Search result: Catalogue data in Spring Semester 2019
|3. Year, 6. Semester|
| Block Courses|
Registration for Block courses is mandatory. Please register under https://www.uzh.ch/zoolmed/ssl-dir/Blockkurse_UNIETH.php . Registration period: 17.12.2018 - 07.01.2019
|Block Courses during Semester Break|
|551-0396-01L||Immunology I |
Number of participants limited to 30.
Prerequisites: Attendance of the concept courses Immunology I (551-0317-00L) and Immunology II (551-0318-00L)
The enrolment is done by the D-BIOL study administration.
|W||6 credits||7G||A. Oxenius, B. Becher, M. Groettrup, M. Kopf, B. Ludewig, C. Münz, R. Spörri, M. van den Broek|
|Abstract||This block course teaches a wide selection of practical immunological techniques and offers advanced lectures in selected topics in immunology.|
|Objective||The aim of this block course is the acquaintance with a wide spectrum of immunological techniques involving practical experimental work following analysis and interpretation of the experimental data. Along the practical work, advanced lectures in selected topics in immunology, based on the knowledge from the immunology concept course, will be offered. Furthermore, students will have the opportunity to read, interpret and present current papers followed scientific discussions.|
|Content||The aim of this block course is the acquaintance with a wide spectrum of immunological techniques involving practical experimental work following analysis and interpretation of the experimental data. Along the practical work, advanced lectures in selected topics in immunology, based on the knowledge from the immunology concept course, will be offered. Furthermore, students will have the opportunity to read, interpret and present current papers followed scientific discussions.|
|Lecture notes||A script for the course will be available online (the link will be provided in the immunology concept lecture, 551-0318-00L).|
|Prerequisites / Notice||Requirement for the registration for this block course is the attendance of the immunology concept courses 551-0317-00L and 551-0318-00L.|
Evaluation of achievements is done on an individual basis by each participating lecturer.
Maximum participants: 12 (D-BIOL)
Only students of the Biology BSc are admitted! The enrolment is done by the D-BIOL study administration.
The excursion fee has to be payed until March 18th, 2019. Unpaid places will be given to students on the waiting list until April 1st, 2019.
|W||6 credits||12P||R. Berndt, A. Guggisberg|
|Abstract||The practical focuses on the flora and vegetation of selected areas of the Alps and covers the altitudinal range between the foothill and the alpine zone. During two excursions to Visp and Kandersteg the students will deepen their knowledge of plant species and learn to recognize important vegetation units and their ecological characteristics. An introduction will be provided in Zurich.|
|Objective||Knowledge of the most important vegetation types, their flora and ecological conditions in the northern Alps (Berner Oberland) and in an intramontane xeric valley (Wallis). Consolidation of taxonomic and plant morphological knowledge. Experience in plant determination using scientific determination keys. Basics of scientific collecting and pressing of plants (part colline/montane).|
|Content||Lectures/course: Consolidation of plant families and morphology. Climatic, geological and biogeographic divisions of the Alps. Introduction to plant nomenclature. |
Excursions: Identification of vascular plant species. Characteristic vegetation types of xeric intramontane valleys and the Bernese Alps and their ecological conditions. Interaction between plants and their environment: Examples from pollination, reproduction and dispersal strategies; adaptations of plant species to their environment.
|Literature||-Baltisberger M., Nyffeler R. & Widmer A. 2013: Systematische Botanik. 4., vollständig überarbeitete und erweiterte Aufl. v/d/f Hochschulverlag AG an der ETH Zürich.|
-Hess H.E., Landolt E., Hirzel R. & Baltisberger M. 2015: Bestimmungsschlüssel zur Flora der Schweiz. 7., aktualisierte und überarbeitete Aufl., Birkhäuser Verlag, Basel/Boston/Berlin.
|Prerequisites / Notice||We only admit students to the practical who have successfully completed the introductory lectures of Prof. Leuchtmann and the associated exercises and excursions. In addition, it is expected that the participants know how to use a determination key (Bestimmungsschlüssel zur Flora der Schweiz) and understand the necessary descriptive terminology.|
Students from other universities are requested to contact the lecturers.
Part I - colline/montane (Valais):
3.6. Introduction (Zürich, ETH Centre, CHN D-46)
11.-15.6. Excursion to Valais (Visp)
18.6. Exam (Zürich, ETH Centre, CHN building, room to be announced)
Part II - subalpine/alpine:
18.6. Introduction for subsequent week (Zurich, ETH Centre, CHN building)
24.6.-22.6. Excursion northern Alps (Kandersteg): upper montane to alpine zone
1.7. Exam and visit of Herbarium (Zurich, Botanical Garden, University of Zurich).
The excursion will take place in the mountains under any weather conditions. The participants should be able to cope with rough and steep terrain and should bring appropriate equipment. Sturdy mountain boots are mandatory!
The ETH Departments of Biology and Environmental Systems Sciences financially support this excursion. The costs amount CHF 500.- per student and cover transport, accommodation and full board.
|551-0438-00L||Protein Folding, Assembly and Degradation |
Number of participants limited to 6.
The enrolment is done by the D-BIOL study administration.
|W||6 credits||7G||R. Glockshuber, E. Weber-Ban|
|Abstract||Students will carry out defined research projects related to the current research topics of the groups of Prof. Glockshuber and Prof. Weber-Ban. The topics include mechanistic studies on the assembly of adhesive pili from pathogenic bacteria, disulfide bond formation in the bacterial periplasm, ATP-dependent chaperone-protease complexes and formation of amyloid deposits in Alzheimer's disese.|
|Objective||The course should enable the students to understand and apply biophysical methods, in particular kinetic and spectroscopic methods, to unravel the mechanism of complex reactions of biological macromolecules and assemblies in a quantitative manner.|
|Content||The students will be tutored in their experimental work by doctoral or postdoctoral students from the Glockshuber or Weber-Ban group. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as excercises on the numeric evaluation of biophysical data, and literature work.|
Participation in one of the following projects will be possible:
Projects of the Glockshuber group:
- Purification, biophysical characterization and structure determiation of enzymes required for disulfide bond formation in the periplasm of Gram-negative bacteria.
- Mechanistic studies on the assembly of type 1 pili from pathogenic Escherichia coli strains. In vitro reconstitution of pilus assembly from all purified components. Characterization of folding, stability and assembly behaviour of individual pilus subunits.
- Identification of intermediates in the aggregation of the human Abeta peptide
Experimental work on these projects involves
- Molecular cloning, recombinant protein production in E. coli and protein purification
- Protein crystallization
- Thermodynamic and kinetic characterization of conformational changes in proteins and protein-ligand interactions by fluorescence and circular dischoism spectroscopy
- Analysis of rapid reactions by stopped-flow fluorescence
- Negative-stain electron microscopy
- Light scattering
Projects of the Weber-Ban group:
- Generation and purification of site-directed variants of the E. coli ClpA/P protease and chaperone-proteasome complexes from other organisms, their biophysical characterization, including rapid kinetics by stopped-flow methods, ATPase activity measurtements, negative-stain electron microscopy and light scattering
|Prerequisites / Notice||Attendance of the concept course "Biomolecular Structure and Mechanism I" (551-0307-00L) in the autumn semester is highly recommended for acquiring the theoretical background to this block course.|
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