Suchergebnis: Katalogdaten im Frühjahrssemester 2021
Biologie Master | ||||||
Wahlvertiefungen | ||||||
Wahlvertiefung: Molekulare Gesundheitswissenschaften | ||||||
Wahlpflicht Masterkurse | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
---|---|---|---|---|---|---|
551-1310-00L | A Problem-Based Approach to Cellular Biochemistry Number of participants limited to 12. | W | 6 KP | 2G | M. Peter, V. Korkhov, G. Neurohr, V. Panse, A. E. Smith, F. van Drogen | |
Kurzbeschreibung | Independent, guided acquisition of a defined area of research, identification of key open questions, development of an experimental strategy to address a defined question, and formulation of this strategy within the framework of a research grant. | |||||
Lernziel | Working independently, students will acquire an overview of a defined research area, and identify important open questions. In addition, they will develop an experimental strategy to address a defined question, and to formulate this strategy within the framework of a research grant. | |||||
Inhalt | The students will work in groups of two to three, in close contact with a tutor (ETH Prof or senior scientist). A research overview with open questions and a research grant will be developed independently by the students, with guidance from the tutor through regular mandatory meetings. The students will write both the research overview with open questions and the grant in short reports, and present them to their colleagues. | |||||
Literatur | The identification of appropriate literature is a component of the course. | |||||
Voraussetzungen / Besonderes | This course will be taught in English, and requires extensive independent work. | |||||
551-0512-00L | Current Topics in Molecular and Cellular Neurobiology Findet dieses Semester nicht statt. Number of participants limited to 8 | W | 2 KP | 1S | U. Suter | |
Kurzbeschreibung | The course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature. | |||||
Lernziel | The course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn e.g. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking. | |||||
Inhalt | You will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance. You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation). | |||||
Skript | Presentations will be made available after the seminars. | |||||
Literatur | We cover a range of themes related to development and neurobiology. Before starting your preparations, you are required to check with Laura Montani (Link), who helps you with finding an appropriate paper. | |||||
Voraussetzungen / Besonderes | You must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%). | |||||
551-0140-00L | Epigenetics | W | 4 KP | 2V | A. Wutz, U. Grossniklaus, R. Paro, R. Santoro | |
Kurzbeschreibung | Epigenetik untersucht die Vererbung von Merkmalen, die nicht auf eine Veränderung der DNA Sequenz zurückgeführt werden kann. Die Vorlesung gibt einen Überblick über epigenetische Phänomene und erklärt die zugrundeliegenden molekularen Mechanismen. Die Rolle von epigenetischen Prozessen bei der Krebsentstehung und anderen Krankheiten wird diskutiert. | |||||
Lernziel | Das Ziel des Kurses ist das Verständnis von epigenetischen Mechanismen und deren Funktion in der Entwicklung von Organismen, bei Regenerationsprozessen oder bei der Entstehung von Krankheiten. | |||||
Inhalt | Themen - Historischer Überblick, Konzepte und Vergleich Genetik vs. Epigenetik - Biologie von Chromatin: Struktur und Funktion, Organisation im Kern und die Rolle von Histon Modifikationen bei Prozessen wie Transkription und Replikation. - DNA-Methylierung als epigenetische Modifikation - Weitergabe epigenetischer Modifikationen während der Zellteilung: das Zellgedächtnis - Stabilität/Revertierbarkeit epigenetischer Modifikationen: zelluläre Plastizität und Stammzellen. - Genomisches Imprinting in Pflanzen und in Säugern - X Chromosom Inaktivierung und Dosiskompensation - Positionseffekte, Paramutationen und Transvektion - RNA-induziertes Gensilencing - die Rolle von epigenetischen Prozessen bei der Krebsentstehung oder der Zellalterung. | |||||
701-1350-00L | Case Studies in Environment and Health | W | 4 KP | 2V | K. McNeill, T. Julian, M. Scheringer | |
Kurzbeschreibung | This course will focus on a few individual chemicals and pathogens from different standpoints: their basic chemistry or biology, their environmental behavior, (eco)toxicology, and human health impacts. The course will draw out the common points in each chemical or pathogen's history. | |||||
Lernziel | This course aims to illustrate how the individual properties of chemicals and pathogens along with societal pressures lead to environmental and human health crises. The ultimate goal of the course is to identify common aspects that will improve prediction of environmental crises before they occur. Students are expected to participate actively in the course, which includes the critical reading of the pertinent literature and class presentations. | |||||
