Search result: Catalogue data in Spring Semester 2018

Number	Title	Type	ECTS	Hours	Lecturers
MAS in Medical Physics
Specialization: General Medical Physics and Biomedical Engineering
Major in Radiation Therapy
Electives
227-0390-00L	Elements of Microscopy	W	4 credits	3G	M. Stampanoni, G. Csúcs, A. Sologubenko
Abstract	The lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging.
Learning objective	Solid introduction to the basics of microscopy, either with visible light, electrons or X-rays.
Content	It would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level. The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy. During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated.
Literature	Available Online.
227-0946-00L	Molecular Imaging - Basic Principles and Biomedical Applications	W	2 credits	2V	M. Rudin
Abstract	Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications.
Learning objective	Molecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research.
Content	Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications.
227-0948-00L	Magnetic Resonance Imaging in Medicine	W	4 credits	3G	S. Kozerke, M. Weiger Senften
Abstract	Introduction to magnetic resonance imaging and spectroscopy, encoding and contrast mechanisms and their application in medicine.
Learning objective	Understand the basic principles of signal generation, image encoding and decoding, contrast manipulation and the application thereof to assess anatomical and functional information in-vivo.
Content	Introduction to magnetic resonance imaging including basic phenomena of nuclear magnetic resonance; 2- and 3-dimensional imaging procedures; fast and parallel imaging techniques; image reconstruction; pulse sequences and image contrast manipulation; equipment; advanced techniques for identifying activated brain areas; perfusion and flow; diffusion tensor imaging and fiber tracking; contrast agents; localized magnetic resonance spectroscopy and spectroscopic imaging; diagnostic applications and applications in research.
Lecture notes	D. Meier, P. Boesiger, S. Kozerke Magnetic Resonance Imaging and Spectroscopy
376-1984-00L	Lasers in Medicine	W	3 credits	3G	M. Frenz
Abstract	The lecture will provide answers to questions such as: Why lasers? How do lasers work? How does light interact with tissue? We will concentrate on three major interaction categories: Therapeutic (from cell surgery to vision correction and general surgery), Diagnostic (from detection of neural cell activity to diagnostics of cancer), and Imaging (from single molecules to optical tomography).
Learning objective	Introduction into medical laser applications. Understanding of the physics underlaying the laser-tissue-interaction in order to understand the influence of different irradiation parameters on tissue effects. Basics of diagnostic laser applications as well as laser safety.
Content	Lasers become increasingly important in almost all medical disciplines especially where they can be used selectively to treat soft and hard tissue in a non-invasive manner or for diagnostic purposes. Basic mechanisms of light propagation in tissue as well as laser-tissue-interactions i.e. photochemical, photothermal and photomechanical interaction will be discussed. The influence of laser wavelength and pulse duration on the interaction process will be studied. Different laser and beam delivery systems used in medicine will be presented. Different clinical laser applications in ophthalmology, urology, gynecology and ENT-surgery will be discussed. Diagnostic applications as well as biomedical imaging techniques are considered. Laser safety.
Lecture notes	will be published in the Internet
Literature	- M. Born, E. Wolf, "Principles of Optics", Pergamon Press - B.E.A. Saleh, M.C. Teich, "Fundamentals of Photonics", John Wiley and Sons, Inc. - A.E. Siegman, "Lasers", University Science Books - O. Svelto, "Principles of Lasers", Plenum Press - J. Eichler, T. Seiler, "Lasertechnik in der Medizin", Springer Verlag - M.H. Niemz, "Laser-Tissue Interaction", Springer Verlag - A.J. Welch, M.J.C. van Gemert, "Optical-thermal response of laser-irradiated tissue", Plenum Press
402-0343-00L	Physics Against Cancer: The Physics of Imaging and Treating Cancer	W	6 credits	2V + 1U	A. J. Lomax, U. Schneider
Abstract	Radiotherapy is a rapidly developing and technology driven medical discipline that is heavily dependent on physics and engineering. In this lecture series, we will review and describe some of the current developments in radiotherapy, particularly from the physics and technological view point, and will indicate in which direction future research in radiotherapy will lie.
Learning objective	Radiotherapy is a rapidly developing and technology driven medical discipline that is heavily dependent on physics and engineering. In the last few years, a multitude of new techniques, equipment and technology have been introduced, all with the primary aim of more accurately targeting and treating cancerous tissues, leading to a precise, predictable and effective therapy technique. In this lecture series, we will review and describe some of the current developments in radiotherapy, particularly from the physics and technological view point, and will indicate in which direction future research in radiotherapy will lie. Our ultimate aim is to provide the student with a taste for the critical role that physics plays in this rapidly evolving discipline and to show that there is much interesting physics still to be done.
