Suchergebnis: Katalogdaten im Frühjahrssemester 2020

Biologie Bachelor Information
3. Studienjahr, 6. Semester
Blockkurse
Anmeldung zu Blockkursen muss zwingend über die website Link
Anmeldung möglich von 16.12.2019 - 06.01.2020

Bitte die ETH Aufnahmekriterien für die Aufnahme von Studierenden der ETH in ETH Blockkurse auf der Blockkurs-Anmeldeseite unter "Zuteilung" beachten.
Blockkurse im 1. Semesterviertel
Von 18.2.2020 bis 11.3.2020
NummerTitelTypECTSUmfangDozierende
551-0342-00LMetabolomics Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.

The enrolment is done by the D-BIOL study administration.
W6 KP7GN. Zamboni, U. Sauer
KurzbeschreibungThe course covers all basic aspects of metabolome measurements, from sample sampling to mass spectrometry and data analysis. Participants work in groups and independently perform and interpret metabolomic experiments.
LernzielPerforming and reporting a metabolomic experiment, understanding pro and cons of mass spectrometry based metabolomics. Knowledge of workflows and tools to assist experiment interpretation, and metabolite identification.
InhaltBasics of metabolomics: workflows, sample preparation, targeted and untargeted mass spectrometry, instrumentation, separation techniques (GC, LC, CE), metabolite identification, data interpretation and integration, normalization, QCs, maintenance.

Soft skills to be trained: project planning, presentation, reporting, independent working style, team work.
551-0339-00LMolecular Mechanisms of Cell Dynamics Belegung eingeschränkt - Details anzeigen
Number of participants limited to 13.

The enrolment is done by the D-BIOL study administration.
W6 KP7GE. Dultz, Y. Barral, U. Kutay, M. Peter, K. Weis
KurzbeschreibungApplication of current strategies to study the dynamics of complex and highly regulated cellular processes.
LernzielThe students learn to evaluate and to apply current strategies to study the dynamics of complex and highly regulated cellular processes.
InhaltDuring this Block-Course, the students will learn to (1) describe the important mechanisms and regulators of dynamic processes in cells, (2) perform standard lab techniques and quantitate dynamic cellular processes, (3) evaluate and compare experimental strategies and model systems, (4) independently search and critically evaluate scientific literature on a specific problem and present it in a seminar, and (5) formulate scientific concepts (preparation and presentation of a poster).
Students will work in small groups in individual labs on one research project (8 full days of practical work; every group of students will stay in the same lab during the entire course). The projects are close to the actual research carried out in the participating research groups, but with a clear connection to the subject of the course.
LiteraturDocumentation and recommended literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesThis course will be taught in english.
551-1516-00LNeuron-Glia Interactions and Myelination in Health and Disease Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.

The enrolment is done by the D-BIOL study administration.
W6 KP7GU. Suter
KurzbeschreibungThe course provides general basic insights and new perspectives in the development, plasticity and repair of the nervous system. The focus is on molecular, cellular and transgenic approaches.
LernzielThrough a combination of practical work with lectures, discussions, project preparations and presentations, the students learns basic principles of neural plasticity and repair in health and disease. The course is closely linked to ongoing research projects in the lab to provide the participants with direct insights into current experimental approaches and strategies.
551-0118-00LCell Biology of Plant-Fungus Interaction Belegung eingeschränkt - Details anzeigen
Number of participants limited to 5.

