Suchergebnis: Katalogdaten im Frühjahrssemester 2018
MAS in Medizinphysik  | ||||||
 Fachrichtung: Allg. Medizinphysik und Biomedizinisches Ingenieurwesen | ||||||
| Vertiefung Radiation Therapy | ||||||
| Kernfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
|---|---|---|---|---|---|---|
| 227-0968-00L | Monte Carlo in Medical Physics | W | 4 KP | 3G | M. Stampanoni, M. K. Fix | |
| Kurzbeschreibung | Introduction in basics of Monte Carlo simulations in the field of medical radiation physics. General recipe for Monte Carlo simulations in medical physics from code selection to fine-tuning the implementation. Characterization of radiation by means of Monte Carlo simulations. | |||||
| Lernziel | Understanding the concept of the Monte Carlo method. Getting familiar with the Monte Carlo technique, knowing different codes and several applications of this method. Learn how to use Monte Carlo in the field of applied medical radiation physics. Understand the usage of Monte Carlo to characterize the physical behaviour of ionizing radiation in medical physics. Share the enthusiasm about the potential of the Monte Carlo technique and its usefulness in an interdisciplinary environment. | |||||
| Inhalt | The lecture provides the basic principles of the Monte Carlo method in medical radiation physics. Some fundamental concepts on applications of ionizing radiation in clinical medical physics will be reviewed. Several techniques in order to increase the simulation efficiency of Monte Carlo will be discussed. A general recipe for performing Monte Carlo simulations will be compiled. This recipe will be demonstrated for typical clinical devices generating ionizing radiation, which will help to understand implementation of a Monte Carlo model. Next, more patient related effects including the estimation of the dose distribution in the patient, patient movements and imaging of the patient's anatomy. A further part of the lecture covers the simulation of radioactive sources as well as heavy ion treatment modalities. The field of verification and quality assurance procedures from the perspective of Monte Carlo simulations will be discussed. To complete the course potential future applications of Monte Carlo methods in the evolving field of treating patients with ionizing radiation. | |||||
| Skript | A script will be provided. | |||||
| 402-0342-00L | Medical Physics II | W | 6 KP | 2V + 1U | P. Manser | |
| Kurzbeschreibung | Applications of ionizing radiation in medicine such as radiation therapy, nuclear medicine and radiation diagnostics. Theory of dosimetry based on cavity theory and clinical consequences. Fundamentals of dose calculation, optimization and evaluation. Concepts of external beam radiation therapy and brachytherapy. Recent and future developments: IMRT, IGRT, SRS/SBRT, particle therapy. | |||||
| Lernziel | Getting familiar with the different medical applications of ionizing radiation in the fields of radiation therapy, nuclear medicine, and radiation diagnostics. Dealing with concepts such as external beam radiation therapy as well as brachytherapy for the treatment of cancer patients. Understanding the fundamental cavity theory for dose measurements and its consequences on clinical practice. Understanding different delivery techniques such as IMRT, IGRT, SRS/SBRT, brachytherapy, particle therapy using protons, heavy ions or neutrons. Understanding the principles of dose calculation, optimization and evaluation for radiation therapy, nuclear medicine and radiation diagnostic applications. Finally, the lecture aims to demonstrate that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
| Inhalt | In this lecture, the use of ionizing radiation in different clinical applications is discussed. Primarily, we will concentrate on radiation therapy and will cover applications such as external beam radiotherapy with photons and electrons, intensity modulated radiotherapy (IMRT), image guided radiotherapy (IGRT), stereotactic radiotherapy and radiosurgery, brachytherapy, particle therapy using protons, heavy ions or neutrons. In addition, dosimetric methods based on cavity theory are reviewed and principles of treatment planning (dose calculation, optimization and evaluation) are discussed. Next to these topics, applications in nuclear medicine and radiation diagnostics are explained with the clear focus on dosimetric concepts and behaviour. | |||||
| Skript | A script will be provided. | |||||
| Voraussetzungen / Besonderes | It is recommended that the students have taken the lecture Medical Physics I in advance. | |||||
| Praktika | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 465-0420-00L | Strahlenschutz-Sachverstand  Nur für MAS in Medizinphysik | W | 4 KP | 6G | externe Veranstalter | |
| Kurzbeschreibung | Der Kurs umfasst alle Inhalte in Theorie und Praxis, die für eine anerkannte Ausbildung zu Strahlenschutz-Sachverständigen beim Umgang mit offenem radioaktivem Material in einem Arbeitsbereich B/C notwendig sind. Nach erfolgreich abgeschlossener Prüfung wird ein vom BAG anerkanntes Zertifikat ausgestellt. Dieses erlaubt auch den Einsatz als Strahlenschutz-Beauftragte im Aufsichtsbereich des ENSI. | |||||
| Lernziel | Die Teilnehmenden erwerben in der Ausbildung die Kompetenzen, Fähigkeiten und Kenntnisse, um die Funktion des Strahlenschutz-Sachverständigen beim Umgang mit offenem radioaktiven Material im Arbeitsbereich B/C anerkannt gemäss Strahlenschutz Ausbildungsverordnung (814.501.261) ausüben zu dürfen. | |||||
| Inhalt | - Grundkenntnisse der Strahlenphysik und der Strahlenbiologie - Dosisabschätzung bei interner und externer Bestrahlung - Kenntnis der für den Umgang mit offenen und geschlossenen Strahlenquellen massgeblichen Gesetzen und Verordnungen - Erkennen und abschätzen von Gefährdungspotenzialen - Festlegen von Strahlenschutz-Betriebsvorschriften, Sicherheitsplänen sowie baulicher, organisatorischer und operationeller Massnahmen - Kenntnis und Anwendung von Messgeräten - Planung und Durchführung der Personen- und Arbeitsplatzüberwachung | |||||
| 465-0800-00L | Practical Work Nur für MAS in Medizinphysik | W | 4 KP | externe Veranstalter | ||
| Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Wahlfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 227-0390-00L | Elements of Microscopy | W | 4 KP | 3G | M. Stampanoni, G. Csúcs, A. Sologubenko | |
| Kurzbeschreibung | The lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging. | |||||
| Lernziel | Solid introduction to the basics of microscopy, either with visible light, electrons or X-rays. | |||||
| Inhalt | It would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level. The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy. During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated. | |||||
| Literatur | Available Online. | |||||
| 227-0946-00L | Molecular Imaging - Basic Principles and Biomedical Applications | W | 2 KP | 2V | M. Rudin | |
| Kurzbeschreibung | Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications. | |||||
| Lernziel | Molecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research. | |||||
| Inhalt | Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications. | |||||
| 227-0948-00L | Magnetic Resonance Imaging in Medicine | W | 4 KP | 3G | S. Kozerke, M. Weiger Senften | |
| Kurzbeschreibung | Introduction to magnetic resonance imaging and spectroscopy, encoding and contrast mechanisms and their application in medicine. | |||||
| Lernziel | Understand the basic principles of signal generation, image encoding and decoding, contrast manipulation and the application thereof to assess anatomical and functional information in-vivo. | |||||
| Inhalt | Introduction to magnetic resonance imaging including basic phenomena of nuclear magnetic resonance; 2- and 3-dimensional imaging procedures; fast and parallel imaging techniques; image reconstruction; pulse sequences and image contrast manipulation; equipment; advanced techniques for identifying activated brain areas; perfusion and flow; diffusion tensor imaging and fiber tracking; contrast agents; localized magnetic resonance spectroscopy and spectroscopic imaging; diagnostic applications and applications in research. | |||||
| Skript | D. Meier, P. Boesiger, S. Kozerke Magnetic Resonance Imaging and Spectroscopy | |||||
| 376-1984-00L | Lasers in Medicine | W | 3 KP | 3G | M. Frenz | |
| Kurzbeschreibung | Fragen wie "Was ist ein Laser, wie funktioniert er und was macht ihn so interessant für die Medizin?", aber auch "Wie breitet sich Licht im Gewebe aus und welche Wechselwirkungen treten dabei auf?" sollen beantwortet werden. Speziell wird auf therapeutische, diagnostische und bildgebende Anwendungen anhand von ausgewählten Beispielen eingegangen. | |||||
| Lernziel | Einführung in die für medizinische Anwendungen relevanten Lasertechniken. Vermittlung der physikalischen Grundlagen der Laser-Gewebe-Wechselwirkung mit dem Ziel, den Einfluss der unterschiedlichen Bestrahlungsparameter auf den Gewebeeffekt zu verstehen. Grundlagen der diagnostischen Laseranwendungen und der Lasersicherheit. | |||||
| Inhalt | Die Anwendung des Lasers in der Medizin gewinnt zunehmend dort an Bedeutung, wo seine speziellen Eigenschaften gezielt zur berührungslosen, selektiven und spezifischen Wirkung auf Weich- und Hartgewebe für minimal invasive Therapieformen oder zur Eröffnung neuer therapeutischer und diagnostischer Methoden eingesetzt werden können. Grundlegende Arbeiten zum Verständnis der Lichtausbreitung im Gewebe (Absorptions-, Reflexions- und Transmissionsvermögen) und die unterschiedlichen Formen der Wechselwirkung (photochemische, thermische, ablative und optomechanische Wirkung) werden eingehend behandelt. Speziell wird auf den Einfluss der Wellenlänge und der Bestrahlungszeit auf den Wechselwirkungsmechanismus eingegangen. Die unterschiedlichen medizinisch genutzten Lasertypen und Strahlführungssysteme werden hinsichtlich ihres Einsatzes im Bereich der Medizin anhand ausgesuchter Anwendungsbeispiele diskutiert. Neben den therapeutischen Wirkungen wird auf den Einsatz des Lasers in der medizinischen Diagnostik (z.B. Tumor-Fluoreszenzdiagnostik, Bildgebung) eingegangen. Die beim Einsatz des Lasers in der Medizin erforderlichen Schutzmassnahmen werden diskutiert. | |||||
