# Search result: Catalogue data in Spring Semester 2021

Statistics Master The following courses belong to the curriculum of the Master's Programme in Statistics. The corresponding credits do not count as external credits even for course units where an enrolment at ETH Zurich is not possible. | ||||||

Master Studies (Programme Regulations 2020) | ||||||

Core Courses | ||||||

Statistical Modelling Course units are offered in the autumn semester. | ||||||

Applied Statistics | ||||||

Number | Title | Type | ECTS | Hours | Lecturers | |
---|---|---|---|---|---|---|

401-3632-00L | Computational Statistics | W | 8 credits | 3V + 1U | M. Mächler | |

Abstract | We discuss modern statistical methods for data analysis, including methods for data exploration, prediction and inference. We pay attention to algorithmic aspects, theoretical properties and practical considerations. The class is hands-on and methods are applied using the statistical programming language R. | |||||

Objective | The student obtains an overview of modern statistical methods for data analysis, including their algorithmic aspects and theoretical properties. The methods are applied using the statistical programming language R. | |||||

Content | See the class website | |||||

Prerequisites / Notice | At least one semester of (basic) probability and statistics. Programming experience is helpful but not required. | |||||

Mathematical Statistics Course units are offered in the autumn semester. | ||||||

Subject Specific Electives | ||||||

Number | Title | Type | ECTS | Hours | Lecturers | |

252-3900-00L | Big Data for Engineers This course is not intended for Computer Science and Data Science MSc students! | W | 6 credits | 2V + 2U + 1A | G. Fourny | |

Abstract | This course is part of the series of database lectures offered to all ETH departments, together with Information Systems for Engineers. It introduces the most recent advances in the database field: how do we scale storage and querying to Petabytes of data, with trillions of records? How do we deal with heterogeneous data sets? How do we deal with alternate data shapes like trees and graphs? | |||||

Objective | This lesson is complementary with Information Systems for Engineers as they cover different time periods of database history and practices -- you can even take both lectures at the same time. The key challenge of the information society is to turn data into information, information into knowledge, knowledge into value. This has become increasingly complex. Data comes in larger volumes, diverse shapes, from different sources. Data is more heterogeneous and less structured than forty years ago. Nevertheless, it still needs to be processed fast, with support for complex operations. This combination of requirements, together with the technologies that have emerged in order to address them, is typically referred to as "Big Data." This revolution has led to a completely new way to do business, e.g., develop new products and business models, but also to do science -- which is sometimes referred to as data-driven science or the "fourth paradigm". Unfortunately, the quantity of data produced and available -- now in the Zettabyte range (that's 21 zeros) per year -- keeps growing faster than our ability to process it. Hence, new architectures and approaches for processing it were and are still needed. Harnessing them must involve a deep understanding of data not only in the large, but also in the small. The field of databases evolves at a fast pace. In order to be prepared, to the extent possible, to the (r)evolutions that will take place in the next few decades, the emphasis of the lecture will be on the paradigms and core design ideas, while today's technologies will serve as supporting illustrations thereof. After visiting this lecture, you should have gained an overview and understanding of the Big Data landscape, which is the basis on which one can make informed decisions, i.e., pick and orchestrate the relevant technologies together for addressing each business use case efficiently and consistently. | |||||

Content | This course gives an overview of database technologies and of the most important database design principles that lay the foundations of the Big Data universe. It targets specifically students with a scientific or Engineering, but not Computer Science, background. We take the monolithic, one-machine relational stack from the 1970s, smash it down and rebuild it on top of large clusters: starting with distributed storage, and all the way up to syntax, models, validation, processing, indexing, and querying. A broad range of aspects is covered with a focus on how they fit all together in the big picture of the Big Data ecosystem. No data is harmed during this course, however, please be psychologically prepared that our data may not always be in normal form. - physical storage: distributed file systems (HDFS), object storage(S3), key-value stores - logical storage: document stores (MongoDB), column stores (HBase) - data formats and syntaxes (XML, JSON, RDF, CSV, YAML, protocol buffers, Avro) - data shapes and models (tables, trees) - type systems and schemas: atomic types, structured types (arrays, maps), set-based type systems (?, *, +) - an overview of functional, declarative programming languages across data shapes (SQL, JSONiq) - the most important query paradigms (selection, projection, joining, grouping, ordering, windowing) - paradigms for parallel processing, two-stage (MapReduce) and DAG-based (Spark) - resource management (YARN) - what a data center is made of and why it matters (racks, nodes, ...) - underlying architectures (internal machinery of HDFS, HBase, Spark) - optimization techniques (functional and declarative paradigms, query plans, rewrites, indexing) - applications. Large scale analytics and machine learning are outside of the scope of this course. | |||||

