Search result: Catalogue data in Spring Semester 2018

Biology Master Information
Elective Major Subject Areas
Elective Major: Microbiology and Immunology
Compulsory Concept Courses
551-0314-00LMicrobiology (Part II)O3 credits2VW.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli
AbstractAdvanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
ObjectiveThis concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
ContentAdvanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
Lecture notesUpdated handouts will be provided during the class.
LiteratureCurrent literature references will be provided during the lectures.
Prerequisites / NoticeEnglish
551-0318-00LImmunology IIO3 credits2VM. Kopf, S. R. Leibundgut, A. Oxenius, E. Slack, further lecturers
AbstractIntroduction into the cellular and molecular basis of the immune system and immune responses against diverse pathogens, tumors, transplants, and self (autoimmunity)
ObjectiveThe lectures will provide a detailed understanding:
- how innate and adaptive immune responses interact at the cellular and molecular level.
- how the immune system recognizes and fights against pathogenic microorganisms including viruses, bacteria, and parasites.
- why lymphocytes tolerate self molecules.
- about function and dysfunction the intestinal immune system.
- immunopathology and inflammatory diseases.
ContentThe aim of lecture is to understand:
> How pathogens are recognized by the innate immune system
> Immune defense against various pathogens
> Immunology of the skin, lung and intestines
> Tumor immunology
> Migration and homing of immune cells
> tolerance and autoimmunity
> T cell memory
Lecture notesPresentations of the lecturers are available at the Moodle link
LiteratureRecommended: Kuby Immunology (Freeman)
Elective Compulsory Master Courses
701-1310-00LEnvironmental MicrobiologyW3 credits2VM. H. Schroth, M. Lever
AbstractMicroorganisms catalyze a large number of reactions that are of great importance to terrestrial and aquatic environments. To improve our understanding of the dynamics of a specific environment, it is important to gain a better understanding of microbial structures and their functions under varying environmental conditions.
ObjectiveStudents will learn basic concepts in microbial ecology. Qualitative and quantitative concepts will be presented to assess microbial communities and associated processes in terrestrial and aquatic environments. Microbial diversity in such ecosystems will be illustrated in discussions of selected habitats.
ContentLectures will cover general concepts of environmental microbiology including (i) quantification of microbial processes, (ii) energy fluxes in microbial ecosystems, (iii) application of state-of-the-art microbiological and molecular tools, and (iv) use of isotope methods for identification of microbial structures and functions.
Topics to illustrate the microbial diversity of terrestrial and aquatic ecosystems will include (i) interactions between microbes and mineral/metallic solid phases, (ii) microbial carbon and nutrient cycling, (iii) microbial processes involved in the turnover of greenhouse gases, (iv) biofilms and microbial mats, (v) bioremediation, (vi) microorganisms in extreme habitats, and (vii) microbial evolution and astrobiology.
Lecture notesavailable at time of lecture - will be distributed electronically as pdf's
LiteratureBrock Biology of Microorganisms, Madigan M. et al., Pearson, 14th ed., 2015
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.
Requires application; selected applicants will be notified before the first week of lectures.
W4 credits2SW.‑D. Hardt, L. Eberl, U. F. Greber, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander
AbstractLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
ObjectiveWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Contentfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
Lecture notesTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteratureTeachers will provide the research papers to be discussed.
Prerequisites / NoticeRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to Link and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
551-1118-00LCutting Edge Topics: Immunology and Infection Biology II Information W2 credits1SA. Oxenius, B. Becher, C. Halin Winter, N. C. Joller, M. Kopf, S. R. Leibundgut, C. Münz, R. Spörri, M. van den Broek
AbstractWeekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion.
ObjectiveWeekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion.
The aim of this course is to confront students with current research topics and with scientific presentation. The course offers the opportunity to gain in depth knowledge about diverse topics which are often only briefly touched in the concept courses and to engage in discussion with experts in the field.
ContentImmunology and infection biology.
The specific topics are variable and depend each semester on the list of invited experts.
551-1104-00LSelected Topics in Forest Mycology
Does not take place this semester.
W2 credits1V
AbstractLifestyles and functions of symbiotic, saprobic and pathogenic fungi, communities of mycorrhizas and its functional aspects, evolution and phylogenetic aspects of plant-fungal interactions, inter- and intraspecific interactions of mycelia, role of fungi in nutrient mobilisation and weathering.
ObjectiveIn-depth knowledge of the biology and ecology of fungi in the forest. Self-examination of the current literature.
ContentIn-depth treatment of selected topics of fungi in the forest ecosystem: Lifestyles and functions of symbiotic, saprobic and pathogenic fungi, communities of mycorrhizas and its functional aspects, evolution and phylogenetic aspects of plant-fungal interactions, inter- and intraspecific interactions of mycelia, role of fungi in nutrient mobilisation and weathering.
Basics will be presented in lectures. In addition, individual study of the learning matter with the help of current literature and presentations.
Lecture notesDocuments for the course will be handed out.
LiteratureSmith S.E. and Read D.J. 1997. Mycorrhizal Symbiosis. Academic Press, 2nd ed., pp. 605.
551-0216-00LField Course in Mycology Restricted registration - show details
Number of participants limited to 8.
W3 credits3.5PA. Leuchtmann
