Suchergebnis: Katalogdaten im Herbstsemester 2019

Chemie- und Bioingenieurwissenschaften Master Information
Master-Studium (Studienreglement 2005)
Wahlfächer
NummerTitelTypECTSUmfangDozierende
151-0109-00LTurbulent FlowsW4 KP2V + 1UP. Jenny
KurzbeschreibungInhalt
- Laminare und turbulente Strömungen, Turbulenzentstehung - Statistische Beschreibung: Mittelung, Turbulenzenergie, Dissipation, Schliessungsproblem - Skalenbetrachtungen. Homogene isotrope Turbulenz, Korrelationen, Fourierzerlegung, Energiespektrum - Freie Turbulenz. Nachlauf, Freistrahl, Mischungsschicht - Wandturbulenz. Turbulente Grenzschicht, Kanalströmung - Turbulenzberechnung
LernzielDie Vorlesung vermittelt einen Einblick in grundlegende physikalische Phänomene turbulenter Strömungen und in Gesetzmässigkeiten zu ihrer Beschreibung, basierend auf den strömungsmechanischen Grundgleichungen und daraus abgeleiteten Gleichungen. Grundlagen zur Berechnung turbulenter Strömungen und Elemente der Turbulenzmodellierung werden dargestellt.
Inhalt- Eigenschaften laminarer, transitioneller und turbulenter Strömungen
- Turbulenzbeeinflussung und Turbulenzentstehung, hydrodynamische Instabilität und Transition
- Statistische Beschreibung: Mittelung, Gleichungen für mittlere Strömung, turbulente Schwankungen, Turbulenzenergie, Reynoldsspannungen, Dissipation. Schliessungsproblem
- Skalenbetrachtungen. Homogene isotrope Turbulenz, Korrelationen, Fourierzerlegung, Energiespektrum, Gitterturbulenz
- Freie Turbulenz. Nachlauf, Freistrahl, Mischungsschicht
- Wandturbulenz. Turbulente Grenzschicht, Kanalströmung
- Grundlagen zur Berechnung turbulenter Strömungen und Elemente der Turbulenzmodellierung (Wirbelzähigkeitsmodelle, k-epsilon-Modell).
SkriptLecture notes in English, zusätzliches schriftliches Begleitmaterial auf Deutsch
LiteraturS.B. Pope, Turbulent Flows, Cambridge University Press, 2000
151-0951-00LProcess Design and SafetyW4 KP2V + 1UF. Trachsel, C. Hutter
KurzbeschreibungDie Vorlesung Process Design and Safety vermittelt die Grunldagen der Projektierung, Scale-up, Dimensionierung und Sicherheit verfahrenstechnischer Anlagen und Apparate.
LernzielVermitteln der Grundlagen zur verfahrenstechnischen Dimensionierung wichtiger Komponenten in Chemieanlagen.
InhaltGrundlagen des Anlagen und Apparatebaus;
Projektierung,
Kostenschätzung,
Werkstoffe in der Verfahrenstechnik,
Rohrleitungen und Armaturen,
Pumpen,
Reaktoren und Scale-up,
Sicherheit verfahrenstechnischer Prozesse,
Patente
SkriptDie Vorlesungsfolien werden verteilt.
LiteraturCoulson and Richardson's: Chemical Engineering , Vol 6: Chemical Engineering Design, (1996)
Voraussetzungen / BesonderesEin 1-tägiger Besuch einer chemischen Anlage wird innerhalb der Vorlesung organisiert.
151-0927-00LRate-Controlled Separations in Fine ChemistryW6 KP3V + 1UM. Mazzotti
KurzbeschreibungDie Studenten sollen einen vertieften Einblick in die Grundlagen der Trennverfahren erhalten, die in modernen Life Sciences Prozessen - spez. Feinchemie und Biotechnologie - zur Anwendung kommen.
LernzielDie Studenten sollen einen vertieften Einblick in die Grundlagen der Trennverfahren erhalten, die in modernen Life Sciences Prozessen - spez. Feinchemie und Biotechnologie - zur Anwendung kommen.
InhaltThe class covers separation techniques that are central in the purification and downstream processing of chemicals and bio-pharmaceuticals. Examples from both areas illustrate the utility of the methods: 1) Liquid-liquid extraction; 2) Adsorption and chromatography; 3) Membrane processes; 4) Crystallization and precipitation.
SkriptBeilagen in der Vorlesung
LiteraturBücher werden in der Vorlesung besprochen
Voraussetzungen / BesonderesBesonderes: Teile der Vorlesung werden in Englisch gehalten.

