Search result: Catalogue data in Spring Semester 2020
Food Science Master  | ||||||
 Minors | ||||||
| Food Toxicology | ||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|---|
| 752-1300-01L | Food Toxicology | W+ | 2 credits | 1V | S. J. Sturla, N. Antczak | |
| Abstract | Builds on a foundation in Toxicology fundamentals to address situations and toxins relevant to Food Science, Nutrition, and Food Safety & Quality. | |||||
| Learning objective | Course objectives are for the student to have a broad awareness of toxicant classes and toxicants relevant to food, and to know their identities (i.e. chemical structure or biological nature), origins, relevance of human exposures, general mode of biological action, and potential mitigation strategies. | |||||
| Content | Builds on a foundation in Toxicology fundamentals to address situations relevant to Food Science, Nutrition, and Food Safety & Quality. Representative topics: Toxic Phytochemicals and Mycotoxins, Industrial Contaminants and Packaging Materials, Toxicants formed During Food Processing, Alcohol and Tobacco. The class is comprised of bi-weekly lectures, independent reading, and preparation of an independent evaluation of a food-related toxin. | |||||
| Literature | Reading from the primary literature will be referenced in class and posted to the course website. | |||||
| Prerequisites / Notice | The course "Introduction to Toxicology" (752-1300-00V) is a prerequisite for the students who want to take this course. Equivalent course may be accepted; contact the instructor. | |||||
| 752-2123-00L | Risk Awareness, Risk Acceptance and Trust | W | 3 credits | 2V | M. Siegrist | |
| Abstract | The course provides an overview about risk perception and acceptance of new technologies. In addition, the most important findings of the research related to decisions under uncertainty are presented. | |||||
| Learning objective | Students know the most important theoretical approaches in the domains of risk perception and acceptance of new technologies. Furthermore, students understand the paradigms and the research results in the domain of decision making under uncertainty. | |||||
| 701-0998-00L | Environmental and Human Health Risk Assessment of Chemicals | W | 3 credits | 2G | M. Scheringer, B. Escher | |
| Abstract | Application of methods for chemical risk assessment for human health and the environmental according to European and Swiss regulation; hazard and risk; exposure and effect analysis for different types of chemicals. Estimation of missing chemical properties (QSAR methods); critical evaluation of risk assessment methods, presentation of alternative assessment methods. | |||||
| Learning objective | The students are familiar with regulatory approaches to human and environmental risk assessment of chemicals and can perform the main steps of a regulatory risk assessment for an industrial chemical. They are aware of pitfalls and challenges and know about new approaches to risk assessment. | |||||
| Content | Regulatory methods for environmental risk assessment of chemicals (industrial chemicals, pesticides, pharmaceuticals), European regulation REACH, Swiss regulations, international approaches - Human vs. environmental risk assessment - Classification and labelling of chemicals - PBT assessment (persistence, bioaccumulation, toxicity) - Exposure analysis: emission patterns, multimedia fate and transport models for quantifying environmental exposure, Long range transport and persistence, predicted and measured exposure concentration for the environment and humans - Effect analysis: estimation of hazard potential for ecotoxicity and human health, extrapolation methods, classification of chemicals according to modes of toxic action, predictive models (QSAR) - Risk assessment methods (deterministic vs. probabilistic), risk assessment vs. hazard assessment, risk management - uncertainty and sensitivity analyses, precautionary principle - Environmental Quality Assessment (water, sediment, biota), Water Framework Directive) - New methods in environmental risk assessment: mixtures, temporally and spatially explicit risk assessment | |||||
| Lecture notes | Slides of lectures, lecture notes for selected chapters and additional reading material will be made available via ILIAS. Also templates for the exercises and the report will be made available via ILIAS. | |||||
| Literature | - Van Leeuwen, C.J., Vermeire, T. (Eds.) Risk Assessment of Chemicals: An Introduction. Springer, 2007 (als e-book in der ETH-Bibliothek verfügbar). - Scheringer, M., Persistence and Spatial Range of Environmental Chemicals. Wiley-VCH, Weinheim, 2002. | |||||
| Prerequisites / Notice | Block course: Lecture and accompanying exercise where students conduct a comprehensive risk assessment for one selected chemical each according to the European regulation for industrial chemicals. The risk assessment will be presented in class and has to be compiled in a written technical report (Chemical dossier) that will be graded. The overall work load is 90 hours with 30 hours contact time (block course) and 60 hours self-study. | |||||
| 701-1312-00L | Advanced Ecotoxicology | W | 3 credits | 2V | R. Eggen, E. Janssen, K. Schirmer, M. Suter | |
| Abstract | This course will take up the principles of environmental chemistry and ecotoxicology from the bachelor courses and deepen the understanding on selected topics. Linkages will be made between i) bioavailability and effects, ii) structures of compounds and modes of toxic action, iii) effects over various biological levels, moderated by environmental factors, iv) chemical and biological assessments | |||||
| Learning objective | - Understanding the key processes involved in fate, behavior and the bioaccumulation of (mainly) organic contaminants - Overview on and understanding of mechanisms of toxicity - linking structures and characteristics of compounds with effects - processes in hazard assessment and risk assessment - get insight in integrative approaches in ecotoxicology | |||||
| Content | Units 1-3: Fate of contaminants, dynamic interactions with the (a)biotic environment, toxikokinetics - physico-chemical properties - partitioning processes in environmental compartments - partitioning to biota - bioavailability and bioaccumulation concepts - partitioning in biota Units 4-6: Toxicodynamics (effect of contaminants on biota) - internal concentrations; dose-response concept - molecular mechanisms of toxic actions - classification - Exercise: databases and estimation of toxicity Unit 7-10: Toxic effects: from molecular to ecosystems - complex mechanisms and feedback loops - mixtures and multiple stressors - stress- and adaptive responses - dynamic exposures - confounding factors, food web interactions - Exercise: linking compounds with modes of toxic action Unit 11: metal ecotoxicology Unit 12-14: integrative approaches and case studies - bioassays, -omics, systems ecotoxicology, phenotypic anchoring - in vivo versus in vitro biotesting - linking chemical with biological analytics - bioassay-directed fractionation and identification - (inter) national case studies and linkage of learned with approaches in practice | |||||
| Lecture notes | Material will be in the form of copies of overheads, selected publications and exercise material. | |||||
| Literature | R.P. Schwarzenbach, P.M. Gschwend, D.M. Imboden, Environmental Organic Chemistry, third edition, Wiley, 2005 C.J. van Leeuwen, J.L.M. Hermens (Editoren), Risk Assessment of Chemicals: An Introduction, Kluwer, 1995 Principles of ecotoxicology, CH Walker, RM Sibly, SP Hopkin, DB Peakall, fourth edition, CRC Press, 2012 | |||||
| Prerequisites / Notice | Required: 1. Basics in environmental chemistry 2. Basics in environmental toxicology | |||||
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