| Skript | wird im Internet bereitgestellt | |||||
| Literatur | - M. Born, E. Wolf, "Principles of Optics", Pergamon Press - B.E.A. Saleh, M.C. Teich, "Fundamentals of Photonics", John Wiley and Sons, Inc. - A.E. Siegman, "Lasers", University Science Books - O. Svelto, "Principles of Lasers", Plenum Press - J. Eichler, T. Seiler, "Lasertechnik in der Medizin", Springer Verlag - M.H. Niemz, "Laser-Tissue Interaction", Springer Verlag - A.J. Welch, M.J.C. van Gemert, "Optical-thermal response of laser-irradiated tissue", Plenum Press | |||||
| 402-0343-00L | Physics Against Cancer: The Physics of Imaging and Treating Cancer | W | 6 KP | 2V + 1U | A. J. Lomax, U. Schneider | |
| Kurzbeschreibung | Radiotherapy is a rapidly developing and technology driven medical discipline that is heavily dependent on physics and engineering. In this lecture series, we will review and describe some of the current developments in radiotherapy, particularly from the physics and technological view point, and will indicate in which direction future research in radiotherapy will lie. | |||||
| Lernziel | Radiotherapy is a rapidly developing and technology driven medical discipline that is heavily dependent on physics and engineering. In the last few years, a multitude of new techniques, equipment and technology have been introduced, all with the primary aim of more accurately targeting and treating cancerous tissues, leading to a precise, predictable and effective therapy technique. In this lecture series, we will review and describe some of the current developments in radiotherapy, particularly from the physics and technological view point, and will indicate in which direction future research in radiotherapy will lie. Our ultimate aim is to provide the student with a taste for the critical role that physics plays in this rapidly evolving discipline and to show that there is much interesting physics still to be done. | |||||
| Inhalt | The lecture series will begin with a short introduction to radiotherapy and an overview of the lecture series (lecture 1). Lecture 2 will cover the medical imaging as applied to radiotherapy, without which it would be impossible to identify or accurately calculate the deposition of radiation in the patient. This will be followed by a detailed description of the treatment planning process, whereby the distribution of deposited energy within the tumour and patient can be accurately calculated, and the optimal treatment defined (lecture 3). Lecture 4 will follow on with this theme, but concentrating on the more theoretical and mathematical techniques that can be used to evaluate different treatments, using mathematically based biological models for predicting the outcome of treatments. The role of physics modeling, in order to accurately calculate the dose deposited from radiation in the patient, will be examined in lecture 5, together with a review of mathematical tools that can be used to optimize patient treatments. Lecture 6 will investigate a rather different issue, that is the standardization of data sets for radiotherapy and the importance of medical data bases in modern therapy. In lecture 7 we will look in some detail at one of the most advanced radiotherapy delivery techniques, namely Intensity Modulated Radiotherapy (IMRT). In lecture 8, the two topics of imaging and therapy will be somewhat combined, when we will describe the role of imaging in the daily set-up and assessment of patients. Lecture 9 follows up on this theme, in which a major problem of radiotherapy, namely organ motion and changes in patient and tumour geometry during therapy, will be addressed, together with methods for dealing with such problems. Finally, in lectures 10-11, we will describe in some of the multitude of different delivery techniques that are now available, including particle based therapy, rotational (tomo) therapy approaches and robot assisted radiotherapy. In the final lecture, we will provide an overview of the likely avenues of research in the next 5-10 years in radiotherapy. The course will be rounded-off with an opportunity to visit a modern radiotherapy unit, in order to see some of the techniques and delivery methods described in the course in action. | |||||
| Voraussetzungen / Besonderes | Although this course is seen as being complimentary to the Medical Physics I and II course of Dr Manser, no previous knowledge of radiotherapy is necessarily expected or required for interested students who have not attended the other two courses. | |||||
| 465-0968-00L | Medizinphysik in der Praxis | W | 2 KP | 2V | P. Manser, Referent/innen | |
| Kurzbeschreibung | Ziel der Vorlesung ist es, die verschiedenen Aspekte der Medizinischen Physik aus der Sicht des Praktikers kennenzulernen. Ein wichtiger Bestandteil ist dabei, den Dialog zwischen den Studierenden und den Praktikern zu fördern und Kontakte zu schaffen. Hierzu berichten verschiedene Dozenten aus der ganzen Schweiz über ihre Arbeit als Medizinphysiker. | |||||
| Lernziel | Ziel der Vorlesung ist es, die verschiedenen Aspekte der Medizinischen Physik aus der Sicht des Praktikers kennenzulernen. | |||||
| 402-0787-00L | Therapeutic Applications of Particle Physics: Principles and Practice of Particle Therapy | W | 6 KP | 2V + 1U | A. J. Lomax | |
| Kurzbeschreibung | Physics and medical physics aspects of particle physics Subjects: Physics interactions and beam characteristics; medical accelerators; beam delivery; pencil beam scanning; dosimetry and QA; treatment planning; precision and uncertainties; in-vivo dose verification; proton therapy biology. | |||||
| Lernziel | The lecture series is focused on the physics and medical physics aspects of particle therapy. The radiotherapy of tumours using particles (particularly protons) is a rapidly expanding discipline, with many new proton and particle therapy facilities currently being planned and built throughout Europe. In this lecture series, we study in detail the physics background to particle therapy, starting from the fundamental physics interactions of particles with tissue, through to treatment delivery, treatment planning and in-vivo dose verification. The course is aimed at students with a good physics background and an interest in the application of physics to medicine. | |||||
| Voraussetzungen / Besonderes | The former title of this course was "Medical Imaging and Therapeutic Applications of Particle Physics". | |||||
| 227-0384-00L | Ultrasound Fundamentals, Imaging, and Medical Applications Number of participants limited to 25. | W | 4 KP | 3G | O. Göksel | |
| Kurzbeschreibung | Ultrasound is the only imaging modality that is nonionizing (safe), real-time, cost-effective, and portable, with many medical uses in diagnosis, intervention guidance, surgical navigation, and as a therapeutic option. In this course, we introduce conventional and prospective applications of ultrasound, starting with the fundamentals of ultrasound physics and imaging. | |||||
| Lernziel | Students can use the fundamentals of ultrasound, to analyze and evaluate ultrasound imaging techniques and applications, in particular in the field of medicine, as well as to design and implement basic applications. | |||||
| Inhalt | Ultrasound is used in wide range of products, from car parking sensors, to assessing fault lines in tram wheels. Medical imaging is the eye of the doctor into body; and ultrasound is the only imaging modality that is nonionizing (safe), real-time, cheap, and portable. Some of its medical uses include diagnosing breast and prostate cancer, guiding needle insertions/biopsies, screening for fetal anomalies, and monitoring cardiac arrhythmias. Ultrasound physically interacts with the tissue, and thus can also be used therapeutically, e.g., to deliver heat to treat tumors, break kidney stones, and targeted drug delivery. Recent years have seen several novel ultrasound techniques and applications – with many more waiting in the horizon to be discovered. This course covers ultrasonic equipment, physics of wave propagation, numerical methods for its simulation, image generation, beamforming (basic delay-and-sum and advanced methods), transducers (phased-, linear-, convex-arrays), near- and far-field effect, imaging modes (e.g., A-, M-, B-mode), Doppler and harmonic imaging, ultrasound signal processing techniques (e.g., filtering, time-gain-compensation, displacement tracking), image analysis techniques (deconvolution, real-time processing, tracking, segmentation, computer-assisted interventions), acoustic-radiation force, plane-wave imaging, contrast agents, micro-bubbles, elastography, biomechanical characterization, high-intensity focused ultrasound and therapy, lithotripsy, histotripsy, photo-acoustics phenomenon and opto-acoustic imaging, as well as sample non-medical applications such as the basics of non-destructive testing (NDT). | |||||
| Voraussetzungen / Besonderes | Hands-on exercises will help apply concepts learned in the module, and will involve a mix of designing, implementing, and evaluating in simulation environments, such as Matlab FieldII and k-Wave toolboxes. Prerequisites: Familiarity with basic numerical methods. Basic programming skills and experience in Matlab. | |||||
| Vertiefung Biomechanics | ||||||
| Kernfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 376-1712-00L | Finite Element Analysis in Biomedical Engineering | W | 3 KP | 2V | S. J. Ferguson, B. Helgason | |
| Kurzbeschreibung | This course provides an introduction to finite element analysis, with a specific focus on problems and applications from biomedical engineering. | |||||
| Lernziel | Finite element analysis is a powerful simulation method for the (approximate) solution of boundary value problems. While its traditional roots are in the realm of structural engineering, the methods have found wide use in the biomedical engineering domain for the simulation of the mechanical response of the human body and medical devices. This course provides an introduction to finite element analysis, with a specific focus on problems and applications from biomedical engineering. This domain offers many unique challenges, including multi-scale problems, multi-physics simulation, complex and non-linear material behaviour, rate-dependent response, dynamic processes and fluid-solid interactions. Theories taught are reinforced through practical applications in self-programmed and commercial simulation software, using e.g. MATLAB, ANSYS, FEBIO. | |||||