AbstractField excursions with collecting of fungi, and study of collections in the course room. Main focus are small fungi (ascomycetes): you will receive insight into the diversity of fungi and an introduction to species identification. Furthermore, the ecology and function of fungi in selected habitats will be discussed, and selected examples of edible and poisonous mushrooms shown.
ObjectiveExtended knowledge in taxonomy and systematics of fungi, in particular Ascomycetes. Participants know about ecological functions of fungi as mutualists, saprobes or parasites of plants in various ecosystems.
ContentEinführung ins Reich der Pilze, Merkmale der Pilze und Überblick über deren systematische Gliederung. Exkursionen zum Sammeln von Ascomyceten in ausgewählten Lebensräumen. Kennenlernen von notwendigen Sammel- und Präparationstechniken, Einführung in die Ökologie und Funktion der Pilze, Untersuchung und Bestimmen von Pilzen mit optischen Hilfsmitteln im Kursraum, Einblick in Formenvielfalt ausgewählter Pilzgruppen, Beispiele von Speisepilzen und deren Verwendung.
Lecture notesKursunterlagen werden abgegeben
LiteratureSpezialliteratur für die Bestimmung der Familien, Gattungen und Arten der mitteleuropäischen Mykoflora.
Prerequisites / NoticeDer Kurs ist auf maximal 8 Teilnehmende beschränkt. Schriftliche Anmeldung erforderlich. Das Kursgeld von Fr. 270.- muss von den Kursteilnehmern übernommen werden. Vor dem Kurs (Freitag 24. Aug. 2018) findet eine halbtägige Einführung in Zürich statt, deren Besuch ist obligatorisch.
551-1132-00LBasic Virology Information W2 credits1VK. Tobler, C. Fraefel
AbstractIntroduction into the basics of virology, including characterization of viruses, virus-cell interactions, virus-host interactions, virus-host population interactions, basics of prevention and prophylaxis as well as diagnostics.
ObjectiveIntroduction into the basics of virology.
ContentBasics in virology. Characterization of viruses, virus-cell interactions, virus-host interactions, virus-host population interactions, basics of prevention and prophylaxis as well as diagnostics.
Lecture notesThe lecture uses the lecturer's 'Allgemeine Virologie' as a basis.
The lecturer's slides as well as selected primary literature will be provided 24-48 hrs prior to the lecture in pdf format.
LiteratureFlint et al., 2009. Principles of Virology, 3rd Edition.
ASM Press, Washington, DC, USA.
Vol I. ISBN 978-1-55581-479-3
Vol II. ISBN 978-1-55581-480-9
Prerequisites / NoticeBasic knowledge in molecular biology, cell biology, immunology.
551-0140-00LEpigeneticsW4 credits2VR. Paro, U. Grossniklaus, R. Santoro, A. Wutz
AbstractEpigenetics studies the inheritance of traits that cannot be attributed to changes in the DNA sequence. The lecture will present an overview of different epigenetic phenomena and provide detailed insight into the underlying molecular mechanisms. The role of epigenetic processes in the development of cancer and other disorders will be discussed.
ObjectiveThe aim of the course is to gain an understanding of epigenetic mechanisms and their impact on the development of organisms, regenerative processes or manifestation of disease.
- historical overview, concepts and comparison Genetics vs. Epigenetics
- Biology of chromatin: structure and function, organization in the nucleus and the role of histone modifications in processes like transcription and replication
- DNA methylation as an epigenetic modification
- Inheritance of epigenetic modifications during cell division: cellular memory
- Stability and reversibility of epigenetic modifications: cellular plasticity and stem cells
- Genomic imprinting in plants and mammals
- X chromosome inactivation and dosis compensation
- position effects, paramutations and transvection
- RNA-induced gene silencing
- The role of epigenetic processes in cancer development or cell aging
751-4904-00LMicrobial Pest ControlW2 credits2GJ. Enkerli, G. Grabenweger
AbstractThis lecture provides conceptual as well as biological and ecological background on microbial pest management. Methods and techniques applied to develop and monitor microbial control agents are elucidated.
ObjectiveTo know the most important groups of insect pathogens and their characteristics. To become familiar with the basic steps necessary for the development of microbial control agents. To understand the techniques and methods used to monitor field applications and the procedures involved in registration of products for microbial pest management.
ContentDefinitions and general terms used in microbial control are presented. Biological and ecological aspects of all arthropod-pathogenic groups (virus, bacteria, fungi, protozoa and nematodes) as well as their advantages and disadvantages in relation to biocontrol are discussed. Particular emphasis is put on hypocrealean and entomophthoralean fungi. Examples are used to demonstrate how projects in microbial control can be set up, how pathogens can be applied and how efficacy, non-target effects, persistence and dissemination are monitored. Furthermore, the necessary steps for product development, commercial aspects and registration requirements are discussed.
Lecture notesDie grundlegenden Aspekte werden als Skript (Präsentationsunterlagen) abgegeben.
LiteratureHinweise auf zusätzliche Literatur werde in der Lehrveranstaltung gegeben.
551-1126-00LTechnologies in Molecular MicrobiologyW4 credits2VH.‑M. Fischer, B. Christen, M. Christen, further lecturers
AbstractThe lecture course provides an advanced understanding of modern techniques used in molecular microbiology. Current technologies and research directions in molecular microbiology including applied aspects will be illustrated with paper discussions. The format is a lecture course enriched by group activities.
ObjectiveThe lecture course aims at providing principles of modern techniques used in molecular microbiology. Emphasis is on genetic, biochemical, and cellular analysis including also bioinformatics aspects. Discussion of a set of commonly applied technologies will assist students in evaluating current research in molecular microbiology and choosing appropriate methods for their own demands.
ContentImportant genetic, biochemical, biophysical, bioinformatic and structural analysis methods will be presented that are used to gain a deeper understanding of the molecular principles and mechanisms underlying basic physiological processes in prokaryotes. Applied aspects of molecular microbiology and current research in this area will also be covered.

