Search result: Catalogue data in Spring Semester 2022

Biochemistry – Chemical Biology Bachelor Information
Core Courses First Year Examination
NumberTitleTypeECTSHoursLecturers
529-0012-02LGeneral Chemistry (Inorganic Chemistry) IIO4 credits3V + 1UH. Grützmacher, J. Cvengros
Abstract1) General definitions 2) The VSEPR model 3) Qualitative molecular orbital diagrams 4) Closest packing, metal structures 5) The Structures of metalloids
6) Structures of the non-metals 7) Synthesis of the elements 8) Reactivity of the elements 9) Ionic Compounds 10) Ions in Solution 11) Element hydrogen compounds 12) Element halogen compounds 13) Element oxygen compounds 14) Redox chemistry
ObjectiveUnderstanding of the fundamental principles of the structures, properties, and reactivities of the main group elements (groups 1,2 and 13 to 18).
ContentThe course is divided in 14 sections in which the fundamental phenomena of the chemistry of the main group elements are discussed: Part 1: Introduction in the periodical properties of the elements and general definitions –Part 2: The VSEPR model –Part 3: Qualitative molecular orbital diagrams for simple inorganic molecules – Part 4: Closest packing and structures of metals Part 5: The Structures of semimetals (metalloids) of the main group elements –Part 6: Structures of the non-metals– Part 7: Synthesis of the elements. –Part 8: Reactivity of the elements Part 9: Ionic Compounds Part 10: Ions in Solution Part 11: Element hydrogen compounds Part 12: Element halogen compounds Part 13: Element oxygen compounds Part 14: Redox chemistry.
Lecture notesThe transparencies used in the course are accessible via the internet on Link
LiteratureJ. Huheey, E. Keiter, R. Keiter, Inorganic Chemistry, Principles and Reactivity, 4th edition, deGruyter, 2003.