Inhalt | Each class will feature the case study of a different chemical or pathogen that have had a profound effect on human health and the environment. The instructors will present eight to ten of these and the students will present a poster on their own pollutant or pathogen in groups of two. Students will be expected to contribute to the in class discussions and, on their selected topics, to lead the discussion. | |||||
Skript | Handouts will be provided as needed. | |||||
Literatur | Handouts will be provided as needed. | |||||
551-1100-00L | Infectious Agents: From Molecular Biology to Disease Number of participants limited to 22. Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures. (if you missed the deadline, please come to the first date to see, if there are any slots left) | W | 4 KP | 2S | W.‑D. Hardt, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander, weitere Dozierende | |
Kurzbeschreibung | Literature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich. | |||||
Lernziel | Working with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology. | |||||
Inhalt | for each model pathogen (or key technology): 1. introduction to the pathogen 2. Discussion of one current research paper. The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion. | |||||
Skript | Teachers will provide the research papers to be discussed. Students will prepare handouts for the rest of the group for their assigned seminar. | |||||
Literatur | Teachers will provide the research papers to be discussed. | |||||
Voraussetzungen / Besonderes | Restricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to Link and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt. The first seminar date will serve to form groups of students and assign a paper to each group. | |||||
227-0396-00L | EXCITE Interdisciplinary Summer School on Bio-Medical Imaging The school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process. Students have to apply for acceptance. To apply a curriculum vitae and an application letter need to be submitted. Further information can be found at: Link. | W | 4 KP | 6G | S. Kozerke, G. Csúcs, J. Klohs-Füchtemeier, S. F. Noerrelykke, M. P. Wolf | |
Kurzbeschreibung | Two-week summer school organized by EXCITE (Center for EXperimental & Clinical Imaging TEchnologies Zurich) on biological and medical imaging. The course covers X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, optoacoustic imaging, infrared and optical microscopy, electron microscopy, image processing and analysis. | |||||
Lernziel | Students understand basic concepts and implementations of biological and medical imaging. Based on relative advantages and limitations of each method they can identify preferred procedures and applications. Common foundations and conceptual differences of the methods can be explained. | |||||
Inhalt | Two-week summer school on biological and medical imaging. The course covers concepts and implementations of X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, optoacoustic imaging, infrared and optical microscopy and electron microscopy. Multi-modal and multi-scale imaging and supporting technologies such as image analysis and modeling are discussed. Dedicated modules for physical and life scientists taking into account the various backgrounds are offered. | |||||
Skript | Presentation slides, Web links | |||||
Voraussetzungen / Besonderes | The school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process. To apply a curriculum vitae, a statement of purpose and applicants references need to be submitted. Further information can be found at: Link | |||||
227-0946-00L | Molecular Imaging - Basic Principles and Biomedical Applications | W | 3 KP | 2V + 1A | D. Razansky | |
Kurzbeschreibung | Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications. | |||||
Lernziel | Molecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research. | |||||
Inhalt | Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications. | |||||
551-1132-00L | Allgemeine Virologie | W | 2 KP | 1V | K. Tobler, C. Fraefel | |
Kurzbeschreibung | Einführung in die Grundlagen der Virologie, welche die Charakterisierung von Viren, die Interaktionen der Viren mit infizierten Zellen, Wirten und Populationen, die Grundlagen des Schutzes vor Infektion und die Virusdiagnostik beinhaltet. | |||||
Lernziel | Einführung in die Grundlagen der Virologie. | |||||
Inhalt | Grundlagen der Virologie. Charakterisierung von Viren. Virus-Zell-Interaktionen. Virus-Wirt-Interaktionen. Virus-Population-Interaktionen. Schutz vor Virusinfektion. Virusdiagnostik. | |||||
