Suchergebnis: Katalogdaten im Herbstsemester 2020

Nummer	Titel	Typ	ECTS	Umfang	Dozierende
Gesundheitswissenschaften und Technologie Master
Vertiefung in Molekulare Gesundheitswissenschaften
Wahlfächer
327-2125-00L	Microscopy Training SEM I - Introduction to SEM The number of participants is limited. In case of overbooking, the course will be repeated once. All registrations will be recorded on the waiting list. For PhD students, postdocs and others, a fee will be charged (http://www.scopem.ethz.ch/education/MTP.html). All applicants must additionally register on this form: Link The selected applicants will be contacted and asked for confirmation a few weeks before the course date.	W	2 KP	3P	P. Zeng, A. G. Bittermann, S. Gerstl, L. Grafulha Morales, K. Kunze, J. Reuteler
Kurzbeschreibung	This introductory course on Scanning Electron Microscopy (SEM) emphasizes hands-on learning. Using ScopeM SEMs, students have the opportunity to study their own samples (or samples provided) and solve practical problems by applying knowledge acquired during the lectures. At the end of the course, students will be able to apply SEM for their (future) research projects.
Lernziel	- Set-up, align and operate a SEM successfully and safely. - Understand important operational parameters of SEM and optimize microscope performance. - Explain different signals in SEM and obtain secondary electron (SE) and backscatter electron (BSE) images. - Operate the SEM in low-vacuum mode. - Make use of EDX for semi-quantitative elemental analysis. - Prepare samples with different techniques and equipment for imaging and analysis by SEM.
Inhalt	During the course, students learn through lectures, demonstrations, and hands-on sessions how to setup and operate SEM instruments, including low-vacuum and low-voltage applications. This course gives basic skills for students new to SEM. At the end of the course, students are able to align an SEM, to obtain secondary electron (SE) and backscatter electron (BSE) images and to perform energy dispersive X-ray spectroscopy (EDX) semi-quantitative analysis. Emphasis is put on procedures to optimize SEM parameters in order to best solve practical problems and deal with a wide range of materials. Lectures: - Introduction on Electron Microscopy and instrumentation - electron sources, electron lenses and probe formation - beam/specimen interaction, image formation, image contrast and imaging modes. - sample preparation techniques for EM - X-ray micro-analysis (theory and detection), qualitative and semi-quantitative EDX and point analysis, linescan and spectral mapping Practicals: - Brief description and demonstration of the SEM microscope - Practice on image formation, image contrast (and image processing) - Student participation on sample preparation techniques - Scanning Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities - Practice on real-world samples and report results
Skript	Lecture notes will be distributed.
Literatur	- Peter Goodhew, John Humphreys, Richard Beanland: Electron Microscopy and Analysis, 3rd ed., CRC Press, 2000 - Joseph Goldstein, et al, Scanning Electron Microscopy and X-Ray Microanalysis, 4th ed, Srpinger US, 2018 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007
Voraussetzungen / Besonderes	No mandatory prerequisites.
327-2126-00L	Microscopy Training TEM I - Introduction to TEM The number of participants is limited. In case of overbooking, the course will be repeated once. All registrations will be recorded on the waiting list. For PhD students, postdocs and others, a fee will be charged (http://www.scopem.ethz.ch/education/MTP.html). All applicants must additionally register on this form: Link The selected applicants will be contacted and asked for confirmation a few weeks before the course date.	W	2 KP	3P	P. Zeng, E. J. Barthazy Meier, A. G. Bittermann, F. Gramm, A. Sologubenko, M. Willinger
Kurzbeschreibung	The introductory course on Transmission Electron Microscopy (TEM) provides theoretical and hands-on learning for beginners who are interested in using TEM for their Master or PhD thesis. TEM sample preparation techniques are also discussed. During hands-on sessions at different TEM instruments, students will have the opportunity to examine their own samples if time allows.