C.E.Housecroft, E.C.Constable, Chemistry, 4th edition, Pearson Prentice Hall, 2010.
Prerequisites / NoticeBasis for the understanding of this lecture is the course Allgemeine Chemie 1.
529-0012-03LGeneral Chemistry (Organic Chemistry) IIO4 credits3V + 1UP. Chen
AbstractClassification of organic reactions, reactive intermediates: radicals, carbocations, carbanions, acids & bases, electrophilic aromatic substitution, electrophilic addition to double bonds, HSAB concept, nucleophilic substitution at sp3 hybridized carbon centres (SN1/SN2 reactions), nucleophilic aromatic substitutions, eliminations, oxidations, reductions.
ObjectiveUnderstanding of fundamental reactivity principles and the relationship between structure and reactivity. Knowledge of the most important reaction types and of selected classes of compounds.
ContentClassification of organic reactions, reactive intermediates: radicals, carbocations, carbanions, acids & bases, electrophilic aromatic substitution, electrophilic addition to double bonds, HSAB concept, nucleophilic substitution at sp3 hybridized carbon centres (SN1/SN2 reactions), nucleophilic aromatic substitutions, eliminations, oxidations, reductions.
Lecture notespdf file available at the beginning of the course
Literature[1] P. Sykes, "Reaktionsmechanismen der Organischen Chemie", VCH Verlagsgesellschaft, Weinheim 1988.
[2] Carey/Sundberg, Advanced Organic Chemistry, Part A and B, 3rd ed., Plenum Press, New York, 1990/1991. Deutsch: Organische Chemie.
[3] Vollhardt/Schore, Organic Chemistry, 2th ed., Freeman, New York, 1994 Deutsche Fassung: Organische Chemie 1995, Verlag Chemie, Wein¬heim, 1324 S. Dazu: N. Schore, Arbeitsbuch zu Vollhardt, Organische Chemie, 2. Aufl. Verlag Chemie, Weinheim, 1995, ca 400 S.
[4] J. March, Advanced Organic Chemistry; Reactions, Mechanisms, and Structure, 5th ed., Wiley, New York, 1992.
[5] Streitwieser/Heathcock, Organische Chemie, 2. Auflage, Verlag Chemie, Weinheim, 1994.
[6] Streitwieser/Heathcock/Kosower, Introduction to Organic Chemistry, 4th ed., MacMillan Publishing Company, New York, 1992.
[7] P. Y. Bruice, Organische Chemie, 5. Auflage, Pearson Verlag, 2007.
529-0012-01LPhysical Chemistry I: ThermodynamicsO4 credits3V + 1UA. Barnes, T. Segawa
AbstractFoundations of chemical thermodynamics: Entropy, chemical thermodynamics, laws of thermodynamics, partition functions, chemical reactions, reaction free energies, equilibrium conditions, chemical potential, standard states, ideal and real systems and gases, phase equilibria, colligative properties, with applications to current research at the ETHZ.
ObjectiveUnderstanding of entropy and thermodynamic principles.
ContentThe first, second and third law of thermodynamics: empirical temperature and thermodynamic temperature scale, internal energy, entropy, thermal equilibrium. Models and standard states: ideal gases, ideal solutions and mixtures, real gases, real solutions and mixtures, activity, tables of standard thermodynamic quantities. Reaction thermodynamics: the chemical potential, reaction parameters and equilibrium conditions, equilibrium constants and their pressure and temperature dependence. Phase equilibria.
Lecture notesSee homepage of the lecture.
LiteratureSee homepage of the lecture.
Prerequisites / NoticeRequirements: Allgemeine Chemie I, Grundlagen der Mathematik
551-0126-00LFundamentals of Biology II: Cells Information O6 credits5GK. Weis, F. Allain, Y. Barral, W.‑D. Hardt, U. Kutay, M. Peter, I. Zemp
AbstractThe lecture provides an introduction to the function and regulations of cells.
ObjectiveIntroduction to the function and regulation of cells
ContentThe lecture introduces a basic understanding of the structure, organization, function and regulation of the cell. The lecture is divided into two main sections:
Part 1: Cell Biology of Prokaryotes, evolution, populations
This section covers the general principles of the structure and regulation of prokaryotic cells, and explains the genetics and the evolution of bacteria.
Part II: Unifying concepts in Eukarya
This part of the lecture gives a broad introduction into the general structure of eukaryotic cells and illustrates key concepts such as intracellular architecture, transport mechanisms and the regulation of gene expression in eukaryotes.
Lecture notesThe newly conceived lecture is supported by scripts.
LiteratureThe lecture is supported by scripts. Furthermore, the textbook "Molecular Biology of the Cell", Alberts et al. 6th edition, Taylor and Francis, and "Brock Biology of Microorganisms", Madigan et al. 15th edition, Pearson can be used as support for the lecture.
401-0272-00LMathematical Foundations I: Analysis BO3 credits2V + 1UL. Kobel-Keller
AbstractBasics about multidimensional analysis.
Ordinary differential equations as mathematical models to describe processes (continuation from Analysis A).
Numerical, analytical and geometrical aspects of differential equations.
ObjectiveIntroduction to calculus in several dimensions.
Building simple models and analysing them mathematically.
Knowledge of the basic concepts.
ContentBasics about multidimensional analysis.
Differential equations as mathematical models to describe processes. Numerical, analytical and geometrical aspects of differential equations.
Literature- G. B. Thomas, M. D. Weir, J. Hass: Analysis 2, Lehr- und Übungsbuch, Pearson-Verlag
- D. W. Jordan, P. Smith: Mathematische Methoden für die Praxis, Spektrum Akademischer Verlag
- M. Akveld/R. Sperb: Analysis I, Analysis II (vdf)
- L. Papula: Mathematik für Ingenieure und Naturwissenschaftler Bde 1,2,3. (Vieweg)
Further reading suggestions will be indicated during the lecture.
401-0643-00LStatistics I Information Restricted registration - show details O3 credits2V + 1UM. Kalisch
AbstractIntroduction to basic methods and fundamental concepts of statistics and probability theory for non-mathematicians. The concepts are presented on the basis of some descriptive examples.
ObjectiveGrundverständnis für die Gesetze des Zufalls und des Denkens in Wahrscheinlichkeiten. Kenntnis von Methoden zur Darstellung von Daten und zu ihrer quantitativen Interpretation unter Berücksichtigung der statistischen Unsicherheit.
ContentModelle und Statistik für Zähldaten: Diskrete Wahrscheinlichkeitsmodelle, Binomial-Verteilung, Tests und Vertrauensintervalle für eine Wahrscheinlichkeit, Poisson-Verteilung und deren Statistik, weitere Verteilungen.
