Search result: Catalogue data in Spring Semester 2018
MAS in Medical Physics  | ||||||
 Specialization: General Medical Physics and Biomedical Engineering | ||||||
| Major in Biocompatible Materials | ||||||
| Core Courses 376-1622-00L Practical Methods in Tissue Engineering (offered in the Autumn Semester) and 376-1624-00L Practical Methods in Biofabrication (offered in the Spring Semester) are mutually exclusive to be eligible for credits. | ||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|---|
| 151-0980-00L | Biofluiddynamics | W | 4 credits | 2V + 1U | D. Obrist, P. Jenny | |
| Abstract | Introduction to the fluid dynamics of the human body and the modeling of physiological flow processes (biomedical fluid dynamics). | |||||
| Learning objective | A basic understanding of fluid dynamical processes in the human body. Knowledge of the basic concepts of fluid dynamics and the ability to apply these concepts appropriately. | |||||
| Content | This lecture is an introduction to the fluid dynamics of the human body (biomedical fluid dynamics). For selected topics of human physiology, we introduce fundamental concepts of fluid dynamics (e.g., creeping flow, incompressible flow, flow in porous media, flow with particles, fluid-structure interaction) and use them to model physiological flow processes. The list of studied topics includes the cardiovascular system and related diseases, blood rheology, microcirculation, respiratory fluid dynamics and fluid dynamics of the inner ear. | |||||
| Lecture notes | Lecture notes are provided electronically. | |||||
| Literature | A list of books on selected topics of biofluiddynamics can be found on the course web page. | |||||
| 376-1308-00L | Development Strategies for Medical Implants  Number of participants limited to 25 until 30. Assignments will be considered chronological. | W | 3 credits | 2V + 1U | J. Mayer-Spetzler, M. Rubert | |
| Abstract | Introduction to development strategies for implantable devices considering the interdependecies of biocompatibility, clinical and economical requirements ; discussion of the state of the art and actual trends in in orthopedics, sports medicine, traumatology and cardio-vascular surgery as well as regenerative medicine (tissue engineering). | |||||
| Learning objective | Basic considerations in implant development Concept of structural and surface biocompatiblity and its relevance for the design of implant and surgical technique Understanding of conflicting factors, e.g. clinical need, economics and regulatory requirements Concepts of tissue engineering, its strengths and weaknesses as current and future clinical solution | |||||
| Content | Biocompatibility as bionic guide line for the development of medical implants; implant and implantation related tissue reactions, biocompatible materials and material processing technologies; implant testing and regulatory procedures; discussion of the state of the art and actual trends in implant development in orthopedics, sports medicine, traumatology, spinal and cardio-vascular surgery; introduction to tissue engineering. Selected topics will be further illustrated by commented movies from surgeries. Seminar: Group seminars on selected controversial topics in implant development. Participation is mandatory Planned excursions (limited availability, not mandatory, to be confirmed): 1. Participation (as visitor) on a life surgery (travel at own expense) | |||||
| Lecture notes | Scribt (electronically available): - presented slides - selected scientific papers for further reading | |||||
| Literature | Textbooks on selected topics will be introduced during the lectures | |||||
| Prerequisites / Notice | Achieved Bachelor degree is mandatory The number of participants in the course is limited to 25-30 students in total. Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is on the student's own responsability. | |||||
| 376-1392-00L | Mechanobiology: Implications for Development, Regeneration and Tissue Engineering | W | 3 credits | 2G | A. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong | |
| Abstract | This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs. | |||||
| Learning objective | This course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena. | |||||
| Content | Typically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance. The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering. | |||||
| Lecture notes | n/a | |||||
| Literature | Topical Scientific Manuscripts | |||||
| 376-1614-00L | Principles in Tissue Engineering | W | 3 credits | 2V | K. Maniura, J. Möller, M. Zenobi-Wong | |
| Abstract | Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Learning objective | Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed. | |||||
| Content | This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||
| Lecture notes | Handouts provided during the classes and references therin. | |||||
| Literature | The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 | |||||
| 376-1624-00L | Practical Methods in Biofabrication Number of participants limited to 12. | W | 5 credits | 4P | M. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak | |
| Abstract | Biofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft. | |||||
| Learning objective | The objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project. | |||||
| Prerequisites / Notice | Not recommended if passed 376-1622-00 Practical Methods in Tissue Engineering | |||||
| Practical Work | ||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |
| 465-0800-00L | Practical Work Only for MAS in Medical Physics | O | 4 credits | external organisers | ||
| Abstract | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
| Learning objective | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
| Electives | ||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |
| 151-0622-00L | Measuring on the Nanometer Scale | W | 2 credits | 2G | A. Stemmer, T. Wagner | |
| Abstract | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Learning objective | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||
| Content | Conventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters. | |||||
| Lecture notes | Class notes and special papers will be distributed. | |||||
Page
1
of
1
