Suchergebnis: Katalogdaten im Herbstsemester 2020

Nummer	Titel	Typ	ECTS	Umfang	Dozierende
Biologie Master
Wahlvertiefungen
Wahlvertiefung: Biologische Chemie
Wahlpflicht Masterkurse
529-0733-01L	Enzymes	W	6 KP	3G	D. Hilvert
Kurzbeschreibung	Vermittlung eines Überblicks über die Chemie von Enzymen, enzymkatalysierten Reaktionen, metabolischen Prozessen.
Lernziel	Vermittlung eines Überblicks über die Chemie von Enzymen, enzymkatalysierten Reaktionen, metabolischen Prozessen.
Inhalt	Prinzipien der enzymatischen Katalyse, Enzymkinetiken, Mechanismen enzymkatalysierter Reaktionen (Gruppentransferreaktion, Kohlenstoff-Kohlenstoff-Bindungsknüpfungen, Eliminierungen, Isomerisierungen und Umlagerungen), Kofaktorenchemie, Enzyme in der organischen Synthese und in der Naturstoffbiosynthese, katalytische Antikörper.
Skript	A script will not be handed out.
Literatur	General: T. Bugg, An Introduction to Enzyme and Coenzyme Chemistry, Blackwell Science Ltd., Oxford, 1997. In addition, citations from the original literature relevant to the individual lectures will be assigned weekly.
529-0004-01L	Classical Simulation of (Bio)Molecular Systems	W	6 KP	4G	P. H. Hünenberger, S. Riniker
Kurzbeschreibung	Molecular models, classical force fields, configuration sampling, molecular dynamics simulation, boundary conditions, electrostatic interactions, analysis of trajectories, free-energy calculations, structure refinement, applications in chemistry and biology. Exercises: hands-on computer exercises for learning progressively how to perform an analyze classical simulations (using the package GROMOS).
Lernziel	Introduction to classical (atomistic) computer simulation of (bio)molecular systems, development of skills to carry out and interpret these simulations.
Inhalt	Molecular models, classical force fields, configuration sampling, molecular dynamics simulation, boundary conditions, electrostatic interactions, analysis of trajectories, free-energy calculations, structure refinement, applications in chemistry and biology. Exercises: hands-on computer exercises for learning progressively how to perform an analyze classical simulations (using the package GROMOS).
Skript	Script booklet (copies of powerpoint slides) distributed at the first or second lecture.
Literatur	See: www.csms.ethz.ch/education/CSBMS
Voraussetzungen / Besonderes	Since the exercises on the computer do convey and test essentially different skills than those being conveyed during the lectures and tested at the oral exam, the results of the exercises are taken into account when evaluating the results of the exam (learning component, possible bonus of up to 0.25 points on the exam mark). For more information about the lecture: www.csms.ethz.ch/education/CSBMS
529-0233-01L	Organic Synthesis: Methods and Strategies	W	6 KP	3G	E. M. Carreira
Kurzbeschreibung	The complex relation between structural analysis, methods leading to desired transformations, and insight into reaction mechanisms is exemplified. Relations between retrosynthetic analysis of target structures, synthetic methods and their combination in a synthetic strategy.
Lernziel	Extension and deepening of the knowledge in organic synthesis and the principles of structure and reactivity.
Inhalt	Begriffe der Planung (Strategie und Taktik) der organischen Synthese, Retrosynthetische Analyse, Vertiefung der Beziehungen zwischen Struktur und Reaktivität im Zusammenhang mit der Synthese organischer Verbindungen zunehmender Komplexität. Vertiefung und Ergänzung der Kenntnisse synthetischer Methoden.
Literatur	K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, Wiley-VCH 1996. K. C. Nicolaou, S. A. Snyder, Classics in Total Synthesis II, Wiley-VCH 2003. K. C. Nicolaou, J. Chen, Classics in Total Synthesis III, Wiley-VCH 2011.
Voraussetzungen / Besonderes	OC I-IV
529-0243-01L	Transition Metal Catalysis: From Mechanisms to Applications	W	6 KP	3G	B. Morandi
Kurzbeschreibung	Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint
Lernziel	Understanding and critical evaluation of current research in transition metal catalysis. Design of mechanistic experiments to elucidate reaction mechanisms. Synthetic relevance of transition metal catalysis. Students will also learn about writing an original research proposal during a workshop.
Inhalt	Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint. Synthetic applications of these reactions. Introduction and application of tools for the elucidation of mechanisms. Selected examples of topics include: C-H activation, C-O activation, C-C activation, redox active ligands, main group redox catalysis, bimetallic catalysis.
