Suchergebnis: Katalogdaten im Frühjahrssemester 2019

MAS in Medizinphysik Information
Fachrichtung: Allg. Medizinphysik und Biomedizinisches Ingenieurwesen
Vertiefung Biocompatible Materials
Kernfächer
Von den beiden Lerneinheiten 376-1622-00L Practical Methods in Tissue Engineering (angeboten im Herbstsemester) und 376-1624-00L Practical Methods in Biofabrication (angeboten im Frühjahrssemester) dürfen nicht beide angerechnet werden.
NummerTitelTypECTSUmfangDozierende
151-0980-00LBiofluiddynamicsW4 KP2V + 1UD. Obrist, P. Jenny
KurzbeschreibungIntroduction to the fluid dynamics of the human body and the modeling of physiological flow processes (biomedical fluid dynamics).
LernzielA basic understanding of fluid dynamical processes in the human body. Knowledge of the basic concepts of fluid dynamics and the ability to apply these concepts appropriately.
InhaltThis lecture is an introduction to the fluid dynamics of the human body (biomedical fluid dynamics). For selected topics of human physiology, we introduce fundamental concepts of fluid dynamics (e.g., creeping flow, incompressible flow, flow in porous media, flow with particles, fluid-structure interaction) and use them to model physiological flow processes. The list of studied topics includes the cardiovascular system and related diseases, blood rheology, microcirculation, respiratory fluid dynamics and fluid dynamics of the inner ear.
SkriptLecture notes are provided electronically.
LiteraturA list of books on selected topics of biofluiddynamics can be found on the course web page.
376-1308-00LDevelopment Strategies for Medical Implants Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 25 bis 30.
Die Einschreibungen werden nach chronologischem Eingang berücksichtigt.
W3 KP2V + 1UJ. Mayer-Spetzler, M. Rubert
KurzbeschreibungIntroduction to development strategies for implantable devices considering the interdependecies of biocompatibility, clinical and economical requirements ; discussion of the state of the art and actual trends in in orthopedics, sports medicine, traumatology and cardio-vascular surgery as well as regenerative medicine (tissue engineering).
LernzielBasic considerations in implant development
Concept of structural and surface biocompatiblity and its relevance for the design of implant and surgical technique
Understanding of conflicting factors, e.g. clinical need, economics and regulatory requirements
Concepts of tissue engineering, its strengths and weaknesses as current and future clinical solution
InhaltBiocompatibility as bionic guide line for the development of medical implants; implant and implantation related tissue reactions, biocompatible materials and material processing technologies; implant testing and regulatory procedures; discussion of the state of the art and actual trends in implant development in orthopedics, sports medicine, traumatology, spinal and cardio-vascular surgery; introduction to tissue engineering. Selected topics will be further illustrated by commented movies from surgeries.

Seminar:
Group seminars on selected controversial topics in implant development. Participation is mandatory

Planned excursions (limited availability, not mandatory, to be confirmed):
1. Participation (as visitor) on a life surgery (travel at own expense)
SkriptScribt (electronically available):
- presented slides
- selected scientific papers for further reading
LiteraturReference to key papers will be provided during the lectures
Voraussetzungen / BesonderesAchieved Bachelor degree is mandatory

The number of participants in the course is limited to 25-30 students in total.

Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is on the student's own responsability.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 KP2GA. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
InhaltTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include osteogenesis (bones), chondrogenesis (cartilage), and tendogenesis (tendons). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Skriptn/a
LiteraturTopical Scientific Manuscripts
376-1614-00LPrinciples in Tissue EngineeringW3 KP2VK. Maniura, J. Möller, M. Zenobi-Wong
KurzbeschreibungFundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
LernzielUnderstanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed.
InhaltThis class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
SkriptHandouts provided during the classes and references therin.
LiteraturThe molecular Biology of the Cell, Alberts et al., 5th Edition, 2009.
Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002
376-1624-00LPractical Methods in Biofabrication Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.
W5 KP4PM. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak
KurzbeschreibungBiofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft.
LernzielThe objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project.
Voraussetzungen / BesonderesNot recommended if passed 376-1622-00 Practical Methods in Tissue Engineering
Praktika
NummerTitelTypECTSUmfangDozierende
465-0800-00LPractical Work Belegung eingeschränkt - Details anzeigen
Nur für MAS in Medizinphysik
O4 KPexterne Veranstalter
KurzbeschreibungThe practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution.
LernzielThe practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem.
Wahlfächer
NummerTitelTypECTSUmfangDozierende
151-0622-00LMeasuring on the Nanometer ScaleW2 KP2GA. Stemmer
KurzbeschreibungIntroduction to theory and practical application of measuring techniques suitable for the nano domain.
LernzielIntroduction to theory and practical application of measuring techniques suitable for the nano domain.
InhaltConventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters.
SkriptClass notes and special papers will be distributed.
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