Suchergebnis: Katalogdaten im Herbstsemester 2016
MAS in Medizinphysik | ||||||
Obligatorische Fächer (für beide Fachrichtungen) | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
---|---|---|---|---|---|---|
465-0957-00L | Anatomy and Physiology for Medical Physicists I | O | 2 KP | 2V | F. Kuhn | |
Kurzbeschreibung | Introduction to structure and function of the human body. The lectures will be based on current clinical practices in Radiology, Neuroradiology and Nuclear Medicine. | |||||
Lernziel | Physiological and anatomical knowledge of the human body to ensure the correct understanding of basic concepts and to facilitate the collaboration of medical physicists and other health professionals. | |||||
Inhalt | 'Anatomy and physiology for medical physicists I & II' provides insights into structure and function of the human body. The content is presented in an accessible manner targeted to physicist working in a medical environment. The lectures will be based on current clinical practices in Radiology, Neuroradiology and Nuclear Medicine. After an introduction to cells and tissues the following systems will be addressed: 1) Support & Movement (musculoskeletal system, biomechanics); 2) Neuroscience (central and peripheral nervous system); 3) Auto-regulation (endocrine system) & Internal Transport (blood & cardiovascular system); 4) Environmental Exchange (respiratory, urinary, digestive & reproductive system). | |||||
465-0953-00L | Biostatistics | O | 4 KP | 2V + 1U | B. Sick | |
Kurzbeschreibung | Der Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Klassifikation und Prognose, Diagnostische Tests, Bestimmung der Zuverlässigkeit von Messungen | |||||
Lernziel | ||||||
227-0385-10L | Biomedical Imaging | O | 6 KP | 5G | S. Kozerke, K. P. Prüssmann, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | To understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. The mathematical framework is developed to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. Matlab exercises are used to implement and study basic concepts. | |||||
Inhalt | - X-ray imaging - Computed tomography - Single photon emission tomography - Positron emission tomography - Magnetic resonance imaging - Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts | |||||
Literatur | Webb A, Smith N.B. Introduction to Medical Imaging: Physics, Engineering and Clinical Applications; Cambridge University Press 2011 | |||||
Voraussetzungen / Besonderes | Analysis, Linear Algebra, Physics, Basics of Signal Theory, Basic skills in Matlab programming | |||||
465-0966-00L | Physics in Radiodiagnostic and Nuclear Medicine | O | 2 KP | 3G | F. Bochud | |
Kurzbeschreibung | The course is dedicated to introduce MAS students from Medical Physics to the field of radiodiagnostic and nuclear medicine. Dedicated practicals will illustrate the theory with an emphasis on the relationship between dose and image quality as well as the security problems related to the work with radiations. | |||||
Lernziel | This 1-week theory and practical class offers the possibility to enjoy a variety of research and clinical areas in diagnostic and nuclear medicine. It gives insight into practical concepts and techniques that are discussed thoroughly as the class is performed within actual laboratories with real radiation sources. | |||||
Inhalt | The course starts with the physical basis of radiography (from X-ray production to image detectors) and continues with the basic parameters of image quality in radiography (contrast, resolution, noise) and their measurement methods. Specific applications of radiation diagnostic are then considered separately. The physics of fluoroscopy and mammography is presented with emphasis on the type of detectors. Computer tomography starts from mono- to multi-detector row technology and finishes with the dose indicators and the impacts of acquisition parameters on patient dose. Nuclear medicine is approached through the production and labeling of radiopharmaceuticals before explaining the aspects related to quality control like the stability of the compounds, nuclide- and radionuclide purity as well as apyrogeneicity and sterility. Imaging aspects of nuclear medicine are treated in details for SPECT and PET through the instrumentation, the reconstruction algorithms and the corresponding image quality. Finally, the aspects related to patient dose and radiation protection of the personnel are considered separately for diagnostic radiology and nuclear medicine. The general frameworks of external as well as internal irradiation are presented and practical examples of dose calculations are explained. | |||||