Voraussetzungen: Thermische Verfahrenstechnik I (151-0926-00) und Mathematische Methoden in den Chemieingenieurwissenschaften (151-0940-00)
529-0611-00LMolecular Aspects of Catalysts and Surfaces
Only for Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.
W7 KP4GJ. A. van Bokhoven, D. Ferri
KurzbeschreibungBasic elements of surface science important for materials and catalysis research. Physical and chemical methods important for research in surface science, material science and catalysis are considered and their application is demonstrated on practical examples.
LernzielBasic aspects of surface science. Understanding of principles of most important experimental methods used in research concerned with surface science, material science and catalysis.
InhaltMethods which are covered embrace: Gas adsorption and surface area analysis, IR-Spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, X-ray absorption, solid state NMR, Electron Microscopy and others.
529-0615-00LBiochemical and Polymer Reaction Engineering
Only for Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.
W7 KP3GP. Arosio
KurzbeschreibungPolymerization reactions and processes. Homogeneous and heterogeneous (emulsion) kinetics of free radical polymerization. Post treatment of polymer colloids. Bioprocesses for the production of molecules and therapeutic proteins. Kinetics and design of aggregation processes of macromolecules and proteins.
LernzielThe aim of the course is to learn how to design polymerization reactors and bioreactors to produce polymers and proteins with the specific product qualities that are required by different applications in chemical, pharmaceutical and food industry. This activity includes the post-treatment of polymer latexes, the downstream processing of proteins and the analysis of their colloidal behavior.
InhaltWe will cover the fundamental processes and the operation units involved in the production of polymeric materials and proteins. In particular, the following topics are discussed: Overview on the different polymerization processes. Kinetics of free-radical polymerization and use of population balance models. Production of polymers with controlled characteristics in terms of molecular weight distribution. Kinetics and control of emulsion polymerization. Surfactants and colloidal stability. Aggregation kinetics and aggregate structure in conditions of diffusion and reaction limited aggregation. Modeling and design of colloid aggregation processes. Physico-chemical characterization of proteins and description of enzymatic reactions. Operation units in bioprocessing: upstream, reactor design and downstream. Industrial production of therapeutic proteins. Characterization and engineering of protein aggregation. Protein aggregation in biology and in biotechnology as functional materials.
SkriptScripts are available on the web page of the Arosio-group: Link
Additional handout of slides will be provided during the lectures.
LiteraturR.J. Hunter, Foundations of Colloid Science, Oxford University Press, 2nd edition, 2001
D. Ramkrishna, Population Balances, Academic Press, 2000
H.W. Blanch, D. S. Clark, Biochemical Engineering, CRC Press, 1995
529-0613-00LProcess Simulation and Flowsheeting
Only for Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.
W7 KP3GG. Guillén Gosálbez
KurzbeschreibungThis course encompasses the theoretical principles of chemical process simulation, as well as its practical application in process analysis and optimization. The techniques for simulating stationary and dynamic processes are presented, and illustrated with case studies. Commercial software packages are presented as a key engineering tool for solving process flowsheeting and simulation problems.
LernzielThis course aims to develop the competency of chemical engineers in process flowsheeting and simulation. Specifically, students will develop the following skills:
- Deep understanding of chemical engineering fundamentals: the acquisition of new concepts and the application of previous knowledge in the area of chemical process systems and their mechanisms are crucial to intelligently simulate and evaluate processes.
- Modeling of general chemical processes and systems: students have to be able to identify the boundaries of the system to be studied and develop the set of relevant mathematical relations, which describe the process behavior.
- Mathematical reasoning and computational skills: the familiarization with mathematical algorithms and computational tools is essential to be capable of achieving rapid and reliable solutions to simulation and optimization problems. Hence, students will learn the mathematical principles necessary for process simulation and optimization, as well as the structure and application of process simulation software. Thus, they will be able develop criteria to correctly use commercial software packages and critically evaluate their results.
InhaltOverview of process simulation and flowsheeting
- Definition and fundamentals
- Fields of application
- Case studies

Process simulation
- Modeling strategies of process systems
- Mass and energy balances and degrees of freedom of process units and process systems

Process flowsheeting
- Flowsheet partitioning and tearing
- Solution methods for process flowsheeting
- Simultaneous methods
- Sequential methods

Process optimization and analysis
- Classification of optimization problems
- Linear programming
- Non-linear programming
- Optimization methods in process flowsheeting

