Search result: Catalogue data in Autumn Semester 2019

Human Medicine Bachelor Information
Courses in Organ Systems and Clinical Practice
Examination Block A
NumberTitleTypeECTSHoursLecturers
377-0301-11LBlood, Immune System Restricted registration - show details
Die Lehrveranstaltung findet in Deutsch und Englisch statt.
O4 credits5VF. Sallusto, L. Flatz, G. Guarda, M. G. Manz, A. Theocharides, O. Ullrich, further lecturers
AbstractThis course will focus on the components and functions of the hematopoietic and the immune systems and on diseases affecting or caused by these systems.
Learning objective1. The organization and development of hematopoiesis including hematopoietic stem cell development; the role of hematopoietic growth and transcription factors in hematopoiesis; the role of hemoglobin in health and disease; erythrocyte physiology and iron metabolism; the principles of blood groups and blood transfusions; the principles of coagulation and the pharmacology of coagulation; the role of platelets and pharmacological platelet inhibition; to define thrombophilia and to understand thrombotic events; the role of leukocytes in health and disease; the analysis of blood samples; the principles of hematopoietic stem cell transplantation.
2. The development of the immune system; the structure and function of primary and secondary lymphoid organs; the cellular and molecular mechanisms of the innate and adaptive immune systems; the effector mechanisms of immune responses against pathogens; basic concepts of immune-mediated diseases (allergy and autoimmunity), tumor immunology, immunodeficiency, organ transplantation; basic knowledge of therapies.
Content1. Introduction to hematopoiesis, hematopoietic growth factors, hematopoietic transcription factors, erythrocyte physiology, blood groups, blood transfusion, iron metabolism, platelets, coagulation cascade, fibrinolysis, hemoglobin, hemoglobinopathies, leukocytes (granulocytes, monocytes), clinical presentation of neutropenia, pharmacology of hemostasis, clinical presentation of thrombophilia, basics of hematopoietic stem cell transplantation, some aspects of laboratory medicine in hematology, virtual microscopy of blood and bone marrow smears.
2. Structure and anatomical position of primary and secondary lymphoid organs, cells and molecules of the innate immune system, T and B cell development and receptor diversity, major histocompatibility complex (MHC) and antigen presentation, effector B cells and antibodies, effector T cells, regulatory T cells and cytokines, allergy and hypersensitivities, autoimmunity and anti-inflammatory drugs, transplantation and immunosuppressive drugs, immunodeficiency, immune response in cancer and immunotherapies.
Lecture notesThe course is supported by a Moodle page through which students have access to all necessary documentation.
LiteratureThe essential course material will be available on the course's Moodle Page in the form of lesson handouts
Suggested reference books include:
Blood:
Hoffbrand's Essential Haematology
Immune system:
Herbert Hof, Rüdiger Dörries; unter Mitarbeit von: Gernot Geginat, Dirk Schlüter und Constanze Wendt Medizinische Mikrobiologie Thieme 2017
http://www.library.ethz.ch/DADS:default_scope:ebi01_prod010873047
Abbas AK, Lichtman AH, Pillai S. Basic Immunology: Functions and Disorders of the Immune System, 5th ed.
W. B. Saunders Co., 2016;
https://institut.elsevierelibrary.de/product/basic-immunology85281
Prerequisites / NoticeThe Immune system part of this course builds on the content of the "Infection and Immunology" course.
377-0301-02LNutrition and Digestion Restricted registration - show details
Only for Human Medicine BSc
O5 credits5VW. Langhans, L. Käser, C. Stockmann
AbstractThis module imparts basic knowledge about the morphology and function of the digestive system and the importance of nutrition for health. One focus is on the understanding of the relationships among food intake, digestion, nutrient absorption and metabolism including the disturbances of these processes and the related diseases.
Learning objectiveThe aim of this module is that the students know and understand the morphology and function of the digestive system including its associated glands as well as the importance of nutrition for health. In particular, the students shall understand the relationships between food intake and digestion as well absorption and metabolism of particular nutrients. This knowledge shall enable the students to deduct the pathophysiology and pathology of the most important diseases of the digestive system and shall give them an idea of the pertinent diagnostics and therapy.
377-0301-03LEndocrinology, Metabolism Restricted registration - show details
Only for Human Medicine BSc
O5 credits5VM. Stoffel, F. Beuschlein, A. Hall, C. Wolfrum
AbstractDiscussion of normal structure and function of the endocrine systems, their interaction with the autonomic nervous system and their role in metabolism. In addition, pathophysiological and clinical aspects, diagnostics and therapeutic concepts of the most important endocrine diseases and related metabolic disorders as well as respective preventive measures are adressed.