Fachrichtung: Strahlentherapie | ||||||
Kernfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
402-0341-00L | Medical Physics I | O | 6 KP | 2V + 1U | P. Manser | |
Kurzbeschreibung | Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations. | |||||
Lernziel | Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
Inhalt | The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications. | |||||
Skript | A script will be provided. | |||||
227-0943-00L | Radiobiology | O | 2 KP | 2V | M. Pruschy | |
Kurzbeschreibung | The purpose of this course is to impart basic knowledge in radiobiology in order to handle ionizing radiation and to provide a basis for predicting the radiation risk. | |||||
Lernziel | By the end of this course the participants will be able to: a) interpret the 5 Rs of radiation oncology in the context of the hallmarks of cancer b) understand factors which underpin the differing radiosensitivities of different tumors c) follow rational strategies for combined treatment modalities of ionizing radiation with targeted agents d) understand differences in the radiation response of normal tissue versus tumor tissue e) understand different treatment responses of the tumor and the normal tissue to differential clinical-related parameters of radiotherapy (dose rate, LET etc.). | |||||
Inhalt | Einführung in die Strahlenbiologie ionisierender Strahlen: Allgemeine Grundlagen und Begriffsbestimmungen; Mechanismen der biologischen Strahlenwirkung; Strahlenwirkung auf Zellen, Gewebe und Organe; Modifikation der biologischen Strahlenwirkung; Strahlenzytogenetik: Chromosomenveränderungen, DNA-Defekte, Reparaturprozesse; Molekulare Strahlenbiologie: Bedeutung inter- und intrazellulärer Signalübermittlungsprozesse, Apoptose, Zellzyklus-Checkpoints; Strahlenrisiko: Strahlensyndrome, Krebsinduktion, Mutationsauslösung, pränatale Strahlenwirkung; Strahlenbiologische Grundlagen des Strahlenschutzes; Nutzen-Risiko-Abwägungen bei der medizinischen Strahlenanwendung; Prädiktive strahlenbiologische Methoden zur Optimierung der therapeutischen Strahlenanwendung. | |||||
Skript | Beilagen mit zusammenfassenden Texten, Tabellen, Bild- und Grafikdarstellungen werden abgegeben | |||||
Literatur | Literaturliste wird abgegeben. Für NDS-Absolventen empfohlen: Hall EJ; Giacchia A: Radiobiology for the Radiologist, 7th Edition, 2011 | |||||
Voraussetzungen / Besonderes | The former number of this course unit is 465-0951-00L. | |||||
Praktika | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
465-0956-00L | Dosimetrie Findet dieses Semester nicht statt. Nur für MAS in Medizinphysik | O | 4 KP | 6G | ||
Kurzbeschreibung | Dosimetrie in der Strahlentherapie. Planung und Durchführung einer perkutanen Strahlenexposition an einem anthropomorphen Phantom. Überprüfung der resultierenden Dosisverteilungen. | |||||
Lernziel | Praktische Umsetzung der Lerninhalte der Vorlesungen Medizinphysik I & II bezüglich Dosimetrie bei perkutanen Strahlenexpositinen | |||||
Inhalt | Dosimetrie in der Strahlentherapie. Planung und Durchführung einer perkutanen Strahlenexposition an einem anthropomorphen Phantom. Überprüfung der resultierenden Dosisverteilungen. | |||||
Skript | Die Kursunterlagen werden im Blockkurs abgegeben. | |||||
Voraussetzungen / Besonderes | Voraussetzung: Besuch der Vorlesung Medizinische Physik I | |||||
Fachrichtung: Allg. Medizinphysik und Biomedizinisches Ingenieurwesen | ||||||
Vertiefung Radiation Therapy | ||||||
Kernfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
402-0345-00L | Introduction to Medical Physics Findet dieses Semester nicht statt. | W | 4 KP | 2V | A. J. Lomax | |
Kurzbeschreibung | Medical physics is a fascinating and worthwhile scientific discipline, providing many professional opportunities to apply physics to the care of patients, either in the clinic or in industry. It is also an area allowing for exciting, interesting and fulfilling areas of research. | |||||