List of topics:
- Analysis of genes, genomes and transcriptomes
- Analysis of proteins, proteomes and microbial systems
- Synthetic biology
Lecture notesUpdated handouts will be provided during the class.
LiteratureCurrent literature references, relevant papers and handouts will be provided during the lectures.
Prerequisites / NoticeThe following lecturers will contribute to the course:

Prof. Beat Christen (ETH)
Dr. Matthias Christen (ETH)
Prof. Hans-Martin Fischer (ETH)
Dr. Jonas Grossmann (FGCZ)
Dr. Florian Freimoser (Agroscope)
Dr. Bernd Roschitzki (FGCZ)
Dr. Roman Spörri (ETH)
227-0390-00LElements of MicroscopyW4 credits3GM. Stampanoni, G. Csúcs, A. Sologubenko
AbstractThe lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging.
ObjectiveSolid introduction to the basics of microscopy, either with visible light, electrons or X-rays.
ContentIt would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level.
The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy.
During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated.
LiteratureAvailable Online.
701-1708-00LInfectious Disease DynamicsW4 credits2VS. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler
AbstractThis course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations.
ObjectiveAttendees will learn about:
* the impact of important infectious pathogens and their evolution on human, natural and managed populations
* the population biological impact of interventions such as treatment or vaccination
* the impact of population structure on disease transmission