| Inhalt | (Theory) The Finite Element and Finite Difference methods Gallerkin, weighted residuals, discretization (Theory) Mechanical analysis of structures Trusses, beams, solids and shells, DOFs, hand calculations of simple FE problems, underlying PDEs (Application) Mechanical analysis of structures Truss systems, beam systems, 2D solids, meshing, organ level analysis of bones (Theory and Application) Mechanical analysis of structures Micro- and multi-scale analysis, voxel models, solver limitations, large scale solvers (Theory) Non-linear mechanical analysis of structures Large strain, Newton-Rhapson, plasticity (Application) Non-linear mechanical analysis of structures Plasticity (bone), hyperelasticity, viscoelasticity (Theory and Application) Contact analysis Friction, bonding, rough contact, implants, bone-cement composites, pushout tests (Theory) Flow in Porous Media Potential problems, Terzhagi's consolidation (Application) Flow in Porous Media Confined and unconfined compression of cartilage (Theory) Heat Transfer and Mass Transport Diffusion, conduction and convection, equivalency of equations (Application) Heat Transfer and Mass Transport Sequentially-coupled poroelastic and transport models for solute transport (Theory) Computational Biofluid Dynamics Newtonian vs. Non-Newtonian fluid, potential flow (Application) Computational Biofluid Dynamics Flow between micro-rough parallel plates | |||||
| Skript | Handouts consisting of (i) lecturers' script, (ii) selected excerpts from relevant textbooks, (iii) selected excerpts from theory manuals of commercial simulation software, (iv) relevant scientific publications. | |||||
| Voraussetzungen / Besonderes | Familiarity with basic numerical methods. Programming experience with MATLAB. | |||||
| 376-1397-00L | Orthopaedic Biomechanics | W | 4 KP | 3G | R. Müller, G. H. Van Lenthe | |
| Kurzbeschreibung | This course is aimed at studying the mechanical and structural engineering of the musculoskeletal system alongside the analysis and design of orthopaedic solutions to musculoskeletal failure. | |||||
| Lernziel | To apply engineering and design principles to orthopaedic biomechanics, to quantitatively assess the musculoskeletal system and model it, and to review rigid-body dynamics in an interesting context. | |||||
| Inhalt | Engineering principles are very important in the development and application of quantitative approaches in biology and medicine. This course includes a general introduction to structure and function of the musculoskeletal system: anatomy and physiology of musculoskeletal tissues and joints; biomechanical methods to assess and quantify tissues and large joint systems. These methods will also be applied to musculoskeletal failure, joint replacement and reconstruction; implants; biomaterials and tissue engineering. | |||||
| Skript | Stored on ILIAS. | |||||
| Literatur | Orthopaedic Biomechanics: Mechanics and Design in Musculoskeletal Systems Authors: Donald L. Bartel, Dwight T. Davy, Tony M. Keaveny Publisher: Prentice Hall; Copyright: 2007 ISBN-10: 0130089095; ISBN-13: 9780130089090 | |||||
| Voraussetzungen / Besonderes | Lectures will be given in English. | |||||
| 376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | W | 3 KP | 2G | A. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong | |
| Kurzbeschreibung | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | |||||
| Lernziel | This course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena. | |||||
| Inhalt | Typically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance. The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering. | |||||
| Skript | n/a | |||||
| Literatur | Topical Scientific Manuscripts | |||||
| Praktika | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 465-0800-00L | Practical Work Nur für MAS in Medizinphysik | O | 4 KP | externe Veranstalter | ||
| Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Wahlfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 151-0630-00L | Nanorobotics | W | 4 KP | 2V + 1U | S. Pané Vidal | |
| Kurzbeschreibung | Nanorobotics is an interdisciplinary field that includes topics from nanotechnology and robotics. The aim of this course is to expose students to the fundamental and essential aspects of this emerging field. | |||||
| Lernziel | The aim of this course is to expose students to the fundamental and essential aspects of this emerging field. These topics include basic principles of nanorobotics, building parts for nanorobotic systems, powering and locomotion of nanorobots, manipulation, assembly and sensing using nanorobots, molecular motors, and nanorobotics for nanomedicine. | |||||
| 151-0980-00L | Biofluiddynamics | W | 4 KP | 2V + 1U | D. Obrist, P. Jenny | |
| Kurzbeschreibung | Introduction to the fluid dynamics of the human body and the modeling of physiological flow processes (biomedical fluid dynamics). | |||||
| Lernziel | A basic understanding of fluid dynamical processes in the human body. Knowledge of the basic concepts of fluid dynamics and the ability to apply these concepts appropriately. | |||||
| Inhalt | This lecture is an introduction to the fluid dynamics of the human body (biomedical fluid dynamics). For selected topics of human physiology, we introduce fundamental concepts of fluid dynamics (e.g., creeping flow, incompressible flow, flow in porous media, flow with particles, fluid-structure interaction) and use them to model physiological flow processes. The list of studied topics includes the cardiovascular system and related diseases, blood rheology, microcirculation, respiratory fluid dynamics and fluid dynamics of the inner ear. | |||||
| Skript | Lecture notes are provided electronically. | |||||
| Literatur | A list of books on selected topics of biofluiddynamics can be found on the course web page. | |||||
| 376-1150-00L | Clinical Challenges in Musculoskeletal Disorders | W | 2 KP | 2G | M. Leunig, S. J. Ferguson, A. Müller | |
| Kurzbeschreibung | This course reviews musculoskeletal disorders focusing on the clinical presentation, current treatment approaches and future challenges and opportunities to overcome failures. | |||||
| Lernziel | Appreciation of the surgical and technical challenges, and future perspectives offered through advances in surgical technique, new biomaterials and advanced medical device construction methods. | |||||
| Inhalt | Foot deformities, knee injuries, knee OA, hip disorders in the child and adolescent, hip OA, spine deformities, degenerative spine disease, shoulder in-stability, hand, rheumatoid diseases, neuromuscular diseases, sport injuries and prevention | |||||
| 376-1168-00L | Sports Biomechanics | W | 3 KP | 2V | S. Lorenzetti | |
| Kurzbeschreibung | Various types of sport are studied from a mechanical point of view. Of particular interest are the key parameters of a sport as well as the performance relevant indicators. | |||||
| Lernziel | The aim of this lecture is to enable the students to study a sport from a biomechanical viewpoint and to develop significant models for which evaluations of the limitations and verifications can be carried out. | |||||
| Inhalt | Sport biomechanics is concerned with the physical and mechanical basic principles of sports. The lecture requires an in-depth mechanical understanding on the side of the student. In this respect, the pre-attendance of the lectures Biomechanics II and Movement and Sports Biomechanics or an equivalent course is expected. The human body is treated as a mechanical system during sport. The interaction of the active and passive movements and outside influences is analysed. Using sports such as ski-jumping, cycling, or weight training, applicable models are created, analyzed and suitable measuring methods are introduced. In particular, the constraints as well as the limitations of the models are of great relevance. The students develop their own models for different sport types, critically discuss the advantages and disadvantages and evaluate applicable measurement methods. | |||||
| Skript | Handout will be distributed. | |||||
| 376-1217-00L | Rehabilitation Engineering I: Motor Functions | W | 4 KP | 2V + 1U | R. Riener, J. Duarte Barriga | |
| Kurzbeschreibung | “Rehabilitation engineering” is the application of science and technology to ameliorate the handicaps of individuals with disabilities in order to reintegrate them into society. The goal of this lecture is to present classical and new rehabilitation engineering principles and examples applied to compensate or enhance especially motor deficits. | |||||
| Lernziel | Provide theoretical and practical knowledge of principles and applications used to rehabilitate individuals with motor disabilities. | |||||
| Inhalt | “Rehabilitation” is the (re)integration of an individual with a disability into society. Rehabilitation engineering is “the application of science and technology to ameliorate the handicaps of individuals with disability”. Such handicaps can be classified into motor, sensor, and cognitive (also communicational) disabilities. In general, one can distinguish orthotic and prosthetic methods to overcome these disabilities. Orthoses support existing but affected body functions (e.g., glasses, crutches), while prostheses compensate for lost body functions (e.g., cochlea implant, artificial limbs). In case of sensory disorders, the lost function can also be substituted by other modalities (e.g. tactile Braille display for vision impaired persons). The goal of this lecture is to present classical and new technical principles as well as specific examples applied to compensate or enhance mainly motor deficits. Modern methods rely more and more on the application of multi-modal and interactive techniques. Multi-modal means that visual, acoustical, tactile, and kinaesthetic sensor channels are exploited by displaying the patient with a maximum amount of information in order to compensate his/her impairment. Interaction means that the exchange of information and energy occurs bi-directionally between the rehabilitation device and the human being. Thus, the device cooperates with the patient rather than imposing an inflexible strategy (e.g., movement) upon the patient. Multi-modality and interactivity have the potential to increase the therapeutical outcome compared to classical rehabilitation strategies. In the 1 h exercise the students will learn how to solve representative problems with computational methods applied to exoprosthetics, wheelchair dynamics, rehabilitation robotics and neuroprosthetics. | |||||