Commercial software for simulation: Aspen Plus
- Thermodynamic property methods
- Reaction and reactors
- Separation / columns
- Convergence, optimisation & debugging
LiteraturAn exemplary literature list is provided below:
- Biegler, L.T., Grossmann I.E., Westerberg A.W., 1997, systematic methods of chemical process design. Prentice Hall, Upper Saddle River, US.
- Boyadjiev, C., 2010, Theoretical chemical engineering: modeling and simulation. Springer Verlag, Berlin, Germany.
- Ingham, J., Dunn, I.J., Heinzle, E., Prenosil, J.E., Snape, J.B., 2007, Chemical engineering dynamics: an introduction to modelling and computer simulation. John Wiley & Sons, United States.
- Reklaitis, G.V., 1983, Introduction to material and energy balances. John Wiley & Sons, United States.
Voraussetzungen / BesonderesA basic understanding of material and energy balances, thermodynamic property methods and typical unit operations (e.g., reactors, flash separations, distillation/absorption columns etc.) is required.
529-0619-00LChemical Product Design
Only for Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.

Prerequisites: Basic chemistry and chemical engineering knowledge (Diffusion, Thermodynamics, Kinetics,...).
W7 KP3GW. J. Stark
KurzbeschreibungThe 'Chemical Product Design' course teaches students quantitative concepts to analyze, select and transform theoretical concepts from chemistry and engineering into valuable real-world products. Basic chemistry and chemical engineering knowledge is required (Diffusion, Thermodynamics, Kinetics, ..).
LernzielThis course starts with analyzing existing chemical needs and unmet technical challenges. We then develop the skills to critically analyze a specific chemical idea for a product, to rapidly test feasibility or chance for success and to eventually realize its manufacturing. The chemical engineering basics are then used to assess performance of products or devices with non-traditional functions based on dynamic properties (e.g. responsive building materials; personal medical diagnostics on paper strips). The course teaches the interface between laboratory and market with a specific focus on evaluating the chemical value of a given process or compound, and the necessary steps to pursue the resulting project within an entrepreneurial environment. We therefore extend the questions of process design ('how do we make something?') to the question of 'what should we make?
InhaltPart A: The 'Chemical Product Design' course starts with discussing questions along, 'What is a chemical product, and why do people pay for it? How does a given compound in a specific setting provide a service?' We then learn how to translate new, often ill-defined wishes or ideas into quantifiable specifications.

Part B: Thermodynamic and kinetic data allow sharp selection criteria for successful products. We learn how to deal with insufficient data and development of robust case models to evaluate their technical and financial constraints. How can parameters of a running process in one industry be scaled into another industry? Can dimensionless engineering numbers be applied beyond traditional chemical processes?

Part C: Manufacturing of commodity products, devices and molecular products: Chemical reactors, separation and detection or isolation units as part of a toolbox. Planning of manufacturing and decisions based on hard data. Providing quantitative answers on potential value generated.

Students are expected to actively develop chemical products along the course. Contributions will be made individually, or in small groups, where a larger topic is studied.
LiteraturCussler, E.L., Moggridge, C.D., Chemical Product Design, Cambridge University Press, Cambridge, UK, 2nd edition, 2011.

