Search result: Catalogue data in Spring Semester 2019

Health Sciences and Technology Master Information
Major in Human Movement Science and Sport
Electives
Elective Courses II
NumberTitleTypeECTSHoursLecturers
227-0384-00LUltrasound Fundamentals, Imaging, and Medical Applications Restricted registration - show details
Number of participants limited to 60.
W4 credits3GO. Göksel
AbstractUltrasound is the only imaging modality that is nonionizing (safe), real-time, cost-effective, and portable, with many medical uses in diagnosis, intervention guidance, surgical navigation, and as a therapeutic option. In this course, we introduce conventional and prospective applications of ultrasound, starting with the fundamentals of ultrasound physics and imaging.
ObjectiveStudents can use the fundamentals of ultrasound, to analyze and evaluate ultrasound imaging techniques and applications, in particular in the field of medicine, as well as to design and implement basic applications.
ContentUltrasound is used in wide range of products, from car parking sensors, to assessing fault lines in tram wheels. Medical imaging is the eye of the doctor into body; and ultrasound is the only imaging modality that is nonionizing (safe), real-time, cheap, and portable. Some of its medical uses include diagnosing breast and prostate cancer, guiding needle insertions/biopsies, screening for fetal anomalies, and monitoring cardiac arrhythmias. Ultrasound physically interacts with the tissue, and thus can also be used therapeutically, e.g., to deliver heat to treat tumors, break kidney stones, and targeted drug delivery. Recent years have seen several novel ultrasound techniques and applications – with many more waiting in the horizon to be discovered.

This course covers ultrasonic equipment, physics of wave propagation, numerical methods for its simulation, image generation, beamforming (basic delay-and-sum and advanced methods), transducers (phased-, linear-, convex-arrays), near- and far-field effect, imaging modes (e.g., A-, M-, B-mode), Doppler and harmonic imaging, ultrasound signal processing techniques (e.g., filtering, time-gain-compensation, displacement tracking), image analysis techniques (deconvolution, real-time processing, tracking, segmentation, computer-assisted interventions), acoustic-radiation force, plane-wave imaging, contrast agents, micro-bubbles, elastography, biomechanical characterization, high-intensity focused ultrasound and therapy, lithotripsy, histotripsy, photo-acoustics phenomenon and opto-acoustic imaging, as well as sample non-medical applications such as the basics of non-destructive testing (NDT).

Hands-on exercises: These will help to apply the concepts learned in the course, using simulation environments (such as Matlab k-Wave and FieldII toolboxes). The exercises will involve a mix of design, implementation, and evaluation examples commonly encountered in practical applications.

Project: These will be part of the assessment in grading. Projects will be carried out throughout the course, individually or in small groups. Project reporting and presentations will be due at the end of the semester. Topics highly relevant in the field of ultrasound are offered as suggested projects. Students are also welcome to propose custom project topics of their own.
Prerequisites / NoticePrerequisites: Familiarity with basic numerical methods.
Basic programming skills in Matlab.
327-2125-00LMicroscopy Training SEM I - Introduction to SEM Restricted registration - show details
Limited number of participants.

Master students will have priority over PhD students. PhD students may still enroll, but will be asked for a fee (Link).
W2 credits3PK. Kunze, A. G. Bittermann, S. Gerstl, L. Grafulha Morales, J. Reuteler
AbstractThe introductory course on Scanning Electron Microscopy (SEM) emphasizes hands-on learning. Using 2 SEM instruments, students have the opportunity to study their own samples, or standard test samples, as well as solving exercises provided by ScopeM scientists.
Objective- Set-up, align and operate a SEM successfully and safely.
- Accomplish imaging tasks successfully and optimize microscope performances.
- Master the operation of a low-vacuum and field-emission SEM and EDX instrument.
- Perform sample preparation with corresponding techniques and equipment for imaging and analysis
- Acquire techniques in obtaining secondary electron and backscatter electron micrographs
- Perform EDX qualitative and semi-quantitative analysis
ContentDuring the course, students learn through lectures, demonstrations, and hands-on sessions how to setup and operate SEM instruments, including low-vacuum and low-voltage applications.
This course gives basic skills for students new to SEM. At the end of the course, students with no prior experience are able to align a SEM, to obtain secondary electron (SE) and backscatter electron (BSE) micrographs and to perform energy dispersive X-ray spectroscopy (EDX) qualitative and semi-quantitative analysis. The procedures to better utilize SEM to solve practical problems and to optimize SEM analysis for a wide range of materials will be emphasized.

