Suchergebnis: Katalogdaten im Frühjahrssemester 2020

Biologie Bachelor Information
3. Studienjahr, 6. Semester
Blockkurse
Anmeldung zu Blockkursen muss zwingend über die website Link
Anmeldung möglich von 16.12.2019 - 06.01.2020

Bitte die ETH Aufnahmekriterien für die Aufnahme von Studierenden der ETH in ETH Blockkurse auf der Blockkurs-Anmeldeseite unter "Zuteilung" beachten.
Blockkurse im 3. Semesterviertel
Von 3.4.2020 bis 6.5.2020
NummerTitelTypECTSUmfangDozierende
551-0362-00LMolecular Health: Biomedical Analysis of the Extracellular Interactome Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.

The enrolment is done by the D-BIOL study administration.
W6 KP7GB. Wollscheid, E. Tschudy-Milani
KurzbeschreibungIn this course you will learn to measure, integrate, analyze and validate the cellular surfaceome as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to establish the surfaceome proteotype and its signaling interaction networks.
Lernziel"If a cell surface molecule such as the B cell receptor would have the size of a human being, then the cell surface of a B cell would have roughly the size of three times NYC Central Park." How many people/proteins/proteoforms reside in this space ("Surfaceome")? Similar to humans, proteins don't act alone. Function is encoded in dynamic protein-protein interactions. How are these proteoforms organized in signaling islands/networks in order to fulfill specific cellular functions ("Interactome")? What are the ligands interacting with the surfaceome to communicate information from other cells & tissues in the body? What goes wrong in these signaling islands if we get sick?

In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome and its signaling islands as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to generate unprecedented data to establish the surfaceome proteotype and its signaling interaction networks. This digital proteotype data layer provides the basis for generating qualitative and quantitative surfaceome models explaining how molecular nanoscale organization influences cellular signaling and biological function.
Inhalt"If a cell surface molecule such as the B cell receptor would have the size of a human being, then the cell surface of a B cell would have roughly the size of three times NYC Central Park." How many people/proteins/proteoforms reside in this space ("Surfaceome")? Similar to humans, proteins don't act alone. Function is encoded in dynamic protein-protein interactions. How are these proteoforms organized in signaling islands/networks in order to fulfill specific cellular functions ("Interactome")? What are the ligands interacting with the surfaceome to communicate information from other cells & tissues in the body? What goes wrong in these signaling islands if we get sick?

In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome and its signaling islands as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to generate unprecedented data to establish the surfaceome proteotype and its signaling interaction networks. This digital proteotype data layer provides the basis for generating qualitative and quantitative surfaceome models explaining how molecular nanoscale organization influences cellular signaling and biological function.
LiteraturD. Bausch-Fluck, E. S. Milani, B. Wollscheid, Surfaceome nanoscale organization and extracellular interaction networks, Curr. Opin. Chem. Biol. 48, 26–33 (2019).

Link
Voraussetzungen / BesonderesThis course requires a basic knowledge in mass spectrometry based proteomics and experience in computational data processing using R or MatLab. Ideally this course should be combined with course 551-0352-00L "Introduction to Mass Spectrometry-based Proteomics".
529-0810-01LOrganische Chemie II (für D-BIOL) Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 12

Bitte melden Sie sich möglichst vor Ablauf der Herbstsemester-Vorlesungszeit bei Prof. C. Thilgen (Link) an. Sie erhalten eine Rückmeldung, ob Sie am Praktikum teilnehmen können.

Die Belegung erfolgt nur über das Studiensekretariat D-BIOL.

Die Lehrsprache hängt de facto von der betreuenden Person ab.
W12 KP4PC. Thilgen
KurzbeschreibungBearbeiten eines organisch-synthetischen Teilprojekts aus der aktuellen Forschung einer Gruppe des Laboratoriums für Organische Chemie unter der Anleitung von Doktorierenden.
LernzielErlernen von Planung und Durchführung anspruchsvoller Mehrstufensynthesen unter Einbezug moderner Methoden; vertieftes Verständnis organisch-chemischer Reaktionen durch Experimente; Entwickeln eines organisch-synthetischen Forschungsprojekts; akkurates Protokollieren, Verfassen eines Berichts im Stil einer Veröffentlichung und Präsentieren der Ergebnisse in Form eines Kurzvortrags.
InhaltBearbeiten eines organisch-synthetischen Teilprojekts aus der aktuellen Forschung einer Gruppe des Laboratoriums für Organische Chemie unter der Anleitung von Doktorierenden.
SkriptKein Skript.
LiteraturKeine Pflichtliteratur. Literatur wird von den betreuenden Doktorierenden angegeben bzw. zur Verfügung gestellt.
Voraussetzungen / BesonderesVoraussetzungen: bestandenes Praktikum Organische Chemie I (529-0229-00); bestandene Sessionsprüfung Organische Chemie I (529-0221-00 bzw. 529-1011-00) / Organische Chemie II (529-0222-00 bzw. 529-1012-00). Die Zahl der Teilnehmenden ist auf 12 beschränkt.
551-0344-00LPlant-Microbe Interactions Belegung eingeschränkt - Details anzeigen
Number of participants limited to 10.