Literature | Papers from scientific conferences and journals. References will be given as part of the course material during the semester. | |||||

Prerequisites / Notice | This course is not intended for Computer Science and Data Science students. Computer Science and Data Science students interested in Big Data MUST attend the Master's level Big Data lecture, offered in Fall. Requirements: programming knowledge (Java, C++, Python, PHP, ...) as well as basic knowledge on databases (SQL). If you have already built your own website with a backend SQL database, this is perfect. Attendance is especially recommended to those who attended Information Systems for Engineers last Fall, which introduced the "good old databases of the 1970s" (SQL, tables and cubes). However, this is not a strict requirement, and it is also possible to take the lectures in reverse order. | |||||

252-0220-00L | Introduction to Machine Learning Limited number of participants. Preference is given to students in programmes in which the course is being offered. All other students will be waitlisted. Please do not contact Prof. Krause for any questions in this regard. If necessary, please contact studiensekretariat@inf.ethz.ch | W | 8 credits | 4V + 2U + 1A | A. Krause, F. Yang | |

Abstract | The course introduces the foundations of learning and making predictions based on data. | |||||

Objective | The course will introduce the foundations of learning and making predictions from data. We will study basic concepts such as trading goodness of fit and model complexitiy. We will discuss important machine learning algorithms used in practice, and provide hands-on experience in a course project. | |||||

Content | - Linear regression (overfitting, cross-validation/bootstrap, model selection, regularization, [stochastic] gradient descent) - Linear classification: Logistic regression (feature selection, sparsity, multi-class) - Kernels and the kernel trick (Properties of kernels; applications to linear and logistic regression); k-nearest neighbor - Neural networks (backpropagation, regularization, convolutional neural networks) - Unsupervised learning (k-means, PCA, neural network autoencoders) - The statistical perspective (regularization as prior; loss as likelihood; learning as MAP inference) - Statistical decision theory (decision making based on statistical models and utility functions) - Discriminative vs. generative modeling (benefits and challenges in modeling joint vy. conditional distributions) - Bayes' classifiers (Naive Bayes, Gaussian Bayes; MLE) - Bayesian approaches to unsupervised learning (Gaussian mixtures, EM) | |||||

Literature | Textbook: Kevin Murphy, Machine Learning: A Probabilistic Perspective, MIT Press | |||||

Prerequisites / Notice | Designed to provide a basis for following courses: - Advanced Machine Learning - Deep Learning - Probabilistic Artificial Intelligence - Seminar "Advanced Topics in Machine Learning" | |||||

401-4632-15L | Causality | W | 4 credits | 2G | C. Heinze-Deml | |

Abstract | In statistics, we are used to search for the best predictors of some random variable. In many situations, however, we are interested in predicting a system's behavior under manipulations. For such an analysis, we require knowledge about the underlying causal structure of the system. In this course, we study concepts and theory behind causal inference. | |||||

Objective | After this course, you should be able to - understand the language and concepts of causal inference - know the assumptions under which one can infer causal relations from observational and/or interventional data - describe and apply different methods for causal structure learning - given data and a causal structure, derive causal effects and predictions of interventional experiments | |||||

Prerequisites / Notice | Prerequisites: basic knowledge of probability theory and regression | |||||

401-3602-00L | Applied Stochastic Processes | W | 8 credits | 3V + 1U | V. Tassion | |

Abstract | Poisson processes; renewal processes; Markov chains in discrete and in continuous time; some applications. | |||||