Modelle und Statistik für Messdaten: Beschreibende Statistik, Zufallsvariablen mit Dichten, t-Test und Wilcoxon-Test und zugehörige Vertrauensintervalle.
Regression: Das Modell der linearen Regression, Tests und Vertrauensintervalle, Residuenanalyse.
Lecture notesEs steht ein kurzes Skript zur Verfügung.
Literature- W. A. Stahel, Statistische Datenanalyse: Eine Einführung für Naturwissenschaftler, 5. Aufl., Vieweg, Braunschweig/Wiesbaden, 2007
Prerequisites / NoticeVoraussetzungen: Grundlegende Mathematik-Kenntnisse wie sie im ersten Semester erworben werden.
Second and Third Year Core Courses
Examination Blocks
Examination Block 1
NumberTitleTypeECTSHoursLecturers
529-0222-00LOrganic Chemistry IIO3 credits2V + 1UB. Morandi, J. W. Bode
AbstractThis course builds on the material learned in Organic Chemistry I or Organic Chemistry II for Biology/Pharmacy Students. Topics include advanced concepts and mechanisms of organic reactions and introductions to pericyclic and organometallic reactions. The basics or retro- and forward synthesis are also introduced.
ObjectiveGoals of this course include a deeper understanding of basic organic reactions and mechanisms as well as advanced transformations. Reactive intermediates including carbenes and nitrenes are covered, along with methods for their generation and use in complex molecule synthesis. Frontier molecular orbital theory (FMO) is introduced and used to rationalize pericyclic reactions including Diels Alder reactions, cycloadditions, and rearrangements (Cope, Claisen). The basic concepts and key reactions of catalytic organometallic chemistry, which are key methods in modern organic synthesis, are introduced, with an emphasis on their catalytic cycles and elementary steps. All of these topics are combined in an overview of strategies for complex molecule synthesis, with specific examples from natural product derived molecules used as medicines.
ContentRedox neutral reactions and rearrangements, advanced transformations of functional groups and reaction mechanisms, carbenes and nitrenes, frontier molecular orbital theory (FMO), cycloadditions and pericyclic reactions, introduction to organometallic chemistry and catalytic cross couplings, protecting groups, retrosynthetic analysis of complex organic molecules, planning and execution of multi-step reactions.
Lecture notesThe lecture notes and additional documents including problem sets are available as PDF files online, without charge. Link: Link
LiteratureClayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012.
402-0044-00LPhysics IIO4 credits3V + 1UJ. Home
AbstractIntroduction to the concepts and tools in physics with the help of demonstration experiments: electromagnetism, optics, introduction to modern physics.
ObjectiveThe concepts and tools in physics, as well as the methods of an experimental science are taught. The student should learn to identify, communicate and solve physical problems in his/her own field of science.
ContentElectromagnetism (electric current, magnetic fields, electromagnetic induction, magnetic materials, Maxwell's equations)
Optics (light, geometrical optics, interference and diffraction)
Short introduction to quantum physics
Lecture notesThe lecture follows the book "Physik" by Paul A. Tipler.
LiteraturePaul A. Tipler and Gene Mosca
Physik
Springer Spektrum Verlag
529-0058-00LAnalytical Chemistry IIO3 credits3GD. Günther, D. Bleiner, T. Bucheli, M.‑O. Ebert, G. Schwarz
AbstractEnhanced knowledge about the elemental analysis and spectrocopical techniques with close relation to practical applications. This course is based on the knowledge from analytical chemistry I. Separation methods are included.
ObjectiveUse and applications of the elemental analysis and spectroscopical knowledge to solve relevant analytical problems.
ContentCombined application of spectroscopic methods for structure determination, and practical application of element analysis. More complex NMR methods: recording techniques, application of exchange phenomena, double resonance, spin-lattice relaxation, nuclear Overhauser effect, applications of experimental 2d and multipulse NMR spectroscopy, shift reagents. Application of chromatographic and electrophoretic separation methods: basics, working technique, quality assessment of a separation method, van-Deemter equation, gas chromatography, liquid chromatography (HPLC, ion chromatography, gel permeation, packing materials, gradient elution, retention index), electrophoresis, electroosmotic flow, zone electrophoresis, capillary electrophoresis, isoelectrical focussing, electrochromatography, 2d gel electrophoresis, SDS-PAGE, field flow fractionation, enhanced knowledge in atomic absorption spectroscopy, atomic emission spectroscopy, X-ray fluorescence spectroscopy, ICP-OES, ICP-MS.
Lecture notesScript will be available
LiteratureLiterature will be within the script.
Prerequisites / NoticeExercises for spectra interpretation are part of the lecture. In addition the lecture 529-0289-00 "Instrumentalanalyse organischer Verbindungen" (4th semester) is recommended.
Prerequisite: 529-0051-00 "Analytische Chemie I" (3rd semester)
535-0522-00LPharmacology and Toxicology IIO2 credits2VU. Quitterer
AbstractThe two-semester lecture course will provide a basic understanding of mechanisms of drug action, pharmacological properties and therapeutic uses of important classes of drugs. The lectures are intended for students of pharmacy and health sciences.
ObjectiveThe lectures will provide a comprehensive survey of pharmacology and toxicology. Special emphasis is placed on the interrelationship between pharmacological, pathophysiological and clinical aspects.
ContentTopics include disease-relevant macroscopic, microscopic, pathobiochemical and functional disturbances of specific organs and organ systems. The lectures integrate disease pathology with mechanisms of drug action, usage, pharmacokinetics, side effects, toxicology, contraindications and dosage of relevant drug classes. Basic principles of clinical pharmacology and pharmacotherapy will be covered.
Lecture notesA script is provided for each lecture, which contains major contents of the lecture and defines exam-relevant topics. The scripts do not replace the lectures.
LiteratureKlaus Aktories, Ulrich Förstermann, Franz Hofmann, Klaus Starke.
Allgemeine und spezielle Pharmakologie und Toxikologie.
12. Auflage, 1146 Seiten
2017
Urban & Fischer Verlag/Elsevier GmbH,
ISBN-10: 3437425250; ISBN-13: 978-3437425257