- Discussion of students' sample/interest
- Introduction and discussion on Electron Microscopy and instrumentation
- Lectures on electron sources, electron lenses and probe formation
- Lectures on beam/specimen interaction, image formation, image contrast and imaging modes.
- Lectures on sample preparation techniques for EM
- Brief description and demonstration of the SEM microscope
- Practice on beam/specimen interaction, image formation, image contrast (and image processing)
- Student participation on sample preparation techniques
- Scanning Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities
- Lecture and demonstrations on X-ray micro-analysis (theory and detection), qualitative and semi-quantitative EDX and point analysis, linescans and spectral mapping
- Practice on real-world samples and report results
Literature- Detailed course manual
- Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996
- Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990
- Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007
Prerequisites / NoticeNo mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite.
327-2126-00LMicroscopy Training TEM I - Introduction to TEM Restricted registration - show details
Number of participants limited to 6. Master students will have priority over PhD students. PhD students may still enroll, but will be asked for a fee (Link).

TEM 1 registration form: Link
W2 credits3PM. Willinger, E. J. Barthazy Meier, A. G. Bittermann, F. Gramm
AbstractThe introductory course on Transmission Electron Microscopy (TEM) provides theoretical and hands-on learning for new operators, utilizing lectures, demonstrations, and hands-on sessions.
Objective- Overview of TEM theory, instrumentation, operation and applications.
- Alignment and operation of a TEM, as well as acquisition and interpretation of images, diffraction patterns, accomplishing basic tasks successfully.
- Knowledge of electron imaging modes (including Scanning Transmission Electron Microscopy), magnification calibration, and image acquisition using CCD cameras.
- To set up the TEM to acquire diffraction patterns, perform camera length calibration, as well as measure and interpret diffraction patterns.
- Overview of techniques for specimen preparation.
ContentUsing two Transmission Electron Microscopes the students learn how to align a TEM, select parameters for acquisition of images in bright field (BF) and dark field (DF), perform scanning transmission electron microscopy (STEM) imaging, phase contrast imaging, and acquire electron diffraction patterns. The participants will also learn basic and advanced use of digital cameras and digital imaging methods.

- Introduction and discussion on Electron Microscopy and instrumentation.
- Lectures on electron sources, electron lenses and probe formation.
- Lectures on beam/specimen interaction, image formation, image contrast and imaging modes.
- Lectures on sample preparation techniques for EM.
- Brief description and demonstration of the TEM microscope.
- Practice on beam/specimen interaction, image formation, Image contrast (and image processing).
- Demonstration of Transmission Electron Microscopes and imaging modes (Phase contrast, BF, DF, STEM).
- Student participation on sample preparation techniques.
- Transmission Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities.
- TEM alignment, calibration, correction to improve image contrast and quality.
- Electron diffraction.
- Practice on real-world samples and report results.
Literature- Detailed course manual
- Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996
- Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990
- Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007
Prerequisites / NoticeNo mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite.
363-1066-00LDesigning Effective Projects for Promoting Health@Work Restricted registration - show details
Number of participants limited to 30.
W3 credits2GG. Bauer, R. Brauchli, G. J. Jenny
AbstractThe fast changing, flexible and performance-oriented economy implies increasing challenges and opportunities for the health of employees. Creating good working conditions and promoting healthy lifestyles of employees becomes more and more important for employers and employees. Students learn how to develop an effective, real-life project of their choice to promote health@work.
ObjectiveStudents become familiar with challenges and opportunities of a changing world of work. They get an overview of intervention approaches and principles in the fields of worksite health promotion as well as work and organizational psychology. On this basis, they learn how to develop an effective, real life worksite health promotion project of their choice – addressing lifestyle factors or working conditions.
During the project work, they learn to follow the typical phases of selecting/framing a relevant work-related health issue, conducting an analysis, formulating smart objectives, developing a realistic action plan, estimating the time and money needed for these actions, and finally evaluating the impact of the project. This will strengthen their general project management skills.
Students will know how to apply key quality criteria of health promotion projects: 1.) how to follow a systematic, evidence-based approach (project management), 2.) how to assure involvement of and thus acceptance by the users (participation), 3.) how to consider both individual, lifestyle-related and organizational, work-related factors (comprehensiveness), and 4.) how to integrate the project into the routine of the organization to assure sustainability (integration). This will increase the impact of future health promotion projects developed by the students.
D-MTEC students will be able to systematically address employee health and performance in their future management practice. D-HEST students will be able to apply their health promotion knowledge to the challenging context of corporations. D-USYS students will be able to consider lifestyle factors and the working environment in their future work. The exchange among these interdisciplinary student groups will foster their ability to solve real life problems in a transdisciplinary manner. Finally, students get acquainted how to design their future work in a health promoting way.
Content1. Challenges in health@work and intervention approaches
2. Lifestyle interventions at work incl. digital tools
3. Personal and organizational strategies for promoting healthy work
4. Core concepts, values and principles in promoting health@work;
introduction to project work & 7-pillar planning model
5. Framing and analysis of health@work issues
6. Participatory priority setting in health@work projects and defining outcome objectives
7. Combining levels of interventions and defining process objectives
8. Project management
9. Evaluation of process and outcomes
10. Preparation* & presentation of posters of group work