Learning objectiveDie Studierenden sollen nach erfolgreichem Abschluss dieses Moduls zu Folgendem befähigt sein:
1. Systematik des endokrinen Systems erklären.
2. Aufbau und Funktion des Hypothalamus, Hypophyse, Nebenniere, endokrinen Pankreas, Schilddrüse, Eierstöcke, Hoden
3. Prinzipien und Regulation des Knochen, Kalzium und Phosphat-Stoffwechsels, Energiehaushaltes, Glukosestoffwechsel, Lipidstoffwechsel, Blutdruck.
4. Kenntnisse von hormonell regulierten Stoffwechselprozessen (Kohlenhydrate, Eiweiss und Fett).
5. Die wichtigsten endokrinen Krankheitsbilder und Tumoren, deren Entstehung, Klinik, Diagnostik und Therapie, kennen.
6. Die wichtigsten Massnahmen zur Prävention von Stoffwechselerkrankungen und die zugrunde liegenden Mechanismen kennen.
ContentDie Studierenden lernen in diesem Modul Anatomie, Physiologie, und Pathophysiologie der endokrinen Drüsen, sowie die Klinik, Diagnostik, Therapie und Prävention der wichtigsten Krankheitsbilder des Hormonsystems kennen. Dies beinhaltet:

• Systematik des endokrinen Systems: Aufbau und anatomische Lage der verschiedenen Hormondrüsen.
• Neuronale Innervation und vaskuläres Versorgungsgebiet der Hormondrüsen.
• Hormonklassen: Protein- und Polypeptidhormone , Amino- und Aminosäurederivate Steroidhormone, Biosynthese von Protein- und Polypeptidhormonen, Biosynthese von Amino- und Aminosäuren-derivathormonen, Biosynthese von Steroidhormonen, Speicherung von Hormonen, Sekretion von Hormonen, Transport von Hormonen, Halbwertszeiten, Abbau und Ausscheidung von Hormonen.
Übertragung von Informationen durch Hormone: Hormonwirkung an Rezeptoren, Struktur und Funktionsweise von membranassoziierten Hormonrezeptoren, Struktur und Funktion von Zellkernrezeptoren, Regulation der Hormonsekretion.
• Aufbau und Funktion des Hypothalamus, Aufbau und Funktion der Hypophyse.
• Aufbau und Funktion der Schilddrüse, Unter- und Überfunktion der Schilddrüse, Prinzipien der Diagnostik und Therapie von Schilddrüsenerkrankungen. Symptome, Anamnese und klinische Untersuchung bei Schilddrüsenerkrankungen,
• Knochen, Kalzium und Phosphatstoffwechsel.
• Regulation des Glukose-, Lipid- und Protein-Stoffwechsels, Essstörungen, Etiologie, Diagnostik, Therapie und Prävention der Adpositas.
• Aufbau und Funktion des endokrinen Pankreas, Pathogenese verschiedener Typen des Diabetes mellitus. Prinzipien der Diagnostik und Therapie und Prävention des Typ1 und Typ 2 Diabetes, Risikofaktoren und Komplikationen. Symptome, Anamnese und klinische Untersuchung bei Diabetes mellitus,
• Aufbau und Funktion der Nebenniere, Pathogenese, Prinzipien der Diagnostik und Therapie von Erkrankungen mit Über- und Unterfunktion der Nebenniere. Symptome, Anamnese und klinische Untersuchung bei Über- und Unterfunktion der Nebenniere.
• Aufbau und Funktion der Ovarien und Testes, Prinzipien der Reproduktionsphysiologie.
Lecture notesThere is no traditional script for this course. Instead the course is supported by a Moodle page through which students have access to all necessary texts, exercises, videos and activities.
LiteratureThe essential course material will be available on the course's Moodle Page in the form of scripts and lesson handouts.
The course does not have an "official" textbook, but students may find a general reference book on the topic interesting. For this purpose the text "Endokrinologie und Stoffwechsel” von Stefan Fischli und Giatgen A. Spinas (Herausgeber), Thieme Verlag, may be helpful.
Prerequisites / NoticeThe course builds on the content of the "Chemie für Mediziner", "Biochemie", “Pathobiochemie”, "Pharmakologie für Mediziner" and "Molekulare Genetik und Zellbiologie" course and “Nutrition and Digestion”.
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