The enrolment is done by the D-BIOL study administration.
W6 KP7GC. Sánchez-Rodríguez
KurzbeschreibungThe course is a collaboration of the Plant Cell Biology groups of ETHZ and UZH. The students will learn key concepts related with the remarkable ability of plants to adapt to challenges provided by their environment (both biotic, such as pathogens, and abiotic, like nutrient deficiencies). A multidisciplinary approach including molecular genetics, cell biology, biochemistry and bioinformatics tool
LernzielIn this course, students will get cell biological and molecular genetics insights into the developmental plasticity of plants to adapt to their environmental conditions using the model plant Arabidopsis thaliana. With this aim, they will actively participate in ongoing research projects tutored by doctoral students.
InhaltStudents will be engaged in research projects aimed to understand the specialized mechanisms evolved by the plants to grow under challenging environments. In a lecture series, the theoretical background for the projects and their interrelationship is provided.
Students will design and perform experiments, evaluate experimental results, present their projects, and discuss recent publications to understand the relevance of their work in the context of the current state of plant development and stress response.
SkriptNo script
LiteraturThe recommended literature and list of individual reading assignments will be provided during the course
Voraussetzungen / BesonderesAll general lectures will be held at ETH Centrum (LFW building). Students will be divided into small groups to carry out experiments at ETH (Central; LFW) and UZH (Botanical Garden)
Blockkurse im 2. Semesterviertel
Von 12.3.2020 bis 2.4.2020
NummerTitelTypECTSUmfangDozierende
376-1346-00LStudy of Epigenetic Mechanisms in Mental Health Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.

The enrolment is done by the D-BIOL study administration.
W6 KP7GI. Mansuy
KurzbeschreibungThis block course is focused on the study of the epigenetic mechanisms that regulate complex brain functions and behavior. It provides an overview of molecular methods used in experimental mice or in human samples to investigate epigenetic processes that control genome activity and gene expression, and are associated with cognitive functions and behavioral responses.
LernzielThe purpose is to learn the principles of major methods in epigenetics that allow examine genome activity at the level of DNA, RNA or protein, in the context of complex brain functions.
Inhalt4 independent projects for 3 students each covering various aspects of epigenetic mechanisms. It will focus on state-of-the-art techniques to measure or manipulate gene expression and gene activity in the adult brain or in cell culture, and analyse the effects in vitro or in vivo using omics analyses, molecular and biochemical tools and behavioral testing.
SkriptProvided at the beginning of the practical.
551-0352-00LIntroduction to Mass Spectrometry-based Proteomics Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.

The enrolment is done by the D-BIOL study administration.
W6 KP7GL. Gillet, P. Picotti
KurzbeschreibungProtein-Analyse durch Massenspektrometrie
Die folgende Thematik wird abgedeckt: Grundlagen der biologischen Massenspektrometrie einschliesslich Instrumentation, Datenaufnahme und -bearbeitung; Anwendung zur Identifizierung und Charakterisierung von Proteinen; Probevorbereitung; Proteomic-Strategien einschliesslich quantitative Analysen.
LernzielProbenvorbereitung fuer die MS Analyse (Trypsin Verdau, C18 Aufreinigung)
Prinzipien LC-MS basierter Datenaquisition (QTOF und/oder Ion Trap Instrumenten)
Qualitative Proteom Analyse (Protein Identifizierung mit Hilfe von Mascot und/oder Sequest Software)
Quantitative Proteom Analyse (unmarkierte und Isotopen markierte Strategien)
Analyse und Auswertung von Datensätzen zur Detektion von hoch- bzw. runter-regulierten Proteinen
551-0434-00LNMR Spectroscopy in Biology Belegung eingeschränkt - Details anzeigen
Number of participants limited to 6.

The enrolment is done by the D-BIOL study administration.
W6 KP7GF. Allain, A. D. Gossert, K. Wüthrich
KurzbeschreibungIn this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wüthrich and Dr. Gossert. The students will be tutored in their experimental work by experienced postdoc students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as exercises and literature work.
LernzielThe course provides first "hands on" insight into applications of NMR spectroscopy in biological sciences. The course should enable the students to understand the potential and limitations of NMR applied to biological problems.
InhaltThe topics include studies of proteins, RNA and protein-RNA interactions,

Participation in one of the following projects will be possible:
- NMR of RNA
- NMR of several protein-RNA complexes (hnRNPF, nPTB, SR proteins)
- NMR studies of protein-ligand interactions
- dynamics of protein-RNA complexes
- Segmental isotopic labeling to study multidomain proteins
- NMR Methods Development
SkriptNo script
LiteraturLists of individual reading assignments will be handed out.
529-0810-01LOrganische Chemie II (für D-BIOL) Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 12

Bitte melden Sie sich möglichst vor Ablauf der Herbstsemester-Vorlesungszeit bei Prof. C. Thilgen (Link) an. Sie erhalten eine Rückmeldung, ob Sie am Praktikum teilnehmen können.