Lernziel	Understanding of 1. the set-up and individual components of a TEM 2. the basics of electron optics and image formation 3. the basics of electron beam – sample interactions 4. the contrast mechanism 5. various sample preparation techniques Learning how to 1. align and operate a TEM 2. acquire data using different operation modes of a TEM instrument, i.e. Bright-field and Dark-field imaging 3. record electron diffraction patterns and index diffraction patterns 4. interpret TEM data
Inhalt	Lectures: - basics of electron optics and the TEM instrument set-up - TEM imaging modes and image contrast - STEM operation mode - Sample preparation techniques for hard and soft materials Practicals: - Demo, practical demonstration of a TEM: instrument components, alignment, etc. - Hands-on training for students: sample loading, instrument alignment and data acquisition. - Sample preparation for different types of materials - Practical work with TEMs - Demonstration of advanced Transmission Electron Microscopy techniques
Skript	Lecture notes will be distributed.
Literatur	- Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007
Voraussetzungen / Besonderes	No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551-1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite.
376-0121-00L	Multiscale Bone Biomechanics Number of participants limited to 30	W	6 KP	4S	R. Müller, X.‑H. Qin
Kurzbeschreibung	The seminar provides state-of-the-art insight to the biomechanical function of bone from molecules, to cells, tissue and up to the organ. Multiscale imaging and simulation allows linking different levels of hierarchy, where systems biology helps understanding the mechanobiological response of bone to loading and injury in scenarios relevant for personalized health and translational medicine.
Lernziel	The learning objectives include 1. advanced knowledge of the state-of-the-are in multiscale bone biomechanics; 2. basic understanding of the biological principles governing bone in health, disease and treatment from molecules, to cells, tissue and up to the organ; 3. good understanding of the prevalent biomechanical testing and imaging techniques on the various levels of bone hierarchy; 4. practical implementation of state-of-the-art multiscale simulation techniques; 5. improved programing skills through the use of python; 6. hands on experience in designing solutions for clinical and industrial problems; 7. encouragement of critical thinking and creating an environment for independent and self-directed studying.
Inhalt	Bone is one of the most investigated biological materials due to its primary function of providing skeletal stability. Bone is susceptible to different local stimuli including mechanical forces and has great capabilities in adapting its mechanical properties to the changes in its environment. Nevertheless, aging or hormonal changes can make bone lose its ability to remodel appropriately, with loss of strength and increased fracture risk as a result, leading to devastating diseases such as osteoporosis. To better understand the biomechanical function of bone, one has to understand the hierarchical organization of this fascinating material down from the molecules, to the cells, tissue and up to the organ. Multiscale imaging and simulation allows to link these different levels of hierarchy. Incorporating systems biology approaches, not only biomechanical strength of the material can be assessed but also the mechanobiological response of the bone triggered by loading and injury in scenarios relevant for personalized health and translational medicine. Watching cells working together to build and repair bone in a coordinated fashion is a spectacle, which will need dynamic image content and deep discussions in the lecture room to probe the imagination of the individual student interested in the topic. For the seminar, concepts of video lectures will be used in a flipped class room setup, where students can study the basic biology, engineering and mathematical concepts in video tutorials online (TORQUES). All videos and animations will be incorporated in Moodle and PolyBook allowing studying and interactive course participation online. It is anticipated that the students need to prepare 2x45 minutes for the study of the actual lecture material. On the Friday afternoon, the first time slot (12-13) will be used for students, who want to schedule one-to-one meetings with the lecturer/tutors to discuss course content. In the later time slots (13-16), short clips with video/animation content will be used to introduce problems and discuss specific scientific findings using multiscale imaging and simulation technology in a flipped classroom. The students will have to form small groups to try to solve such problems and to present their solutions for advanced multiscale investigation of bone ranging from basic science to personalized health and onto translational medicine. Towards the end of the semester, students will have to present self-selected publications associated with the different topics of the lecture identified through PubMed or the Web of Science.
Skript	Material will be provided in Moodle and PolyBook.
Voraussetzungen / Besonderes	Prior experience with the programming language python is beneficial but not mandatory. ETH offers courses for practical programming with python.
