Search result: Catalogue data in Spring Semester 2018

Number	Title	Type	ECTS	Hours	Lecturers
MAS in Medical Physics
Specialization: General Medical Physics and Biomedical Engineering
Major in Bioengineering
Core Courses
376-1392-00L	Mechanobiology: Implications for Development, Regeneration and Tissue Engineering	W	3 credits	2G	A. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
Abstract	This course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
Learning objective	This course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
Content	Typically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance. The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Lecture notes	n/a
Literature	Topical Scientific Manuscripts
376-1614-00L	Principles in Tissue Engineering	W	3 credits	2V	K. Maniura, J. Möller, M. Zenobi-Wong
Abstract	Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
Learning objective	Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed.
Content	This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
Lecture notes	Handouts provided during the classes and references therin.
Literature	The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002

Practical Work
Number	Title	Type	ECTS	Hours	Lecturers
465-0800-00L	Practical Work Only for MAS in Medical Physics	O	4 credits		external organisers
Abstract	The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution.
Learning objective	The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem.

Electives 376-1622-00L Practical Methods in Tissue Engineering (offered in the Autumn Semester) and 376-1624-00L Practical Methods in Biofabrication (offered in the Spring Semester) are mutually exclusive to be eligible for credits.
Number	Title	Type	ECTS	Hours	Lecturers
151-0622-00L	Measuring on the Nanometer Scale	W	2 credits	2G	A. Stemmer, T. Wagner
Abstract	Introduction to theory and practical application of measuring techniques suitable for the nano domain.
Learning objective	Introduction to theory and practical application of measuring techniques suitable for the nano domain.
Content	Conventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters.
Lecture notes	Class notes and special papers will be distributed.
151-0630-00L	Nanorobotics	W	4 credits	2V + 1U	S. Pané Vidal
Abstract	Nanorobotics is an interdisciplinary field that includes topics from nanotechnology and robotics. The aim of this course is to expose students to the fundamental and essential aspects of this emerging field.
Learning objective	The aim of this course is to expose students to the fundamental and essential aspects of this emerging field. These topics include basic principles of nanorobotics, building parts for nanorobotic systems, powering and locomotion of nanorobots, manipulation, assembly and sensing using nanorobots, molecular motors, and nanorobotics for nanomedicine.
227-0946-00L	Molecular Imaging - Basic Principles and Biomedical Applications	W	2 credits	2V	M. Rudin
Abstract	Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications.
Learning objective	Molecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research.
Content	Concept: What is molecular imaging. Discussion/comparison of the various imaging modalities used in molecular imaging. Design of target specific probes: specificity, delivery, amplification strategies. Biomedical Applications.
376-1624-00L	Practical Methods in Biofabrication Number of participants limited to 12.	W	5 credits	4P	M. Zenobi-Wong, S. Schürle-Finke, K. Würtz-Kozak
Abstract	Biofabrication involves the assembly of materials, cells, and biological building blocks into grafts for tissue engineering and in vitro models. The student learns techniques involving the fabrication and characterization of tissue engineered scaffolds and the design of 3D models based on medical imaging data. They apply this knowledge to design, manufacture and evaluate a biofabricated graft.
Learning objective	The objective of this course is to give students hands-on experience with the tools required to fabricate tissue engineered grafts. During the first part of this course, students will gain practical knowledge in hydrogel synthesis and characterization, fuse deposition modelling and stereolithography, bioprinting and bioink design, electrospinning, and cell culture and viability testing. They will also learn the properties of common biocompatible materials used in fabrication and how to select materials based on the application requirements. The students learn principles for design of 3D models. Finally the students will apply their knowledge to a problem-based project.
Prerequisites / Notice	Not recommended if passed 376-1622-00 Practical Methods in Tissue Engineering

Page 1 of 1