Die Belegung erfolgt nur über das Studiensekretariat D-BIOL.

Die Lehrsprache hängt de facto von der betreuenden Person ab.
W12 KP4PC. Thilgen
KurzbeschreibungBearbeiten eines organisch-synthetischen Teilprojekts aus der aktuellen Forschung einer Gruppe des Laboratoriums für Organische Chemie unter der Anleitung von Doktorierenden.
LernzielErlernen von Planung und Durchführung anspruchsvoller Mehrstufensynthesen unter Einbezug moderner Methoden; vertieftes Verständnis organisch-chemischer Reaktionen durch Experimente; Entwickeln eines organisch-synthetischen Forschungsprojekts; akkurates Protokollieren, Verfassen eines Berichts im Stil einer Veröffentlichung und Präsentieren der Ergebnisse in Form eines Kurzvortrags.
InhaltBearbeiten eines organisch-synthetischen Teilprojekts aus der aktuellen Forschung einer Gruppe des Laboratoriums für Organische Chemie unter der Anleitung von Doktorierenden.
SkriptKein Skript.
LiteraturKeine Pflichtliteratur. Literatur wird von den betreuenden Doktorierenden angegeben bzw. zur Verfügung gestellt.
Voraussetzungen / BesonderesVoraussetzungen: bestandenes Praktikum Organische Chemie I (529-0229-00); bestandene Sessionsprüfung Organische Chemie I (529-0221-00 bzw. 529-1011-00) / Organische Chemie II (529-0222-00 bzw. 529-1012-00). Die Zahl der Teilnehmenden ist auf 12 beschränkt.
551-1147-00LBioactive Natural Products from Bacteria Belegung eingeschränkt - Details anzeigen
Number of participants limited to 7.

The enrolment is done by the D-BIOL study administration.
W6 KP7GJ. Piel
KurzbeschreibungLab course. In small groups projects of relevance to current research questions in the field of bacterial natural product biosynthesis are addressed.
LernzielIntroduction to relevant subjects of the secondary metabolism of bacteria. Training in practical work in a research laboratory. Scientific writing in form of a research report.
InhaltResearch project on bacteria that produce bioactive natural products (e.g., Streptomycetes, Cyanobacteria, uncultivated bacteria). The techniques used will depend on the project, e.g. PCR, cloning, natural product analysis, precursor feeding studies, enzyme expression and analysis.
Skriptnone.
LiteraturWill be provided for each of the projects at the beginning of the course.
551-1554-00LMultigene Expression in Mammalian Cells Belegung eingeschränkt - Details anzeigen
Number of participants limited to 5.

The enrolment is done by the D-BIOL study administration.
W6 KP7GP. Berger, G. Schertler
KurzbeschreibungGenetic engineering of mammalian cells with multiple expression cassettes is an essential need in contemporary cell biology. It is useful for protein expression for structural studies, the reprogramming of somatic cells, or for the expression of several fluorescently-tagged sensors. In this course, we use MultiLabel (Kriz et al., Nat. Commun., 2010) to create multigene expression plasmids.
LernzielStudents will learn to design and clone multigene expression constructs for mammalian cells. The functionality of the constructs will be tested by immunofluorescence microscopy or Western blotting.
InhaltWe will clone fluorescently-tagged markers for subcellular compartments, assemble them to a multigene expression construct and transfect them into mammalian cells. These markers of subcellular compartments will be used to study the trafficking of activated receptors (e.g. serotonin receptor). Pictures will be taken on our microscopes and then we will quantify colocalization.
Skriptnone
551-0436-00LCryo-electron Microscopic Studies of Ribosomal Complexes with Biomedically Important Viral mRNAs Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.