376-0303-00L	Colloquium in Translational Science (Autumn Semester)	W	1 KP	1K	M. Ristow, A. Alimonti, N. Cesarovic, C. Ewald, V. Falk, J. Goldhahn, K. Maniura, J. Mitchell, R. M. Rossi, S. Schürle-Finke, G. Shivashankar, E. Vayena, V. Vogel
Kurzbeschreibung	Current topics in translational medicine presented by speakers from academia and industry.
Lernziel	Getting insight into actual areas and problems of translational medicine.
Inhalt	Timely and concise presentations of postgraduate students, post-docs, senior scientists, professors, as well as external guests from both academics and industry will present topics of their interest related to translational medicine.
Voraussetzungen / Besonderes	No compulsory prerequisites, but student should have basic knowledge about biomedical research.
376-1151-00L	Translation of Basic Research Findings from Genetics and Molecular Mechanisms of Aging Findet dieses Semester nicht statt. Number of participants limited to 30.	W	3 KP	2V	C. Ewald
Kurzbeschreibung	Recently, several start-up companies are aiming to translate basic molecular findings into new drugs/therapeutic interventions to slow aging or post-pone age-related diseases (e.g., Google founded Calico or Craig Venter's Human Longevity, Inc.). This course will teach students the basic skill sets to formulate their own ideas, design experiments to test them and explains the next steps to translat
Lernziel	The overall goal of this course is to be able to analyse current therapeutic interventions to identify an unmet need in molecular biology of aging and apply scientific thinking to discover new mechanisms that could be used as a novel therapeutic intervention. Learning objectives include: 1. Evaluate the current problem of our aging population, the impact of age-dependent diseases and current strategies to prevent these age-dependent diseases. 2. Analyse/compare current molecular/genetic strategies that address these aging problems. 3. Analyse case studies about biotech companies in the aging sector. Apply the scientific methods to formulate basic research questions to address these problems. 4. Generate own hypotheses (educated guess/idea), design experiments to test them, and map out the next steps to translate them.
Inhalt	Overview of aging and age-related diseases. Key discoveries in molecular biology of aging. Case studies of biotech companies addressing age-related complications. Brief introduction from bench to bedside with focus on start-up companies.
Voraussetzungen / Besonderes	No compulsory prerequisites, but student should have basic knowledge about genetics and molecular biology.
376-1353-00L	Nanostructured Materials Safety	W	2 KP	1V	P. Wick
Kurzbeschreibung	Fundamentals in nanostructured material - living system interactions focusing on the main exposure routes, lung, gastrointestinal tract, skin and intravenous injection
Lernziel	Understanding the potential side effects of nanomaterials in a context-specific way, enabling to evaluate nanomaterial safety and provide knowledge to design safer materials
Skript	Handouts provided during the classes and references therein as well as primary literature as case studies will be posted to the course website
Voraussetzungen / Besonderes	course "Introduction to Toxicology"
376-1622-00L	Practical Methods in Tissue Engineering Number of participants limited to 12.	W	5 KP	4P	M. Zenobi-Wong, S. J. Ferguson, S. Grad, S. Schürle-Finke
Kurzbeschreibung	The goal of this course is to teach MSc students the necessary skills for doing research in the fields of tissue engineering and regenerative medicine.
Lernziel	Practical exercises on topics including sterile cell culture, light microscopy and histology, and biomaterials are covered. Practical work on manufacturing and evaluating hydrogels and scaffolds for tissue engineering will be performed in small groups. In addition to practical lab work, the course will teach skills in data acquisition/analysis.
Voraussetzungen / Besonderes	A Windows laptop (or Windows on Mac) is required for certain of the lab modules.