Original Literature: Issues and Trends in the Teaching of Process and Product Design, Biegler, L.T., Grossmann, I.E., Westerber, A.W., AIChE J., 56 (5) 1120-25, 2010.
529-0643-00LProcess Design and Development Information
Only for Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.
W7 KP3GG. Storti
KurzbeschreibungThe course is focused on the design of Chemical Processes, with emphasis on the preliminary stage of the design approach, where process creation and quick selection among many alternatives are important. The main concepts behind more detailed process design and process simulation are also examined in the last part of the course.
LernzielThe course is focused on the design of Chemical Processes, with emphasis on the preliminary stage of the design approach, where process creation and quick selection among many alternatives are important. The main concepts behind more detailed process design and process simulation are also examined in the last part of the course.
InhaltProcess creation: decomposition strategies (reduction of differences - vinyl chloride production and hierarchical decomposition - ethanol production). Identification of the "base case design". Heuristics for process synthesis.
Preliminary process evaluation: simplified material and energy balances (linear balances), degrees of freedom, short-cut models, flowsheet solution algorithm).
Process Integration: sequencing of distillation columns, synthesis of heat exchanger networks.
Process economic evaluation: equipment sizing and costing, time value of money, cash flow calculations.
Batch Processes: scheduling, sizing and inventories.
Detailed Process Design: unit operation models, flash solution algorithms (different iterative methods, inside-out method), sequencing of nonideal distillation columns, networks of chemical reactors.
Skriptno script
LiteraturL.T.Biegler et al., Systematic Methods of Chemical Process Design, Prentice Hall, 1997.
W.D.Seider et al., Process Design Principles, J. Wiley & Sons, 1998.
J.M.Douglas, Conceptual Design of Chemical Processes, McGraw-Hill, 1988.
Voraussetzungen / BesonderesPrerequisite: Thermal Unit Operations
529-0617-00LCatalysis Engineering
Only for Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.
W7 KP3GJ. Pérez-Ramírez, S. J. Mitchell
KurzbeschreibungThe purpose of the "Catalysis Engineering" course is to provide students with tools that enable the optimal design of catalytic materials and reactor engineering concepts favoring more sustainable manufacturing processes within the chemical industry.
LernzielThe course aims at illustrating, from conception to implementation, the design of sustainable catalytic processes by integration of the microlevel (catalyst), mesolevel (reactor), and macrolevel (process). The word "sustainable" implies intensified processes with an improved exploitation of raw materials, wider use of renewable feedstocks, reduction of energy consumption, and minimized environmental impact. By the use of modern case studies of industrial relevance, aspects of catalyst preparation and characterization, kinetics, mass and heat transport, and deactivation are discussed. Emphasis is put on understanding the interaction among these basic elements in order to select the optimal catalytic process. Since no textbooks covering this area are available at this time and the intention of this course is unique, the lectures will be based on own texts and journal articles. During the course, there will be specific topics addressed by industrial contributors.
InhaltThe following general aspects:

- Catalyst preparation and characterization
- Kinetics
- Mass and heat transport
- Selectivity
- Deactivation

will be demonstrated for modern catalytic materials and processes of industrial relevance such as:

- Chlorine recycling
- N2O abatement
- Chemoselective hydrogenations
- Hierarchical zeolite catalysts
- Syngas conversion
- Biomass to chemicals and fuels
SkriptThe course material is based on an own script, journal articles, and slides.
Voraussetzungen / BesonderesIt is assumed that students selecting this course are familiar with general concepts of catalysis, reactor design, and transport phenomena.
529-0837-00LBiomicrofluidic Engineering Belegung eingeschränkt - Details anzeigen
Number of participants limited to 5.

Only for Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.
W7 KP3GA. de Mello
KurzbeschreibungMicrofluidics describes the behaviour, control and manipulation of fluids that are geometrically constrained within sub-microliter environments. The use of microfluidic devices offers an opportunity to control physical and chemical processes with unrivalled precision, and in turn provides a route to performing chemistry and biology in an ultra-fast and high-efficiency manner.
LernzielThe course will present the theoretical concepts behind the operation and functioning of microfluidic systems, the methods of microfluidic device manufacture and the application of microfluidic architectures and tools to important problems faced in modern day chemical and biological analysis. A key feature of the course will be a research project. The project will run from mid October until mid December. The aim of the project is to develop an understanding of the process of microfluidic design and how microfluidic tools can be applied to chemical or biological problems. The project will involve literature analysis, CFD simulations and experimental work. Students will be expected to present their results through a paper and class presentation.

In general the course will: Introduce the key phenomena that dictate how fluids behave when contained within small volume systems; Explain why the miniaturisation of basic laboratory instrumentation leads to significant gains in experimental “performance”; Present the structure, operation and performance of key microfluidic components; Showcase how microfluidic tools have been used to address important problems in chemistry and biology; Allow students to use this knowledge to design microfluidic tools for specific chemical/biological applications.
InhaltSpecific topics that will be addressed during the course include:

Theoretical Concepts: Scaling laws, features of thermal/mass transport, diffusion, basic description of fluid flow in small volumes, microfluidic mixing strategies • Microfluidic Device Manufacture: Basic principles of conventional lithography of rigid materials, ‘soft’ lithography, polymer machining (injection molding, hot embossing and 3D printing) • Analytical Separations: Principles of electrophoresis, electroosmosis, high performance capillary electrophoresis, scaling laws, chip-based electrophoresis and isoelectric focusing • Heat & Mass Transfer: Heat transfer, mass transfer, unit operations, dimensionless numbers, scaling laws, continuous and segmented flows • Computational Fluid Dynamics: Introduction to COMSOL, essentials of microfluidic modelling, application to microfluidic problems • DNA Analysis: Amplification and analysis of nucleic acids on the microscale, oligonucleotide microarrays for high-throughput sequence analysis • Droplet-based Microfluidics: Principles behind the formation, manipulation and use of liquid/liquid segmented flows in high-throughput experimentation • Small Volume Analysis: Application of optical methods for high-throughput and high-content detection in sub-nL volumes • Cellular Analysis: Application of microfluidic tools for high-throughput cell-based analysis, flow cytometry and single cell analysis.
SkriptLecture handouts, background literature, problem sheets and notes will be made accessible to enrolled students through the lecture Moodle site.
LiteraturThere is no textbook associated with the course. However, the following articles provide useful background reading prior to enrolment:

