Search result: Catalogue data in Autumn Semester 2022
Chemical and Bioengineering Master  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Biochemical Engineering | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0837-01L | Biomicrofluidic Engineering  Number of participants limited to 25. | W+ | 6 credits | 3G | A. de Mello | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Microfluidics describes the behaviour, control and manipulation of fluids geometrically constrained within sub-uL environments. Microfluidic devices enable physical and chemical processes to be controlled with exquisite precision and in an fast and efficient manner. This course introduces the underlying concepts, features and applications of microfluidic systems in the chemical and life sciences. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | We will investigate the theoretical concepts behind microfluidic device operation, the methods of microfluidic device manufacture and the application of microfluidic architectures to important problems faced in modern day chemical and biological analysis. A central component of this course is a research project. This will allow students to develop a practical understanding of the benefits of miniaturization in chemical and biological experimentation. Projects will be performed in groups of between four and six students and will include both experimental and simulation aspects. Each group, under the guidance of a mentor, will plan and execute a novel research project. The results of this activity will be disseminated through an 'academic-style" research article and a "conference-style" oral presentation. Course grades will be evaluated through both a written exam and the project grade. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Specific topics covered in the course include, but are not limited to: 1. Theoretical Concepts Scaling laws, features of thermal/mass transport, diffusion, basic description of fluid flow in small volumes, microfluidic mixing strategies. 2. Microfluidic Device Manufacture Basic principles of conventional lithography of rigid materials, ‘soft’ lithography, polymer machining (injection molding, hot embossing, and 3D-printing). 3. Electrokinetics Principles of electrophoresis, electroosmosis, high performance capillary electrophoresis, electrokinetic scaling laws, chip-based electrophoresis and isoelectric focusing. 4. Mass Transfer Phenomena Key features of mass transport in microfluidic systems, diffusive transport, diffusion-convection, Péclet number, Taylor-Aris diffusion, chaotic mixing and Damköhler numbers. 5. Heat Transfer Phenomena Key features of thermal transport in microfluidic systems, conduction, convection, heat transfer by convection in internal flows, heat transfer processes in microfluidic devices. 6. Microfluidic Systems for Materials Synthesis Microfluidic reactors for the controlled synthesis of colloidal nanomaterials, advanced automation for bespoke materials discovery & characterization. 7. Point-of-Care Diagnostics Microscale tools for diagnostics, challenges associated with point-of-care (PoC) diagnostic testing, requirements for PoC devices, common PoC device formats, applications of PoC diagnostics in the developing world. 8. Microscale DNA Amplification Amplification and analysis of nucleic acids using batch, continuous flow and droplet-based microfluidic reactors. 9. Small volume Molecular Detection Spectroscopic approaches for analyte detection in small volumes with a particular focus on single molecule detection. 10. Droplets and Segmented Flows Formation, manipulation and use of liquid/liquid segmented flows in chemical and biological experimentation. 11. Single Cell Analysis Applications of microfluidic tools in cellular analysis, flow cytometry, enzymatic assays and single cell analysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture handouts, background literature, problem sheets and notes will be provided electronically through the course Moodle site. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | There is no set text for the course. All relevant literature will be provided electronically through the course Moodle site. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 529-0615-01L | Biochemical and Polymer Reaction Engineering | W+ | 6 credits | 3G | P. Arosio | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Polymerization reactions and processes. Homogeneous and heterogeneous (emulsion) kinetics of free radical polymerization. Post treatment of polymer colloids. Bioprocesses for the production of molecules and therapeutic proteins. Kinetics and design of aggregation processes of macromolecules and proteins. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of the course is to learn how to design polymerization reactors and bioreactors to produce polymers and proteins with the specific product qualities that are required by different applications in chemical, pharmaceutical and food industry. This activity includes the post-treatment of polymer latexes, the downstream processing of proteins and the analysis of their colloidal behavior. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | We will cover the fundamental processes and the operation units involved in the production of polymeric materials and proteins. In particular, the following topics are discussed: Overview on the different polymerization processes. Kinetics of free-radical polymerization and use of population balance models. Production of polymers with controlled characteristics in terms of molecular weight distribution. Kinetics and control of emulsion polymerization. Surfactants and colloidal stability. Aggregation kinetics and aggregate structure in conditions of diffusion and reaction limited aggregation. Modeling and design of colloid aggregation processes. Physico-chemical characterization of proteins and description of enzymatic reactions. Operation units in bioprocessing: upstream, reactor design and downstream. Industrial production of therapeutic proteins. Characterization and engineering of protein aggregation. Protein aggregation in biology and in biotechnology as functional materials. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts are available on the web page of the Arosio-group: http://www.arosiogroup.ethz.ch/education.html Additional handout of slides will be provided during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | R.J. Hunter, Foundations of Colloid Science, Oxford University Press, 2nd edition, 2001 D. Ramkrishna, Population Balances, Academic Press, 2000 H.W. Blanch, D. S. Clark, Biochemical Engineering, CRC Press, 1995 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Products and Materials | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0619-01L | Chemical Product Design Prerequisites: Basic chemistry and chemical engineering knowledge (Diffusion, Thermodynamics, Kinetics,...). | W+ | 6 credits | 3G | W. J. Stark | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The 'Chemical Product Design' course teaches students quantitative concepts to analyze, select and transform theoretical concepts from chemistry and engineering into valuable real-world products. Basic chemistry and chemical engineering knowledge is required (Diffusion, Thermodynamics, Kinetics, ..). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | This course starts with analyzing existing chemical needs and unmet technical challenges. We then develop the skills to critically analyze a specific chemical idea for a product, to rapidly test feasibility or chance for success and to eventually realize its manufacturing. The chemical engineering basics are then used to assess performance of products or devices with non-traditional functions based on dynamic properties (e.g. responsive building materials; personal medical diagnostics on paper strips). The course teaches the interface between laboratory and market with a specific focus on evaluating the chemical value of a given process or compound, and the necessary steps to pursue the resulting project within an entrepreneurial environment. We therefore extend the questions of process design ('how do we make something?') to the question of 'what should we make? | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Part A: The 'Chemical Product Design' course starts with discussing questions along, 'What is a chemical product, and why do people pay for it? How does a given compound in a specific setting provide a service?' We then learn how to translate new, often ill-defined wishes or ideas into quantifiable specifications. Part B: Thermodynamic and kinetic data allow sharp selection criteria for successful products. We learn how to deal with insufficient data and development of robust case models to evaluate their technical and financial constraints. How can parameters of a running process in one industry be scaled into another industry? Can dimensionless engineering numbers be applied beyond traditional chemical processes? Part C: Manufacturing of commodity products, devices and molecular products: Chemical reactors, separation and detection or isolation units as part of a toolbox. Planning of manufacturing and decisions based on hard data. Providing quantitative answers on potential value generated. Students are expected to actively develop chemical products along the course. Contributions will be made individually, or in small groups, where a larger topic is studied. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Cussler, E.L., Moggridge, C.D., Chemical Product Design, Cambridge University Press, Cambridge, UK, 2nd edition, 2011. Original Literature: Issues and Trends in the Teaching of Process and Product Design, Biegler, L.T., Grossmann, I.E., Westerber, A.W., AIChE J., 56 (5) 1120-25, 2010. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisites: Basic chemistry and chemical engineering knowledge (Diffusion, Thermodynamics, Kinetics,...). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Process Design | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0643-01L | Process Design and Development | W+ | 6 credits | 3G | G. Guillén Gosálbez | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course is focused on the design of Chemical Processes, with emphasis on the preliminary stages of the design approach, where process creation and quick selection among many alternatives are important. The main concepts behind more detailed process design and process simulation are also examined. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The course is focused on the design of Chemical Processes, with emphasis on the preliminary stage of the design approach, where process creation and quick selection among many alternatives are important. The main concepts behind more detailed process design and process simulation are also examined. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Process creation: heuristics vs. mathematical programming. Heuristics for reaction and separation operations, heat transfer and pressure change. Introduction to optimization in process engineering and the modeling software GAMS. Process economic evaluation: equipment sizing and costing, time value of money, cash flow calculations. Process environmental evaluation: Life Cycle Assessment (LCA). Process integration: sequencing of distillation columns using mixed-integer linear programming (MILP), and synthesis of heat exchanger networks using mixed-integer nonlinear programming (MINLP). Batch processes: scheduling, sizing, and inventories. Principles of molecular design using mixed-integer programming. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | no script | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Main books 1. Biegler, L.T., Grossmann, I.E., Westerberg, A.W. Systematic methods of chemical process design, Prentice Hall International PTR (1997). 2. Douglas, J.M. Conceptual design of chemical processes, McGraw-Hill (1988). 