Objective | Stochastic processes are a way to describe and study the behaviour of systems that evolve in some random way. In this course, the evolution will be with respect to a scalar parameter interpreted as time, so that we discuss the temporal evolution of the system. We present several classes of stochastic processes, analyse their properties and behaviour and show by some examples how they can be used. The main emphasis is on theory; in that sense, "applied" should be understood to mean "applicable". | |||||

Literature | R. N. Bhattacharya and E. C. Waymire, "Stochastic Processes with Applications", SIAM (2009), available online: http://epubs.siam.org/doi/book/10.1137/1.9780898718997 R. Durrett, "Essentials of Stochastic Processes", Springer (2012), available online: http://link.springer.com/book/10.1007/978-1-4614-3615-7/page/1 M. Lefebvre, "Applied Stochastic Processes", Springer (2007), available online: http://link.springer.com/book/10.1007/978-0-387-48976-6/page/1 S. I. Resnick, "Adventures in Stochastic Processes", Birkhäuser (2005) | |||||

Prerequisites / Notice | Prerequisites are familiarity with (measure-theoretic) probability theory as it is treated in the course "Probability Theory" (401-3601-00L). | |||||

401-3642-00L | Brownian Motion and Stochastic Calculus | W | 10 credits | 4V + 1U | W. Werner | |

Abstract | This course covers some basic objects of stochastic analysis. In particular, the following topics are discussed: construction and properties of Brownian motion, stochastic integration, Ito's formula and applications, stochastic differential equations and connection with partial differential equations. | |||||

Objective | This course covers some basic objects of stochastic analysis. In particular, the following topics are discussed: construction and properties of Brownian motion, stochastic integration, Ito's formula and applications, stochastic differential equations and connection with partial differential equations. | |||||

Lecture notes | Lecture notes will be distributed in class. | |||||

Literature | - J.-F. Le Gall, Brownian Motion, Martingales, and Stochastic Calculus, Springer (2016). - I. Karatzas, S. Shreve, Brownian Motion and Stochastic Calculus, Springer (1991). - D. Revuz, M. Yor, Continuous Martingales and Brownian Motion, Springer (2005). - L.C.G. Rogers, D. Williams, Diffusions, Markov Processes and Martingales, vol. 1 and 2, Cambridge University Press (2000). - D.W. Stroock, S.R.S. Varadhan, Multidimensional Diffusion Processes, Springer (2006). | |||||

Prerequisites / Notice | Familiarity with measure-theoretic probability as in the standard D-MATH course "Probability Theory" will be assumed. Textbook accounts can be found for example in - J. Jacod, P. Protter, Probability Essentials, Springer (2004). - R. Durrett, Probability: Theory and Examples, Cambridge University Press (2010). | |||||

401-6228-00L | Programming with R for Reproducible Research | W | 1 credit | 1G | M. Mächler | |

Abstract | Deeper understanding of R: Function calls, rather than "commands". Reproducible research and data analysis via Sweave and Rmarkdown. Limits of floating point arithmetic. Understanding how functions work. Environments, packages, namespaces. Closures, i.e., Functions returning functions. Lists and [mc]lapply() for easy parallelization. Performance measurement and improvements. | |||||

Objective | Learn to understand R as a (very versatile and flexible) programming language and learn about some of its lower level functionalities which are needed to understand *why* R works the way it does. | |||||

Content | See "Skript": https://github.com/mmaechler/ProgRRR/tree/master/ETH | |||||

Lecture notes | Material available from Github https://github.com/mmaechler/ProgRRR/tree/master/ETH (typically will be updated during course) | |||||

Literature | Norman Matloff (2011) The Art of R Programming - A tour of statistical software design. no starch press, San Francisco. on stock at Polybuchhandlung (CHF 42.-). More material, notably H.Wickam's "Advanced R" : see my ProgRRR github page. | |||||

Prerequisites / Notice | R Knowledge on the same level as after *both* parts of the ETH lecture 401-6217-00L Using R for Data Analysis and Graphics Link An interest to dig deeper than average R users do. Bring your own laptop with a recent version of R installed | |||||

401-4627-00L | Empirical Process Theory and Applications | W | 4 credits | 2V | S. van de Geer | |