Skript	Lecture slides will be provided online. A Handout summarizing important concepts in organometallic and physical organic chemistry will also be provided. Useful references and handouts will also be provided during the workshop. Slides will be uploaded 1-2 days before each lecture on http://morandi.ethz.ch/education.html
Literatur	Primary literature and review articles will be cited during the course. The following textbooks can provide useful support for the course: - Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books. - Crabtree R., The Organometallic Chemistry of the Transition Metals, John Wiley & Sons, Inc. - Hartwig J., Organotransition Metal Chemistry: From Bonding to Catalysis, University Science Books. - J. P. Collman, L. S. Hegedus, J. R. Norton, R. G. Finke, Principles and Applications of Organotransition Metal Chemistry.
Voraussetzungen / Besonderes	Required level: Courses in organic and physical chemistry (kinetics in particular) of the first and second year as well as ACIII Special requirement: each participant will have to come up with an independent research proposal to be presented orally (or handed in in written form) at the end of the semester. A dedicated workshop will be organized in the middle of the semester to introduce the students to proposal writing and presentation.
529-0041-00L	Moderne Massenspektroskopie, gekoppelte Analysenmethoden, Chemometrie	W	6 KP	3G	R. Zenobi, M. Badertscher, D. Günther, B. Hattendorf, P. Sinués Martinez-Lozano
Kurzbeschreibung	Moderne Massenspektrometrie, Kopplung von Trenn- mit Identifikationsmethoden, Speziierung, Oberflächenanalytische Methoden, und Chemometrie
Lernziel	Umfassende Kenntnis der vorgestellten analytischen Methoden und ihre Anwendungen in der Praxis.
Inhalt	Kopplung von Trenn- mit Identifikationsmethoden wie GC-MS, LC-MS, GC-IR, LC-IR, LC-NMR etc.; Wichtigkeit der Speziierung. Moderne Massenspektrometrie: Flugzeit- und Ionen-Cyclotron-Resonanz-Massenspektrometrie, ICP-MS. Weiche Ionisationsmethoden, Desorptions-Methoden, Spray-Methoden. Oberflächenanalytische Methoden (ESCA, Auger, SIMS, Rastermikroskopie-Verfahren). Einsatz der Informatik zur Verarbeitung analytisch-chemischer Daten (Chemometrie).
Skript	Ein Skript wird zum Selbstkostenpreis abgegeben.
Literatur	Hinweise zur aktuellen Literatur werden in der Vorlesung bezw. im Skript gegeben
Voraussetzungen / Besonderes	Übungen sind in die Vorlesung integriert Voraussetzung: 529-0051-00 "Analytische Chemie I (3. Semester)" 529-0058-00 "Analytische Chemie II (4. Semester)" (oder äquivalent)
529-0240-00L	Chemical Biology - Peptides	W	6 KP	3G	H. Wennemers
Kurzbeschreibung	An advanced course on the synthesis, properties and function of peptides in chemistry and biology.
Lernziel	Knowledge of the synthesis, properties and function of peptides in chemistry and biology.
Inhalt	Advanced peptide synthesis, conformational properties, combinatorial chemistry, therapeutic peptides, peptide based materials, peptides in nanotechnology, peptides in asymmetric catalysis.
Skript	Citations from the original literature relevant to the individual lectures will be assigned weekly.
Literatur	Norbert Sewald, Hans Dieter Jakubke "Peptides: Chemistry and Biology", 1st edition, Wiley VCH, 2002.
636-0108-00L	Biological Engineering and Biotechnology Attention: This course was offered in previous semesters with the number: 636-0003-00L "Biological Engineering and Biotechnology". Students that already passed course 636-0003-00L cannot receive credits for course 636-0108-00L.	W	4 KP	3V	M. Fussenegger
Kurzbeschreibung	Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
Lernziel	Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
Inhalt	1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development.
Skript	Handout during the course.
551-1407-00L	RNA Biology Lecture Series I: Transcription & Processing & Translation	W	4 KP	2V	F. Allain, N. Ban, S. Jonas, U. Kutay, weitere Dozierende
Kurzbeschreibung	This course covers aspects of RNA biology related to gene expression at the posttranscriptional level. These include RNA transcription, processing, alternative splicing, editing, export and translation.
Lernziel	The students should obtain an understanding of these processes, which are at work during gene expression.
Inhalt	Transcription & 3'end formation ; splicing, alternative splicing, RNA editing; the ribosome & translation, translation regulation, RNP biogenesis & nuclear export, mRNA surveillance & mRNA turnover; signal transduction & RNA.
Voraussetzungen / Besonderes	Basic knowledge of cell and molecular biology.
