Search result: Catalogue data in Spring Semester 2022
MAS in Medical Physics  | ||||||
 Specialisation in General Medical Physics | ||||||
| Major in Biocompatible Materials | ||||||
| Core Courses 376-1622-00L Practical Methods in Tissue Engineering (offered in the Autumn Semester) and 376-1624-00L Practical Methods in Biofabrication (offered in the Spring Semester) are mutually exclusive to be eligible for credits. | ||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|---|
| 151-0980-00L | Biofluiddynamics | W | 4 credits | 2V + 1U | D. Obrist, P. Jenny | |
| Abstract | Introduction to the fluid dynamics of the human body and the modeling of physiological flow processes (biomedical fluid dynamics). | |||||
| Learning objective | A basic understanding of fluid dynamical processes in the human body. Knowledge of the basic concepts of fluid dynamics and the ability to apply these concepts appropriately. | |||||
| Content | This lecture is an introduction to the fluid dynamics of the human body (biomedical fluid dynamics). For selected topics of human physiology, we introduce fundamental concepts of fluid dynamics (e.g., creeping flow, incompressible flow, flow in porous media, flow with particles, fluid-structure interaction) and use them to model physiological flow processes. The list of studied topics includes the cardiovascular system and related diseases, blood rheology, microcirculation, respiratory fluid dynamics and fluid dynamics of the inner ear. | |||||
| Lecture notes | Lecture notes are provided electronically. | |||||
| Literature | A list of books on selected topics of biofluiddynamics can be found on the course web page. | |||||
| 376-1308-00L | Development Strategies for Medical Implants  Number of participants limited to 25 - 30. Assignments will be considered in chronological order. | W | 3 credits | 2V + 1U | J. Mayer-Spetzler, N. Mathavan | |
| Abstract | Introduction to development strategies for implantable devices considering the interdependecies of biocompatibility, clinical, regulatory and economical requirements ; discussion of the state of the art and actual trends in in orthopedics, sports medicine and cardio-vascular surgery as well as regenerative medicine (tissue engineering). | |||||
| Learning objective | Basic considerations in implant development Concept of structural and surface biocompatiblity and its relevance for the design of implant and surgical technique Understanding of conflicting factors, e.g. clinical need, economics and regulatory requirements Concepts of tissue engineering, its strengths and weaknesses as current and future clinical solution | |||||
| Content | Understanding of clinical and economical needs as guide lines for the development of medical implants; implant and implantation related tissue reactions, biocompatible materials and material processing technologies; implant testing and regulatory procedures; discussion of the state of the art and actual trends in implant development in sports medicine, spinal and cardio-vascular surgery; introduction to tissue engineering. Selected topics will be further illustrated by commented movies from surgeries. Seminar: Group seminars on selected controversial topics in implant development. Participation is mandatory Planned excursions (limited availability, not mandatory, to be confirmed): 1. Participation (as visitor) on a life surgery (travel at own expense) | |||||
| Lecture notes | Scribt (electronically available): - presented slides - selected scientific papers for further reading | |||||
| Literature | Reference to key papers will be provided during the lectures | |||||
| Prerequisites / Notice | Only Master students, achieved Bachelor degree is a pre-condition The number of participants in the course is limited to 30 students in total. Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is on the student's own responsability. | |||||
| 376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | W | 3 credits | 2G | G. Shivashankar | |
| Abstract | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | |||||
| Learning objective | The goal of this course is to provide an introduction to the emerging field of “Mechanobiology”. | |||||
| Content | We will focus on cells and tissues and introduce the major methods employed in uncovering the principles of mechanobiology. We will first discuss the cellular mechanotransduction mechanisms and how they regulate genomes. This will be followed by an analysis of the mechanobiological underpinnings of cellular differentiation, cell-state transitions and homeostasis. Developing on this understanding, we will then introduce the mechanobiological basis of cellular ageing and its impact on tissue regeneration, including neurodegeneration and musculoskeletal systems. We will then highlight the importance of tissue organoid models as routes to regenerative medicine. We will also discuss the impact of mechanobiology on host-pathogen interactions. Finally, we will introduce the broad area of mechanopathology and the development of cell-state biomarkers as readouts of tissue homeostasis and disease pathologies. Collectively, the course will provide a quantitate framework to understand the mechanobiological processes at cellular scale and how they intersect with tissue function and diseases. Lecture 1: Introduction to the course: forces, signalling and cell behaviour Lecture 2: Methods to engineer and sense mechanobiological processes Lecture 3: Mechanisms of cellular mechanosensing and cytoskeletal remodelling Lecture 4: Nuclear mechanotransduction pathways Lecture 5: Genome organization, regulation and genome integrity Lecture 6: Differentiation, development and reprogramming Lecture 7: Tissue microenvironment, cell behaviour and homeostasis Lecture 8: Cellular aging and tissue regeneration Lecture 9: Neurodegeneration and regeneration Lecture 10: Musculoskeletal systems and regeneration Lecture 11: Tissue organoid models and regenerative medicine Lecture 12: Microbial systems and host-pathogen interactions Lecture13: Mechanopathology and cell-state biomarkers Lecture14: Concluding lecture and case studies | |||||
| Lecture notes | n/a | |||||
| Literature | Topical Scientific Manuscripts | |||||
| 376-1614-00L | Principles in Tissue Engineering | W | 3 credits | 2V | K. Maniura, M. Rottmar, M. Zenobi-Wong | |
| Abstract | Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Learning objective | Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed. | |||||
| Content | This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Lecture notes | Handouts provided during the classes and references therin. | |||||
| Literature | The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 | |||||
| 376-1624-00L | Practical Methods in Biofabrication Number of participants limited to 16. | W | 5 credits | 4P | M. Zenobi-Wong, S. J. Ferguson, S. Schürle-Finke | |
| Abstract | Biofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft. | |||||
| Learning objective | The objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based Project in the second half of the Semester. The Project requires significant time outside of class Hours, strong commitment and ability to work independently. | |||||
| Prerequisites / Notice | Not recommended if passed 376-1622-00 Practical Methods in Tissue Engineering | |||||
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