1. The origins and the future of microfluidics; G.M. Whitesides, Nature, 442, 368–373 (2006)
2. Control and detection of chemical reactions in microfluidic systems; A.J. deMello, Nature, 442, 394–402 (2006)
3. Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences; D.T. Chiu, A.J. deMello, D. Di Carlo, P.S. Doyle, C. Hansen, R.M. Maceiczyk, R.C.R. Wootton, Chem, 2, 201-223 (2017)
529-0745-00LGeneral and Environmental Toxicology
Only for Chemistry MSc and Chemical and Bioengineering MSc, Programme Regulations 2005.

IMPORTANT NOTICE for Chemistry and Chemical and Bioengineering students: There are two different version of this course for the two regulations (2005/2018), please make sure to register for the correct version according to the regulations you are enrolled in.
W7 KP3VM. Arand, H. Nägeli, B. B. Stieger, I. Werner
KurzbeschreibungVerständnis der Chemikalienwirkung auf biologische Systeme. Wertung der Effekte nach verschiedenen biomedizinischen Gesichtspunkten.
LernzielVerständnis der Chemikalienwirkung auf biologische Systeme. Wertung der Effekte nach verschiedenen biomedizinischen Gesichtspunkten.
InhaltDarstellung der wichtigsten Interaktionen von Fremdstoffen mit zellulären Strukturen wie Membranen, Enzymen und Nukleinsäuren. Bedeutung von Aufnahme, Verteilung, Ausscheidung und chemisch-biologischen Umwandlungsprozessen. Bedeutung von Gemischen. Darstellung wichtiger Toxizitätsmechanismen wie Immunotoxizität, Neurotoxizität, Entwicklungs- und Reproduktionstoxizität oder Gentoxizität anhand von Beispielen von Fremdstoffen und Auswirkungen auf kritische Organe.
SkriptUnterlagen werden in der Vorlesung abgegeben.
LiteraturLehrbücher in Pharmakologie und Toxikologie (vgl. Liste im Kursmaterial)
Voraussetzungen / BesonderesVoraussetzungen: Grundlagen in Säugetierbiologie, Chemie und Biochemie
529-0659-00LElektrochemie Information W6 KP3GP. Novák
KurzbeschreibungElektrolyte: Leitfähigkeit, Überführungszahl, Diffusion, Migration, Konvektion. Phasengrenze Elektrode/ Elektrolyt, Nernst-Gleichung, Potentialverlauf als Funktion des Umsatzes. Kinetik, Überspannung. Elektrokatalyse. Poröse Elektroden, Festkörperelektrochemie, Stromdichteverteilung, Elektroanal. Methoden. Anwendungen: Elektrolyse, Galvanotechnik, Batterien, Elektrosynthese, Sensoren, Korrosion.
LernzielDie Studierenden sind mit den Grundlagen der Elektrochemie vertraut und haben die Fähigkeit erworben, elektrochemische Vorgänge in technischen Prozessen und Produkten zu beschreiben und Berechnungen dazu durchführen zu können.
InhaltHistorische Entwicklung und Anwendungsgebiete der Elektrochemie. Elektrochemische Zellen: Elektroden, Elektrolyt, Ladungsdurchtritt, Stofffluss, Stoffumsatz. Elektrolyte: Struktur der Lösungen, Leitfähigkeit, Überführungszahl, feste Elektrolyte, Polymerelektrolyte. Stofftransport im Elektrolyten: Diffusion, Migration, Konvektion, Grenzstrom. Zellspannung, Elektrodenpotential, Potentialreihe. Reversible Elektrodenreaktionen: Nernst’ sche Gleichung, Potentialverlauf als Funktion des Umsatzes. Phasengrenze Elektrode / Elektrolyt: elektrochemische Doppelschicht, Austauschstromdichte. Kinetik elektrochemischer Reaktionen: globale und lokale Stromdichte, Überspannung, Tafel’sche und Butler / Volmer-Gleichung. Elektrokatalyse. Poröse Elektroden, Festkörperelektrochemie, Stromdichteverteilung in den Elektroden und im Elektrolyten, elektrochemisches Engineering. Elektroanalytische Methoden: Chronopotentiometrie, Cyclovoltammetrie, elektrochemische Impedanz. Anwendungen: Elektrolyse, Galvanotechnik, Batterien, Superkondensatoren, Brennstoffzellen, Elektrosynthese, elektrochemische Sensoren, Korrosion.
LiteraturC.H. Hamann, W. Vielstich, Elektrochemie, Wiley-VCH 2005 (4. Ausgabe)
[English version available as well]
151-0209-00LRenewable Energy Technologies Information W4 KP3GA. Steinfeld
KurzbeschreibungRenewable energy technologies: solar, biomass, wind, geothermal, hydro, waste-to-energy. Focus is on the engineering aspects.
LernzielStudents learn the potential and limitations of renewable energy technologies and their contribution towards sustainable energy utilization.
Voraussetzungen / BesonderesPrerequisite: strong background on the fundamentals of engineering thermodynamics, equivalent to the material taught in the courses Thermodynamics I, II, and III of D-MAVT.
376-1714-00LBiocompatible MaterialsW4 KP3GK. Maniura, M. Rottmar, M. Zenobi-Wong
KurzbeschreibungIntroduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced.
LernzielThe course covers the follwing topics:
1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials.
2. The concept of biocompatibility.
3. Introduction into methodology used in biomaterials research and application.
4. Introduction to different material classes in use for medical applications.
InhaltIntroduction into natural and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering, drug delivery and for medical devices are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed.
A link between academic research and industrial entrepreneurship is demonstrated by external guest speakers, who present their current research topics.
SkriptHandouts are deposited online (moodle).
LiteraturLiterature:
- Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013
- Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011