3. Seider, W.D., Seader, J.D., Lwin, D.R., Widagdo, S. Product and process design principles: synthesis, analysis, and evaluation, John Wiley & Sons, Inc. (2010). 4. Sinnot, R.K., Towler, G. Chemical Engineering Design, Butterworth-Heinemann (2009). 5. Smith, R. Chemical process design and integration, Wiley (2005). Other references 6. Edgar, T. F., Himmelblau, D. M. Optimization of chemical process, Mcgraw Hill Chemical Engineering Series (2001). 7. Haydary, J. Chemical Process Design and Simulation, Wiley (2019). 8. Turton, R., Shaeiwitz, A., Bhattacharyya, D., Whiting, W. Synthesis and Design of Chemical Processes, Prentice Hall (2013). 9. Klöpffer, W., Grahl, B. Life Cycle Assessment (LCA): A Guide to Best Practice, Wiley (2014). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisite: Basic knowledge on unit operations, mainly reaction engineering and distillation. It is recommended that the student takes the module "Process Simulation and Flowsheeting" before "Process Design and Development", but it is not mandatory. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0613-01L | Process Simulation and Flowsheeting | W+ | 6 credits | 3G | G. Guillén Gosálbez | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This course encompasses the theoretical principles of chemical process simulation and optimization, as well as its practical application in process analysis. The techniques for simulating stationary and dynamic processes are presented, and illustrated with case studies. Commercial software packages (Aspen) are introduced for solving process flowsheeting and optimization problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | This course aims to develop the competency of chemical engineers in process flowsheeting, process simulation and process optimization. Specifically, students will develop the following skills: - Deep understanding of chemical engineering fundamentals: the acquisition of new concepts and the application of previous knowledge in the area of chemical process systems and their mechanisms are crucial to intelligently simulate and evaluate processes. - Modeling of general chemical processes and systems: students should be able to identify the boundaries of the system to be studied and develop the set of relevant mathematical relations, which describe the process behavior. - Mathematical reasoning and computational skills: the familiarization with mathematical algorithms and computational tools is essential to be capable of achieving rapid and reliable solutions to simulation and optimization problems. Hence, students will learn the mathematical principles necessary for process simulation and optimization, as well as the structure and application of process simulation software. Thus, they will be able to develop criteria to correctly use commercial software packages and critically evaluate their results. - Process optimization: the students will learn how to formulate optimization problems in mathematical terms, the main type of optimization problems that exist (i.e., LP, NLP, MILP and MINLP) and the fundamentals of the optimization algorithms implemented in commercial solvers. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Overview of process simulation and flowsheeting: - Definition and fundamentals - Fields of application - Case studies Process simulation: - Modeling strategies of process systems - Mass and energy balances and degrees of freedom of process units and process systems Process flowsheeting: - Flowsheet partitioning and tearing - Solution methods for process flowsheeting - Simultaneous methods - Sequential methods Process optimization and analysis: - Classification of optimization problems - Linear programming, LP - Non-linear programming, NLP - Mixed-integer linear programming, MILP - Mixed-integer nonlinear programming, MINLP Commercial software for simulation (Aspen Plus): - Thermodynamic property methods - Reaction and reactors - Separation / columns - Convergence, optimisation & debugging | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | An exemplary literature list is provided below: - Biegler, L.T., Grossmann, I.E., Westerberg, A.W. Systematic methods of chemical process design, Prentice Hall International PTR (1997). - Douglas, J.M. Conceptual design of chemical processes, McGraw-Hill (1988). - Edgar, T. F., Himmelblau, D. M. Optimization of chemical process, Mcgraw Hill Chemical Engineering Series (2001). - Haydary, J. Chemical Process Design and Simulation, Wiley (2019). - Seider, W.D., Seader, J.D., Lwin, D.R., Widagdo, S. Product and process design principles: synthesis, analysis, and evaluation, John Wiley & Sons, Inc. (2010). - Sinnot, R.K., Towler, G. Chemical Engineering Design, Butterworth-Heinemann (2009). - Smith, R. Chemical process design and integration, Wiley (2005). - Turton, R., A. Shaeiwitz, Bhattacharyya, D., Whiting, W. Synthesis and Design of Chemical Processes, Prentice Hall (2013). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | A basic understanding of material and energy balances, thermodynamic property methods and typical unit operations (e.g., reactors, flash separations, distillation/absorption columns etc.) is required. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Catalysis and Separation | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 151-0927-00L | Rate-Controlled Separations in Fine Chemistry | W+ | 6 credits | 3V + 1U | M. Mazzotti, V. Becattini | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The students are supposed to obtain detailed insight into the fundamentals of separation processes that are frequently applied in modern life science processes in particular, fine chemistry and biotechnology, and in energy-related applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The students are supposed to obtain detailed insight into the fundamentals of separation processes that are frequently applied in modern life sicence processes in particular, fine chemistry and biotechnology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The class covers separation techniques that are central in the purification and downstream processing of chemicals and bio-pharmaceuticals. Examples from both areas illustrate the utility of the methods: 1) Adsorption and chromatography; 2) Membrane processes; 3) Crystallization and precipitation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handouts during the class | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Recommendations for text books will be covered in the class | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Requirements (recommended, not mandatory): Thermal separation Processes I (151-0926-00) and Modelling and mathematical methods in process and chemical engineering (151-0940-00) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 529-0617-01L | Catalysis Engineering | W+ | 6 credits | 3G | J. Pérez-Ramírez, S. J. Mitchell | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Heterogeneous catalysis, an enabling foundation of the chemical industry, spearheads innovation toward key sustainability targets in clean energy, carbon neutrality, and zero waste. The Catalysis Engineering course provides students with concepts bridging from the molecular-level design of catalytic materials to their technical application. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | To accelerate the discovery and implementation of sustainable technologies, this vibrant discipline is constantly refining its design principles, particularly at the nanoscale, a shift facilitated by the availability of increasingly powerful tools that permit the continued development of fundamental knowledge over different time and length scales. During this course, you will learn current concepts for the defossilization of the chemical industry and strategies for achieving this goal from idea to implementation. By introducing topical case studies both in lectures and through a semester project, you will see aspects of catalyst synthesis and characterization, kinetics, mass and heat transport, deactivation and process design, sustainability metrics, and the potential of digital tools to guide catalyst design. Since this area is rapidly advancing and no textbooks are available, the lectures follow slides and journal articles. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The aspects described above will be demonstrated through industrially-relevant examples such as: - Natural gas valorization - CO2 conversion to energy vectors - Plastics upcycling - Concept for a glycerol biorefinery - Halogen chemistry on catalytic surfaces - Ensemble design for selective hydrogenations - Single-atom catalysis - Hierarchical zeolite catalysts A supervised semester project conducted in small groups provides a taster of catalysis research on a timely topic. Students will learn basic skills including critical literature analysis, problem definition and solving, methods of catalyst synthesis, characterization, and testing, and data evaluation and communication through a short talk. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | The course material is based on slides and journal articles. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | It is assumed that students selecting this course are familiar with basic concepts of chemistry and catalysis (chemistry or chemical engineering background). Other students are welcome to contact us to discuss the requirement for prior knowledge. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Case Study | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0459-01L | Case Studies in Process Design | O | 3 credits | 3A | G. Guillén Gosálbez | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The learning objective is to design, simulate and optimize a real (bio-)chemical process from a process systems perspective. Specifically, a commercial process simulation software (Aspen) will be used for the process simulation and optimization. Students have to integrate knowledge and develop engineering thinking and skills acquired in the other courses of the curriculum. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Simulate and optimize a chemical production process using commercial process simulation software. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Create a model describing the production process - Students will apply a commercial process simulator systematically for process creation and analysis. - Students will create a process simulation flowsheet for steady-state simulation. Evaluate the performance of the production process - Students will analyse and understand the degrees of freedom in modelling process units and flowsheets. - Students will understand the role of process simulators in process creation. - Students will make design specifications and follow the iterations implemented to satisfy them. - Students will judge the role of process simulators in equipment sizing and costing and profitability analysis. - Students will assess the economic performance of the process, including operating costs (OPEX), and capital investment (CAPEX), based on the outcome of the simulation model. - Students will assess the environmental impact of the production process following the Life Cycle Assessment (LCA) methodology. Optimize the design and operating conditions of the production process - Students will carry out sensitivity analyses and optimizations considering technical and economic criteria. - Students will generate process integration alternatives to improve the initial design. - Students will optimize the production process considering economic and environmental criteria. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Before the case study week, students are encouraged to participate in the exercises of the course "Process Simulation and Flowsheeting" in order to get familiar with the Aspen Plus simulation software (this is highly recommended, but not mandatory). The problem statement and detailed instructions are provided in the project brief made available at the beginning of the case study week. During the case study week: - Students work in teams of 4-6 people. - Students have to pose and solve process equipment and system design related problems. - Students have to coordinate the activities, the preparation of the written report and the oral presentation. - Students get support from project assistants and the course supervisor. The groups deliver the written report on a predefined date. The students receive the feedback and are asked to implement some changes in their reports. A final presentation takes place summarizing the main findings of the project. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Research Project or Industry Internship | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0300-10L | Research Project | W | 13 credits | 16A | Supervisors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | In a research project students extend their knowledge in a particular field, get acquainted with the scientific way of working, and learn to work on an actual research topic. Research projects are carried out in a core or optional subject area as chosen by the student. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | First contact with experimental techniques of chemical engineering in a research group. Critical evaluation and presentation of the results in a scientific report. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | This laboratory project is organised during the spring vacation before the sixth semester. The participant can choose his topic from the list of projects suggested. Main emphasis during this research work is to get experience in using different engineering tools and evaluation and the interpretation of the results. Those are presented as a scientific report. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0301-00L | Industry Internship | W | 13 credits | Supervisors | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Internship in industry with a minimum duration of 7 weeks | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of the internship is to make students acquainted with industrial work environments. During this time, they will have the opportunity to get involved in current projects of the host institution. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | This laboratory project is organised during the spring vacation before the sixth semester. The participant can choose his topic from the list of projects suggested. Main emphasis during this research work is to get experience in using different engineering tools and evaluation and the interpretation of the results. Those are presented as a scientific report. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Master's Thesis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0600-10L | Master's Thesis Only students who fulfill the following criteria are allowed to begin with their Master's thesis: a. successful completion of the Bachelor's programme; b. fulfilling of any additional requirements necessary to gain admission to the Master's programme. Duration of the Master's Thesis 20 weeks. | O | 25 credits | 54D | Supervisors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Electives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Biochemical Engineering | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 636-0108-00L | Biological Engineering and Biotechnology | W | 4 credits | 3V | M. Fussenegger | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handout during the course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 636-0007-00L | Computational Systems Biology | W | 6 credits | 3V + 2U | J. Stelling | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Study of fundamental concepts, models and computational methods for the analysis of complex biological networks. Topics: Systems approaches in biology, biology and reaction network fundamentals, modeling and simulation approaches (topological, probabilistic, stoichiometric, qualitative, linear / nonlinear ODEs, stochastic), and systems analysis (complexity reduction, stability, identification). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of this course is to provide an introductory overview of mathematical and computational methods for the modeling, simulation and analysis of biological networks. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Biology has witnessed an unprecedented increase in experimental data and, correspondingly, an increased need for computational methods to analyze this data. The explosion of sequenced genomes, and subsequently, of bioinformatics methods for the storage, analysis and comparison of genetic sequences provides a prominent example. Recently, however, an additional area of research, captured by the label "Systems Biology", focuses on how networks, which are more than the mere sum of their parts' properties, establish biological functions. This is essentially a task of reverse engineering. The aim of this course is to provide an introductory overview of corresponding computational methods for the modeling, simulation and analysis of biological networks. We will start with an introduction into the basic units, functions and design principles that are relevant for biology at the level of individual cells. Making extensive use of example systems, the course will then focus on methods and algorithms that allow for the investigation of biological networks with increasing detail. These include (i) graph theoretical approaches for revealing large-scale network organization, (ii) probabilistic (Bayesian) network representations, (iii) structural network analysis based on reaction stoichiometries, (iv) qualitative methods for dynamic modeling and simulation (Boolean and piece-wise linear approaches), (v) mechanistic modeling using ordinary differential equations (ODEs) and finally (vi) stochastic simulation methods. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | http://www.csb.ethz.ch/education/lectures.