Skript | Die Vorlesung ist auf dem Lehrbuch "Allgemeine Virologie" von Kurt Tobler, Mathias Ackermann und Cornel Fraefel aufgebaut. Die Präsentationsfolien und ausgewählte Primärliteratur werden 24 bis 48 Stunden vor den Lektionen als .pdf-Dateien bereitgestellt. | |||||
Literatur | Kurt Tobler, Mathias Ackermann und Cornel Fraefel, Allgemeine Virologie, 2016, 1. Auflage UTB-Band-Nr.:4516 Haupt Verlag Bern ISBN: 978-3-8252-4516-0 | |||||
Voraussetzungen / Besonderes | Grundkenntnisse in Molekularbiologie, Zellbiologie und Immunologie | |||||
376-1306-00L | Clinical Neuroscience (University of Zurich) No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH. UZH Module Code: BIO389 Mind the enrolment deadlines at UZH: Link | W | 3 KP | 3V | G. Schratt, Uni-Dozierende | |
Kurzbeschreibung | The lecture series "Clinical Neuroscience" presents a comprehensive, condensed overview of the most important neurological diseases, their clinical presentation, diagnosis, therapy options and possible causes. Patient demonstrations (Übungen) follow every lecture that is dedicated to a particular disease. | |||||
Lernziel | By the end of this module students should be able to: - demonstrate their understanding and deep knowledge concerning the main neurological diseases - identify and explain the different clinical presentation of these diseases, the methodology of diagnosis and the current therapies available - summarize and critically review scientific literature efficiently and effectively | |||||
376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | W | 3 KP | 2G | G. Shivashankar | |
Kurzbeschreibung | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | |||||
Lernziel | The goal of this course is to provide an introduction to the emerging field of “Mechanobiology”. | |||||
Inhalt | We will focus on cells and tissues and introduce the major methods employed in uncovering the principles of mechanobiology. We will first discuss the cellular mechanotransduction mechanisms and how they regulate genomes. This will be followed by an analysis of the mechanobiological underpinnings of cellular differentiation, cell-state transitions and homeostasis. Developing on this understanding, we will then introduce the mechanobiological basis of cellular ageing and its impact on tissue regeneration, including neurodegeneration and musculoskeletal systems. We will then highlight the importance of tissue organoid models as routes to regenerative medicine. We will also discuss the impact of mechanobiology on host-pathogen interactions. Finally, we will introduce the broad area of mechanopathology and the development of cell-state biomarkers as readouts of tissue homeostasis and disease pathologies. Collectively, the course will provide a quantitate framework to understand the mechanobiological processes at cellular scale and how they intersect with tissue function and diseases. Lecture 1: Introduction to the course: forces, signalling and cell behaviour Lecture 2: Methods to engineer and sense mechanobiological processes Lecture 3: Mechanisms of cellular mechanosensing and cytoskeletal remodelling Lecture 4: Nuclear mechanotransduction pathways Lecture 5: Genome organization, regulation and genome integrity Lecture 6: Differentiation, development and reprogramming Lecture 7: Tissue microenvironment, cell behaviour and homeostasis Lecture 8: Cellular aging and tissue regeneration Lecture 9: Neurodegeneration and regeneration Lecture 10: Musculoskeletal systems and regeneration Lecture 11: Tissue organoid models and regenerative medicine Lecture 12: Microbial systems and host-pathogen interactions Lecture13: Mechanopathology and cell-state biomarkers Lecture14: Concluding lecture and case studies | |||||
Skript | n/a | |||||
Literatur | Topical Scientific Manuscripts | |||||
551-0364-00L | Functional Genomics Information for UZH students: Enrolment to this course unit only possible at ETH. No enrolment to module BIO 254 at UZH. Please mind the ETH enrolment deadlines for UZH students: Link | W | 3 KP | 2V | C. von Mering, C. Beyer, B. Bodenmiller, M. Gstaiger, H. Rehrauer, R. Schlapbach, K. Shimizu, N. Zamboni, weitere Dozierende | |
Kurzbeschreibung | Functional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data. | |||||
Lernziel | Functional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data. Such data provide the basis for systems biology efforts to elucidate the structure, dynamics and regulation of cellular networks. | |||||
Inhalt | The curriculum of the Functional Genomics course emphasizes an in depth understanding of new technology platforms for modern genomics and advanced genetics, including the application of functional genomics approaches such as advanced sequencing, proteomics, metabolomics, clustering and classification. Students will learn quality controls and standards (benchmarking) that apply to the generation of quantitative data and will be able to analyze and interpret these data. The training obtained in the Functional Genomics course will be immediately applicable to experimental research and design of systems biology projects. | |||||
