Search result: Catalogue data in Spring Semester 2022
MAS in Medical Physics  | ||||||
 Specialisation in General Medical Physics | ||||||
| Major in Biomechanics | ||||||
| Core Courses | ||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|---|
| 376-1712-00L | Finite Element Analysis in Biomedical Engineering | W | 3 credits | 2V | S. J. Ferguson, B. Helgason | |
| Abstract | This course provides an introduction to finite element analysis, with a specific focus on problems and applications from biomedical engineering. | |||||
| Learning objective | Finite element analysis is a powerful simulation method for the (approximate) solution of boundary value problems. While its traditional roots are in the realm of structural engineering, the methods have found wide use in the biomedical engineering domain for the simulation of the mechanical response of the human body and medical devices. This course provides an introduction to finite element analysis, with a specific focus on problems and applications from biomedical engineering. This domain offers many unique challenges, including multi-scale problems, multi-physics simulation, complex and non-linear material behaviour, rate-dependent response, dynamic processes and fluid-solid interactions. Theories taught are reinforced through practical applications in self-programmed and commercial simulation software, using e.g. MATLAB, ANSYS, FEBIO. | |||||
| Content | (Theory) The Finite Element and Finite Difference methods Gallerkin, weighted residuals, discretization (Theory) Mechanical analysis of structures Trusses, beams, solids and shells, DOFs, hand calculations of simple FE problems, underlying PDEs (Application) Mechanical analysis of structures Truss systems, beam systems, 2D solids, meshing, organ level analysis of bones (Theory and Application) Mechanical analysis of structures Micro- and multi-scale analysis, voxel models, solver limitations, large scale solvers (Theory) Non-linear mechanical analysis of structures Large strain, Newton-Rhapson, plasticity (Application) Non-linear mechanical analysis of structures Plasticity (bone), hyperelasticity, viscoelasticity (Theory and Application) Contact analysis Friction, bonding, rough contact, implants, bone-cement composites, pushout tests (Theory) Flow in Porous Media Potential problems, Terzhagi's consolidation (Application) Flow in Porous Media Confined and unconfined compression of cartilage (Theory) Heat Transfer and Mass Transport Diffusion, conduction and convection, equivalency of equations (Application) Heat Transfer and Mass Transport Sequentially-coupled poroelastic and transport models for solute transport (Theory) Computational Biofluid Dynamics Newtonian vs. Non-Newtonian fluid, potential flow (Application) Computational Biofluid Dynamics Flow between micro-rough parallel plates | |||||
| Lecture notes | Handouts consisting of (i) lecturers' script, (ii) selected excerpts from relevant textbooks, (iii) selected excerpts from theory manuals of commercial simulation software, (iv) relevant scientific publications. | |||||
| Prerequisites / Notice | Familiarity with basic numerical methods. Programming experience with MATLAB. | |||||
| 376-1397-00L | Orthopaedic Biomechanics  Number of participants limited to 48. | W | 3 credits | 2G | R. Müller, J. Schwiedrzik | |
| Abstract | This course is aimed at studying the mechanical and structural engineering of the musculoskeletal system alongside the analysis and design of orthopaedic solutions to musculoskeletal failure. | |||||
| Learning objective | To apply engineering and design principles to orthopaedic biomechanics, to quantitatively assess the musculoskeletal system and model it, and to review rigid-body dynamics in an interesting context. | |||||
| Content | Engineering principles are very important in the development and application of quantitative approaches in biology and medicine. This course includes a general introduction to structure and function of the musculoskeletal system: anatomy and physiology of musculoskeletal tissues and joints; biomechanical methods to assess and quantify tissues and large joint systems. These methods will also be applied to musculoskeletal failure, joint replacement and reconstruction; implants; biomaterials and tissue engineering. | |||||
| Lecture notes | Stored on Moodle. | |||||
| Literature | Orthopaedic Biomechanics: Mechanics and Design in Musculoskeletal Systems Authors: Donald L. Bartel, Dwight T. Davy, Tony M. Keaveny Publisher: Prentice Hall; Copyright: 2007 ISBN-10: 0130089095; ISBN-13: 9780130089090 | |||||
| Prerequisites / Notice | Lectures will be given in English. | |||||
| 376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | W | 3 credits | 2G | G. Shivashankar | |
| Abstract | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | |||||
| Learning objective | The goal of this course is to provide an introduction to the emerging field of “Mechanobiology”. | |||||
| Content | We will focus on cells and tissues and introduce the major methods employed in uncovering the principles of mechanobiology. We will first discuss the cellular mechanotransduction mechanisms and how they regulate genomes. This will be followed by an analysis of the mechanobiological underpinnings of cellular differentiation, cell-state transitions and homeostasis. Developing on this understanding, we will then introduce the mechanobiological basis of cellular ageing and its impact on tissue regeneration, including neurodegeneration and musculoskeletal systems. We will then highlight the importance of tissue organoid models as routes to regenerative medicine. We will also discuss the impact of mechanobiology on host-pathogen interactions. Finally, we will introduce the broad area of mechanopathology and the development of cell-state biomarkers as readouts of tissue homeostasis and disease pathologies. Collectively, the course will provide a quantitate framework to understand the mechanobiological processes at cellular scale and how they intersect with tissue function and diseases. Lecture 1: Introduction to the course: forces, signalling and cell behaviour Lecture 2: Methods to engineer and sense mechanobiological processes Lecture 3: Mechanisms of cellular mechanosensing and cytoskeletal remodelling Lecture 4: Nuclear mechanotransduction pathways Lecture 5: Genome organization, regulation and genome integrity Lecture 6: Differentiation, development and reprogramming Lecture 7: Tissue microenvironment, cell behaviour and homeostasis Lecture 8: Cellular aging and tissue regeneration Lecture 9: Neurodegeneration and regeneration Lecture 10: Musculoskeletal systems and regeneration Lecture 11: Tissue organoid models and regenerative medicine Lecture 12: Microbial systems and host-pathogen interactions Lecture13: Mechanopathology and cell-state biomarkers Lecture14: Concluding lecture and case studies | |||||
| Lecture notes | n/a | |||||
| Literature | Topical Scientific Manuscripts | |||||
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