Abstract | Empirical process theory provides a rich toolbox for studying the properties of empirical risk minimizers, such as least squares and maximum likelihood estimators, support vector machines, etc. | |||||

Objective | ||||||

Content | In this series of lectures, we will start with considering exponential inequalities, including concentration inequalities, for the deviation of averages from their mean. We furthermore present some notions from approximation theory, because this enables us to assess the modulus of continuity of empirical processes. We introduce e.g., Vapnik Chervonenkis dimension: a combinatorial concept (from learning theory) of the "size" of a collection of sets or functions. As statistical applications, we study consistency and exponential inequalities for empirical risk minimizers, and asymptotic normality in semi-parametric models. We moreover examine regularization and model selection. | |||||

401-4637-67L | On Hypothesis Testing | W | 4 credits | 2V | F. Balabdaoui | |

Abstract | This course is a review of the main results in decision theory. | |||||

Objective | The goal of this course is to present a review for the most fundamental results in statistical testing. This entails reviewing the Neyman-Pearson Lemma for simple hypotheses and the Karlin-Rubin Theorem for monotone likelihood ratio parametric families. The students will also encounter the important concept of p-values and their use in some multiple testing situations. Further methods for constructing tests will be also presented including likelihood ratio and chi-square tests. Some non-parametric tests will be reviewed such as the Kolmogorov goodness-of-fit test and the two sample Wilcoxon rank test. The most important theoretical results will reproved and also illustrated via different examples. Four sessions of exercises will be scheduled (the students will be handed in an exercise sheet a week before discussing solutions in class). | |||||

Literature | - Statistical Inference (Casella & Berger) - Testing Statistical Hypotheses (Lehmann and Romano) | |||||

401-3629-00L | Quantitative Risk Management | W | 4 credits | 2V + 1U | P. Cheridito | |

Abstract | This course introduces methods from probability theory and statistics that can be used to model financial risks. Topics addressed include loss distributions, risk measures, extreme value theory, multivariate models, copulas, dependence structures and operational risk. | |||||

Objective | The goal is to learn the most important methods from probability theory and statistics used in financial risk modeling. | |||||

Content | 1. Introduction 2. Basic Concepts in Risk Management 3. Empirical Properties of Financial Data 4. Financial Time Series 5. Extreme Value Theory 6. Multivariate Models 7. Copulas and Dependence 8. Operational Risk | |||||

Lecture notes | Course material is available on https://people.math.ethz.ch/~patrickc/qrm | |||||

Literature | Quantitative Risk Management: Concepts, Techniques and Tools AJ McNeil, R Frey and P Embrechts Princeton University Press, Princeton, 2015 (Revised Edition) http://press.princeton.edu/titles/10496.html | |||||

Prerequisites / Notice | The course corresponds to the Risk Management requirement for the SAA ("Aktuar SAV Ausbildung") as well as for the Master of Science UZH-ETH in Quantitative Finance. | |||||

261-5110-00L | Optimization for Data Science | W | 10 credits | 3V + 2U + 4A | B. Gärtner, D. Steurer, N. He | |

Abstract | This course provides an in-depth theoretical treatment of optimization methods that are particularly relevant in data science. | |||||

Objective | Understanding the theoretical guarantees (and their limits) of relevant optimization methods used in data science. Learning general paradigms to deal with optimization problems arising in data science. | |||||

Content | This course provides an in-depth theoretical treatment of optimization methods that are particularly relevant in machine learning and data science. In the first part of the course, we will first give a brief introduction to convex optimization, with some basic motivating examples from machine learning. Then we will analyse classical and more recent first and second order methods for convex optimization: gradient descent, Nesterov's accelerated method, proximal and splitting algorithms, subgradient descent, stochastic gradient descent, variance-reduced methods, Newton's method, and Quasi-Newton methods. The emphasis will be on analysis techniques that occur repeatedly in convergence analyses for various classes of convex functions. We will also discuss some classical and recent theoretical results for nonconvex optimization. In the second part, we discuss convex programming relaxations as a powerful and versatile paradigm for designing efficient algorithms to solve computational problems arising in data science. We will learn about this paradigm and develop a unified perspective on it through the lens of the sum-of-squares semidefinite programming hierarchy. As applications, we are discussing non-negative matrix factorization, compressed sensing and sparse linear regression, matrix completion and phase retrieval, as well as robust estimation. | |||||