551-0223-00L	Immunology III	W	4 KP	2V	M. Kopf, S. B. Freigang, J. Kisielow, S. R. Leibundgut, A. Oxenius, C. Schneider, E. Slack, R. Spörri, L. Tortola
Kurzbeschreibung	Diese Vorlesung liefert einen detaillierten Einblick in die - Entwicklung von T Zellen und B Zellen - Dynamik einer Immunantwort bei akuten und chronischen Infektionen - Mechanismen von Immunpathologie - neue Impfstoffstrategien
Lernziel	Sie verstehen - die Entwicklung, Aktivierung, und Differenzierung verschiedener Typen von T Zellen und deren Effektormechanismen während einer Immunantwort - die Erkennung von pathogenen Mikroorganismen und molekulare Ereignisse nach Infektion einer Zelle - Ereignisse und Signale für die Reifung von naiven B Zellen zu antikörperproduzierenden Plasmazellen und Gedächtniszellen, - Optimierung von B Zellantworten durch das intelligente Design neuer Impfstoffe
Inhalt	o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections
Literatur	Unterlagen zur Vorlesung sind erhältlich bei: https://moodle-app2.let.ethz.ch/course/view.php?id=2581¬ifyeditingon=1
Voraussetzungen / Besonderes	Immunology I and II recommended but not compulsory
551-0309-00L	Concepts in Modern Genetics Information for UZH students: Enrolment to this course unit only possible at ETH. No enrolment to module BIO348 at UZH. Please mind the ETH enrolment deadlines for UZH students: Link	W	6 KP	4V	Y. Barral, D. Bopp, A. Hajnal, O. Voinnet
Kurzbeschreibung	Concepts of modern genetics and genomics, including principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference.
Lernziel	This course focuses on the concepts of classical and modern genetics and genomics.
Inhalt	The topics include principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference.
Skript	Scripts and additional material will be provided during the semester.
551-0317-00L	Immunology I	W	3 KP	2V	M. Kopf, A. Oxenius
Kurzbeschreibung	Einführung in strukturelle und funktionelle Eigenschaften des Immunsystems. Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort.
Lernziel	Einführung in strukturelle und funktionelle Eigenschaften des Immunsystems. Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort.
Inhalt	- Einleitung und historischer Hintergrund - Angeborene und adaptive Immunantwort, Zellen und Organe des Immunsystems - B Zellen und Antikörper - Generation von Diversität - Antigen-Präsentation und Histoinkompatibilitätsantigene (MHC) - Thymus und T Zellselektion - Autoimmunität - Zytotoxische T Zellen und NK Zellen - Th1 und Th2 Zellen, regulatorische T Zellen - Allergien - Hypersensitivititäten - Impfungen und immun-therapeutische Interventionen
Skript	Die Studenten haben elekronischen Zugriff auf die Vorlesungsunterlagen. Der Link ist unter "Lernmaterialien" zu finden.
Literatur	- Kuby, Immunology, 7th edition, Freemen + Co., New York, 2009
Voraussetzungen / Besonderes	Immunology I (WS) und Immunology II (SS) werden in einer Sessionsprüfung im Anschluss an Immunology II als eine Lerneinheit geprüft.
551-0512-00L	Current Topics in Molecular and Cellular Neurobiology Findet dieses Semester nicht statt. Number of participants limited to 8.	W	2 KP	1S	U. Suter
Kurzbeschreibung	The course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature.
Lernziel	The course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn i.e. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking.
Inhalt	You will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance. You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation).
Skript	Presentations will be made available after the seminars.
Voraussetzungen / Besonderes	You must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%).
551-0571-00L	From DNA to Diversity (University of Zurich) Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: BIO336 Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/chmobilityin.html	W	2 KP	2V	A. Hajnal, D. Bopp
Kurzbeschreibung	The evolution of the various body-plans is investigated by means of comparison of developmentally essential control genes of molecularly analysed model organisms.
Lernziel	By the end of this module, each student should be able to - recognize the universal principles underlying the development of different animal body plans. - explain how the genes encoding the molecular toolkit have evolved to create animal diversity. - relate changes in gene structure or function to evolutionary changes in animal development. Key skills: By the end of this module, each student should be able to - present and discuss a relevant evolutionary topic in an oral presentation - select and integrate key concepts in animal evolution from primary literature - participate in discussions on topics presented by others
551-1003-00L	Methoden der Biologischen Analytik	W	3 KP	3G	M. Badertscher, P. Picotti, K. Weis
Kurzbeschreibung	529-1042-00 Grundlagen der wichtigsten Trennmethoden und der Interpretation von Molekülspektren. 551-1003-00 Der Kurs befasst sich mit den Methoden und ausgewählten Anwendungen von Methoden der Nukleinsäuresequenzierung, der massenspektrometrischen Analyse von Proteinen und Proteomen und Licht-und Fluoreszenz gestützten Methoden der Mikroskopie.