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | U. Alon, An introduction to systems biology. Chapman & Hall / CRC, 2006. Z. Szallasi et al. (eds.), System modeling in cellular biology. MIT Press, 2010. B. Ingalls, Mathematical modeling in systems biology: an introduction. MIT Press, 2013 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 376-1714-00L | Biocompatible Materials | W | 4 credits | 3V | K. Maniura, M. Rottmar, M. Zenobi-Wong | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The course covers the follwing topics: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. 4. Introduction to different material classes in use for medical applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Introduction into natural and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering, drug delivery and for medical devices are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. A link between academic research and industrial entrepreneurship is demonstrated by external guest speakers, who present their current research topics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handouts are deposited online (moodle). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Literature: - Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 - Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts and references therin. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0615-01L | Biochemical and Polymer Reaction Engineering | W | 6 credits | 3G | P. Arosio | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Polymerization reactions and processes. Homogeneous and heterogeneous (emulsion) kinetics of free radical polymerization. Post treatment of polymer colloids. Bioprocesses for the production of molecules and therapeutic proteins. Kinetics and design of aggregation processes of macromolecules and proteins. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of the course is to learn how to design polymerization reactors and bioreactors to produce polymers and proteins with the specific product qualities that are required by different applications in chemical, pharmaceutical and food industry. This activity includes the post-treatment of polymer latexes, the downstream processing of proteins and the analysis of their colloidal behavior. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | We will cover the fundamental processes and the operation units involved in the production of polymeric materials and proteins. In particular, the following topics are discussed: Overview on the different polymerization processes. Kinetics of free-radical polymerization and use of population balance models. Production of polymers with controlled characteristics in terms of molecular weight distribution. Kinetics and control of emulsion polymerization. Surfactants and colloidal stability. Aggregation kinetics and aggregate structure in conditions of diffusion and reaction limited aggregation. Modeling and design of colloid aggregation processes. Physico-chemical characterization of proteins and description of enzymatic reactions. Operation units in bioprocessing: upstream, reactor design and downstream. Industrial production of therapeutic proteins. Characterization and engineering of protein aggregation. Protein aggregation in biology and in biotechnology as functional materials. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts are available on the web page of the Arosio-group: http://www.arosiogroup.ethz.ch/education.html Additional handout of slides will be provided during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | R.J. Hunter, Foundations of Colloid Science, Oxford University Press, 2nd edition, 2001 D. Ramkrishna, Population Balances, Academic Press, 2000 H.W. Blanch, D. S. Clark, Biochemical Engineering, CRC Press, 1995 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0837-01L | Biomicrofluidic Engineering Number of participants limited to 25. | W | 6 credits | 3G | A. de Mello | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Microfluidics describes the behaviour, control and manipulation of fluids geometrically constrained within sub-uL environments. Microfluidic devices enable physical and chemical processes to be controlled with exquisite precision and in an fast and efficient manner. This course introduces the underlying concepts, features and applications of microfluidic systems in the chemical and life sciences. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | We will investigate the theoretical concepts behind microfluidic device operation, the methods of microfluidic device manufacture and the application of microfluidic architectures to important problems faced in modern day chemical and biological analysis. A central component of this course is a research project. This will allow students to develop a practical understanding of the benefits of miniaturization in chemical and biological experimentation. Projects will be performed in groups of between four and six students and will include both experimental and simulation aspects. Each group, under the guidance of a mentor, will plan and execute a novel research project. The results of this activity will be disseminated through an 'academic-style" research article and a "conference-style" oral presentation. Course grades will be evaluated through both a written exam and the project grade. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Specific topics covered in the course include, but are not limited to: 1. Theoretical Concepts Scaling laws, features of thermal/mass transport, diffusion, basic description of fluid flow in small volumes, microfluidic mixing strategies. 2. Microfluidic Device Manufacture Basic principles of conventional lithography of rigid materials, ‘soft’ lithography, polymer machining (injection molding, hot embossing, and 3D-printing). 3. Electrokinetics Principles of electrophoresis, electroosmosis, high performance capillary electrophoresis, electrokinetic scaling laws, chip-based electrophoresis and isoelectric focusing. 