Prerequisites / Notice | As background, we require material taught in the course "252-0209-00L Algorithms, Probability, and Computing". It is not necessary that participants have actually taken the course, but they should be prepared to catch up if necessary. | |||||

252-0526-00L | Statistical Learning Theory | W | 8 credits | 3V + 2U + 2A | J. M. Buhmann, C. Cotrini Jimenez | |

Abstract | The course covers advanced methods of statistical learning: - Variational methods and optimization. - Deterministic annealing. - Clustering for diverse types of data. - Model validation by information theory. | |||||

Objective | The course surveys recent methods of statistical learning. The fundamentals of machine learning, as presented in the courses "Introduction to Machine Learning" and "Advanced Machine Learning", are expanded from the perspective of statistical learning. | |||||

Content | - Variational methods and optimization. We consider optimization approaches for problems where the optimizer is a probability distribution. We will discuss concepts like maximum entropy, information bottleneck, and deterministic annealing. - Clustering. This is the problem of sorting data into groups without using training samples. We discuss alternative notions of "similarity" between data points and adequate optimization procedures. - Model selection and validation. This refers to the question of how complex the chosen model should be. In particular, we present an information theoretic approach for model validation. - Statistical physics models. We discuss approaches for approximately optimizing large systems, which originate in statistical physics (free energy minimization applied to spin glasses and other models). We also study sampling methods based on these models. | |||||

Lecture notes | A draft of a script will be provided. Lecture slides will be made available. | |||||

Literature | Hastie, Tibshirani, Friedman: The Elements of Statistical Learning, Springer, 2001. L. Devroye, L. Gyorfi, and G. Lugosi: A probabilistic theory of pattern recognition. Springer, New York, 1996 | |||||

Prerequisites / Notice | Knowledge of machine learning (introduction to machine learning and/or advanced machine learning) Basic knowledge of statistics. | |||||

227-0432-00L | Learning, Classification and Compression | W | 4 credits | 2V + 1U | E. Riegler | |

Abstract | The focus of the course is aligned to a theoretical approach of learning theory and classification and an introduction to lossy and lossless compression for general sets and measures. We will mainly focus on a probabilistic approach, where an underlying distribution must be learned/compressed. The concepts acquired in the course are of broad and general interest in data sciences. | |||||

Objective | After attending this lecture and participating in the exercise sessions, students will have acquired a working knowledge of learning theory, classification, and compression. | |||||

Content | 1. Learning Theory (a) Framework of Learning (b) Hypothesis Spaces and Target Functions (c) Reproducing Kernel Hilbert Spaces (d) Bias-Variance Tradeoff (e) Estimation of Sample and Approximation Error 2. Classification (a) Binary Classifier (b) Support Vector Machines (separable case) (c) Support Vector Machines (nonseparable case) (d) Kernel Trick 3. Lossy and Lossless Compression (a) Basics of Compression (b) Compressed Sensing for General Sets and Measures (c) Quantization and Rate Distortion Theory for General Sets and Measures | |||||

Lecture notes | Detailed lecture notes will be provided. | |||||

Prerequisites / Notice | This course is aimed at students with a solid background in measure theory and linear algebra and basic knowledge in functional analysis. | |||||

252-3005-00L | Natural Language Processing Number of participants limited to 400. | W | 5 credits | 2V + 1U + 1A | R. Cotterell | |

Abstract | This course presents topics in natural language processing with an emphasis on modern techniques, primarily focusing on statistical and deep learning approaches. The course provides an overview of the primary areas of research in language processing as well as a detailed exploration of the models and techniques used both in research and in commercial natural language systems. | |||||

Objective | The objective of the course is to learn the basic concepts in the statistical processing of natural languages. The course will be project-oriented so that the students can also gain hands-on experience with state-of-the-art tools and techniques. | |||||

Content | This course presents an introduction to general topics and techniques used in natural language processing today, primarily focusing on statistical approaches. The course provides an overview of the primary areas of research in language processing as well as a detailed exploration of the models and techniques used both in research and in commercial natural language systems. | |||||