| Skript | Lecture notes will be distributed at the beginning of the lecture (1st session) | |||||
| Literatur | Introductory Books Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press. Advances in Rehabilitation Robotics – Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004. Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001. Control of Movement for the Physically Disabled. Eds.: D. Popovic, T. Sinkjaer. Springer Verlag London, 2000. Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005. Biomechanics and Neural Control of Posture and Movement. Eds.: J.M. Winters, P.E. Crago. Springer New York, 2000. Selected Journal Articles Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195. Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432 Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700. Colombo, G., Jörg, M., Jezernik, S. (2002) Automatisiertes Lokomotionstraining auf dem Laufband. Automatisierungstechnik at, vol. 50, pp. 287-295. Cooper, R. (1993) Stability of a wheelchair controlled by a human. IEEE Transactions on Rehabilitation Engineering 1, pp. 193-206. Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87 Leifer, L. (1981): Rehabilitive robotics, Robot Age, pp. 4-11 Platz, T. (2003): Evidenzbasierte Armrehabilitation: Eine systematische Literaturübersicht, Nervenarzt, 74, pp. 841-849 Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250. Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10. Riener, R., Fuhr, T., Schneider, J. (2002) On the complexity of biomechanical models used for neuroprosthesis development. International Journal of Mechanics in Medicine and Biology 2, pp. 389-404. Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894. | |||||
| Voraussetzungen / Besonderes | Target Group: Students of higher semesters and PhD students of - D-MAVT, D-ITET, D-INFK - Biomedical Engineering - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome | |||||
| 376-1308-00L | Development Strategies for Medical Implants Maximale Teilnehmerzahl: 25 bis 30. Die Einschreibungen werden nach chronologischem Eingang berücksichtigt. | W | 3 KP | 2V + 1U | J. Mayer-Spetzler, M. Rubert | |
| Kurzbeschreibung | Introduction to development strategies for implantable devices considering the interdependecies of biocompatibility, clinical and economical requirements ; discussion of the state of the art and actual trends in in orthopedics, sports medicine, traumatology and cardio-vascular surgery as well as regenerative medicine (tissue engineering). | |||||
| Lernziel | Basic considerations in implant development Concept of structural and surface biocompatiblity and its relevance for the design of implant and surgical technique Understanding of conflicting factors, e.g. clinical need, economics and regulatory requirements Concepts of tissue engineering, its strengths and weaknesses as current and future clinical solution | |||||
| Inhalt | Biocompatibility as bionic guide line for the development of medical implants; implant and implantation related tissue reactions, biocompatible materials and material processing technologies; implant testing and regulatory procedures; discussion of the state of the art and actual trends in implant development in orthopedics, sports medicine, traumatology, spinal and cardio-vascular surgery; introduction to tissue engineering. Selected topics will be further illustrated by commented movies from surgeries. Seminar: Group seminars on selected controversial topics in implant development. Participation is mandatory Planned excursions (limited availability, not mandatory, to be confirmed): 1. Participation (as visitor) on a life surgery (travel at own expense) | |||||
| Skript | Scribt (electronically available): - presented slides - selected scientific papers for further reading | |||||
| Literatur | Textbooks on selected topics will be introduced during the lectures | |||||
| Voraussetzungen / Besonderes | Achieved Bachelor degree is mandatory The number of participants in the course is limited to 25-30 students in total. Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is on the student's own responsability. | |||||
| 376-1721-00L | Bone Biology and Consequences for Human Health | W | 2 KP | 2V | G. A. Kuhn, J. Goldhahn, E. Wehrle | |
| Kurzbeschreibung | Bone is a complex tissue that continuously adapts to mechanical and metabolic demands. Failure of this remodeling results in reduced mechanic stability ot the skeleton. This course will provide the basic knowledge to understand the biology and pathophysiology of bone necessary for engineering of bone tissue and design of implants. | |||||
| Lernziel | After completing this course, students will be able to understand: a) the biological and mechanical aspects of normal bone remodeling b) pathological changes and their consequences for the musculoskeletal system c) the consequences for implant design, tissue engineering and treatment interventions. | |||||
| Inhalt | Bone adapts continuously to mechanical and metabolic demands by complex remodeling processes. This course will deal with biological processes in bone tissue from cell to tissue level. This lecture will cover mechanisms of bone building (anabolic side), bone resorption (catabolic side), their coupling, and regulation mechanisms. It will also cover pathological changes and typical diseases like osteoporosis. Consequences for musculoskeletal health and their clinical relevance will be discussed. Requirements for tissue engineering as well as implant modification will be presented. Actual examples from research and development will be utilized for illustration. | |||||
| Vertiefung Bioimaging | ||||||
| Kernfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 227-0390-00L | Elements of Microscopy | W | 4 KP | 3G | M. Stampanoni, G. Csúcs, A. Sologubenko | |
| Kurzbeschreibung | The lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging. | |||||
| Lernziel | Solid introduction to the basics of microscopy, either with visible light, electrons or X-rays. | |||||
| Inhalt | It would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level. The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy. During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated. | |||||
| Literatur | Available Online. | |||||
| 227-0946-00L | Molecular Imaging - Basic Principles and Biomedical Applications | W | 2 KP | 2V | M. Rudin | |
| Kurzbeschreibung | Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications. | |||||
| Lernziel | Molecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research. | |||||
| Inhalt | Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications. | |||||
| 227-0948-00L | Magnetic Resonance Imaging in Medicine | W | 4 KP | 3G | S. Kozerke, M. Weiger Senften | |
| Kurzbeschreibung | Introduction to magnetic resonance imaging and spectroscopy, encoding and contrast mechanisms and their application in medicine. | |||||
| Lernziel | Understand the basic principles of signal generation, image encoding and decoding, contrast manipulation and the application thereof to assess anatomical and functional information in-vivo. | |||||
| Inhalt | Introduction to magnetic resonance imaging including basic phenomena of nuclear magnetic resonance; 2- and 3-dimensional imaging procedures; fast and parallel imaging techniques; image reconstruction; pulse sequences and image contrast manipulation; equipment; advanced techniques for identifying activated brain areas; perfusion and flow; diffusion tensor imaging and fiber tracking; contrast agents; localized magnetic resonance spectroscopy and spectroscopic imaging; diagnostic applications and applications in research. | |||||
| Skript | D. Meier, P. Boesiger, S. Kozerke Magnetic Resonance Imaging and Spectroscopy | |||||
| 227-0384-00L | Ultrasound Fundamentals, Imaging, and Medical Applications Number of participants limited to 25. | W | 4 KP | 3G | O. Göksel | |
| Kurzbeschreibung | Ultrasound is the only imaging modality that is nonionizing (safe), real-time, cost-effective, and portable, with many medical uses in diagnosis, intervention guidance, surgical navigation, and as a therapeutic option. In this course, we introduce conventional and prospective applications of ultrasound, starting with the fundamentals of ultrasound physics and imaging. | |||||
| Lernziel | Students can use the fundamentals of ultrasound, to analyze and evaluate ultrasound imaging techniques and applications, in particular in the field of medicine, as well as to design and implement basic applications. | |||||
| Inhalt | Ultrasound is used in wide range of products, from car parking sensors, to assessing fault lines in tram wheels. Medical imaging is the eye of the doctor into body; and ultrasound is the only imaging modality that is nonionizing (safe), real-time, cheap, and portable. Some of its medical uses include diagnosing breast and prostate cancer, guiding needle insertions/biopsies, screening for fetal anomalies, and monitoring cardiac arrhythmias. Ultrasound physically interacts with the tissue, and thus can also be used therapeutically, e.g., to deliver heat to treat tumors, break kidney stones, and targeted drug delivery. Recent years have seen several novel ultrasound techniques and applications – with many more waiting in the horizon to be discovered. This course covers ultrasonic equipment, physics of wave propagation, numerical methods for its simulation, image generation, beamforming (basic delay-and-sum and advanced methods), transducers (phased-, linear-, convex-arrays), near- and far-field effect, imaging modes (e.g., A-, M-, B-mode), Doppler and harmonic imaging, ultrasound signal processing techniques (e.g., filtering, time-gain-compensation, displacement tracking), image analysis techniques (deconvolution, real-time processing, tracking, segmentation, computer-assisted interventions), acoustic-radiation force, plane-wave imaging, contrast agents, micro-bubbles, elastography, biomechanical characterization, high-intensity focused ultrasound and therapy, lithotripsy, histotripsy, photo-acoustics phenomenon and opto-acoustic imaging, as well as sample non-medical applications such as the basics of non-destructive testing (NDT). | |||||
