and biological experimentation. 11. Single Cell Analysis Applications of microfluidic tools in cellular analysis, flow cytometry, enzymatic assays and single cell analysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture handouts, background literature, problem sheets and notes will be provided electronically through the course Moodle site. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | There is no set text for the course. All relevant literature will be provided electronically through the course Moodle site. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 529-0615-01L | Biochemical and Polymer Reaction Engineering | W+ | 6 credits | 3G | P. Arosio | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Polymerization reactions and processes. Homogeneous and heterogeneous (emulsion) kinetics of free radical polymerization. Post treatment of polymer colloids. Bioprocesses for the production of molecules and therapeutic proteins. Kinetics and design of aggregation processes of macromolecules and proteins. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of the course is to learn how to design polymerization reactors and bioreactors to produce polymers and proteins with the specific product qualities that are required by different applications in chemical, pharmaceutical and food industry. This activity includes the post-treatment of polymer latexes, the downstream processing of proteins and the analysis of their colloidal behavior. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | We will cover the fundamental processes and the operation units involved in the production of polymeric materials and proteins. In particular, the following topics are discussed: Overview on the different polymerization processes. Kinetics of free-radical polymerization and use of population balance models. Production of polymers with controlled characteristics in terms of molecular weight distribution. Kinetics and control of emulsion polymerization. Surfactants and colloidal stability. Aggregation kinetics and aggregate structure in conditions of diffusion and reaction limited aggregation. Modeling and design of colloid aggregation processes. Physico-chemical characterization of proteins and description of enzymatic reactions. Operation units in bioprocessing: upstream, reactor design and downstream. Industrial production of therapeutic proteins. Characterization and engineering of protein aggregation. Protein aggregation in biology and in biotechnology as functional materials. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts are available on the web page of the Arosio-group: http://www.arosiogroup.ethz.ch/education.html Additional handout of slides will be provided during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | R.J. Hunter, Foundations of Colloid Science, Oxford University Press, 2nd edition, 2001 D. Ramkrishna, Population Balances, Academic Press, 2000 H.W. Blanch, D. S. Clark, Biochemical Engineering, CRC Press, 1995 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Products and Materials | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0619-01L | Chemical Product Design Prerequisites: Basic chemistry and chemical engineering knowledge (Diffusion, Thermodynamics, Kinetics,...). | W+ | 6 credits | 3G | W. J. Stark | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The 'Chemical Product Design' course teaches students quantitative concepts to analyze, select and transform theoretical concepts from chemistry and engineering into valuable real-world products. Basic chemistry and chemical engineering knowledge is required (Diffusion, Thermodynamics, Kinetics, ..). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | This course starts with analyzing existing chemical needs and unmet technical challenges. We then develop the skills to critically analyze a specific chemical idea for a product, to rapidly test feasibility or chance for success and to eventually realize its manufacturing. The chemical engineering basics are then used to assess performance of products or devices with non-traditional functions based on dynamic properties (e.g. responsive building materials; personal medical diagnostics on paper strips). The course teaches the interface between laboratory and market with a specific focus on evaluating the chemical value of a given process or compound, and the necessary steps to pursue the resulting project within an entrepreneurial environment. We therefore extend the questions of process design ('how do we make something?') to the question of 'what should we make? | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Part A: The 'Chemical Product Design' course starts with discussing questions along, 'What is a chemical product, and why do people pay for it? How does a given compound in a specific setting provide a service?' We then learn how to translate new, often ill-defined wishes or ideas into quantifiable specifications. Part B: Thermodynamic and kinetic data allow sharp selection criteria for successful products. We learn how to deal with insufficient data and development of robust case models to evaluate their technical and financial constraints. How can parameters of a running process in one industry be scaled into another industry? Can dimensionless engineering numbers be applied beyond traditional chemical processes? Part C: Manufacturing of commodity products, devices and molecular products: Chemical reactors, separation and detection or isolation units as part of a toolbox. Planning of manufacturing and decisions based on hard data. Providing quantitative answers on potential value generated. Students are expected to actively develop chemical products along the course. Contributions will be made individually, or in small groups, where a larger topic is studied. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Cussler, E.L., Moggridge, C.D., Chemical Product Design, Cambridge University Press, Cambridge, UK, 2nd edition, 2011. Original Literature: Issues and Trends in the Teaching of Process and Product Design, Biegler, L.T., Grossmann, I.E., Westerber, A.W., AIChE J., 56 (5) 1120-25, 2010. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisites: Basic chemistry and chemical engineering knowledge (Diffusion, Thermodynamics, Kinetics,...). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Process Design | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0643-01L | Process Design and Development | W+ | 6 credits | 3G | G. Guillén Gosálbez | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course is focused on the design of Chemical Processes, with emphasis on the preliminary stages of the design approach, where process creation and quick selection among many alternatives are important. The main concepts behind more detailed process design and process simulation are also examined. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The course is focused on the design of Chemical Processes, with emphasis on the preliminary stage of the design approach, where process creation and quick selection among many alternatives are important. The main concepts behind more detailed process design and process simulation are also examined. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Process creation: heuristics vs. mathematical programming. Heuristics for reaction and separation operations, heat transfer and pressure change. Introduction to optimization in process engineering and the modeling software GAMS. Process economic evaluation: equipment sizing and costing, time value of money, cash flow calculations. Process environmental evaluation: Life Cycle Assessment (LCA). Process integration: sequencing of distillation columns using mixed-integer linear programming (MILP), and synthesis of heat exchanger networks using mixed-integer nonlinear programming (MINLP). Batch processes: scheduling, sizing, and inventories. Principles of molecular design using mixed-integer programming. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | no script | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Main books 1. Biegler, L.T., Grossmann, I.E., Westerberg, A.W. Systematic methods of chemical process design, Prentice Hall International PTR (1997). 2. Douglas, J.M. Conceptual design of chemical processes, McGraw-Hill (1988). 3. Seider, W.D., Seader, J.D., Lwin, D.R., Widagdo, S. Product and process design principles: synthesis, analysis, and evaluation, John Wiley & Sons, Inc. (2010). 4. Sinnot, R.K., Towler, G. Chemical Engineering Design, Butterworth-Heinemann (2009). 5. Smith, R. Chemical process design and integration, Wiley (2005). Other references 6. Edgar, T. F., Himmelblau, D. M. Optimization of chemical process, Mcgraw Hill Chemical Engineering Series (2001). 7. Haydary, J. Chemical Process Design and Simulation, Wiley (2019). 8. Turton, R., Shaeiwitz, A., Bhattacharyya, D., Whiting, W. Synthesis and Design of Chemical Processes, Prentice Hall (2013). 9. Klöpffer, W., Grahl, B. Life Cycle Assessment (LCA): A Guide to Best Practice, Wiley (2014). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisite: Basic knowledge on unit operations, mainly reaction engineering and distillation. It is recommended that the student takes the module "Process Simulation and Flowsheeting" before "Process Design and Development", but it is not mandatory. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0613-01L | Process Simulation and Flowsheeting | W+ | 6 credits | 3G | G. Guillén Gosálbez | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This course encompasses the theoretical principles of chemical process simulation and optimization, as well as its practical application in process analysis. The techniques for simulating stationary and dynamic processes are presented, and illustrated with case studies. Commercial software packages (Aspen) are introduced for solving process flowsheeting and optimization problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | This course aims to develop the competency of chemical engineers in process flowsheeting, process simulation and process optimization. Specifically, students will develop the following skills: - Deep understanding of chemical engineering fundamentals: the acquisition of new concepts and the application of previous knowledge in the area of chemical process systems and their mechanisms are crucial to intelligently simulate and evaluate processes. - Modeling of general chemical processes and systems: students should be able to identify the boundaries of the system to be studied and develop the set of relevant mathematical relations, which describe the process behavior. - Mathematical reasoning and computational skills: the familiarization with mathematical algorithms and computational tools is essential to be capable of achieving rapid and reliable solutions to simulation and optimization problems. Hence, students will learn the mathematical principles necessary for process simulation and optimization, as well as the structure and application of process simulation software. Thus, they will be able to develop criteria to correctly use commercial software packages and critically evaluate their results. - Process optimization: the students will learn how to formulate optimization problems in mathematical terms, the main type of optimization problems that exist (i.e., LP, NLP, MILP and MINLP) and the fundamentals of the optimization algorithms implemented in commercial solvers. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Overview of process simulation and flowsheeting: - Definition and fundamentals - Fields of application - Case studies Process simulation: - Modeling strategies of process systems - Mass and energy balances and degrees of freedom of process units and process systems Process flowsheeting: - Flowsheet partitioning and tearing - Solution methods for process flowsheeting - Simultaneous methods - Sequential methods Process optimization and analysis: - Classification of optimization problems - Linear programming, LP - Non-linear programming, NLP - Mixed-integer linear programming, MILP - Mixed-integer nonlinear programming, MINLP Commercial software for simulation (Aspen Plus): - Thermodynamic property methods - Reaction and reactors - Separation / columns - Convergence, optimisation & debugging | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | An exemplary literature list is provided below: - Biegler, L.T., Grossmann, I.E., Westerberg, A.W. Systematic methods of chemical process design, Prentice Hall International PTR (1997). - Douglas, J.M. Conceptual design of chemical processes, McGraw-Hill (1988). - Edgar, T. F., Himmelblau, D. M. Optimization of chemical process, Mcgraw Hill Chemical Engineering Series (2001). - Haydary, J. Chemical Process Design and Simulation, Wiley (2019). - Seider, W.D., Seader, J.D., Lwin, D.R., Widagdo, S. Product and process design principles: synthesis, analysis, and evaluation, John Wiley & Sons, Inc. (2010). - Sinnot, R.K., Towler, G. Chemical Engineering Design, Butterworth-Heinemann (2009). - Smith, R. Chemical process design and integration, Wiley (2005). - Turton, R., A. Shaeiwitz, Bhattacharyya, D., Whiting, W. Synthesis and Design of Chemical Processes, Prentice Hall (2013). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | A basic understanding of material and energy balances, thermodynamic property methods and typical unit operations (e.g., reactors, flash separations, distillation/absorption columns etc.) is required. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Catalysis and Separation | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 151-0927-00L | Rate-Controlled Separations in Fine Chemistry | W+ | 6 credits | 3V + 1U | M. Mazzotti, V. Becattini | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The students are supposed to obtain detailed insight into the fundamentals of separation processes that are frequently applied in modern life science processes in particular, fine chemistry and biotechnology, and in energy-related applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The students are supposed to obtain detailed insight into the fundamentals of separation processes that are frequently applied in modern life sicence processes in particular, fine chemistry and biotechnology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The class covers separation techniques that are central in the purification and downstream processing of chemicals and bio-pharmaceuticals. Examples from both areas illustrate the utility of the methods: 1) Adsorption and chromatography; 2) Membrane processes; 3) Crystallization and precipitation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handouts during the class | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Recommendations for text books will be covered in the class | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Requirements (recommended, not mandatory): Thermal separation Processes I (151-0926-00) and Modelling and mathematical methods in process and chemical engineering (151-0940-00) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 529-0617-01L | Catalysis Engineering | W+ | 6 credits | 3G | J. Pérez-Ramírez, S. J. Mitchell | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Heterogeneous catalysis, an enabling foundation of the chemical industry, spearheads innovation toward key sustainability targets in clean energy, carbon neutrality, and zero waste. The Catalysis Engineering course provides students with concepts bridging from the molecular-level design of catalytic materials to their technical application. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | To accelerate the discovery and implementation of sustainable technologies, this vibrant discipline is constantly refining its design principles, particularly at the nanoscale, a shift facilitated by the availability of increasingly powerful tools that permit the continued development of fundamental knowledge over different time and length scales. During this course, you will learn current concepts for the defossilization of the chemical industry and strategies for achieving this goal from idea to implementation. By introducing topical case studies both in lectures and through a semester project, you will see aspects of catalyst synthesis and characterization, kinetics, mass and heat transport, deactivation and process design, sustainability metrics, and the potential of digital tools to guide catalyst design. Since this area is rapidly advancing and no textbooks are available, the lectures follow slides and journal articles. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The aspects described above will be demonstrated through industrially-relevant examples such as: - Natural gas valorization - CO2 conversion to energy vectors - Plastics upcycling - Concept for a glycerol biorefinery - Halogen chemistry on catalytic surfaces - Ensemble design for selective hydrogenations - Single-atom catalysis - Hierarchical zeolite catalysts A supervised semester project conducted in small groups provides a taster of catalysis research on a timely topic. Students will learn basic skills including critical literature analysis, problem definition and solving, methods of catalyst synthesis, characterization, and testing, and data evaluation and communication through a short talk. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | The course material is based on slides and journal articles. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | It is assumed that students selecting this course are familiar with basic concepts of chemistry and catalysis (chemistry or chemical engineering background). Other students are welcome to contact us to discuss the requirement for prior knowledge. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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