Each lecture combines an input by an expert in the respective field and group discussions. During 8 sessions students will directly apply the acquired knowledge to an own, individual project on a self-chosen topic on health@work. Tutors closely support the students in designing their projects. During the last two dates, the students present their projects to the entire class in a poster format. This presentation will be commented by the course leader and serves as the final course assessment.
Prerequisites / NoticeA course for students dedicated to applied learning through projects. As the whole course is designed as a hands-on workshop for the students, active participation in all lectures is expected. Class size limited to 30 students.
376-0131-00LLaboratory Course in Movement Biomechanics Restricted registration - show details
Only for Health Sciences and Technology MSc.
W3 credits4PR. List, B. Postolka
AbstractSelected experiments in Biomechanics. The practical course includes basic experiments to learn measurement methods and practical applications in Biomechanics.
ObjectiveStudents can gain their first experience in the practical application of measurement methods in Biomechanics by means of basic experimentation. They also learn how to keep records in the laboratory journal.
ContentVarious experiments are offered in the field of Biomechanics.
Lecture notesTexts and further handouts will be provided.
376-0202-00LNeural Control of Movement and Motor LearningW4 credits3GN. Wenderoth
AbstractThis course extends the students' knowledge regarding the neural control of movement and motor learning. Particular emphasis will be put on those methods and experimental findings that have shaped current knowledge of this area.
ObjectiveKnowledge of the physiological and anatomic basis underlying the neural control of movement and motor learning. One central element is that students have first hands-on experience in the lab where small experiments are independently executed, analysed and interpreted.
376-0204-00LExercise SciencesW4 credits3GE. de Bruin, P. Eggenberger, A. Krebs
AbstractEvidence-based findings on the training of endurance, strength, and speed, planning and periodization of training, as well as motor learning will be presented and discussed in relation to specific age groups (childhood to older age), and performance levels. The theoretical knowledge will be applied in an annual training plan for an individually chosen sport/performance level.
ObjectiveUnderstand and critically evaluate evidence-based training recommendations for specific groups (children/youth, adults, older adults, recreational/high performance sport) and apply and evaluate this knowledge within a goal-oriented training plan.
ContentLecture:
- Evidence-based research in exercise sciences
- Endurance, strength, and speed training
- Training in childhood and youth
- Training in older age
- Analysis of a specific sport, planning and periodization models
- Motor learning in sports practice

Training sessions:
- Development of a goal-oriented annual training plan for an individually chosen sport/performance level, based on evidence from the exercise sciences.

Practice in the gym:
- Practical examples for the training of strength and speed
- Motor learning experiments
Lecture notesLecture slides and papers on the Moodle platform.
LiteratureG.G. Haff & N.T. Triplett (eds): Essentials of Strength Training and Conditioning. Human Kinetics, 4th edition, 2016.