Literature | Jacob Eisenstein: Introduction to Natural Language Processing (Adaptive Computation and Machine Learning series) | |||||

636-0702-00L | Statistical Models in Computational Biology | W | 6 credits | 2V + 1U + 2A | N. Beerenwinkel | |

Abstract | The course offers an introduction to graphical models and their application to complex biological systems. Graphical models combine a statistical methodology with efficient algorithms for inference in settings of high dimension and uncertainty. The unifying graphical model framework is developed and used to examine several classical and topical computational biology methods. | |||||

Objective | The goal of this course is to establish the common language of graphical models for applications in computational biology and to see this methodology at work for several real-world data sets. | |||||

Content | Graphical models are a marriage between probability theory and graph theory. They combine the notion of probabilities with efficient algorithms for inference among many random variables. Graphical models play an important role in computational biology, because they explicitly address two features that are inherent to biological systems: complexity and uncertainty. We will develop the basic theory and the common underlying formalism of graphical models and discuss several computational biology applications. Topics covered include conditional independence, Bayesian networks, Markov random fields, Gaussian graphical models, EM algorithm, junction tree algorithm, model selection, Dirichlet process mixture, causality, the pair hidden Markov model for sequence alignment, probabilistic phylogenetic models, phylo-HMMs, microarray experiments and gene regulatory networks, protein interaction networks, learning from perturbation experiments, time series data and dynamic Bayesian networks. Some of the biological applications will be explored in small data analysis problems as part of the exercises. | |||||

Lecture notes | no | |||||

Literature | - Airoldi EM (2007) Getting started in probabilistic graphical models. PLoS Comput Biol 3(12): e252. doi:10.1371/journal.pcbi.0030252 - Bishop CM. Pattern Recognition and Machine Learning. Springer, 2007. - Durbin R, Eddy S, Krogh A, Mitchinson G. Biological Sequence Analysis. Cambridge university Press, 2004 | |||||

701-0104-00L | Statistical Modelling of Spatial Data | W | 3 credits | 2G | A. J. Papritz | |

Abstract | In environmental sciences one often deals with spatial data. When analysing such data the focus is either on exploring their structure (dependence on explanatory variables, autocorrelation) and/or on spatial prediction. The course provides an introduction to geostatistical methods that are useful for such analyses. | |||||

Objective | The course will provide an overview of the basic concepts and stochastic models that are used to model spatial data. In addition, participants will learn a number of geostatistical techniques and acquire familiarity with R software that is useful for analyzing spatial data. | |||||

Content | After an introductory discussion of the types of problems and the kind of data that arise in environmental research, an introduction into linear geostatistics (models: stationary and intrinsic random processes, modelling large-scale spatial patterns by linear regression, modelling autocorrelation by variogram; kriging: mean square prediction of spatial data) will be taught. The lectures will be complemented by data analyses that the participants have to do themselves. | |||||

Lecture notes | Slides, descriptions of the problems for the data analyses and solutions to them will be provided. | |||||

Literature | P.J. Diggle & P.J. Ribeiro Jr. 2007. Model-based Geostatistics. Springer. | |||||

Prerequisites / Notice | Familiarity with linear regression analysis (e.g. equivalent to the first part of the course 401-0649-00L Applied Statistical Regression) and with the software R (e.g. 401-6215-00L Using R for Data Analysis and Graphics (Part I), 401-6217-00L Using R for Data Analysis and Graphics (Part II)) are required for attending the course. | |||||

401-6222-00L | Robust and Nonlinear Regression Does not take place this semester. | W | 2 credits | 1V + 1U | ||

Abstract | In a first part, the basic ideas of robust fitting techniques are explained theoretically and practically using regression models and explorative multivariate analysis. The second part addresses the challenges of fitting nonlinear regression functions and finding reliable confidence intervals. | |||||

Objective | Participants are familiar with common robust fitting methods for the linear regression models as well as for exploratory multivariate analysis and are able to assess their suitability for the data at hand. They know the challenges that arise in fitting of nonlinear regression functions, and know the difference between classical and profile based methods to determine confidence intervals. They can apply the discussed methods in practise by using the statistics software R. | |||||