The enrolment is done by the D-BIOL study administration.
W6 KP7GN. Ban, D. Böhringer, M. A. Leibundgut
KurzbeschreibungSome viral mRNAs, such as from Hepatitis C virus, hijack cellular translational machinery by binding directly to the ribosome and circumventing the need for cellular initiation factors. They accomplish this through structured elements within the mRNAs called internal ribosome entry sites (IRESs). Participants of this course will visualize ribosomes in complex with viral IRESs at high resolution.
LernzielThe goal of the course is to acquire the most important techniques and methods for the purification and structural characterisation of macromolecular complexes by transmission electron microscopy. The emphasis of the course is on the special practical requirements for the application of these techniques on macromolecular structures in the MDa range.
InhaltProtein synthesis is a very energy intensive process that can consume over half the total metabolism of a cell. In eukaryotes, translation is therefore tightly regulated at the stage of initiation. Regulatory processes are much more complex at this step than in prokaryotes and a large number of RNA modification processes and translation initiation factors are required to ensure faithful initiation, elongation and termination of translation. Viral messenger RNAs are often produced by their own machinery, however, and need to be incorporated into the host translation machinery without the usual processing and therefore many viruses have developed strategies to circumvent the need for initiation factors. They accomplish this through highly structured elements within their RNA called internal ribosome entry sites (IRESs) that are able to initiate translation without the normal signals. Some viral IRESs, such as the IRESs from polio-virus or HIV, require most of the normal eIFs and even additional proteins. Others, such as the hepatitis C virus IRES, are able to bind directly to the ribosome and need only a few of the normal initiation factors. Within the Ban lab, we have studied, and continue to investigate, medically relevant viral IRESs. The course will involve producing, and attempting to determine the structures of, IRESs that have yet to have had their ribosome-bound structures resolved.

A variety of purification techniques, including preparative gel electrophoresis and ultracentrifugation, will be used during the purification of macromolecular complexes. Purified assemblies will be then investigated functionally. Students will then characterise their samples structurally through transmission electron cryo-microscopy (cryo-EM), including sample preparation, microscopy, data evaluation and the calculation of densities. Finally, students will learn how to build and refine molecular models into parts of the calculated cryo-EM density. The participants will be working on a closed project related to current research within the laboratory and throughout the course the practical work will be accompanied by brief theoretical introductions. The principal aim of the course is to strengthen the skills required to independently conduct meaningful biophysical and biochemical experiments and to provide an early introduction into the structural characterisation of cellular macromolecular assemblies.
SkriptA script will be distributed at the beginning of the course that will cover the experiments to be performed, provide references to the relevant literature and suggest points for further consideration for interested students.
LiteraturLiterature
A basic overview is provided within the references below. Further reading and citations shall be detailed in the course script.
- A. Fersht, Structure and mechanism in protein science, Freeman, 1999 (Chapters 1 and 6).
- M. van Heel et al., Single-particle electron cryo microscopy: towards atomic resolution, Quart. Rev. Biophys. (33), 307-369 (2000).
Voraussetzungen / BesonderesThe course will be held in English. Students should have either completed courses:
551-0307-00L Biomolecular Structure and Mechanism I: Protein Structure and Function
551-0307-01L Biomolecular Structure and Mechanism II: Large Cellular Machines
or equivalent courses covering the structure and function of biological macromolecules.
Blockkurse im 3. Semesterviertel
Von 3.4.2020 bis 6.5.2020
NummerTitelTypECTSUmfangDozierende
551-0362-00LMolecular Health: Biomedical Analysis of the Extracellular Interactome Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.

The enrolment is done by the D-BIOL study administration.
W6 KP7GB. Wollscheid, E. Tschudy-Milani
KurzbeschreibungIn this course you will learn to measure, integrate, analyze and validate the cellular surfaceome as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to establish the surfaceome proteotype and its signaling interaction networks.
Lernziel"If a cell surface molecule such as the B cell receptor would have the size of a human being, then the cell surface of a B cell would have roughly the size of three times NYC Central Park." How many people/proteins/proteoforms reside in this space ("Surfaceome")? Similar to humans, proteins don't act alone. Function is encoded in dynamic protein-protein interactions. How are these proteoforms organized in signaling islands/networks in order to fulfill specific cellular functions ("Interactome")? What are the ligands interacting with the surfaceome to communicate information from other cells & tissues in the body? What goes wrong in these signaling islands if we get sick?

