Search result: Catalogue data in Autumn Semester 2018

Chemistry Master Information
Master Studies (Programme Regulations 2018)
Organic Chemistry
529-0243-01LTransition Metal Catalysis: From Mechanisms to Applications Information W6 credits3GB. Morandi
AbstractDetailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint
ObjectiveUnderstanding and critical evaluation of current research in transition metal catalysis. Design of mechanistic experiments to elucidate reaction mechanisms. Synthetic relevance of transition metal catalysis. Students will also learn about writing an original research proposal during a workshop.
ContentDetailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint. Synthetic applications of these reactions. Introduction and application of tools for the elucidation of mechanisms. Selected examples of topics include: C-H activation, C-O activation, C-C activation, gold catalysis, redox active ligands, main group redox catalysis, frustrated Lewis pairs.
Lecture notesLecture slides will be provided online. A Handout summarizing important concepts in organometallic and physical organic chemistry will also be provided. Useful references and handouts will also be provided during the workshop.

Slides will be uploaded 1-2 days before each lecture on (password will be given during the first lecture or can be requested by email)
LiteraturePrimary literature and review articles will be cited during the course.

The following textbooks can provide useful support for the course:

- Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books.
- Crabtree R., The Organometallic Chemistry of the Transition Metals, John Wiley & Sons, Inc.
- Hartwig J., Organotransition Metal Chemistry: From Bonding to Catalysis, University Science Books.
- J. P. Collman, L. S. Hegedus, J. R. Norton, R. G. Finke, Principles and Applications of Organotransition Metal Chemistry.
Prerequisites / NoticeRequired level: Courses in organic and physical chemistry of the first and second year as well as ACIII

Special requirement: each participant will have to come up with an independent research proposal to be presented orally at the end of the semester. A dedicated workshop will be organized in the middle of the semester to introduce the students to proposal writing and presentation.
529-0233-01LOrganic Synthesis: Methods and Strategies Information W6 credits3GE. M. Carreira
AbstractThe complex relation between structural analysis, methods leading to desired transformations, and insight into reaction mechanisms is exemplified. Relations between retrosynthetic analysis of target structures, synthetic methods and their combination in a synthetic strategy.
ObjectiveExtension and deepening of the knowledge in organic synthesis.
ContentConcepts of the planning of organic synthesis (strategy and tactics), retrosynthetic analysis. Structure-reactivity relation in the context of the synthesis of complex molecules.
LiteratureK. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, Wiley-VCH 1996.
K. C. Nicolaou, S. A. Snyder, Classics in Total Synthesis II, Wiley-VCH 2003.
K. C. Nicolaou, J. Chen, Classics in Total Synthesis III, Wiley-VCH 2011.
Prerequisites / NoticeOC I-IV
529-0241-10LAdvanced Methods and Strategies in SynthesisW6 credits3GJ. W. Bode
AbstractAdvanced Modern Methods and Strategies in Synthesis
ObjectiveKnowledge of modern methods in asymmetric stereocontrol, enantioselective catalysis, and organic reaction mechanisms.
ContentCurrent trends in methods for and approaches to synthesis of complex natural products, pharmaceuticals, and biological molecules; fragment coupling and protecting group strategies; chemical ligation and biomolecules synthesis; enantioselective catalysis including ligand design and optimization; cross coupling reactions from preactivated precursors; C-H activation and oxidation chemistry; building block synthesis with chiral auxiliaries and reagents; new concepts in asymmetric catalysis. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized.
Lecture noteswill be provided in class and online
LiteratureSuggesting Textbooks
1. Walsh and Kozlowski, Fundamentals of Asymmetric Catalysis, 1st Ed., University Science Books, 2009.
2. Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006.
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