(available online via ETH library)

Handouts and references therin.
636-0007-00LComputational Systems Biology Information W6 KP3V + 2UJ. Stelling
KurzbeschreibungStudy of fundamental concepts, models and computational methods for the analysis of complex biological networks. Topics: Systems approaches in biology, biology and reaction network fundamentals, modeling and simulation approaches (topological, probabilistic, stoichiometric, qualitative, linear / nonlinear ODEs, stochastic), and systems analysis (complexity reduction, stability, identification).
LernzielThe aim of this course is to provide an introductory overview of mathematical and computational methods for the modeling, simulation and analysis of biological networks.
InhaltBiology has witnessed an unprecedented increase in experimental data and, correspondingly, an increased need for computational methods to analyze this data. The explosion of sequenced genomes, and subsequently, of bioinformatics methods for the storage, analysis and comparison of genetic sequences provides a prominent example. Recently, however, an additional area of research, captured by the label "Systems Biology", focuses on how networks, which are more than the mere sum of their parts' properties, establish biological functions. This is essentially a task of reverse engineering. The aim of this course is to provide an introductory overview of corresponding computational methods for the modeling, simulation and analysis of biological networks. We will start with an introduction into the basic units, functions and design principles that are relevant for biology at the level of individual cells. Making extensive use of example systems, the course will then focus on methods and algorithms that allow for the investigation of biological networks with increasing detail. These include (i) graph theoretical approaches for revealing large-scale network organization, (ii) probabilistic (Bayesian) network representations, (iii) structural network analysis based on reaction stoichiometries, (iv) qualitative methods for dynamic modeling and simulation (Boolean and piece-wise linear approaches), (v) mechanistic modeling using ordinary differential equations (ODEs) and finally (vi) stochastic simulation methods.
SkriptLink
LiteraturU. Alon, An introduction to systems biology. Chapman & Hall / CRC, 2006.

Z. Szallasi et al. (eds.), System modeling in cellular biology. MIT Press, 2010.

B. Ingalls, Mathematical modeling in systems biology: an introduction. MIT Press, 2013
636-0108-00LBiological Engineering and Biotechnology
Attention: This course was offered in previous semesters with the number: 636-0003-00L "Biological Engineering and Biotechnology". Students that already passed course 636-0003-00L cannot receive credits for course 636-0108-00L.
W4 KP3VM. Fussenegger
KurzbeschreibungBiological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
LernzielBiological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
Inhalt1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development.
SkriptHandout during the course.
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