| Voraussetzungen / Besonderes | Hands-on exercises will help apply concepts learned in the module, and will involve a mix of designing, implementing, and evaluating in simulation environments, such as Matlab FieldII and k-Wave toolboxes. Prerequisites: Familiarity with basic numerical methods. Basic programming skills and experience in Matlab. | |||||
| Praktika | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 465-0800-00L | Practical Work Nur für MAS in Medizinphysik | O | 4 KP | externe Veranstalter | ||
| Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Wahlfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 151-0622-00L | Measuring on the Nanometer Scale | W | 2 KP | 2G | A. Stemmer, T. Wagner | |
| Kurzbeschreibung | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Lernziel | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Inhalt | Conventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters. | |||||
| Skript | Class notes and special papers will be distributed. | |||||
| 227-0391-00L | Medical Image Analysis Basic knowledge of computer vision would be helpful. | W | 3 KP | 2G | E. Konukoglu, P. C. Cattin, M. A. Reyes Aguirre | |
| Kurzbeschreibung | It is the objective of this lecture to introduce the basic concepts used in Medical Image Analysis. In particular the lecture focuses on shape representation schemes, segmentation techniques, machine learning based predictive models and various image registration methods commonly used in Medical Image Analysis applications. | |||||
| Lernziel | This lecture aims to give an overview of the basic concepts of Medical Image Analysis and its application areas. | |||||
| Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. Preferred: Basic knowledge of computer vision and machine learning would be helpful. The course will be held in English. | |||||
| 227-0966-00L | Quantitative Big Imaging: From Images to Statistics | W | 4 KP | 2V + 1U | K. S. Mader, M. Stampanoni | |
| Kurzbeschreibung | The lecture focuses on the challenging task of extracting robust, quantitative metrics from imaging data and is intended to bridge the gap between pure signal processing and the experimental science of imaging. The course will focus on techniques, scalability, and science-driven analysis. | |||||
| Lernziel | 1. Introduction of applied image processing for research science covering basic image processing, quantitative methods, and statistics. 2. Understanding of imaging as a means to accomplish a scientific goal. 3. Ability to apply quantitative methods to complex 3D data to determine the validity of a hypothesis | |||||
| Inhalt | Imaging is a well established field and is rapidly growing as technological improvements push the limits of resolution in space, time, material and functional sensitivity. These improvements have meant bigger, more diverse datasets being acquired at an ever increasing rate. With methods varying from focused ion beams to X-rays to magnetic resonance, the sources for these images are exceptionally heterogeneous; however, the tools and techniques for processing these images and transforming them into quantitative, biologically or materially meaningful information are similar. The course consists of equal parts theory and practical analysis of first synthetic and then real imaging datasets. Basic aspects of image processing are covered such as filtering, thresholding, and morphology. From these concepts a series of tools will be developed for analyzing arbitrary images in a very generic manner. Specifically a series of methods will be covered, e.g. characterizing shape, thickness, tortuosity, alignment, and spatial distribution of material features like pores. From these metrics the statistics aspect of the course will be developed where reproducibility, robustness, and sensitivity will be investigated in order to accurately determine the precision and accuracy of these quantitative measurements. A major emphasis of the course will be scalability and the tools of the 'Big Data' trend will be discussed and how cluster, cloud, and new high-performance large dataset techniques can be applied to analyze imaging datasets. In addition, given the importance of multi-scale systems, a data-management and analysis approach based on modern databases will be presented for storing complex hierarchical information in a flexible manner. Finally as a concluding project the students will apply the learned methods on real experimental data from the latest 3D experiments taken from either their own work / research or partnered with an experimental imaging group. The course provides the necessary background to perform the quantitative evaluation of complicated 3D imaging data in a minimally subjective or arbitrary manner to answer questions coming from the fields of physics, biology, medicine, material science, and paleontology. | |||||
| Skript | Available online. | |||||
| Literatur | Will be indicated during the lecture. | |||||
| Voraussetzungen / Besonderes | Ideally students will have some familiarity with basic manipulation and programming in languages like Matlab and R. Interested students who are worried about their skill level in this regard are encouraged to contact Kevin Mader directly (mader@biomed.ee.ethz.ch). More advanced students who are familiar with Java, C++, and Python will have to opportunity to develop more of their own tools. | |||||
| 227-0967-00L | Computational Neuroimaging Clinic | W | 3 KP | 2V | K. Stephan | |
| Kurzbeschreibung | This seminar teaches problem solving skills for computational neuroimaging, based on joint analyses of neuroimaging and behavioural data. It deals with a wide variety of real-life problems that are brought to this meeting from the neuroimaging community at Zurich, e.g. mass-univariate and multivariate analyses of fMRI/EEG data, or generative models of fMRI, EEG, or behavioural data. | |||||
| Lernziel | 1. Consolidation of theoretical knowledge (obtained in one of the following courses: 'Methods & models for fMRI data analysis', 'Translational Neuromodeling', 'Computational Psychiatry') in a practical setting. 2. Acquisition of practical problem solving strategies for computational modeling of neuroimaging data. | |||||
| Inhalt | This seminar teaches problem solving skills for computational neuroimaging, based on joint analyses of neuroimaging and behavioural data. It deals with a wide variety of real-life problems that are brought to this meeting from the neuroimaging community at Zurich, e.g. mass-univariate and multivariate analyses of fMRI/EEG data, or generative models of fMRI, EEG, or behavioural data. . | |||||
| Voraussetzungen / Besonderes | The participants are expected to have successfully completed at least one of the following courses: 'Methods & models for fMRI data analysis', 'Translational Neuromodeling', 'Computational Psychiatry' | |||||
| 227-1034-00L | Computational Vision (University of Zurich) No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH. UZH Module Code: INI402 Mind the enrolment deadlines at UZH: https://www.uzh.ch/cmsssl/en/studies/application/mobilitaet.html | W | 6 KP | 2V + 1U | D. Kiper, K. A. Martin | |
| Kurzbeschreibung | This course focuses on neural computations that underlie visual perception. We study how visual signals are processed in the retina, LGN and visual cortex. We study the morpholgy and functional architecture of cortical circuits responsible for pattern, motion, color, and three-dimensional vision. | |||||
| Lernziel | This course considers the operation of circuits in the process of neural computations. The evolution of neural systems will be considered to demonstrate how neural structures and mechanisms are optimised for energy capture, transduction, transmission and representation of information. Canonical brain circuits will be described as models for the analysis of sensory information. The concept of receptive fields will be introduced and their role in coding spatial and temporal information will be considered. The constraints of the bandwidth of neural channels and the mechanisms of normalization by neural circuits will be discussed. The visual system will form the basis of case studies in the computation of form, depth, and motion. The role of multiple channels and collective computations for object recognition will be considered. Coordinate transformations of space and time by cortical and subcortical mechanisms will be analysed. The means by which sensory and motor systems are integrated to allow for adaptive behaviour will be considered. | |||||
| Inhalt | This course considers the operation of circuits in the process of neural computations. The evolution of neural systems will be considered to demonstrate how neural structures and mechanisms are optimised for energy capture, transduction, transmission and representation of information. Canonical brain circuits will be described as models for the analysis of sensory information. The concept of receptive fields will be introduced and their role in coding spatial and temporal information will be considered. The constraints of the bandwidth of neural channels and the mechanisms of normalization by neural circuits will be discussed. The visual system will form the basis of case studies in the computation of form, depth, and motion. The role of multiple channels and collective computations for object recognition will be considered. Coordinate transformations of space and time by cortical and subcortical mechanisms will be analysed. The means by which sensory and motor systems are integrated to allow for adaptive behaviour will be considered. | |||||
| Literatur | Books: (recommended references, not required) 1. An Introduction to Natural Computation, D. Ballard (Bradford Books, MIT Press) 1997. 2. The Handbook of Brain Theorie and Neural Networks, M. Arbib (editor), (MIT Press) 1995. | |||||
| Vertiefung Bioengineering | ||||||
| Kernfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | W | 3 KP | 2G | A. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong | |
| Kurzbeschreibung | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | |||||
| Lernziel | This course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena. | |||||
| Inhalt | Typically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance. The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering. | |||||
| Skript | n/a | |||||
| Literatur | Topical Scientific Manuscripts | |||||
| 376-1614-00L | Principles in Tissue Engineering | W | 3 KP | 2V | K. Maniura, J. Möller, M. Zenobi-Wong | |
| Kurzbeschreibung | Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Lernziel | Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed. | |||||
| Inhalt | This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Skript | Handouts provided during the classes and references therin. | |||||
| Literatur | The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 | |||||
| Praktika | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 465-0800-00L | Practical Work Nur für MAS in Medizinphysik | O | 4 KP | externe Veranstalter | ||
| Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Wahlfächer Von den beiden Lerneinheiten 376-1622-00L Practical Methods in Tissue Engineering (angeboten im Herbstsemester) und 376-1624-00L Practical Methods in Biofabrication (angeboten im Frühjahrssemester) dürfen nicht beide angerechnet werden. | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 151-0622-00L | Measuring on the Nanometer Scale | W | 2 KP | 2G | A. Stemmer, T. Wagner | |
| Kurzbeschreibung | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Lernziel | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Inhalt | Conventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters. | |||||
| Skript | Class notes and special papers will be distributed. | |||||
| 151-0630-00L | Nanorobotics | W | 4 KP | 2V + 1U | S. Pané Vidal | |
| Kurzbeschreibung | Nanorobotics is an interdisciplinary field that includes topics from nanotechnology and robotics. The aim of this course is to expose students to the fundamental and essential aspects of this emerging field. | |||||
| Lernziel | The aim of this course is to expose students to the fundamental and essential aspects of this emerging field. These topics include basic principles of nanorobotics, building parts for nanorobotic systems, powering and locomotion of nanorobots, manipulation, assembly and sensing using nanorobots, molecular motors, and nanorobotics for nanomedicine. | |||||
| 227-0946-00L | Molecular Imaging - Basic Principles and Biomedical Applications | W | 2 KP | 2V | M. Rudin | |
| Kurzbeschreibung | Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications. | |||||
| Lernziel | Molecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research. | |||||
| Inhalt | Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications. | |||||
| 376-1624-00L | Practical Methods in Biofabrication Number of participants limited to 12. | W | 5 KP | 4P | M. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak | |
| Kurzbeschreibung | Biofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft. | |||||
| Lernziel | The objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project. | |||||
| Voraussetzungen / Besonderes | Not recommended if passed 376-1622-00 Practical Methods in Tissue Engineering | |||||
| Vertiefung Bioelectronics | ||||||
| Kernfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 227-0390-00L | Elements of Microscopy | W | 4 KP | 3G | M. Stampanoni, G. Csúcs, A. Sologubenko | |
| Kurzbeschreibung | The lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging. | |||||
| Lernziel | Solid introduction to the basics of microscopy, either with visible light, electrons or X-rays. | |||||
| Inhalt | It would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level. The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy. During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated. | |||||
| Literatur | Available Online. | |||||
| Praktika | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 465-0800-00L | Practical Work Nur für MAS in Medizinphysik | O | 4 KP | externe Veranstalter | ||
| Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Wahlfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 151-0172-00L | Microsystems II: Devices and Applications | W | 6 KP | 3V + 3U | C. Hierold, C. I. Roman | |
| Kurzbeschreibung | The students are introduced to the fundamentals and physics of microelectronic devices as well as to microsystems in general (MEMS). They will be able to apply this knowledge for system research and development and to assess and apply principles, concepts and methods from a broad range of technical and scientific disciplines for innovative products. | |||||
| Lernziel | The students are introduced to the fundamentals and physics of microelectronic devices as well as to microsystems in general (MEMS), basic electronic circuits for sensors, RF-MEMS, chemical microsystems, BioMEMS and microfluidics, magnetic sensors and optical devices, and in particular to the concepts of Nanosystems (focus on carbon nanotubes), based on the respective state-of-research in the field. They will be able to apply this knowledge for system research and development and to assess and apply principles, concepts and methods from a broad range of technical and scientific disciplines for innovative products. During the weekly 3 hour module on Mondays dedicated to Übungen the students will learn the basics of Comsol Multiphysics and utilize this software to simulate MEMS devices to understand their operation more deeply and optimize their designs. | |||||
| Inhalt | Transducer fundamentals and test structures Pressure sensors and accelerometers Resonators and gyroscopes RF MEMS Acoustic transducers and energy harvesters Thermal transducers and energy harvesters Optical and magnetic transducers Chemical sensors and biosensors, microfluidics and bioMEMS Nanosystem concepts Basic electronic circuits for sensors and microsystems | |||||
| Skript | Handouts (on-line) | |||||
| 151-0622-00L | Measuring on the Nanometer Scale | W | 2 KP | 2G | A. Stemmer, T. Wagner | |
| Kurzbeschreibung | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Lernziel | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Inhalt | Conventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters. | |||||
| Skript | Class notes and special papers will be distributed. | |||||
| 151-0980-00L | Biofluiddynamics | W | 4 KP | 2V + 1U | D. Obrist, P. Jenny | |
| Kurzbeschreibung | Introduction to the fluid dynamics of the human body and the modeling of physiological flow processes (biomedical fluid dynamics). | |||||
| Lernziel | A basic understanding of fluid dynamical processes in the human body. Knowledge of the basic concepts of fluid dynamics and the ability to apply these concepts appropriately. | |||||
| Inhalt | This lecture is an introduction to the fluid dynamics of the human body (biomedical fluid dynamics). For selected topics of human physiology, we introduce fundamental concepts of fluid dynamics (e.g., creeping flow, incompressible flow, flow in porous media, flow with particles, fluid-structure interaction) and use them to model physiological flow processes. The list of studied topics includes the cardiovascular system and related diseases, blood rheology, microcirculation, respiratory fluid dynamics and fluid dynamics of the inner ear. | |||||
| Skript | Lecture notes are provided electronically. | |||||
| Literatur | A list of books on selected topics of biofluiddynamics can be found on the course web page. | |||||
| 227-1046-00L | Computer Simulations of Sensory Systems | W | 3 KP | 2V + 1U | T. Haslwanter | |
| Kurzbeschreibung | This course deals with computer simulations of the human auditory, visual, and balance system. The lecture will cover the physiological and mechanical mechanisms of these sensory systems. And in the exercises, the simulations will be implemented with Python (or Matlab). The simulations will be such that their output could be used as input for actual neuro-sensory prostheses. | |||||
| Lernziel | Our sensory systems provide us with information about what is happening in the world surrounding us. Thereby they transform incoming mechanical, electromagnetic, and chemical signals into “action potentials”, the language of the central nervous system. The main goal of this lecture is to describe how our sensors achieve these transformations, how they can be reproduced with computational tools. For example, our auditory system performs approximately a “Fourier transformation” of the incoming sound waves; our early visual system is optimized for finding edges in images that are projected onto our retina; and our balance system can be well described with a “control system” that transforms linear and rotational movements into nerve impulses. In the exercises that go with this lecture, we will use Python to reproduce the transformations achieved by our sensory systems. The goal is to write programs whose output could be used as input for actual neurosensory prostheses: such prostheses have become commonplace for the auditory system, and are under development for the visual and the balance system. For the corresponding exercises, at least some basic programing experience is required. | |||||
| Inhalt | The following topics will be covered: • Introduction into the signal processing in nerve cells. • Introduction into Python. • Simplified simulation of nerve cells (Hodgkins-Huxley model). • Description of the auditory system, including the application of Fourier transforms on recorded sounds. • Description of the visual system, including the retina and the information processing in the visual cortex. The corresponding exercises will provide an introduction to digital image processing. • Description of the mechanics of our balance system, and the “Control System”-language that can be used for an efficient description of the corresponding signal processing (essentially Laplace transforms and control systems). | |||||
| Skript | For each module additional material will be provided on the e-learning platform "moodle". The main content of the lecture is also available as a wikibook, under http://en.wikibooks.org/wiki/Sensory_Systems | |||||
