Suchergebnis: Katalogdaten im Frühjahrssemester 2019

MAS in Medizinphysik Information
Fachrichtung: Allg. Medizinphysik und Biomedizinisches Ingenieurwesen
Vertiefung Bioengineering
Kernfächer
NummerTitelTypECTSUmfangDozierende
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 KP2GA. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
InhaltTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include osteogenesis (bones), chondrogenesis (cartilage), and tendogenesis (tendons). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Skriptn/a
LiteraturTopical Scientific Manuscripts
376-1614-00LPrinciples in Tissue EngineeringW3 KP2VK. Maniura, J. Möller, M. Zenobi-Wong
KurzbeschreibungFundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
LernzielUnderstanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed.
InhaltThis class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
SkriptHandouts provided during the classes and references therin.
LiteraturThe molecular Biology of the Cell, Alberts et al., 5th Edition, 2009.
Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002
Praktika
NummerTitelTypECTSUmfangDozierende
465-0800-00LPractical Work Belegung eingeschränkt - Details anzeigen
Nur für MAS in Medizinphysik
O4 KPexterne Veranstalter
KurzbeschreibungThe practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution.
LernzielThe practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem.
Wahlfächer
Von den beiden Lerneinheiten 376-1622-00L Practical Methods in Tissue Engineering (angeboten im Herbstsemester) und 376-1624-00L Practical Methods in Biofabrication (angeboten im Frühjahrssemester) dürfen nicht beide angerechnet werden.
NummerTitelTypECTSUmfangDozierende
151-0622-00LMeasuring on the Nanometer ScaleW2 KP2GA. Stemmer
KurzbeschreibungIntroduction to theory and practical application of measuring techniques suitable for the nano domain.
LernzielIntroduction to theory and practical application of measuring techniques suitable for the nano domain.
InhaltConventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters.
SkriptClass notes and special papers will be distributed.
151-0630-00LNanorobotics Information W4 KP2V + 1US. Pané Vidal
KurzbeschreibungNanorobotics is an interdisciplinary field that includes topics from nanotechnology and robotics. The aim of this course is to expose students to the fundamental and essential aspects of this emerging field.
LernzielThe aim of this course is to expose students to the fundamental and essential aspects of this emerging field. These topics include basic principles of nanorobotics, building parts for nanorobotic systems, powering and locomotion of nanorobots, manipulation, assembly and sensing using nanorobots, molecular motors, and nanorobotics for nanomedicine.
227-0946-00LMolecular Imaging - Basic Principles and Biomedical ApplicationsW2 KP2VM. Rudin
KurzbeschreibungConcept: What is molecular imaging.
Discussion/comparison of the various imaging modalities used in molecular imaging.
Design of target specific probes: specificity, delivery, amplification strategies.
Biomedical Applications.
LernzielMolecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research.
InhaltConcept: What is molecular imaging.
Discussion/comparison of the various imaging modalities used in molecular imaging.
Design of target specific probes: specificity, delivery, amplification strategies.
Biomedical Applications.
376-1624-00LPractical Methods in Biofabrication Belegung eingeschränkt - Details anzeigen
Number of participants limited to 12.
W5 KP4PM. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak
KurzbeschreibungBiofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft.
LernzielThe objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project.
Voraussetzungen / BesonderesNot recommended if passed 376-1622-00 Practical Methods in Tissue Engineering
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