551-1409-00L	RNA Biology Lecture Series II: Non-coding RNAs: Biology and Therapeutics Findet dieses Semester nicht statt.	W	4 KP	2V	J. Hall, M. Stoffel, weitere Dozierende
Kurzbeschreibung	This course covers aspects of RNA biology related to the functions of non-coding RNAs as well as their use as drugs to treat diseases.
Lernziel	The students should get familiar with the wide array of roles, which non-coding RNAs play in cellular functions.
Inhalt	Micro RNAs; computational approaches to miRNAs; micro RNA function in metabolism; viruses and viral RNAs; nucleic acid-based drugs; ncRNA-mediated genome regulation; epigenetic programming of genome remodelling in ciliates; telomerase and telomeres; tRNA biology. http://www.nccr-rna-and-disease.ch/tiki-index.php?page=LectureSeries
Voraussetzungen / Besonderes	Basic knowledge of cell and molecular biology.
529-0241-10L	Advanced Methods and Strategies in Synthesis	W	6 KP	3G	J. W. Bode
Kurzbeschreibung	Advanced Modern Methods and Strategies in Synthesis
Lernziel	Kenntnis der modernen Methoden der asymmetrischen Synthese, der enantioselektiven Katalyse, und organische Reactionsmechanismus.
Inhalt	Aktuelle Trends in Methoden für und Annäherungen an die Synthese von komplexen Naturstoffen, Pharmazeutika und biologischen Molekülen, Fragmentkopplungs- und Schutzgruppenstrategien; chemische Ligation und Biomolekülsynthese; enantioselektive Katalyse einschließlich Ligandendesign und -optimierung; Kreuzkupplungsreaktionen voraktivierter Vorstufen; C-H-Aktivierung und Oxidationen; Bausteinsynthese mit chiralen Auxilliaren und Reagenzien; neue Konzepte in der asymmetrischen Katalyse. Analyse von Schlüsselliteratur inklusive der Erkennung von Trends, bedeutenden Präzedenzfällen und neu aufkommenden Gebieten wird hervorgehoben.
Skript	will be provided in class and online
Literatur	Suggesting Textbooks 1. Walsh and Kozlowski, Fundamentals of Asymmetric Catalysis, 1st Ed., University Science Books, 2009. 2. Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006.
227-0939-00L	Cell Biophysics	W	6 KP	4G	T. Zambelli
Kurzbeschreibung	A mathematical description is derived for a variety of biological phenomena at the molecular and cellular level applying the two fundamental principles of thermodynamics (entropy maximization and Gibbs energy minimization).
Lernziel	Engineering uses the laws of physics to predict the behavior of a system. Biological systems are so diverse and complex prompting the question whether we can apply unifying concepts of theoretical physics coping with the multiplicity of life’s mechanisms. Objective of this course is to show that biological phenomena despite their variety can be analytically described using only two concepts from statistical mechanics: maximization of the entropy and minimization of the Gibbs free energy. Starting point of the course is the probability theory, which enables to derive step-by-step the two pillars of statistical mechanics: the maximization of entropy according to the Boltzmann’s law as well as the minimization of the Gibbs free energy. Then, an assortment of biological phenomena at the molecular and cellular level (e.g. cytoskeletal polymerization, action potential, photosynthesis, gene regulation, morphogen patterning) will be examined at the light of these two principles with the aim to derive a quantitative expression describing their behavior according to experimental data. By the end of the course, students will also learn to critically evaluate the concepts of making an assumption and making an approximation.
Inhalt	1. Basics of theory of probability 2. Boltzmann's law 3. Entropy maximization and Gibbs free energy minimization 4. Two-state systems and the MWC model 5. Random walks and macromolecular structures 6. Electrostatics for salty solutions 7. Elasticity: fibers and membranes 8. Diffusion and crowding: cell signaling 9. Molecular motors 10. Action potential: Hodgkin-Huxley model 11. Photosynthesis 12. Gene regulation 13. Development: Turing patterns 14. Sequences and evolution
Literatur	- Statistical Mechanics: K. Dill, S. Bromberg, Molecular Driving Forces, 2nd Edition, Garland Science, 2010. - Biophysics: R. Phillips, J. Kondev, J. Theriot, H. Garcia, Physical Biology of the Cell, 2nd Edition, Garland Science, 2012.
Voraussetzungen / Besonderes	Participants need a good command of differentiation and integration of a function with one or more variables (calculus) as well as of Newton's and Coulomb's laws (basics of mechanics and electrostatics). Notions of vectors in 2D and 3D are beneficial. Theory and corresponding exercises are merged together during the classes.

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