Voraussetzungen / Besonderes | The Functional Genomics course will be taught in English. | |||||
551-0338-00L | Current Approaches in Single Cell Analysis (University of Zurich) Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: BME327 Beachten Sie die Einschreibungstermine an der UZH: Link | W | 2 KP | 2V | B. Bodenmiller, Uni-Dozierende | |
Kurzbeschreibung | In this lecture, we will discuss the most important single cell approaches, the questions they can address and current developments. We will cover single cell: genomics, transcriptomics, proteomics (CyTOF mass cytometry), metabolomics and highly multiplexed imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data. | |||||
Lernziel | On completion of this module the students should be able to: - explain the basic principles of single cell analysis techniques - identify and justify the limitations of the current single cell technologies and suggest reasonable improvements - know the basic challenges in data analysis imposed by the complex multi parameter data. Key skills: On completion of this module the students should be able to: - summarize and discuss the impact these technologies have on biology and medicine - design biological and biomedical experiments for which single cell analysis is essential | |||||
Inhalt | Currently single cell analysis approaches revolutionize the way we study and understand biological systems. In all biological and biomedical settings, cell populations and tissues are highly heterogeneous; this heterogeneity plays a critical role in basic biological processes such as cell cycle, development and organismic function, but is also a major player in disease, e.g. for cancer development, diagnosis and treatment. Currently, single cell analysis techniques are rapidly developing and find broad application, as the single cell measurements not only enable to study cell specific functions, but often reveal unexpected biological mechanisms in so far (assumed) well understood biological processes. In this lecture, we will discuss the most important single cell approaches, the questions they can address and current developments. We will cover single cell genomics, single cell transcriptomics, single cell proteomics (CyTOF mass cytometry), single cell metabolomics and highly multiplexed single cell imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data. | |||||
551-1404-00L | RNA and Proteins: Post-Transcriptional Regulation of Gene Expression (University of Zurich) Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: BCH252 Beachten Sie die Einschreibungstermine an der UZH: Link | W | 3 KP | 2V | Uni-Dozierende | |
Kurzbeschreibung | The course introduces the cellular processes and molecular mechanisms involved in regulating genome expression at the post-transcriptional level. Topics will include : -RNA processing, and transport; -protein synthesis and translational control, trafficking and degradation; -RNA-guided regulation (RNA interference, microRNAs); -molecular surveillance and quality control mechanisms | |||||
Lernziel | -Outline the cellular processes used by eukaryotic and prokaryotic cells to control gene expression at the post- transcriptional level. -Describe the molecular mechanisms underlying post-transcriptional gene regulation -Identify experimental approaches used to study post-transcriptional gene regulation and describe their strengths and weaknesses. | |||||
636-0111-00L | Synthetic Biology I Attention: This course was offered in previous semesters with the number: 636-0002-00L "Synthetic Biology I". Students that already passed course 636-0002-00L cannot receive credits for course 636-0111-00L. | W | 4 KP | 3G | S. Panke, J. Stelling | |
Kurzbeschreibung | Theoretical & practical introduction into the design of dynamic biological systems at different levels of abstraction, ranging from biological fundamentals of systems design (introduction to bacterial gene regulation, elements of transcriptional & translational control, advanced genetic engineering) to engineering design principles (standards, abstractions) mathematical modelling & systems desig | |||||
Lernziel | After the course, students will be able to theoretically master the biological and engineering fundamentals required for biological design to be able to participate in the international iGEM competition (see Link). | |||||