In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome and its signaling islands as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to generate unprecedented data to establish the surfaceome proteotype and its signaling interaction networks. This digital proteotype data layer provides the basis for generating qualitative and quantitative surfaceome models explaining how molecular nanoscale organization influences cellular signaling and biological function.
Inhalt"If a cell surface molecule such as the B cell receptor would have the size of a human being, then the cell surface of a B cell would have roughly the size of three times NYC Central Park." How many people/proteins/proteoforms reside in this space ("Surfaceome")? Similar to humans, proteins don't act alone. Function is encoded in dynamic protein-protein interactions. How are these proteoforms organized in signaling islands/networks in order to fulfill specific cellular functions ("Interactome")? What are the ligands interacting with the surfaceome to communicate information from other cells & tissues in the body? What goes wrong in these signaling islands if we get sick?

In this course you will learn to measure, integrate, analyze and validate the cellular surfaceome and its signaling islands as a complex information gateway connecting the intracellular to the extracellular interactome. You will apply next generation technologies at the interface of biology, chemistry, medicine and bioinformatics to generate unprecedented data to establish the surfaceome proteotype and its signaling interaction networks. This digital proteotype data layer provides the basis for generating qualitative and quantitative surfaceome models explaining how molecular nanoscale organization influences cellular signaling and biological function.
LiteraturD. Bausch-Fluck, E. S. Milani, B. Wollscheid, Surfaceome nanoscale organization and extracellular interaction networks, Curr. Opin. Chem. Biol. 48, 26–33 (2019).

Link
Voraussetzungen / BesonderesThis course requires a basic knowledge in mass spectrometry based proteomics and experience in computational data processing using R or MatLab. Ideally this course should be combined with course 551-0352-00L "Introduction to Mass Spectrometry-based Proteomics".
529-0810-01LOrganische Chemie II (für D-BIOL) Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 12

Bitte melden Sie sich möglichst vor Ablauf der Herbstsemester-Vorlesungszeit bei Prof. C. Thilgen (Link) an. Sie erhalten eine Rückmeldung, ob Sie am Praktikum teilnehmen können.

Die Belegung erfolgt nur über das Studiensekretariat D-BIOL.

Die Lehrsprache hängt de facto von der betreuenden Person ab.
W12 KP4PC. Thilgen
KurzbeschreibungBearbeiten eines organisch-synthetischen Teilprojekts aus der aktuellen Forschung einer Gruppe des Laboratoriums für Organische Chemie unter der Anleitung von Doktorierenden.
LernzielErlernen von Planung und Durchführung anspruchsvoller Mehrstufensynthesen unter Einbezug moderner Methoden; vertieftes Verständnis organisch-chemischer Reaktionen durch Experimente; Entwickeln eines organisch-synthetischen Forschungsprojekts; akkurates Protokollieren, Verfassen eines Berichts im Stil einer Veröffentlichung und Präsentieren der Ergebnisse in Form eines Kurzvortrags.
InhaltBearbeiten eines organisch-synthetischen Teilprojekts aus der aktuellen Forschung einer Gruppe des Laboratoriums für Organische Chemie unter der Anleitung von Doktorierenden.
SkriptKein Skript.
LiteraturKeine Pflichtliteratur. Literatur wird von den betreuenden Doktorierenden angegeben bzw. zur Verfügung gestellt.
Voraussetzungen / BesonderesVoraussetzungen: bestandenes Praktikum Organische Chemie I (529-0229-00); bestandene Sessionsprüfung Organische Chemie I (529-0221-00 bzw. 529-1011-00) / Organische Chemie II (529-0222-00 bzw. 529-1012-00). Die Zahl der Teilnehmenden ist auf 12 beschränkt.
551-0344-00LPlant-Microbe Interactions Belegung eingeschränkt - Details anzeigen
Number of participants limited to 10.