The classic textbook on pharmacology:
Goodman & Gilman`s The Pharmacological Basis of Therapeutics.
Laurence Brunton, Björn Knollmann, Randa Hilal-Dandan
13th edition, 1440 pages
2017; McGraw - Hill Education
ISBN-10: 1259584739
ISBN-13: 978-1259584732
Prerequisites / NoticeAbschluss Grundstudium.

Gleichzeitiger oder vorgängiger Besuch des Seminars 535-0523-00 Aktuelle Themen aus Pharmakologie und Toxikologie ist dringend empfohlen.
551-1324-00LBiochemistryO5 credits4GK. Locher, N. Ban, R. Glockshuber, J. Piel, E. Weber-Ban
AbstractThe lecture teaches central reactions and metabolic pathways of biochemistry as well as molecular biology with emphasis on chemical and partly biophysical aspects.
ObjectiveUnderstanding of the most important metabolic processes involved in cellular energy production and storage as well as selected biosynthetic processes (incl. sugars, fats, steroids etc). Understanding of the molecular processes involved in replication, transcription and translation.
Prerequisites / NoticeSome lecture units are held in English.
551-1174-00LSystems BiologyO5 credits2V + 2UU. Sauer, S. Brüningk, J. Stelling, N. Zamboni
AbstractThe course teaches computational methods and first hands-on applications by starting from biological problems/phenomena that students in the 4th semester are somewhat familiar with. During the exercises, students will obtain first experience with programming their own analyses/models for data analysis/interpretation.
ObjectiveWe will teach little if any novel biological knowledge or analysis methods, but focus on training the ability of use existing knowledge (for example from enzyme kinetics, regulatory mechanisms or analytical methods) to understand biological problems that arise when considering molecular elements in their context and to translate some of these problems into a form that can be solved by computational methods. Specific goals are:
- understand the limitations of intuitive reasoning
- obtain a first overview of computational approaches in systems biology
- train ability to translate biological problems into computational problems
- solve practical problems by programming with MATLAB
- make first experiences in computational interpretation of biological data
- understand typical abstractions in modeling molecular systems
ContentDuring the first 7 weeks, the will focus on mechanistic modeling. Starting from simple enzyme kinetics, we will move through the dynamics of small pathways that also include regulation and end with flux balance analysis of a medium size metabolic network. During the second 7 weeks, the focus will shift to the analysis of larger data sets, such as metabolomics and transcriptomics that are often generated in biology. Here we will go through multivariate statistical methods that include clustering and principal component analysis, ending with first methods to learn networks from data.
Lecture notesScripts to prepare the lectures will be provided via Moodle
LiteratureThe course is not taught by a particular book, but two books are suggested for further reading:
- Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009
- A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012
Examination Block 2
Starting Autumn Semester 2022.
Core Subjects
NumberTitleTypeECTSHoursLecturers
529-0289-00LSpectra Interpretation of Organic CompoundsO2 credits2GR. Zenobi, K. Eyer, N. Kumar, Y. Yamakoshi
AbstractExercises in interpretation of molecular spectra
ObjectiveMastering the interpretation of molecular spectra.
ContentIn the first part of the lecture, the students work in small groups on solving particular problems in structure elucidation, interpreting mass, 1H-NMR, 13C-NMR, IR, and UV/VIS spectra, optionally in discussion with the lecturers. In the second part the problems are solved by a lecturer.
Lecture notesSpectroscopic problems will be distributed
LiteratureE. Pretsch, P. Bühlmann, M. Badertscher, Structure Determination of Organic Compounds: Tables of Spectral Data, Springer-Verlag, Berlin, 2009, 4th revised and enlarged Engl. ed.