Inhalt | The overall goal of the course is to familiarize the students with the potential, the requirements and the problems of designing dynamic biological elements that are of central importance for manipulating biological systems, primarily (but not exclusively) prokaryotic systems. Next, the students will be taken through a number of successful examples of biological design, such as toggle switches, pulse generators, and oscillating systems, and apply the biological and engineering fundamentals to these examples, so that they get hands-on experience on how to integrate the various disciplines on their way to designing biological systems. | |||||
Skript | Handouts during classes. | |||||
Literatur | Mark Ptashne, A Genetic Switch (3rd ed), Cold Spring Haror Laboratory Press Uri Alon, An Introduction to Systems Biology, Chapman & Hall | |||||
Voraussetzungen / Besonderes | 1) Though we do not place a formal requirement for previous participation in particular courses, we expect all participants to be familiar with a certain level of biology and of mathematics. Specifically, there will be material for self study available on Link as of mid January, and everybody is expected to be fully familiar with this material BEFORE THE CLASS BEGINS to be able to follow the different lectures. Please contact Link for access to material 2) The course is also thought as a preparation for the participation in the international iGEM synthetic biology summer competition (Link, Link). This competition is also the contents of the course Synthetic Biology II. Link | |||||
551-1700-00L | Introduction to Flow Cytometry Number of participants limited to 24. | W | 2 KP | 1V | J. Kisielow, L. Tortola, weitere Dozierende | |
Kurzbeschreibung | The lecture provides an introduction to flow cytometry. We will cover the technology basics, experimental design, data acquisition and analysis of flow and mass cytometry. In addition, various research applications will be discussed. The format is a lecture course enriched by a visit to the ETH Flow Cytometry Core Facility and practical demonstration of the use of analysis and sorting instruments. | |||||
Lernziel | The goal of this course is to provide the basic knowledge of flow and mass cytometry required for planning and execution of cytometric experiments. | |||||
Inhalt | The lecture course aims at teaching principles of flow cytometry. The emphasis is on theoretical principles (signal detection, fluorochromes, signal spill-over and compensation) as well as practical aspects of experimental design and performance (sample preparation, controls, data acquisition and analysis). List of topics: - Principles of Flow Cytometry - Signal processing - Compensation and Controls - Data analysis, gating and presentation - Panel design - Sorting - Mass cytometry - High-dimensional data analysis - Practical demonstration (hardware and software) Modern flow cytometric techniques for immunophenotyping, analysis of proliferation, cell cycle, apoptosis and cell signalling will be introduced. | |||||
Skript | Updated handouts will be provided during the class. | |||||
Literatur | Current literature references on immunophenotyping, analysis of proliferation, cell cycle, apoptosis and cell signalling will be discussed during the lectures. | |||||
701-1708-00L | Infectious Disease Dynamics | W | 4 KP | 2V | S. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler | |
Kurzbeschreibung | This course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations. | |||||
Lernziel | Attendees will learn about: * the impact of important infectious pathogens and their evolution on human, natural and managed populations * the population biological impact of interventions such as treatment or vaccination * the impact of population structure on disease transmission Attendees will learn how: * the emergence spread of infectious diseases is described mathematically * the impact of interventions can be predicted and optimized with mathematical models * population biological models are parameterized from empirical data * genetic information can be used to infer the population biology of the infectious disease The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about"). | |||||
Inhalt | After an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases. | |||||
Skript | Slides and script of the lecture will be available online. | |||||
Literatur | The course is not based on any of the textbooks below, but they are excellent choices as accompanying material: * Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008 * Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990 * Murray, Mathematical Biology, Springer 2002/3 * Nowak & May, Virus Dynamics, Oxford Univ Press 2000 * Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009 | |||||
Voraussetzungen / Besonderes | Basic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage. |
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