Lernziel	529-1042-00 Kenntnis der notwendigen Grundlagen und der Anwendungsmöglichkeiten für den Einsatz von relevanten spektroskopischen und Trennmethoden in der analytisch-chemischen Praxis. 551-1003-00 Kenntnis der notwendigen Grundlagen und der Anwendungsmöglichkeiten der Methoden für die Bestimmung von Nukleinsäuresequenzen, der massenspektrometrischen Analyse von Proteinen und Proteomen und Licht-und Fluoreszenz gestützten Methoden der Mikroskopie.
Inhalt	529-1042-00 Anwendungsorientierte Grundlagen der organischen Instrumentalanalytik und des empirischen Einsatzes von Methoden der Strukturaufklärung (Massenspektrometrie, NMR-, IR-, UV/VIS-Spektroskopie). Grundlagen und Anwendung chromatographischer und elektrophoretischer Trennverfahren. Praxisnahe Anwendung und Vertiefung des Grundwissens anhand von Übungen. 551-1003-00 Der Kurs setzt sich zusammen aus Vorlesungen, die die theoretischen und technischen Grundlagen der betreffenden analytischen Methoden vermitteln und Übungen, die sich mit den Anwendungen der analytischen Methoden in der modernen experimentellen Biologie befassen.
Skript	529-1042-00 Ein umfangreiches Skript ist im HCI-Shop erhältlich. Eine Kurzfassung des Teils "Spektroskopie" definiert die für die Prüfung dieses Teils relevanten Themen.
Literatur	529-1042-00 - Pretsch E., Bühlmann P., Badertscher M. Structure Determination of Organic Compounds, 5th revised and enlarged English edition, Springer-Verlag, Berlin 2009; - Pretsch E., Bühlmann P., Badertscher M., Spektroskopische Daten zur Strukturaufklärung organischer Verbindungen, fünfte Auflage, Springer-Verlag, Berlin 2010; - D.A. Skoog, J.J. Leary, Instrumentelle Analytik, Grundlagen, Geräte, Anwendungen, Springer, Berlin, 1996; - K. Cammann, Instrumentelle Analytische Chemie, Verfahren, Anwendungen, Qualitätssicherung, Spektrum Akademischer Verlag, Heidelberg, 2001; - R. Kellner, J.-M. Mermet, M. Otto, H.M. Widmer, Analytical Chemistry, Wiley-VCH Verlag, Weinheim, 1998; - K. Robards, P.R.Haddad, P.E. Jackson, Principles and practice of modern chromatographic methods, Academic Press, London, 1994;
Voraussetzungen / Besonderes	529-1042-00 Voraussetzungen: - 529-1001-01 V "Allgemeine Chemie I (für Biol./Pharm.Wiss.)" - 529-1001-00 P "Allgemeine Chemie I (für Biol./Pharm.Wiss.)" - 529-1011-00 G "Organische Chemie I (für Biol./Pharm.Wiss.)"
551-1145-00L	Viral and non-Viral Vectors for Human Gene-Therapy - from Pathogens to Safe Medical Applications Findet dieses Semester nicht statt. Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: BIO708 Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html	W	2 KP	3V	Uni-Dozierende
Kurzbeschreibung	Basic aspects of virology, the viral mechanisms for transfer of genetic material into cells, different vector-systems and target cells, animal models, specific applications for inborn diseases of the immune system and of metabolism, adverse effects, and new developments of vector systems will be taught.
Lernziel	Knowledge of important viral and non-viral vector systems. Knowledge of application in human diseases. Knowledge of limiting factors.