The enrolment is done by the D-BIOL study administration.
W6 KP7GH.‑M. Fischer, J. Vorholt-Zambelli
KurzbeschreibungLab course. In small groups projects of relevance to current research questions in the field of plant-microbe interactions are addressed.
LernzielIntroduction to relevant subjects of the biology of plant-associated microorganisms. Training in practical work in a research laboratory. Exposure to current research topics in the field of plant-microbe interactions. Scientific writing in form of a research report.
InhaltResearch project on plant-associated microorganisms (i.e. Bradyrhizobium, Methylobacterium, Sphingomonas). The techniques used will depend on the project, e.g. PCR, cloning, community analysis, plant inoculation experiments, phenotypic analysis, plant transformation, (fluorescence) microscopy, monitoring gene expression
Skriptnone
LiteraturWill be provided for each of the projects at the beginning of the course.
551-1556-00LMacromolecular Structure Determination Using Modern Methods Belegung eingeschränkt - Details anzeigen
Number of participants limited to 11 in the 3rd semester quarter of the spring semester

Number of participants limited to 12 in the 4th semester quarter of the spring semester

The block course will only take place with a minimum of 4 participants.

The enrolment is done by the D-BIOL study administration.
W6 KP7GK. Locher, G. Schertler
KurzbeschreibungThis course will expose the students to two prominent techniques for high-resolution structural characterization of biological macromolecules. The students will have the opportunity to get hands-on experience in either cryo-electron microscopy (ETH) or X-ray crystallography (PSI).
LernzielThe goal of this course is to introduce the students to the principles of high-resolution structure determination. Students will conduct hands-on experiments and use computational techniques for data processing.
InhaltAt the ETH the students will prepare and vitrify a protein and then image it on a cryo-TEM. Next, the students will process the data and build an atomic model into the EM map.

At the PSI the students will purify and crystallize a membrane protein, collect X-ray diffraction data using synchrotron X-ray source or with cryo-EM, analyze and build an atomic model into a density map. They will refine this model and interpret and illustrate the determined structure. The course work is trying to present insights in the use of structural information. The course also includes a demonstration of the Synchrotron capabilities at the Paul Scherrer Institute (SLS).
Voraussetzungen / BesonderesThe students will be split into two groups for the practical part of the work: One group will work at ETH Hönggerberg, the other at the Paul Scherrer Institute (PSI) at Villigen. All students will spend one full day at the PSI for a tour of the facilities, including a visit of the synchrotron beam lines of the Swiss Light Source SLS.

The students joining the ETH Hönggerberg group will spend the majority of the time on data processing and are therefore expected to have some basic knowledge of bash terminal commands. Basic physics, optics and linear algebra knowledge is also helpful. By the end of the course, the students will be expected to understand concepts such as the difference between Fourier and real space, image formation, contrast transfer, fast Fourier transfer and Fourier shell correlation.
551-1312-00LRNA-Biology II Belegung eingeschränkt - Details anzeigen
Number of participants limited to 16.

The enrolment is done by the D-BIOL study administration.
W6 KP7GS. Jonas, F. Allain, C. Beyer, U. Kutay, O. Voinnet, K. Weis
KurzbeschreibungIntroduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells.
LernzielThe students will obtain an overview about the diversity of current RNA-research. They will learn to design experiments and use techniques necessary to analyze different aspects of RNA biology. Through lectures and literature seminars, they will learn about the burning questions of RNA research and discuss approaches to address these questions experimentally. In practical lab projects the students will work in one of the participating laboratories. Finally, they will learn how to present and discuss their data in an appropriate manner. Student assessment is a graded semester performance based on individual performance in the laboratory, the written exam and the project presentation.
SkriptRelevant material from the lectures will be made available during the course via the corresponding Moodle page.
LiteraturDocumentation and recommended literature will be provided at the beginning and during the course.
551-1300-00LCause and Consequences of Unstable Genomes Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.