4. Mass Transfer Phenomena Key features of mass transport in microfluidic systems, diffusive transport, diffusion-convection, Péclet number, Taylor-Aris diffusion, chaotic mixing and Damköhler numbers. 5. Heat Transfer Phenomena Key features of thermal transport in microfluidic systems, conduction, convection, heat transfer by convection in internal flows, heat transfer processes in microfluidic devices. 6. Microfluidic Systems for Materials Synthesis Microfluidic reactors for the controlled synthesis of colloidal nanomaterials, advanced automation for bespoke materials discovery & characterization. 7. Point-of-Care Diagnostics Microscale tools for diagnostics, challenges associated with point-of-care (PoC) diagnostic testing, requirements for PoC devices, common PoC device formats, applications of PoC diagnostics in the developing world. 8. Microscale DNA Amplification Amplification and analysis of nucleic acids using batch, continuous flow and droplet-based microfluidic reactors. 9. Small volume Molecular Detection Spectroscopic approaches for analyte detection in small volumes with a particular focus on single molecule detection. 10. Droplets and Segmented Flows Formation, manipulation and use of liquid/liquid segmented flows in chemical and biological experimentation. 11. Single Cell Analysis Applications of microfluidic tools in cellular analysis, flow cytometry, enzymatic assays and single cell analysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture handouts, background literature, problem sheets and notes will be provided electronically through the course Moodle site. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | There is no set text for the course. All relevant literature will be provided electronically through the course Moodle site. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 551-0357-00L | Cellular Matters: From Milestones to Open Questions The number of participants is limited to 22 and will only take place with a minimum of 11 participants. Please sign up until two weeks before the beginning of the semester (for Autumn 2022: by 05.09.2022 end of day) via e-mail to bml@ethz.ch using in the subject: 551-0357-00. In the email body indicate 1) your name, 2) your e-mail address, 3) master/PhD program. The students admitted to this seminar will be informed by e-mail in the week prior to the beginning of the semester. The first lecture will serve to form groups of students and assign papers. | W | 4 credits | 2S | Y. Barral, F. Allain, P. Arosio, E. Dufresne, D. Hilvert, M. Jagannathan, R. Mezzenga, T. Michaels, G. Neurohr, R. Riek, A. E. Smith, K. Weis, H. Wennemers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | In this course, the students will explore the quite new topic of biomolecular condensates. Concepts and tools from biology, chemistry, biophysics and soft materials will be used, on one hand, to develop an understanding of the biological properties and functions of biomolecular condensates in health and disease, while, on the other, to inspire new materials. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | In terms of content, you, the student, after a general introduction to the topic, will learn about milestone works and current research questions in the young field of biomolecular condensates (properties, functions and applications) from an interdisciplinary point of view in a course which is a combination of literature (presentations given by pairs of students with different scientific backgrounds) and research seminars (presentations given by the lecturers all active experts in the field, with different backgrounds and expertise). As to the skills, you will have the opportunity to learn how to critically read and evaluate scientific literature, how to give scientific presentations to an interdisciplinary audience (each presentation consisting of an introduction, critical description of the results and discussion of their significance) and substantiate your statements, acquire a critical mindset (pros/cons of chosen approaches/methods and limitations, quality of the data, solidity of the conclusions, possible follow-up experiments) that allows you to ask relevant questions and actively participate to the discussion. With the final presentation you will have the unique opportunity to interact closely with the interdisciplinary group of lecturers (all internationally well-established experts) who will guide you in the choice of a subtopic and related literature. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | In the last decade a new kind of compartments within the cell, the so-called biomolecular condensates, have been observed. This discovery is radically changing our understanding of the cell, its organization and dynamics. The emerging picture is that the cytoplasm and nucleoplasm are highly complex fluids that can (meta)stably segregate into membrane-less sub-compartments, similarly to emulsions. The topic of biomolecular condensates goes beyond the boundaries of traditional disciplines and needs a multi-pronged approach that levers on, and cross-fertilizes, biology, physical chemistry, biophysics and soft materials to develop a proper understanding of the properties, functions in health and disease (Alzheimer’s, Parkinson’s, etc.), as well as possible applications of these biomolecular condensates. Each week the lecture will consist of: 1) a short literature seminar: Pairs of students from different scientific backgrounds will be formed and assigned beforehand to present milestone literature to the class and facilitate the ensuing discussion. In the first class the pairs will be formed, the milestone papers made known to the whole class and assigned to the pairs. 2) a research seminar: the presentation of the milestone literature will serve as the introduction to the lecture by one of the lecturers of the course on their own state-of-the-art research in the field. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | The presentations will be made available after the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | The milestone papers will be provided in advance. For the final examination, the students will be helped by the lecturers in identifying a research topic and related literature. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Environment and Energy | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 151-0209-00L | Renewable Energy Technologies | W | 4 credits | 3G | A. Steinfeld, E. Casati | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Renewable energy technologies: solar PV, solar thermal, biomass, wind, geothermal, hydro, waste-to-energy. Focus is on the engineering aspects. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Students learn the potential and limitations of renewable energy technologies and their contribution towards sustainable energy utilization. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture Notes containing copies of the presented slides. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisite: strong background on the fundamentals of engineering thermodynamics, equivalent to the material taught in the courses Thermodynamics I, II, and III of D-MAVT. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0659-00L | Electrochemistry: Fundamentals, Cells & Applications | W | 6 credits | 3G | L. Gubler | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Introduction to electrochemistry from a physical chemistry point of view, focusing on thermodynamics & kinetics of electrochemical reactions, and engineering aspects of electrochemical cells. The topics are of generic nature yet also discussed in the context of specific applications in industrial electrochemistry, energy storage and conversion, electroanalytical techniques, sensors and corrosion. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The course establishes the fundamentals to understand and describe electrochemical reactions and phenomena related to these. The students are familiarized with key concepts and approaches in electrochemistry and selected aspects of materials science and engineering and how they are put to use in selected applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | - Introduction: important quantities & units, terminology; - Chapter I - Redox reactions, Faraday’s laws; - Chapter II - Equilibrium electrochemistry: cells, galvanic and electrolytic cells, thermodynamic state functions, theoretical cell voltage, half-cell / electrode potential, hydrogen electrode, the electrochemical series, Nernst equation; - Chapter III - Electrodes & interfaces: electrochemical potential, phase potentials, work function, Fermi level, the electrified interface, the electrochemical double layer, reference electrodes and laboratory cells; - Chapter IV - Electrolytes: conductivity, aqueous electrolytes, transference effects, liquid junctions, polymer electrolytes, ion-exchange membranes, Donnan exclusion, solid state ion conductors; - Chapter V - Dynamic electrochemistry: overpotentials, description of charge-transfer reaction, Butler-Volmer and Tafel equation, exchange current density, mass transport limitations; - Chapter VI - Industrial electrochemistry: electrochemical engineering, process and reactor types, current density distribution, porous electrodes, chlor-alkali and HCl electrolysis, oxygen depolarized cathode; - Chapter VII - Energy storage & conversion: important primary and secondary battery chemistries, fuel cells, polymer electrolyte fuel cells, low temperature H2 and O2 electrochemistry, electrocatalysis, triple-phase boundary, solid oxide fuel cell, conversion efficiency; - Chapter VIII - Electroanalytical methods & sensors: potentiometry, amperometry, cyclic and stripping voltammetry, rotating disc electrode studies, electrochemical sensors; - Chapter IX - Corrosion: corrosion reactions, Pourbaix diagram, corrosion potential, passivation, corrosion protection | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | lecture notes, exercise & solutions (PDF files) via download website | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | - C.H. Hamann, A. Hamnett, W. Vielstich, Electrochemistry, Wiley-VCH 2007 (2nd Edition), ISBN: 978-3-527-31069-2 [German version available as well] - T.F. Fuller, J.N. Harb, Electrochemical Engineering, Wiley 2018, ISBN: 978-1-119-00425-7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Students should be familiar with the fundamentals of physical chemistry. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0745-01L | General and Environmental Toxicology | W | 6 credits | 3V | M. Arand, H. Nägeli | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Toxicokinetic and toxicodynamic aspects of xenobiotic interactions with cellular structures and mechanisms. Toxic responses at the level of organs (immune-, neuro-, reproductive and genotoxicity) and organisms. Introduction into developmental toxicology and ecotoxicology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding of the impact of chemicals on biological systems; evaluation of the effects from different biomedical perspectives. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Explanation of important interactions between xeniobiotic chemicals and cellular structures such as membranes, enzymes, and nucleic acids. Relevance of intake, distribution, excretion, and biochemical transformation processes. Relevance of mixtures. Explanation of important modes of toxic action such as immuno toxicity, neurotoxicity, reproduction toxicity, genotoxicity based on examples of certain xenobiotics and their effects on important organs. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Course material will be handed out as the lectures progress | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Textbooks of pharmacology and toxicology (cf. list in course material) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Educational basis: basic chemistry, biology and biochemistry | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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