W.E. Amonette, K.L. English, W.J. Kraemer: Evidence-Based Practice in Exercise Science. The Six-Step Approach. Human Kinetics, 2016.
376-0206-00LBiomechanics IIW4 credits3GW. R. Taylor, P. Schütz, F. Vogl
AbstractIntroduction in dynamics, kinetics and kinematic of rigid and elastic multi-body systems with examples in biology, medicine and especially the human movement
ObjectiveThe students are able
- to analyse and describe dynamic systems
- to explain the mechanical laws and use them in biology and medicine
ContentThe human movement from a mechanical point of view. Kinetic and kinematic concepts and their mechanical description. Energy and momentum of a movement. Mechanical description of a multi-body system.
376-0905-00LFunctional Anatomy Information W3 credits2VD. P. Wolfer, I. Amrein
AbstractIntroduction to the anatomy of the musculoskeletal with the goal to better understand movements and the mechanisms of injuries.
Objective- understanding the three-dimensional organization of the human musculoskeletal system
- correct use of anatomical nomenclature in the description of structure and function
- understanding the connections between morphology and normal function of the musculoskeletal system
- knowledge of selected mechanisms of injury in terms of the underlying anatomy
Content- Allgemeine Anatomie des Bewegungsapparates (Bindegewebe, Knochen, Gelenke, Muskeln)
- Becken und freie untere Extremität (Skelett, Gelenke, Muskeln)
- Wirbelsäule, Brustkorb, Bauchwand (Skelett, Gelenke, Muskeln)
- Schulter und freie obere Extremität (Skelett, Gelenke, Muskeln)
Literature- Gehrke T, Sportanatomie, Rowohlt Taschenbuch Verlag
- Weineck J, Sportanatomie, Spitta-Verlag
- Appel H-J, Stang-Voss C, Funktionelle Anatomie, Springer-Verlag
376-1150-00LClinical Challenges in Musculoskeletal Disorders Restricted registration - show details W2 credits2GM. Leunig, S. J. Ferguson, A. Müller
AbstractThis course reviews musculoskeletal disorders focusing on the clinical presentation, current treatment approaches and future challenges and opportunities to overcome failures.
ObjectiveAppreciation of the surgical and technical challenges, and future perspectives offered through advances in surgical technique, new biomaterials and advanced medical device construction methods.
ContentFoot deformities, knee injuries, knee OA, hip disorders in the child and adolescent, hip OA, spine deformities, degenerative spine disease, shoulder in-stability, hand, rheumatoid diseases, neuromuscular diseases, sport injuries and prevention
376-1178-00LHuman Factors IIW3 credits2VM. Menozzi Jäckli, R. Huang, M. Siegrist
AbstractStrategies, abilities and needs of human at work as well as properties of products and systems are factors controlling quality and performance in everyday interactions. In Human Factors II (HF II), cognitive aspects are in focus therefore complementing the more physical oriented approach in HF I. A basic scientific approach is adopted and relevant links to practice are illustrated.
ObjectiveThe goal of the lecture is to empower students in designing products and systems enabling an efficient and qualitatively high standing interaction between human and the environment, considering costs, benefits, health, well-being, and safety as well. The goal is achieved in addressing a broad variety of topics and embedding the discussion in macroscopic factors such as the behavior of consumers and objectives of economy.
ContentCognitive factors in perception, information processing and action. Experimental techniques in assessing human performance and well-being, human factors and ergonomics in development of products and complex systems, innovation, decision taking, consumer behavior.
LiteratureSalvendy G. (ed), Handbook of Human Factors, Wiley & Sons, 2012
376-1217-00LRehabilitation Engineering I: Motor FunctionsW4 credits2V + 1UR. Riener, J. Duarte Barriga
Abstract“Rehabilitation engineering” is the application of science and technology to ameliorate the handicaps of individuals with disabilities in order to reintegrate them into society. The goal of this lecture is to present classical and new rehabilitation engineering principles and examples applied to compensate or enhance especially motor deficits.
ObjectiveProvide theoretical and practical knowledge of principles and applications used to rehabilitate individuals with motor disabilities.
Content“Rehabilitation” is the (re)integration of an individual with a disability into society. Rehabilitation engineering is “the application of science and technology to ameliorate the handicaps of individuals with disability”. Such handicaps can be classified into motor, sensor, and cognitive (also communicational) disabilities. In general, one can distinguish orthotic and prosthetic methods to overcome these disabilities. Orthoses support existing but affected body functions (e.g., glasses, crutches), while prostheses compensate for lost body functions (e.g., cochlea implant, artificial limbs). In case of sensory disorders, the lost function can also be substituted by other modalities (e.g. tactile Braille display for vision impaired persons).