Attendees will learn how:
* the emergence spread of infectious diseases is described mathematically
* the impact of interventions can be predicted and optimized with mathematical models
* population biological models are parameterized from empirical data
* genetic information can be used to infer the population biology of the infectious disease

The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about").
ContentAfter an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases.
Lecture notesSlides and script of the lecture will be available online.
LiteratureThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008
* Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990
* Murray, Mathematical Biology, Springer 2002/3
* Nowak & May, Virus Dynamics, Oxford Univ Press 2000
* Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009
Prerequisites / NoticeBasic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage.
751-4505-00LPlant Pathology IIW2 credits2GB. McDonald, U. Merz
AbstractPlant Pathology II focuses on disease control in agroecosystems based on biological control, pesticide applications and breeding of resistant crop cultivars. The genetics of pathogen-plant interactions will be explored in detail as a basis for understanding the development of boom-and-bust cycles and methods that may be used to prevent the evolution of pathogen virulence and fungicide resistance.
ObjectiveAn understanding of the how biological control, pesticides and plant breeding can be used to achieve sustainable disease control. An understanding of the genetic basis of pathogen-plant interactions and appropriate methods for using resistance to control diseases in agroecosystems.
ContentPlant Pathology II will focus on disease control in agroecosystems based on biological control, pesticide applications and breeding of resistant crop cultivars. The genetics of pathogen-plant interactions will be explored in detail as a basis for understanding the development of boom-and-bust cycles and methods that may be used to prevent the evolution of pathogen virulence and fungicide resistance.

Lecture Topics and Tentative Schedule

Week 1 Biological control: biofumigation, disease declines, suppressive soils.

Week 2 Biological control: competitive exclusion, hyperparasitism.

Week 3 Chemical control: History of fungicides in Europe, fungicide properties, application methods.

Week 4 Fungicide categories and modes of action, antibiotics, fungicide development, fungicide safety and risk assessment (human health).

Week 5 Resistance to fungicides. Genetics of fungicide resistance, ABC transporters, risk assessment, fitness costs. FRAC risk assessment model vs. population genetic risk assessment model.

Week 6 Genetics of pathogen-plant interaction: genetics of pathogens, genetics of plant resistance, major gene and quantitative resistance, acquired resistance. Flor's GFG hypothesis and the quadratic check, the receptor and elicitor model of GFG, the guard model of GFG.

Week 7 Resistance gene structure and genome distribution, conservation of LRR motifs across eukaryotes. Genetic basis of quantitative resistance. QTLs and QRLs. Connections between MGR and QR. Durability of QR.

Week 8 Genetic resistance: Costs, benefits and risks.

Week 9 Non-host resistance. Types of NHR. NHR in Arabidopsis with powdery mildews. NHR in maize and rice. Avirulence genes and pathogen elicitors. PAMPs, effectors, type-III secretion systems, harpins in bacteria. Fungal avirulence genes.

Week 10 Easter holiday no class.

Week 11 Sechselauten holiday no class.

Week 12 Host-specific toxins. GFG for toxins and connection to apoptosis. Fitness costs of virulence alleles. Diversifying selection in NIP1.

Week 13 Boom and bust cycles for resistance genes and fungicides and coevolutionary processes. Pathogen genetic structure and evolutionary potential. Genetic structure of pathogen populations in agroecosystems, risk assessment for pathogen evolution and breeding strategies for durable resistance.

Week 14 Resistance gene and fungicide deployment strategies for agroecosystems.