Content | Robust fitting: influence function, breakdown point, regression M-estimation, regression MM-estimation, robust inference, covariance estimation with high breakdown point, application in principal component analysis and linear discriminant analysis. Nonlinear regression: the nonlinear regression model, estimation methods, approximate tests and confidence intervals, estimation methods, profile t plot, profile traces, parameter transformation, prediction and calibration | |||||

Lecture notes | Lecture notes are available | |||||

Prerequisites / Notice | It is a block course on three Mondays in June | |||||

401-8618-00L | Statistical Methods in Epidemiology (University of Zurich)No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH. UZH Module Code: STA408 Mind the enrolment deadlines at UZH: https://www.uzh.ch/cmsssl/en/studies/application/deadlines.html | W | 5 credits | 3G | University lecturers | |

Abstract | Analysis of case-control and cohort studies. The most relevant measures of effect (odds and rate ratios) are introduced, and methods for adjusting for confounders (Mantel-Haenszel, regression) are thoroughly discussed. Advanced topics such as measurement error and propensity score adjustments are also covered. We will outline statistical methods for case-crossover and case series studies etc. | |||||

Objective | ||||||

401-4626-00L | Advanced Statistical Modelling: Mixed ModelsDoes not take place this semester. | W | 4 credits | 2V | M. Mächler | |

Abstract | Mixed Models = (*| generalized| non-) linear Mixed-effects Models, extend traditional regression models by adding "random effect" terms. In applications, such models are called "hierarchical models", "repeated measures" or "split plot designs". Mixed models are widely used and appropriate in an aera of complex data measured from living creatures from biology to human sciences. | |||||

Objective | - Becoming aware how mixed models are more realistic and more powerful in many cases than traditional ("fixed-effects only") regression models. - Learning to fit such models to data correctly, critically interpreting results for such model fits, and hence learning to work the creative cycle of responsible statistical data analysis: "fit -> interpret & diagnose -> modify the fit -> interpret & ...." - Becoming aware of computational and methodological limitations of these models, even when using state-of-the art software. | |||||

Content | The lecture will build on various examples, use R and notably the `lme4` package, to illustrate concepts. The relevant R scripts are made available online. Inference (significance of factors, confidence intervals) will focus on the more realistic *un*balanced situation where classical (ANOVA, sum of squares etc) methods are known to be deficient. Hence, Maximum Likelihood (ML) and its variant, "REML", will be used for estimation and inference. | |||||

Lecture notes | We will work with an unfinished book proposal from Prof Douglas Bates, Wisconsin, USA which itself is a mixture of theory and worked R code examples. These lecture notes and all R scripts are made available from https://github.com/mmaechler/MEMo | |||||

Literature | (see web page and lecture notes) | |||||

Prerequisites / Notice | - We assume a good working knowledge about multiple linear regression ("the general linear model') and an intermediate (not beginner's) knowledge about model based statistics (estimation, confidence intervals,..). Typically this means at least two classes of (math based) statistics, say 1. Intro to probability and statistics 2. (Applied) regression including Matrix-Vector notation Y = X b + E - Basic (1 semester) "Matrix calculus" / linear algebra is also assumed. - If familiarity with [R](https://www.r-project.org/) is not given, it should be acquired during the course (by the student on own initiative). | |||||

401-8628-00L | Survival Analysis (University of Zurich)No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH. UZH Module Code: STA425 Mind the enrolment deadlines at UZH: https://www.uzh.ch/cmsssl/en/studies/application/deadlines.html | W | 3 credits | 1.5G | University lecturers | |

Abstract | The analysis of survival times, or in more general terms, the analysis of time to event variables is concerned with models for censored observations. Because we cannot always wait until the event of interest actually happens, the methods discussed here are required for an appropriate handling of incomplete observations where we only know that the event of interest did not happen within ... | |||||

Objective | ||||||

Content | During the course, we will study the most important methods and models for censored data, including - general concepts of censoring, - simple summary statistics, - estimation of survival curves, - frequentist inference for two and more groups, and - regression models for censored observations |

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