The goal of this lecture is to present classical and new technical principles as well as specific examples applied to compensate or enhance mainly motor deficits. Modern methods rely more and more on the application of multi-modal and interactive techniques. Multi-modal means that visual, acoustical, tactile, and kinaesthetic sensor channels are exploited by displaying the patient with a maximum amount of information in order to compensate his/her impairment. Interaction means that the exchange of information and energy occurs bi-directionally between the rehabilitation device and the human being. Thus, the device cooperates with the patient rather than imposing an inflexible strategy (e.g., movement) upon the patient. Multi-modality and interactivity have the potential to increase the therapeutical outcome compared to classical rehabilitation strategies.
In the 1 h exercise the students will learn how to solve representative problems with computational methods applied to exoprosthetics, wheelchair dynamics, rehabilitation robotics and neuroprosthetics.
Lecture notesLecture notes will be distributed at the beginning of the lecture (1st session)
LiteratureIntroductory Books

Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press.

Advances in Rehabilitation Robotics – Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004.

Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001.

Control of Movement for the Physically Disabled. Eds.: D. Popovic, T. Sinkjaer. Springer Verlag London, 2000.

Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005.

Biomechanics and Neural Control of Posture and Movement. Eds.: J.M. Winters, P.E. Crago. Springer New York, 2000.

Selected Journal Articles

Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195.

Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432

Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700.

Colombo, G., Jörg, M., Jezernik, S. (2002) Automatisiertes Lokomotionstraining auf dem Laufband. Automatisierungstechnik at, vol. 50, pp. 287-295.

Cooper, R. (1993) Stability of a wheelchair controlled by a human. IEEE Transactions on Rehabilitation Engineering 1, pp. 193-206.

Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87

Leifer, L. (1981): Rehabilitive robotics, Robot Age, pp. 4-11

Platz, T. (2003): Evidenzbasierte Armrehabilitation: Eine systematische Literaturübersicht, Nervenarzt, 74, pp. 841-849

Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250.

Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10.

Riener, R., Fuhr, T., Schneider, J. (2002) On the complexity of biomechanical models used for neuroprosthesis development. International Journal of Mechanics in Medicine and Biology 2, pp. 389-404.

Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894.
Prerequisites / NoticeTarget Group:
Students of higher semesters and PhD students of
- D-MAVT, D-ITET, D-INFK
- Biomedical Engineering
- Medical Faculty, University of Zurich
Students of other departments, faculties, courses are also welcome
376-1308-00LDevelopment Strategies for Medical Implants Restricted registration - show details
Number of participants limited to 25 until 30.
Assignments will be considered chronological.
W3 credits2V + 1UJ. Mayer-Spetzler, M. Rubert
AbstractIntroduction to development strategies for implantable devices considering the interdependecies of biocompatibility, clinical and economical requirements ; discussion of the state of the art and actual trends in in orthopedics, sports medicine, traumatology and cardio-vascular surgery as well as regenerative medicine (tissue engineering).
ObjectiveBasic considerations in implant development
Concept of structural and surface biocompatiblity and its relevance for the design of implant and surgical technique
Understanding of conflicting factors, e.g. clinical need, economics and regulatory requirements
Concepts of tissue engineering, its strengths and weaknesses as current and future clinical solution
ContentBiocompatibility as bionic guide line for the development of medical implants; implant and implantation related tissue reactions, biocompatible materials and material processing technologies; implant testing and regulatory procedures; discussion of the state of the art and actual trends in implant development in orthopedics, sports medicine, traumatology, spinal and cardio-vascular surgery; introduction to tissue engineering. Selected topics will be further illustrated by commented movies from surgeries.

Seminar:
Group seminars on selected controversial topics in implant development. Participation is mandatory

Planned excursions (limited availability, not mandatory, to be confirmed):
1. Participation (as visitor) on a life surgery (travel at own expense)
Lecture notesScribt (electronically available):
- presented slides
- selected scientific papers for further reading
LiteratureReference to key papers will be provided during the lectures
Prerequisites / NoticeAchieved Bachelor degree is mandatory

The number of participants in the course is limited to 25-30 students in total.

Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is on the student's own responsability.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 credits2GA. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
AbstractThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
ObjectiveThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
ContentTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include osteogenesis (bones), chondrogenesis (cartilage), and tendogenesis (tendons). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Lecture notesn/a
LiteratureTopical Scientific Manuscripts
376-1397-00LOrthopaedic Biomechanics Restricted registration - show details
Number of participants limited to 48.
W3 credits2GR. Müller, P. Atkins
AbstractThis course is aimed at studying the mechanical and structural engineering of the musculoskeletal system alongside the analysis and design of orthopaedic solutions to musculoskeletal failure.
ObjectiveTo apply engineering and design principles to orthopaedic biomechanics, to quantitatively assess the musculoskeletal system and model it, and to review rigid-body dynamics in an interesting context.
ContentEngineering principles are very important in the development and application of quantitative approaches in biology and medicine. This course includes a general introduction to structure and function of the musculoskeletal system: anatomy and physiology of musculoskeletal tissues and joints; biomechanical methods to assess and quantify tissues and large joint systems. These methods will also be applied to musculoskeletal failure, joint replacement and reconstruction; implants; biomaterials and tissue engineering.
Lecture notesStored on ILIAS.
LiteratureOrthopaedic Biomechanics:
Mechanics and Design in Musculoskeletal Systems

Authors: Donald L. Bartel, Dwight T. Davy, Tony M. Keaveny
Publisher: Prentice Hall; Copyright: 2007
ISBN-10: 0130089095; ISBN-13: 9780130089090
Prerequisites / NoticeLectures will be given in English.
376-1400-00LTransfer of Technologies into Neurorehabilitation Restricted registration - show details W3 credits2VC. Müller, R. Gassert, R. Riener, H. Van Hedel, N. Wenderoth
AbstractThe course focuses on clinical as well as industrial aspects of advanced technologies and their transfer into neurorehabilitation from both theoretical and practical perspectives. The students will learn the basics of neurorehabilitation and the linkage to technologies, gain insight into the development within the medtech field and learn applications of technologies in clinical settings.
ObjectiveThe students will:
- Learn basics and principles of clinical neuroscience and neurorehabilitation.
- Gain insight into the technical basics of advanced technologies and the transfer into product development processes.
- Gain insight into the application, the development and integration of advanced technologies in clinical settings. This includes the advantages and limitations according to different pathologies and therapy goals.
- Get the opportunity to test advanced technologies in practical settings.
- Learn how to transfer theoretical concepts to actual settings in different working fields.
ContentMain focus:
- Neurobiological principles applied to the field of neurorehabilitation.
- Clinical applications of advanced rehabilitation technologies.
- Visit medical technology companies, rehabilitation centers and labs to gain deeper insight into the development, application and evaluation of advanced technologie
Lecture notesTeaching materials will be provided for the individual events and lectures.
- Slides (pdf files)
- Information sheets and flyers of the visited companies, labs and clinics
376-1620-00LSkeletal Repair Restricted registration - show details
Number of participants limited to 42.