551-1153-00L	Systems Biology of Metabolism Number of participants limited to 15.	W	4 KP	2V	U. Sauer, N. Zamboni, M. Zampieri
Kurzbeschreibung	Starting from contemporary biological problems related to metabolism, the course focuses on systems biological approaches to address them. In a problem-oriented, this-is-how-it-is-done manner, we thereby teach modern methods and concepts.
Lernziel	Develop a deeper understanding of how relevant biological problems can be solved, thereby providing advanced insights to key experimental and computational methods in systems biology.
Inhalt	The course will be given as a mixture of lectures, studies of original research and guided discussions that focus on current research topics. For each particular problem studied, we will work out how the various methods work and what their capabilities/limits are. The problem areas range from microbial metabolism to cancer cell metabolism and from metabolic networks to regulation networks in populations and single cells. Key methods to be covered are various modeling approaches, metabolic flux analyses, metabolomics and other omics.
Skript	Script and original publications will be supplied during the course.
Voraussetzungen / Besonderes	The course extends many of the generally introduced concepts and methods of the Concept Course in Systems Biology. It requires a good knowledge of biochemistry and basics of mathematics and chemistry.
551-1171-00L	Immunology: from Milestones to Current Topics	W	4 KP	2S	B. Ludewig, N. C. Joller, J. Kisielow, C. Münz, A. Oxenius, L. Tortola, M. van den Broek
Kurzbeschreibung	Immunology: from Milestones to Current Topics 2020
Lernziel	The course will cover the current grand topics in immunology: B cells, innate immunity, antigen presentation, tumor immunity, T cells, myeloid cells and stromal cells. For each topic two or four hours will be allocated. Historical milestone papers will be presented by the tutor/lecturer providing an overview on the development of the theoretical framework and critical technological advances. The students will read the historical milestone papers and contribute to the discussion. In the second part of the lecture, students will present recent high impact research papers that have emerged from the landmark achievements of the previously discussed milestone concepts.
Inhalt	Milestones and current grand topics in immunology: B cells, innate immunity, antigen presentation, tumor immunity, T cells, myeloid cells and stromal cells.
Skript	Original and review articles will be distributed by the lecturer.
Literatur	Literaturunterlagen werden vor Beginn des Kurses auf folgender website zugänglich sein: Moodle Course https://moodle-app2.let.ethz.ch/course/view.php?id=13066
551-1303-00L	Cellular Biochemistry of Health and Disease Number of participants limited to 20.	W	4 KP	2S	V. Korkhov, Y. Barral, T. Ishikawa, M. Jagannathan, R. Kroschewski, G. Neurohr, M. Peter, A. E. Smith, B. Snijder, K. Weis
Kurzbeschreibung	During this Masters level seminar style course, students will explore current research topics in cellular biochemistry focused on the structure, function and regulation of selected cell components, and the consequences of dysregulation for pathologies.
Lernziel	Students will work with experts toward a critical analysis of cutting-edge research in the domain of cellular biochemistry, with emphasis on normal cellular processes and the consequences of their dysregulation. At the end of the course, students will be able to introduce, present, evaluate, critically discuss and write about recent scientific articles in the research area of cellular biochemistry.
Inhalt	Guided by an expert in the field, students will engage in classical round-table style discussions of current literature with occasional frontal presentations. Students will alternate as discussion leaders throughout the semester, with the student leader responsible to briefly summarize key general knowledge and context of the assigned primary research paper. Together with the faculty expert, all students will participate in discussion of the primary paper, including the foundation of the biological question, specific questions addressed, key methods, key results, remaining gaps and research implications.
Literatur	The literature will be provided during the course
Voraussetzungen / Besonderes	The course will be taught in English.
551-1323-00L	Grundlagen der Biologie II: Biochemie und Molekularbiologie	W	4 KP	4G	K. Locher, N. Ban, R. Glockshuber, E. Weber-Ban
Kurzbeschreibung	Die Vorlesung vermittelt die Grundlagen der Biochemie und Molekularbiologie mit Betonung der chemischen und biophysikalischen Aspekte.