E. Pretsch, G. Tóth, M. E. Munk, M. Badertscher, Computer-Aided Structure Elucidation: Spectra Interpretation and Structure Generation, Wiley-VCH, Weinheim, 2002.
Prerequisites / NoticeThe course is based on the lectures Analytical Chemistry I (529-0051-00) and Analytical Chemistry II (529-0058-00).
Solutions to the problems will be posted on the internet.
Laboratory Courses
NumberTitleTypeECTSHoursLecturers
551-0128-00LFundamentals of Biology I Restricted registration - show details
Registrations via myStudies until 28.1.2022 at the latest. Subsequent registrations will not be considered.
O8 credits8PM. Gstaiger, A. Cléry, E. Dultz, C. H. Giese, R. Kroschewski, M. Künzler
AbstractThis 1st year Laboratory course introduces the students to the basic experimental techniques used in the classical and modern molecular biosciences. In the first year (Praktikum GL BioI) the students will be introduced into the basic concepts and methods of Microbiology, Biochemistry and Molecular Biology in 12 consecutive course days.
ObjectiveIntroduction to the biology of unicellular organisms and practical experience with biochemical and molecular biology techniques.

General Praktikum-information and course material can be obtained from Moodle

The general Praktikum information (Assignment list, Instructions and Schedule & Performance Sheet) will also be sent to the students directly (E-mail).
ContentThis 1st year Laboratory course introduces the students to the entire range of classical and modern molecular biosciences. Students will participate in 12 consecutive course days. The practical will operate in two shifts on Thursday and Friday.

morning shift 8:00-13:00

afternoon shift 13:30-18:30

Program

Day 1: Handling and detection of microorganisms
Day 2: Morphological, biochemical and genetic differentiation of microorganisms
Day 3: Biotic interactions and genetics of bacteria
Day 4: Metabolism and physiology of bacteria
Day 5: DNA extraction, tranformation (E.coli, yeast)
Day 6: RNA extraction, Life cycle of eukaryotic cells
Day 7: Purification of TAQ polymerase from E coli by ionexchange chromatography
Day 8: Characterizing fractions of the purification of TAQ polymerase (SDS-PAGE, WB)
Day 9: mRNA splicing in yeast by RT-PCR and purified TAQ polymerase
Day 10: Affinity chromatography, protein crystallization and structure
Day 11: Protein folding, protein stability and Enzyme kinetics
Day 12: Protein folding, protein stability and Enzyme kinetics
Lecture notesLaboratory manuals can be downloaded from Moodle
Prerequisites / NoticePLEASE NOTE THE FOLLOWING RULES

Your attendance is obligatory and you have to attend all 12 Praktikum days of GL BioI. Absences are only acceptable if you are able to provide a Doctor’s certificate. The original Dr's certificate has to be given to Dr. M. Gstaiger (HPM F43) within five days of the absence of the Praktikum day.