| Literatur | Open source information is available as wikibook http://en.wikibooks.org/wiki/Sensory_Systems For good overviews I recommend: • L. R. Squire, D. Berg, F. E. Bloom, Lac S. du, A. Ghosh, and N. C. Spitzer. Fundamental Neuroscience, Academic Press - Elsevier, 2012 [ISBN: 9780123858702]. This book covers the biological components, from the functioning of an individual ion channels through the various senses, all the way to consciousness. And while it does not cover the computational aspects, it nevertheless provides an excellent overview of the underlying neural processes of sensory systems. • Principles of Neural Science (5th Ed, 2012), by Eric Kandel, James Schwartz, Thomas Jessell, Steven Siegelbaum, A.J. Hudspeth ISBN 0071390111 / 9780071390118 The standard textbook on neuroscience. • P Wallisch, M Lusignan, M. Benayoun, T. I. Baker, A. S. Dickey, and N. G. Hatsopoulos. MATLAB for Neuroscientists, Academic Press, 2009. Compactly written, it provides a short introduction to MATLAB, as well as a very good overview of MATLAB’s functionality, focusing on applications in different areas of neuroscience. • G. Mather. Foundations of Sensation and Perception, 2nd Ed Psychology Press, 2009 [ISBN: 978-1-84169-698-0 (hardcover), oder 978-1-84169-699-7 (paperback)] A coherent, up-to-date introduction to the basic facts and theories concerning human sensory perception. | |||||
| Voraussetzungen / Besonderes | Since I have to gravel from Linz, Austria, to Zurich to give this lecture, I plan to hold this lecture in blocks (every 2nd week). | |||||
| 376-1614-00L | Principles in Tissue Engineering | W | 3 KP | 2V | K. Maniura, J. Möller, M. Zenobi-Wong | |
| Kurzbeschreibung | Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Lernziel | Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed. | |||||
| Inhalt | This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Skript | Handouts provided during the classes and references therin. | |||||
| Literatur | The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 | |||||
| Vertiefung Neuroinformatics | ||||||
| Kernfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 227-1034-00L | Computational Vision (University of Zurich) No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH. UZH Module Code: INI402 Mind the enrolment deadlines at UZH: https://www.uzh.ch/cmsssl/en/studies/application/mobilitaet.html | W | 6 KP | 2V + 1U | D. Kiper, K. A. Martin | |
| Kurzbeschreibung | This course focuses on neural computations that underlie visual perception. We study how visual signals are processed in the retina, LGN and visual cortex. We study the morpholgy and functional architecture of cortical circuits responsible for pattern, motion, color, and three-dimensional vision. | |||||
| Lernziel | This course considers the operation of circuits in the process of neural computations. The evolution of neural systems will be considered to demonstrate how neural structures and mechanisms are optimised for energy capture, transduction, transmission and representation of information. Canonical brain circuits will be described as models for the analysis of sensory information. The concept of receptive fields will be introduced and their role in coding spatial and temporal information will be considered. The constraints of the bandwidth of neural channels and the mechanisms of normalization by neural circuits will be discussed. The visual system will form the basis of case studies in the computation of form, depth, and motion. The role of multiple channels and collective computations for object recognition will be considered. Coordinate transformations of space and time by cortical and subcortical mechanisms will be analysed. The means by which sensory and motor systems are integrated to allow for adaptive behaviour will be considered. | |||||
| Inhalt | This course considers the operation of circuits in the process of neural computations. The evolution of neural systems will be considered to demonstrate how neural structures and mechanisms are optimised for energy capture, transduction, transmission and representation of information. Canonical brain circuits will be described as models for the analysis of sensory information. The concept of receptive fields will be introduced and their role in coding spatial and temporal information will be considered. The constraints of the bandwidth of neural channels and the mechanisms of normalization by neural circuits will be discussed. The visual system will form the basis of case studies in the computation of form, depth, and motion. The role of multiple channels and collective computations for object recognition will be considered. Coordinate transformations of space and time by cortical and subcortical mechanisms will be analysed. The means by which sensory and motor systems are integrated to allow for adaptive behaviour will be considered. | |||||
| Literatur | Books: (recommended references, not required) 1. An Introduction to Natural Computation, D. Ballard (Bradford Books, MIT Press) 1997. 2. The Handbook of Brain Theorie and Neural Networks, M. Arbib (editor), (MIT Press) 1995. | |||||
| Praktika | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 465-0800-00L | Practical Work Nur für MAS in Medizinphysik | O | 4 KP | externe Veranstalter | ||
| Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Wahlfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 227-1046-00L | Computer Simulations of Sensory Systems | W | 3 KP | 2V + 1U | T. Haslwanter | |
| Kurzbeschreibung | This course deals with computer simulations of the human auditory, visual, and balance system. The lecture will cover the physiological and mechanical mechanisms of these sensory systems. And in the exercises, the simulations will be implemented with Python (or Matlab). The simulations will be such that their output could be used as input for actual neuro-sensory prostheses. | |||||
| Lernziel | Our sensory systems provide us with information about what is happening in the world surrounding us. Thereby they transform incoming mechanical, electromagnetic, and chemical signals into “action potentials”, the language of the central nervous system. The main goal of this lecture is to describe how our sensors achieve these transformations, how they can be reproduced with computational tools. For example, our auditory system performs approximately a “Fourier transformation” of the incoming sound waves; our early visual system is optimized for finding edges in images that are projected onto our retina; and our balance system can be well described with a “control system” that transforms linear and rotational movements into nerve impulses. In the exercises that go with this lecture, we will use Python to reproduce the transformations achieved by our sensory systems. The goal is to write programs whose output could be used as input for actual neurosensory prostheses: such prostheses have become commonplace for the auditory system, and are under development for the visual and the balance system. For the corresponding exercises, at least some basic programing experience is required. | |||||
| Inhalt | The following topics will be covered: • Introduction into the signal processing in nerve cells. • Introduction into Python. • Simplified simulation of nerve cells (Hodgkins-Huxley model). • Description of the auditory system, including the application of Fourier transforms on recorded sounds. • Description of the visual system, including the retina and the information processing in the visual cortex. The corresponding exercises will provide an introduction to digital image processing. • Description of the mechanics of our balance system, and the “Control System”-language that can be used for an efficient description of the corresponding signal processing (essentially Laplace transforms and control systems). | |||||
| Skript | For each module additional material will be provided on the e-learning platform "moodle". The main content of the lecture is also available as a wikibook, under http://en.wikibooks.org/wiki/Sensory_Systems | |||||
| Literatur | Open source information is available as wikibook http://en.wikibooks.org/wiki/Sensory_Systems For good overviews I recommend: • L. R. Squire, D. Berg, F. E. Bloom, Lac S. du, A. Ghosh, and N. C. Spitzer. Fundamental Neuroscience, Academic Press - Elsevier, 2012 [ISBN: 9780123858702]. This book covers the biological components, from the functioning of an individual ion channels through the various senses, all the way to consciousness. And while it does not cover the computational aspects, it nevertheless provides an excellent overview of the underlying neural processes of sensory systems. • Principles of Neural Science (5th Ed, 2012), by Eric Kandel, James Schwartz, Thomas Jessell, Steven Siegelbaum, A.J. Hudspeth ISBN 0071390111 / 9780071390118 The standard textbook on neuroscience. • P Wallisch, M Lusignan, M. Benayoun, T. I. Baker, A. S. Dickey, and N. G. Hatsopoulos. MATLAB for Neuroscientists, Academic Press, 2009. Compactly written, it provides a short introduction to MATLAB, as well as a very good overview of MATLAB’s functionality, focusing on applications in different areas of neuroscience. • G. Mather. Foundations of Sensation and Perception, 2nd Ed Psychology Press, 2009 [ISBN: 978-1-84169-698-0 (hardcover), oder 978-1-84169-699-7 (paperback)] A coherent, up-to-date introduction to the basic facts and theories concerning human sensory perception. | |||||
| Voraussetzungen / Besonderes | Since I have to gravel from Linz, Austria, to Zurich to give this lecture, I plan to hold this lecture in blocks (every 2nd week). | |||||
| 376-1792-00L | Introductory Course in Neuroscience II (University of Zurich) Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: SPV0Y020 Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html | W | 2 KP | 2V | Uni-Dozierende | |
| Kurzbeschreibung | This course discusses behavioral aspects in neuroscience. Modern brain imaging methods are described. Clinical issues including diseases of the nervous system are studied. Sleep research and neuroimmunology are discussed. Finally, the course deals with the basic concepts in psychiatry. | |||||
| Lernziel | ||||||
| Voraussetzungen / Besonderes | Für Doktorierende des Zentrums für Neurowissenschaften Zürich. | |||||