Content	The lecture series will begin with a short introduction to radiotherapy and an overview of the lecture series (lecture 1). Lecture 2 will cover the medical imaging as applied to radiotherapy, without which it would be impossible to identify or accurately calculate the deposition of radiation in the patient. This will be followed by a detailed description of the treatment planning process, whereby the distribution of deposited energy within the tumour and patient can be accurately calculated, and the optimal treatment defined (lecture 3). Lecture 4 will follow on with this theme, but concentrating on the more theoretical and mathematical techniques that can be used to evaluate different treatments, using mathematically based biological models for predicting the outcome of treatments. The role of physics modeling, in order to accurately calculate the dose deposited from radiation in the patient, will be examined in lecture 5, together with a review of mathematical tools that can be used to optimize patient treatments. Lecture 6 will investigate a rather different issue, that is the standardization of data sets for radiotherapy and the importance of medical data bases in modern therapy. In lecture 7 we will look in some detail at one of the most advanced radiotherapy delivery techniques, namely Intensity Modulated Radiotherapy (IMRT). In lecture 8, the two topics of imaging and therapy will be somewhat combined, when we will describe the role of imaging in the daily set-up and assessment of patients. Lecture 9 follows up on this theme, in which a major problem of radiotherapy, namely organ motion and changes in patient and tumour geometry during therapy, will be addressed, together with methods for dealing with such problems. Finally, in lectures 10-11, we will describe in some of the multitude of different delivery techniques that are now available, including particle based therapy, rotational (tomo) therapy approaches and robot assisted radiotherapy. In the final lecture, we will provide an overview of the likely avenues of research in the next 5-10 years in radiotherapy. The course will be rounded-off with an opportunity to visit a modern radiotherapy unit, in order to see some of the techniques and delivery methods described in the course in action.
Prerequisites / Notice	Although this course is seen as being complimentary to the Medical Physics I and II course of Dr Manser, no previous knowledge of radiotherapy is necessarily expected or required for interested students who have not attended the other two courses.
465-0968-00L	Medical Physics in Practice	W	2 credits	2V	P. Manser, Speakers
Abstract	The aim of this lecture is to study different aspects of medical physics from the practical view. One main component is to assist the students for getting in contact with medical physicists and to build a platform for a dialogue. For this purpose, a number of lecturers from entire Switzerland are reportig about their work as a medical physicist.
Learning objective	The aim of this lecture is to study different aspects of medical physics from the practical view.
402-0787-00L	Therapeutic Applications of Particle Physics: Principles and Practice of Particle Therapy	W	6 credits	2V + 1U	A. J. Lomax
Abstract	Physics and medical physics aspects of particle physics Subjects: Physics interactions and beam characteristics; medical accelerators; beam delivery; pencil beam scanning; dosimetry and QA; treatment planning; precision and uncertainties; in-vivo dose verification; proton therapy biology.
Learning objective	The lecture series is focused on the physics and medical physics aspects of particle therapy. The radiotherapy of tumours using particles (particularly protons) is a rapidly expanding discipline, with many new proton and particle therapy facilities currently being planned and built throughout Europe. In this lecture series, we study in detail the physics background to particle therapy, starting from the fundamental physics interactions of particles with tissue, through to treatment delivery, treatment planning and in-vivo dose verification. The course is aimed at students with a good physics background and an interest in the application of physics to medicine.
Prerequisites / Notice	The former title of this course was "Medical Imaging and Therapeutic Applications of Particle Physics".
227-0384-00L	Ultrasound Fundamentals, Imaging, and Medical Applications Number of participants limited to 25.	W	4 credits	3G	O. Göksel
Abstract	Ultrasound is the only imaging modality that is nonionizing (safe), real-time, cost-effective, and portable, with many medical uses in diagnosis, intervention guidance, surgical navigation, and as a therapeutic option. In this course, we introduce conventional and prospective applications of ultrasound, starting with the fundamentals of ultrasound physics and imaging.
Learning objective	Students can use the fundamentals of ultrasound, to analyze and evaluate ultrasound imaging techniques and applications, in particular in the field of medicine, as well as to design and implement basic applications.
Content	Ultrasound is used in wide range of products, from car parking sensors, to assessing fault lines in tram wheels. Medical imaging is the eye of the doctor into body; and ultrasound is the only imaging modality that is nonionizing (safe), real-time, cheap, and portable. Some of its medical uses include diagnosing breast and prostate cancer, guiding needle insertions/biopsies, screening for fetal anomalies, and monitoring cardiac arrhythmias. Ultrasound physically interacts with the tissue, and thus can also be used therapeutically, e.g., to deliver heat to treat tumors, break kidney stones, and targeted drug delivery. Recent years have seen several novel ultrasound techniques and applications – with many more waiting in the horizon to be discovered. This course covers ultrasonic equipment, physics of wave propagation, numerical methods for its simulation, image generation, beamforming (basic delay-and-sum and advanced methods), transducers (phased-, linear-, convex-arrays), near- and far-field effect, imaging modes (e.g., A-, M-, B-mode), Doppler and harmonic imaging, ultrasound signal processing techniques (e.g., filtering, time-gain-compensation, displacement tracking), image analysis techniques (deconvolution, real-time processing, tracking, segmentation, computer-assisted interventions), acoustic-radiation force, plane-wave imaging, contrast agents, micro-bubbles, elastography, biomechanical characterization, high-intensity focused ultrasound and therapy, lithotripsy, histotripsy, photo-acoustics phenomenon and opto-acoustic imaging, as well as sample non-medical applications such as the basics of non-destructive testing (NDT).
Prerequisites / Notice	Hands-on exercises will help apply concepts learned in the module, and will involve a mix of designing, implementing, and evaluating in simulation environments, such as Matlab FieldII and k-Wave toolboxes. Prerequisites: Familiarity with basic numerical methods. Basic programming skills and experience in Matlab.

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