Suchergebnis: Katalogdaten im Frühjahrssemester 2021

Biologie Master Information
Wahlvertiefungen
Wahlvertiefung: Mikrobiologie und Immunologie
Zusätzliche Konzeptkurse
NummerTitelTypECTSUmfangDozierende
752-4006-00LLebensmittel-Mikrobiologie IIW3 KP2VM. Loessner, J. Klumpp
KurzbeschreibungVermittlung von (teilweise vertieften) Basiskenntnissen ueber Methoden fuer Nachweis und die Differenzierung von (nicht nur lebensmittelrelevanten) Mikroorganismen; Herstellung von Lebensmitteln mit Mikroorganismen; Haltbarmachung und Lebensmittelsicherheit; kurzer Ueberblick ueber gesetzliche Regelungen und Hygienemassnahmen.
LernzielDer zweite Teil dieser 1 Jahres-Vorlesung vermittelt (teilweise vertiefte) Basiskenntnisse ueber verschiedene Methoden (klassisch und molekularbiologisch)fuer den Nachweis und die Differenzierung von (nicht nur lebensmittelrelevanten) Mikroorganismen; die Herstellung von Lebensmitteln mit Mikroorganismen; verschiedene Ansaetze zur Haltbarmachung und Lebensmittelsicherheit; und einen kurzen Ueberblick ueber gesetzliche Regelungen und Hygienemassnahmen.
InhaltNachweis und Differenzierung von Mikroorganismen
Kulturmethoden, Mikroskopischer Nachweis, Anreicherung und Separation, Nachweis intrazellulärer Metaboliten und Enzyme, Immunologische Methoden, Gensonden und Microarrays, Nukleinsäureamplifikation, Expression von Reportergenen, Typisierungsmethoden

Herstellung von Lebensmitteln mit Mikroorganismen
Fermentierte pflanzliche Produkte, Brot und Sauerteig, Fermentierte (alkoholische) Getränke, Fermentierte Milchprodukte, Probiotika, Fermentierte Fleischprodukte, Traditionelle Fermentationsprodukte, Kaffee, Tee, Kakao, Tabak; Störungen der Fermentation (Viren, Antibiotika, Desinfektionsmittel)

Haltbarmachung I: Physikalische Verfahren
Erniedrigung der Wasseraktivität, Erniedrigung der Temperatur, Hitzebehandlung, Hochdruckbehandlung, Bestrahlung

Haltbarmachung II. Chemische Verfahren
Natürliche antimikrobielle Stoffe, Räuchern, Konservierungsstoffe, Erniedrigung des pH Wertes, Schutzgas- und Vakuumverpackung

Haltbarmachung III. Biologische Verfahren
Zusatz von Enzymen, Schutzkulturen, Starter- und Reifungskulturen

Qualitätssicherung und Kontrolle
Gesetzliche Kriterien & Verordnungen, Betriebs- & Personalhygiene, Reinigung & Desinfektion, GHP & HACCP
SkriptElektronische PDF Kopien der Praesentationsfolien werden an die Studenten abgegeben
LiteraturHinweise in der ersten Vorlesungsstunde
Voraussetzungen / BesonderesDie Vorlesung "Lebensmittelmikrobiologie I" (oder eine ähnliche Veranstaltung) wird inhaltlich vorausgesetzt
529-0732-00LProteins and Lipids
Hinweis für BSc Biologiestudierende: Nur einer der beiden Konzeptkurse 529-0731-00 Nucleic Acids and Carbohydrates (Herbstsemester) oder 529-0732-00 Proteins and Lipids (Frühlingsemester) kann für das Bachelorstudium angerechnet werden.
W6 KP3GD. Hilvert
KurzbeschreibungAn overview of the relationship between protein sequence, conformation and function.
LernzielOverview of the relationship between protein sequence, conformation and function.
InhaltProteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics.
LiteraturGeneral Literature:
- T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993.
- C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991.
- J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002.
- G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004.

Original Literature:
Citations from the original literature relevant to the individual lectures will be assigned weekly.
551-0326-00LCell Biology Information W6 KP4VS. Werner, H. Gehart, W. Kovacs, M. Schäfer, U. Suter, A. Wutz, weitere Dozierende
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
551-0324-00LSystems Biology Information W6 KP4VP. Picotti, M. Claassen, U. Sauer, B. Snijder, B. Wollscheid
KurzbeschreibungIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
InhaltOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skriptno script
LiteraturThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature may be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0307-01LMolecular and Structural Biology II: Molecular Machines and Cellular Assemblies
D-BIOL students are obliged to take part I and part II as a two-semester course.
W3 KP2VN. Ban, F. Allain, S. Jonas, M. Pilhofer
KurzbeschreibungThis course on advanced topics in Molecular Biology and Biochemistry will cover the structure and function of cellular assemblies. General topics in basic biochemistry will be further developed with examples of the function of large cellular machines involved in DNA packaging, translation, virus architecture, RNA processing, cell-cell interactions, and the molecular basis of CRISPER systems.
LernzielStudents will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation.
InhaltAdvanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies.
SkriptUpdated handouts will be provided during the class.
LiteraturThe lecture will be based on the latest literature. Additional suggested
literature:
Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed.
(1995). Garland, New York.
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