Only for Health Sciences and Technology MSc and Biomedical Engineering MSc.
W3 credits3GS. Grad, D. Eglin, F. Moriarty, M. Stoddart
AbstractThe course gives an introduction into traumatic and degenerative pathologies of skeletal tissues. Emphasis is put on bone, cartilage and intervertebral disc. Established and new treatments are described, including cell, gene and molecular therapy, biomaterials, tissue engineering and infection prevention. In vitro/in vivo models are explained.
ObjectiveThe objectives of this course are to acquire a basic understanding of
(1) important pathologies of skeletal tissues and their consequences for the patient and the public health
(2) current surgical approaches for skeletal repair, their advantages and drawbacks
(3) recent advances in biological strategies for skeletal repair, such as (stem) cell therapy, gene therapy, biomaterials and tissue engineering
(4) pathology, prevention and treatment of implant associated infections
(5) in vitro and in vivo models for basic, translational and pre-clinical studies
ContentAccording to the expected background knowledge, the cellular and extracellular composition and the structure of the skeletal tissues, including bone, cartilage, intervertebral disc, ligament and tendon will briefly be recapitulated. The functions of the healthy tissues and the impact of acute injury (e.g. bone fracture) or progressive degenerative failure (e.g. osteoarthritis) will be demonstrated. Physiological self-repair mechanisms, their limitations, and current (surgical) treatment options will be outlined. Particular emphasis will be put on novel approaches for biological repair or regeneration of critical bone defects, damaged hyaline cartilage of major articulating joints, and degenerative intervertebral disc tissues. These new treatment options include autologous cell therapies, stem cell applications, bioactive factors, gene therapy, biomaterials or biopolymers; while tissue engineering / regenerative medicine is considered as a combination of some of these factors. In vitro bioreactor systems and in vivo animal models will be described for preclinical testing of newly developed materials and techniques. Bacterial infection as a major complication of invasive treatment will be explained, covering also established and new methods for its effective inhibition. Finally, the translation of new therapies for skeletal repair from the laboratory to the clinical application will be illustrated by recent developments.
Prerequisites / NoticeBasic knowledge in the cellular and molecular composition, structure and function of healthy skeletal tissues, especially bone, cartilage and intervertebral disc are required; furthermore, basic understanding of biomaterial properties, cell-surface interactions, and bacterial infection are necessary to follow this course.
376-1624-00LPractical Methods in Biofabrication Restricted registration - show details
Number of participants limited to 12.
W5 credits4PM. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak
AbstractBiofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft.
ObjectiveThe objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project.
Prerequisites / NoticeNot recommended if passed 376-1622-00 Practical Methods in Tissue Engineering
376-1721-00LBone Biology and Consequences for Human HealthW2 credits2VG. A. Kuhn, J. Goldhahn, E. Wehrle
AbstractBone is a complex tissue that continuously adapts to mechanical and metabolic demands. Failure of this remodeling results in reduced mechanic stability ot the skeleton. This course will provide the basic knowledge to understand the biology and pathophysiology of bone necessary for engineering of bone tissue and design of implants.
ObjectiveAfter completing this course, students will be able to understand:
a) the biological and mechanical aspects of normal bone remodeling
b) pathological changes and their consequences for the musculoskeletal system
c) the consequences for implant design, tissue engineering and treatment interventions.
ContentBone adapts continuously to mechanical and metabolic demands by complex remodeling processes. This course will deal with biological processes in bone tissue from cell to tissue level. This lecture will cover mechanisms of bone building (anabolic side), bone resorption (catabolic side), their coupling, and regulation mechanisms. It will also cover pathological changes and typical diseases like osteoporosis. Consequences for musculoskeletal health and their clinical relevance will be discussed. Requirements for tissue engineering as well as implant modification will be presented. Actual examples from research and development will be utilized for illustration.
376-1724-00LAppropriate Health System Design Information Restricted registration - show details
Number of participants limited to 42.
W3 credits2VW. Karlen
AbstractThis course elaborates upon relevant aspects in the conception, implementation and distribution of health devices and systems that effectively meet peoples and societies' needs in a local context. Four key elements of appropriateness (usage, cost, durability and performance) that are integral to the engineering design process are extensively discussed and applied.
ObjectiveThe main goals are to
> Evaluate the appropriateness of health systems to the cultural, financial, environmental and medical context in which they will be applied
and
> Design health systems from a user's perspective for a specific context

At the end of the course, students can
> name, understand and describe the 4 main principles that define appropriate technology
> apply these principles to critically analyze and assess health systems and technology
> project him/herself into a unfamiliar person and context and create hypotheses as to that person's needs, requirements, and priorities
> modify specifications of existing systems to improve appropriateness
> discuss the challenges and illustrate the the ethical and societal consequences of proposed design modifications
> communicate effectively the results of his/her system analysis and implementation strategies to non-specialists
ContentThe course will be interactive and involve roleplay. Please do not sign up for this course if you are not ready to leave your comfort zone in class. The lectures are divided in two parts:
The first part elaborates upon the important concepts of the design of health care devices and systems, and discusses implementation and dissemination strategies. We focus on communities such as low income households, the elderly, and patients with chronic illnesses that have special needs. Topics covered include point-of-care diagnostics, information and communication technologies, mobile health, user interactions, and also the social-cultural considerations.
The second part consists of elaboration of an appropriate device conducted by student groups. Each group will analyse an existing product or solution, critically assess its appropriateness according to the criteria learned in class, and provide explanations as to why the system succeeds or fails. The students will also present design improvements. Grading will be based on a written case report due in the middle of the semester and a final seminar presentation in form of a poster discussion and demo.
LiteratureWHO, "Medical Devices: Managing the Mismatch", 2010.
Link

PATH, "The IC2030 report. Reimagining Global Health," 2015. Link

R. Malkin and K. Von Oldenburg Beer, "Diffusion of novel healthcare technologies to resource poor settings," Annals of Biomedical Engineering, vol. 41, no. 9, pp. 1841:50, 2013.
Prerequisites / NoticeTarget Group:
Students of higher semesters and doctoral students of
- D-MAVT, D-ITET, D-INFK, D-HEST
- Biomedical Engineering, Robotics, Systems and Control
- Medical Faculty, University of Zurich
Students of other departments, faculties, courses are also welcome
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