Lernziel	Behandelt werden Struktur-Funktionsbeziehungen in Proteinen und Nukleinsäuren, Konzepte der Proteinfaltung und der biochemischen Katalyse, die wichtigsten an zellulärer Energiegewinnung und -Speicherung beteiligten Stoffwechselvorgänge, die Biosynthese von Aminosäuren, Zucker, Nukleotiden, Fetten und Steroiden, sowie eine detaillierte Diskussion von Replikation, Transkription und Translation.
Skript	kein Skript
Literatur	obligatorisch: "Biochemistry", Autoren: Berg/Tymoczko/Stryer, Palgrave Macmillan, International edition (wird bei der Polybuchhandlung als englische Version vorbestellt werden)
Voraussetzungen / Besonderes	Einige Vorlesungseinheiten werden in englischer Sprache gehalten.
636-0017-00L	Computational Biology	W	6 KP	3G + 2A	T. Stadler, T. Vaughan
Kurzbeschreibung	The aim of the course is to provide up-to-date knowledge on how we can study biological processes using genetic sequencing data. Computational algorithms extracting biological information from genetic sequence data are discussed, and statistical tools to understand this information in detail are introduced.
Lernziel	Attendees will learn which information is contained in genetic sequencing data and how to extract information from this data using computational tools. The main concepts introduced are: * stochastic models in molecular evolution * phylogenetic & phylodynamic inference * maximum likelihood and Bayesian statistics Attendees will apply these concepts to a number of applications yielding biological insight into: * epidemiology * pathogen evolution * macroevolution of species
Inhalt	The course consists of four parts. We first introduce modern genetic sequencing technology, and algorithms to obtain sequence alignments from the output of the sequencers. We then present methods for direct alignment analysis using approaches such as BLAST and GWAS. Second, we introduce mechanisms and concepts of molecular evolution, i.e. we discuss how genetic sequences change over time. Third, we employ evolutionary concepts to infer ancestral relationships between organisms based on their genetic sequences, i.e. we discuss methods to infer genealogies and phylogenies. Lastly, we introduce the field of phylodynamics, the aim of which is to understand and quantify population dynamic processes (such as transmission in epidemiology or speciation & extinction in macroevolution) based on a phylogeny. Throughout the class, the models and methods are illustrated on different datasets giving insight into the epidemiology and evolution of a range of infectious diseases (e.g. HIV, HCV, influenza, Ebola). Applications of the methods to the field of macroevolution provide insight into the evolution and ecology of different species clades. Students will be trained in the algorithms and their application both on paper and in silico as part of the exercises.
Skript	Lecture slides will be available on moodle.
Literatur	The course is not based on any of the textbooks below, but they are excellent choices as accompanying material: * Yang, Z. 2006. Computational Molecular Evolution. * Felsenstein, J. 2004. Inferring Phylogenies. * Semple, C. & Steel, M. 2003. Phylogenetics. * Drummond, A. & Bouckaert, R. 2015. Bayesian evolutionary analysis with BEAST.
Voraussetzungen / Besonderes	Basic knowledge in linear algebra, analysis, and statistics will be helpful. Programming in R will be required for the project work (compulsory continuous performance assessments). We provide an R tutorial and help sessions during the first two weeks of class to learn the required skills. However, in case you do not have any previous experience with R, we strongly recommend to get familiar with R prior to the semester start. For the D-BSSE students, we highly recommend the voluntary course „Introduction to Programming“, which takes place at D-BSSE from Wednesday, September 12 to Friday, September 14, i.e. BEFORE the official semester starting date http://www.cbb.ethz.ch/news-events.html For the Zurich-based students without R experience, we recommend the R course Link, or working through the script provided as part of this R course.
636-0108-00L	Biological Engineering and Biotechnology Attention: This course was offered in previous semesters with the number: 636-0003-00L "Biological Engineering and Biotechnology". Students that already passed course 636-0003-00L cannot receive credits for course 636-0108-00L.	W	4 KP	3V	M. Fussenegger
Kurzbeschreibung	Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
Lernziel	Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
Inhalt	1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development.
Skript	Handout during the course.

Seite 1 von 2 Alle