The enrolment is done by the D-BIOL study administration.
W6 KP7GJ. Fernandes de Matos, Y. Barral, C. Beyer, K. Bomblies, M. Jagannathan, R. Kroschewski
KurzbeschreibungThe course will introduce students to key concepts and laboratory research within the broad field of "Genome stability".
LernzielStudents will learn to design, apply and evaluate current research strategies in a wide range of modern research areas encompassing the broad field of "Genome stability".
InhaltThe course will consist of lectures, practical laboratory work in small groups, informal progress report sessions, and preparation and presentation of a poster. Lectures will be presented mainly at the start of the course to expose students to key concepts and techniques in the field. Students will team into small groups and work in one laboratory for the rest of the course. Students will meet regularly for informal "progress report" discussions of their projects. Student performance will be assessed based on the quality of their practical work, a written exam on frontal lecture material, and a poster presentation of their practical work.
LiteraturDocumentation and recommended literature in the form of review articles and selected primary literature will be provided during the course.
Voraussetzungen / BesonderesThis course will be taught in English.
551-1302-00LSynthetic Genomics Belegung eingeschränkt - Details anzeigen
Findet dieses Semester nicht statt.
Number of participants limited to 6.

The enrolment is done by the D-BIOL study administration.
W6 KP7GB. Christen
KurzbeschreibungLab course on experimental and computational approaches in synthetic microbiology. Participants work in small groups to address current questions in the field of synthetic genomics.
LernzielThe course covers high-throughput biology techniques and design approaches to engineer large-scale synthetic DNA constructs ranging form pathways to entire bacterial genomes. Training in experimental and computational work in a research laboratory.
InhaltResearch project in synthetic biology. Learn basics of DNA part definition, sequence design, de novo DNA synthesis and assembly strategies used for synthetic genomics. Discuss recent advances and current limitations in the field.

Soft skills to be trained: scientific project planning, team-work, presentation and reporting.
Blockkurse im 4. Semesterviertel
Von 7.5.2020 bis 29.5.2020
NummerTitelTypECTSUmfangDozierende
551-0386-00LMikrobielle Oekologie Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 15

Die Belegung erfolgt durch das D-BIOL Studiensekretariat.
W6 KP7GM. Lever
KurzbeschreibungMikroorganismen können praktisch alle terrestrische und aquatische Habitate besiedeln und die vielfältigsten Stoffwechselprozesse katalysieren. Im Kurs “Mikrobielle Oekologie” werden die grundlegenden Konzepte des mikrobiellen Lebens in natürlichen Habitaten besprochen, mit ausgewählten Experimenten und Exkursionen illustriert und mit Literaturarbeiten vertieft.
LernzielIm Kurs sollen sich die Studierenden mit den grundlegenden Konzepten vertraut machen, die für das mikrobielle Leben in natürlichen Habitaten entscheidend sind. Die Kursteilnehmer sollen die mikrobiellen Strukturen und Funktionen in aquatischen und terrestrischen Systemen sowohl qualitativ als auch quantitativ erfassen können.
InhaltDer Kurs umfasst Vorlesungen, experimentelle Arbeiten, Exkursionen und Literaturstudien. Teile der Vorlesung “Umweltmikrobiologie“ (Dozenten M. Lever & M. Schroth) werden in den Kurs inkorporiert. Im Rahmen von experimentellen Arbeiten werden die Studierenden lernen, traditionelle wie auch molekulare mikrobiologische Methoden gezielt einzusetzen. Darüber hinaus werden die Studierenden lernen, mikrobiell ökologische Fragestellungen mit Hilfe von biogeochemischen Methoden anzugehen. Ausgewählte Facetten der mikrobiellen Ökologie (z.B. Quellen und Senken von Methan, Interaktion von Mikroorganismen mit mineralischen Oberflächen, mikrobielle Energie- und Nährstoffkreisläufe) werden mit Hilfe von Exkursionen und Literaturstudien vertieft.
SkriptSchriftliche Unterlagen werden im Verlaufe des Kurses abgegeben.
LiteraturBrock Biology of Microorganisms, Prentice Hall, 2003
551-0376-00LExperimentelle Pflanzenökologie Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 20
Wird nur bei mindestens 4 Teilnehmenden durchgeführt.