If there will be any exceptional or important situations then you should directly contact the Director of Studies of D-Biol, who will decide if you are allowed to miss a Praktikum day or not.

HIGHLY IMPORTANT!!

1. Due to the increased number of students, the official Praktikum registration has to be done, using myStudies, preferably at the end of HS21 but not later than January 28, 2022.

2. Later registration is NOT possible and can NOT be accepted!

3. The course registration for FS2022 is usually possible at the end of fall semester 2021 and you will obtain an E-mail from the Rectorate when the course registration using myStudies is possible.

The 12 course days of the Praktikum Grundlagen Biologie-I will take place Thursday or Friday during the spring semester 2022. Therefore, you have to make sure already now that you will not have any other activities / commitments during these days. The exact course schedule will be communicated before the beginning of the spring semester.

PRAKTIKUM DAYS FS22 (Thursdays):

24.02.; 03.03.; 10.03.; 17.03.; 24.03.; 31.03.; 07.04.; 28.04.; 5.05.; 12.05.; 19.05.; 02.06.

PRAKTIKUM DAYS FS22 (Fridays):

25.02.; 04.03.; 11.03.; 18.03.; 25.03.; 1.04.; 8.04.; 29.04.; 06.05.; 13.05.; 20.05.; 03.06.

No Praktikum during the Easter vacation: 11.04-22.04.
529-0074-00LBCB IV: Analytical Biochemistry and Biophysics
Only for students of Biochemistry - Chemical Biology
O5 credits7PB. Rubi, J. W. Bode, R. Glockshuber, E. C. Meister
AbstractPractical Introduction to Experimental Methods in Analytical and Bioanalytical Chemistry
ObjectiveTo acquire a sound knowledge of the instrumentation and methods for the analysis of molecules, including organic compounds and biological molecules.

To learnabout the most important practical techniques in analytical chemistry.

To write critical reports for each experiment and analytical technique.
ContentThe course will comprise of maximum 10 experiments from the following themes: Spectroscopic structural characterisation, analytical characterisation, Bio-physical characterisation. Experiments that will be part of this curriculum are: Circular dichroism (CD) spectroscopy, UV spectroscopy, Mass Spectromety, Nuclear Magnetic Resonance, HPLC and Size exclusion separations, Isothermal titration calorimetry as well as a number of other bio-physical and biological characterisation techniques.
Lecture notesLearning Materials will be made available on an online platform (web page or Moodle)
LiteratureLearning Materials will be made available on an online platform (web page or Moodle)
Prerequisites / NoticePrerequisites / Notice 529-0011-04 "Allgemeine Chemie (Praktikum)"
529-0051-00 "Analytische Chemie" I (3. Semester)
529-0058-00 "Analytische Chemie II" (4. Semester) enrolment in parallel to the lab class, or completed in an earlier semester.
551-0128-00L Fundamentals of Biology I

BCB Students should also be enrolled in "Instumentalanalyse organischer Verbindungen".
CompetenciesCompetencies
Subject-specific CompetenciesConcepts and Theoriesassessed
Techniques and Technologiesassessed
Method-specific CompetenciesAnalytical Competenciesassessed
Decision-makingassessed
Media and Digital Technologiesassessed
Problem-solvingassessed
Project Managementfostered
Social CompetenciesCommunicationassessed
Cooperation and Teamworkassessed
Customer Orientationfostered
Leadership and Responsibilityfostered
Self-presentation and Social Influence fostered
Sensitivity to Diversityfostered
Negotiationfostered
Personal CompetenciesAdaptability and Flexibilityfostered
Creative Thinkingfostered
Critical Thinkingassessed
Integrity and Work Ethicsassessed
Self-awareness and Self-reflection assessed
Self-direction and Self-management assessed
Block Courses
Starting Autumn Semester 2022
Electives
Course offerings from 3. year on (starting autumn semester 2022)
Science in Perspective
Science in Perspective
» see Science in Perspective: Type A: Enhancement of Reflection Capability
» Recommended Science in Perspective (Type B) for D-CHAB
Language Courses
» see Science in Perspective: Language Courses ETH/UZH
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