The enrolment is done by the D-BIOL study administration.
W6 KP7GH.‑M. Fischer, J. Vorholt-Zambelli
KurzbeschreibungLab course. In small groups projects of relevance to current research questions in the field of plant-microbe interactions are addressed.
LernzielIntroduction to relevant subjects of the biology of plant-associated microorganisms. Training in practical work in a research laboratory. Exposure to current research topics in the field of plant-microbe interactions. Scientific writing in form of a research report.
InhaltResearch project on plant-associated microorganisms (i.e. Bradyrhizobium, Methylobacterium, Sphingomonas). The techniques used will depend on the project, e.g. PCR, cloning, community analysis, plant inoculation experiments, phenotypic analysis, plant transformation, (fluorescence) microscopy, monitoring gene expression
Skriptnone
LiteraturWill be provided for each of the projects at the beginning of the course.
551-1556-00LMacromolecular Structure Determination Using Modern Methods Belegung eingeschränkt - Details anzeigen
Number of participants limited to 11 in the 3rd semester quarter of the spring semester

Number of participants limited to 12 in the 4th semester quarter of the spring semester

The block course will only take place with a minimum of 4 participants.

The enrolment is done by the D-BIOL study administration.
W6 KP7GK. Locher, G. Schertler
KurzbeschreibungThis course will expose the students to two prominent techniques for high-resolution structural characterization of biological macromolecules. The students will have the opportunity to get hands-on experience in either cryo-electron microscopy (ETH) or X-ray crystallography (PSI).
LernzielThe goal of this course is to introduce the students to the principles of high-resolution structure determination. Students will conduct hands-on experiments and use computational techniques for data processing.
InhaltAt the ETH the students will prepare and vitrify a protein and then image it on a cryo-TEM. Next, the students will process the data and build an atomic model into the EM map.

At the PSI the students will purify and crystallize a membrane protein, collect X-ray diffraction data using synchrotron X-ray source or with cryo-EM, analyze and build an atomic model into a density map. They will refine this model and interpret and illustrate the determined structure. The course work is trying to present insights in the use of structural information. The course also includes a demonstration of the Synchrotron capabilities at the Paul Scherrer Institute (SLS).
Voraussetzungen / BesonderesThe students will be split into two groups for the practical part of the work: One group will work at ETH Hönggerberg, the other at the Paul Scherrer Institute (PSI) at Villigen. All students will spend one full day at the PSI for a tour of the facilities, including a visit of the synchrotron beam lines of the Swiss Light Source SLS.

The students joining the ETH Hönggerberg group will spend the majority of the time on data processing and are therefore expected to have some basic knowledge of bash terminal commands. Basic physics, optics and linear algebra knowledge is also helpful. By the end of the course, the students will be expected to understand concepts such as the difference between Fourier and real space, image formation, contrast transfer, fast Fourier transfer and Fourier shell correlation.
551-1312-00LRNA-Biology II Belegung eingeschränkt - Details anzeigen
Number of participants limited to 16.

The enrolment is done by the D-BIOL study administration.
W6 KP7GS. Jonas, F. Allain, C. Beyer, U. Kutay, O. Voinnet, K. Weis
KurzbeschreibungIntroduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells.
LernzielThe students will obtain an overview about the diversity of current RNA-research. They will learn to design experiments and use techniques necessary to analyze different aspects of RNA biology. Through lectures and literature seminars, they will learn about the burning questions of RNA research and discuss approaches to address these questions experimentally. In practical lab projects the students will work in one of the participating laboratories. Finally, they will learn how to present and discuss their data in an appropriate manner. Student assessment is a graded semester performance based on individual performance in the laboratory, the written exam and the project presentation.
SkriptRelevant material from the lectures will be made available during the course via the corresponding Moodle page.
LiteraturDocumentation and recommended literature will be provided at the beginning and during the course.
551-1300-00LCause and Consequences of Unstable Genomes Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.

The enrolment is done by the D-BIOL study administration.
W6 KP7GJ. Fernandes de Matos, Y. Barral, C. Beyer, K. Bomblies, M. Jagannathan, R. Kroschewski
KurzbeschreibungThe course will introduce students to key concepts and laboratory research within the broad field of "Genome stability".
LernzielStudents will learn to design, apply and evaluate current research strategies in a wide range of modern research areas encompassing the broad field of "Genome stability".
InhaltThe course will consist of lectures, practical laboratory work in small groups, informal progress report sessions, and preparation and presentation of a poster. Lectures will be presented mainly at the start of the course to expose students to key concepts and techniques in the field. Students will team into small groups and work in one laboratory for the rest of the course. Students will meet regularly for informal "progress report" discussions of their projects. Student performance will be assessed based on the quality of their practical work, a written exam on frontal lecture material, and a poster presentation of their practical work.
LiteraturDocumentation and recommended literature in the form of review articles and selected primary literature will be provided during the course.
Voraussetzungen / BesonderesThis course will be taught in English.
551-1302-00LSynthetic Genomics Belegung eingeschränkt - Details anzeigen
Findet dieses Semester nicht statt.
Number of participants limited to 6.

The enrolment is done by the D-BIOL study administration.
W6 KP7GB. Christen
KurzbeschreibungLab course on experimental and computational approaches in synthetic microbiology. Participants work in small groups to address current questions in the field of synthetic genomics.
LernzielThe course covers high-throughput biology techniques and design approaches to engineer large-scale synthetic DNA constructs ranging form pathways to entire bacterial genomes. Training in experimental and computational work in a research laboratory.
InhaltResearch project in synthetic biology. Learn basics of DNA part definition, sequence design, de novo DNA synthesis and assembly strategies used for synthetic genomics. Discuss recent advances and current limitations in the field.

Soft skills to be trained: scientific project planning, team-work, presentation and reporting.
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