Die Belegung erfolgt durch das D-BIOL Studiensekretariat.
W6 KP7GD. Ramseier, H. G. M. Olde Venterink
KurzbeschreibungDer Blockkurs gibt eine Einführung in die experimentelle Pflanzenökologie. Dabei wird mittels Vorlesungen, Demonstrationen, Exkursionen und eigenen Experimenten ein weites Spektrum von praxisnahen (für die Naturschutzpraxis) Experimenten über Einfluss von "global change"-Faktoren auf Ökosysteme bis zu Grundlagenforschung zur Koexistenz von Pflanzen in Ökosystemen abgedeckt.
Lernziel- Kennen lernen und evaluieren verschiedener experimenteller Ansätze, der Messmethoden und der benötigten Instrumente in der experimentellen Pflanzenökologie.
- Erlangung praktischer Fähigkeiten zur Durchführung und Auswertung pflanzenökologischer Experimente
InhaltExperimente in der Pflanzenökologie gewinnen zunehmend an Bedeutung zur Abschätzung des Einflusses von "Global Change" und invasiven Arten auf Ökosysteme und deren Funktionen und "ecosystem Services". Ausserdem gibt es viele Renaturierungsprojekte, wo man vom "trial - error"-Prinzip wegkommen möchte und aufgrund gezielter Experimente den Erfolg von Renaturierungsmassnahmen antizipieren möchte um die Planung entsprechend anpassen zu können.
In diesem Blockkurs wird ein Einblick in dieses Fachgebiet mittels Vorlesungen, Demonstrationen, Exkursionen, Literaturstudium und allem voran Experimenten in Gruppen vermittelt. In einem theoretischen Teil werden unter anderem Vor- und Nachteile verschiedener experimenteller Ansätze, Messmethoden und Geräten diskutiert.
Im praktischen Teil werde die Studierenden gruppenweise Experimente von A bis Z durchführen; dies beinhaltet klare Fragestellungen erarbeiten, Literatursuche, Anlage und Unterhalt der Experimente, Messungen, allenfalls chemische Analysen, Auswertungen und Vorträge. Beispiele von Experimenten: a) Einfluss funktioneller Gruppen auf die kühlende Wirkung von Flachdachbegrünungen; b) Einfluss der Mobilität von Nährstoffen im Boden auf die Konkurrenz und die Koexistenz von Pflanzen; c) Verhindert P-Mangel die weitere Ausbreitung von Amorpha fruticosa, einer invasiven Fabaceae am Tagliamento (N-Italien)? Wie optimieren Samen ihr Keimungsverhalten? Wie kann die Keimung für Renaturierungsprojekte oder Flachdachbegrünungen verbessert werden?
Auf einer der Exkursionen werden wir das Renaturierungsprojekt Seebachtalseen (Link), an welchem einer der Dozenten für die Wieder-etablierung von Flachmoorgesellschaften seit vielen Jahren beteiligt ist, besuchen. Auf einer andern Exkursionen werden wir einen langjährigen Flachdachversuch betreffs Einfluss verschiedener Substrate und unterschiedlicher Substratdicke auf die Entwicklung der Vegetation beleuchten.
SkriptUnterlagen werden im Kurs verteilt
Voraussetzungen / BesonderesDie Art von pflanzenökologischen Versuchen, wie sie innerhalb dieses Kurses angelegt werden, dauern typischerweise 6-8 Wochen. Daher werden sie vor dem eigentlichen Block durch die Studierenden eingerichtet und im Block (letztes Semesterquartal) geerntet. Wir geben zu Beginn des Semesters eine 45 minütige Einführung (Termin nach Absprache), bei welcher die Themenwahl und die Gruppeneinteilung stattfinden wird. Die Experimente werden danach gruppenweise angelegt. Die vor dem eigentlichen Block aufgewendete Zeit kann kompensiert werden.
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