| 376-1796-00L | Advanced Course in Neurobiology II (University of Zurich) Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: SPV0Y009 Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html | W | 2 KP | 2V | J.‑M. Fritschy, Uni-Dozierende | |
| Kurzbeschreibung | The goal of this Advanced Course in Neurobiology is to provide students with a broader knowledge in several important areas of neurobiology. The course consists of four parts: Part I deals with various topics in developmental neurobiology. Part II is devoted to aspects of signal transduction. Part III focuses on synaptic transmission. Part IV gives deeper insights into systems neuroscience. | |||||
| Lernziel | This credit point course is designed for doctoral students who have successfully completed the Introductory Course in Neuroscience at the Neuroscience Center Zürich. The goal is to provide students with a broader and deeper knowledge in several important areas of neurobiology. | |||||
| Voraussetzungen / Besonderes | Für Doktorierende des Zentrums für Neurowissenschaften Zürich. Nicht für Master-Studierende geeignet. | |||||
| Vertiefung Biocompatible Materials | ||||||
| Kernfächer Von den beiden Lerneinheiten 376-1622-00L Practical Methods in Tissue Engineering (angeboten im Herbstsemester) und 376-1624-00L Practical Methods in Biofabrication (angeboten im Frühjahrssemester) dürfen nicht beide angerechnet werden. | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 151-0980-00L | Biofluiddynamics | W | 4 KP | 2V + 1U | D. Obrist, P. Jenny | |
| Kurzbeschreibung | Introduction to the fluid dynamics of the human body and the modeling of physiological flow processes (biomedical fluid dynamics). | |||||
| Lernziel | A basic understanding of fluid dynamical processes in the human body. Knowledge of the basic concepts of fluid dynamics and the ability to apply these concepts appropriately. | |||||
| Inhalt | This lecture is an introduction to the fluid dynamics of the human body (biomedical fluid dynamics). For selected topics of human physiology, we introduce fundamental concepts of fluid dynamics (e.g., creeping flow, incompressible flow, flow in porous media, flow with particles, fluid-structure interaction) and use them to model physiological flow processes. The list of studied topics includes the cardiovascular system and related diseases, blood rheology, microcirculation, respiratory fluid dynamics and fluid dynamics of the inner ear. | |||||
| Skript | Lecture notes are provided electronically. | |||||
| Literatur | A list of books on selected topics of biofluiddynamics can be found on the course web page. | |||||
| 376-1308-00L | Development Strategies for Medical Implants Maximale Teilnehmerzahl: 25 bis 30. Die Einschreibungen werden nach chronologischem Eingang berücksichtigt. | W | 3 KP | 2V + 1U | J. Mayer-Spetzler, M. Rubert | |
| Kurzbeschreibung | Introduction to development strategies for implantable devices considering the interdependecies of biocompatibility, clinical and economical requirements ; discussion of the state of the art and actual trends in in orthopedics, sports medicine, traumatology and cardio-vascular surgery as well as regenerative medicine (tissue engineering). | |||||
| Lernziel | Basic considerations in implant development Concept of structural and surface biocompatiblity and its relevance for the design of implant and surgical technique Understanding of conflicting factors, e.g. clinical need, economics and regulatory requirements Concepts of tissue engineering, its strengths and weaknesses as current and future clinical solution | |||||
| Inhalt | Biocompatibility as bionic guide line for the development of medical implants; implant and implantation related tissue reactions, biocompatible materials and material processing technologies; implant testing and regulatory procedures; discussion of the state of the art and actual trends in implant development in orthopedics, sports medicine, traumatology, spinal and cardio-vascular surgery; introduction to tissue engineering. Selected topics will be further illustrated by commented movies from surgeries. Seminar: Group seminars on selected controversial topics in implant development. Participation is mandatory Planned excursions (limited availability, not mandatory, to be confirmed): 1. Participation (as visitor) on a life surgery (travel at own expense) | |||||
| Skript | Scribt (electronically available): - presented slides - selected scientific papers for further reading | |||||
| Literatur | Textbooks on selected topics will be introduced during the lectures | |||||
| Voraussetzungen / Besonderes | Achieved Bachelor degree is mandatory The number of participants in the course is limited to 25-30 students in total. Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is on the student's own responsability. | |||||
| 376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | W | 3 KP | 2G | A. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong | |
| Kurzbeschreibung | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | |||||
| Lernziel | This course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena. | |||||
| Inhalt | Typically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance. The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering. | |||||
| Skript | n/a | |||||
| Literatur | Topical Scientific Manuscripts | |||||
| 376-1614-00L | Principles in Tissue Engineering | W | 3 KP | 2V | K. Maniura, J. Möller, M. Zenobi-Wong | |
| Kurzbeschreibung | Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Lernziel | Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed. | |||||
| Inhalt | This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Skript | Handouts provided during the classes and references therin. | |||||
| Literatur | The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 | |||||
| 376-1624-00L | Practical Methods in Biofabrication Number of participants limited to 12. | W | 5 KP | 4P | M. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak | |
| Kurzbeschreibung | Biofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft. | |||||
| Lernziel | The objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project. | |||||
| Voraussetzungen / Besonderes | Not recommended if passed 376-1622-00 Practical Methods in Tissue Engineering | |||||
| Praktika | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 465-0800-00L | Practical Work Nur für MAS in Medizinphysik | O | 4 KP | externe Veranstalter | ||
| Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Wahlfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 151-0622-00L | Measuring on the Nanometer Scale | W | 2 KP | 2G | A. Stemmer, T. Wagner | |
| Kurzbeschreibung | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Lernziel | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Inhalt | Conventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters. | |||||
| Skript | Class notes and special papers will be distributed. | |||||
| Vertiefung Molecular Biology and Biophysics | ||||||
| Kernfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 551-1402-00L | Molecular and Structural Biology VI: Biophysical Analysis of Macromolecular Mechanisms This course is strongly recommended for the Masters Major "Biology and Biophysics". | W | 4 KP | 2V | R. Glockshuber, T. Ishikawa, S. Jonas, B. Schuler, E. Weber-Ban | |
| Kurzbeschreibung | The course is focussed on biophysical methods for characterising conformational transitions and reaction mechanisms of proteins and biological mecromolecules, with focus on methods that have not been covered in the Biology Bachelor Curriculum. | |||||
| Lernziel | The goal of the course is to give the students a broad overview on biopyhsical techniques available for studying conformational transitions and complex reaction mechanisms of biological macromolecules. The course is particularly suited for students enrolled in the Majors "Structural Biology and Biophysics", "Biochemistry" and "Chemical Biology" of the Biology MSc curriculum, as well as for MSc students of Chemistry and Interdisciplinary Natural Sciences". | |||||
| Inhalt | The biophysical methods covered in the course include advanced reaction kinetics, methods for the thermodynamic and kinetic analysis of protein-ligand interactions, classical and dynamic light scattering, analytical ultracentrifugation, spectroscopic techniques such as fluorescence anisotropy, fluorescence resonance energy transfer (FRET) and single molecule fluorescence spectrosopy, modern electron microscopy techniques, atomic force microscopy, and isothermal and differential scanning calorimetry. | |||||
| Skript | Course material from the individual lecturers wil be made available at the sharepoint website https://team.biol.ethz.ch/e-learn/551-1402-00L | |||||
| Voraussetzungen / Besonderes | Finished BSc curriculum in Biology, Chemistry or Interdisciplinary Natural Sciences. The course is also adequate for doctoral students with research projects in structural biology, biophysics, biochemistry and chemical biology. | |||||
| Praktika | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 465-0800-00L | Practical Work Nur für MAS in Medizinphysik | O | 4 KP | externe Veranstalter | ||
| Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Wahlfächer | ||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
| 151-0622-00L | Measuring on the Nanometer Scale | W | 2 KP | 2G | A. Stemmer, T. Wagner | |
| Kurzbeschreibung | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Lernziel | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Inhalt | Conventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters. | |||||
| Skript | Class notes and special papers will be distributed. | |||||
| 376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | W | 3 KP | 2G | A. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong | |
| Kurzbeschreibung | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | |||||
| Lernziel | This course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena. | |||||
| Inhalt | Typically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance. The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering. | |||||
| Skript | n/a | |||||
| Literatur | Topical Scientific Manuscripts | |||||