Week 15 Genetic engineering approaches to achieve disease resistant crops.
Lecture notesLecture notes will be available for purchase at the cost of reproduction.
LiteratureLecture notes will be available for purchase at the cost of reproduction.
Prerequisites / NoticePlant Pathology I provides a good preparation for Plant Pathology II, but is not a prerequisite for this course.
Elective Master Courses
551-0512-00LCurrent Topics in Molecular and Cellular Neurobiology Restricted registration - show details
Does not take place this semester.
Number of participants limited to 8
W2 credits1SU. Suter
AbstractThe course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature.
ObjectiveThe course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn e.g. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking.
ContentYou will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance.
You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation).
Lecture notesPresentations will be made available after the seminars.
LiteratureWe cover a range of themes related to development and neurobiology. Before starting your preparations, you are required to check with Laura Montani (Link), who helps you with finding an appropriate paper.
Prerequisites / NoticeYou must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%).
551-0224-00LAdvanced Proteomics Restricted registration - show details
For master students from the 2nd semester on, also doctoral candidates and post docs.
W4 credits6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
AbstractGoal of the course is to analyze current and newly emerging technologies and approaches in protein and proteome analysis with regard to their application in biology, biotechnology and medicine.
Format: Introduction by instructor followed by discussions stimulated by reading assignments and exercises.
ObjectiveTo discuss current and newly emerging technologies and approaches in protein and proteome analysis with regard to their applications in biology, biotechnology, medicine and systems biology.
ContentBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Prerequisites / NoticeNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students Link
Elective Concept Courses
752-4006-00LFood Microbiology IIW3 credits2VJ. Klumpp, M. Schuppler
AbstractThe lecture deals with basic (sometimes advanced) methods for detection and differentiation of (not only food-borne) microorganisms; production of foods by microbial fermentation; different approaches for the preservation of foods; and a short overview on food legals aspects and hygiene measures.
ObjectiveThe second part of this 1 year-lecture deals with basic (sometimes advanced) methods for detection and differentiation of (not only foodborne) microorgansims; production of foods by microbial fermentations; different approaches for the preservation of foods; and a short overview on legal aspects and hygiene control measures.
ContentDetection and Differentiation of Microorganisms
Culture Methods, Microscopy, Enrichment and Separation, Detection of intracellular Metabolites and Enzymes, Immunological Methods, Gene Probes and Microarrays, Nucleic Acid Amplification, Expression of Reportergenes, Typing Methods

Production of Foods with Microorganisms
Fermented Plant Products, Bread and Sour Dough, Fermented (alcoholic) Beverages, Fermented Milk Products, Fermented Meats, Traditional Fermented Foods, Coffee, Tea, Cacao, Tobacco, Fermentation Problems (Viruses, Antibiotics, Disinfectants)

Food Preservation I: Physical Methods
Low Water Activity, Low Temperature, Heat Treatment, High Pressure Treatment, Radiation

Food Preservation II: Chemical Methods
Natural Antimicrobial Substances, Smoking, Preservatives, Low pH, Modified Atmosphere Packaging

Food Preservation III: Biological Methods
Addition of Enzymes, Protective Cultures, Starter- and Ripening Cultures

Quality Assurance and Control
Legal Aspects and Regulations, Factory- and Personal Hygiene, Cleaning & Disinfection, GMP & HACCP
Lecture notesElectronic PDF copies of the presentation slides will be made available to all students.
LiteratureSuggestions in the first lecture
Prerequisites / NoticeThe lecture "Food Microbiology I" (or an equivalent course) is a prerequisite
529-0732-00LProteins and LipidsW6 credits3GD. Hilvert
AbstractAn overview of the relationship between protein sequence, conformation and function.
ObjectiveOverview of the relationship between protein sequence, conformation and function.
ContentProteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics.
LiteratureGeneral Literature:
- T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993.
- C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991.
- J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002.
- G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004.

Original Literature:
Citations from the original literature relevant to the individual lectures will be assigned weekly.
551-0326-00LCell Biology Information W6 credits4VS. Werner, M. Bordoli, W. Kovacs, W. Krek, M. Schäfer, U. Suter, A. Wutz
AbstractThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Objective-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
551-0324-00LSystems BiologyW6 credits4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
AbstractIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Objective- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
ContentOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Lecture notesno script
LiteratureThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
  •  Page  1  of  2 Next page Last page     All