Lernziel | It is the aim of this course to give bachelor and master level students an insight into the wide spectrum of medical applications of physics, and to provide some insight into the work of the medical physicist in clinics, industry and research. | |||||
Inhalt | The lecture series will begin with a short historical overview of medical physics and an overview of the lecture series (lecture 1). This will be followed by two lectures on the physics of medical imaging. Medical imaging is one of the most important areas of preventative medicine and diagnostics, and in these two lectures, we will summarise the physics aspects of all the most important medical imaging modalities (X-ray, nuclear medicine, CT, MRI, Ultrasound imaging etc.). With lectures 4 and 5, we will move onto one of the other major areas of physics applied to medicine, radiotherapy. As the name implies, this is a physics 'heavy' discipline, being dependent as it is on both accelerator and particle physics. However, what is less well known is that this is also the second most successfu l treatment of cancer after surgery and a great success story for the application of physics to medicine. In lectures 6 and 7 will then move on to a very different area, that of bio-photonics and bio-physics. Here we will look into the applications of lasers in medicine, from therapy to their use in particle acceleration for medical applications, as well as a variety of optical techniques for studying biological tissues, cells and structures. In the second half of the lecture series (lectures 8-13) the style changes somewhat, and we will concentrate on professional aspects of medical physics and the role of the medical physicist in various professional scenarios. As such, lectures 8-11 will cover the role of the clinical medical physicist in diagnostic radiology, MRI, nuclear medicine and radiotherapy, whilst the last two lectures will concentrate on their role in industry and research. For many of this second set of lectures, external experts in the various areas will be invited in order to give the student the best possible insight into the life of a professional medical physicist. | |||||
402-0341-00L | Medical Physics I | W | 6 KP | 2V + 1U | P. Manser | |
Kurzbeschreibung | Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations. | |||||
Lernziel | Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
Inhalt | The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications. | |||||
Skript | A script will be provided. | |||||
227-0943-00L | Radiobiology | W | 2 KP | 2V | M. Pruschy | |
Kurzbeschreibung | The purpose of this course is to impart basic knowledge in radiobiology in order to handle ionizing radiation and to provide a basis for predicting the radiation risk. | |||||
Lernziel | By the end of this course the participants will be able to: a) interpret the 5 Rs of radiation oncology in the context of the hallmarks of cancer b) understand factors which underpin the differing radiosensitivities of different tumors c) follow rational strategies for combined treatment modalities of ionizing radiation with targeted agents d) understand differences in the radiation response of normal tissue versus tumor tissue e) understand different treatment responses of the tumor and the normal tissue to differential clinical-related parameters of radiotherapy (dose rate, LET etc.). | |||||
Inhalt | Einführung in die Strahlenbiologie ionisierender Strahlen: Allgemeine Grundlagen und Begriffsbestimmungen; Mechanismen der biologischen Strahlenwirkung; Strahlenwirkung auf Zellen, Gewebe und Organe; Modifikation der biologischen Strahlenwirkung; Strahlenzytogenetik: Chromosomenveränderungen, DNA-Defekte, Reparaturprozesse; Molekulare Strahlenbiologie: Bedeutung inter- und intrazellulärer Signalübermittlungsprozesse, Apoptose, Zellzyklus-Checkpoints; Strahlenrisiko: Strahlensyndrome, Krebsinduktion, Mutationsauslösung, pränatale Strahlenwirkung; Strahlenbiologische Grundlagen des Strahlenschutzes; Nutzen-Risiko-Abwägungen bei der medizinischen Strahlenanwendung; Prädiktive strahlenbiologische Methoden zur Optimierung der therapeutischen Strahlenanwendung. | |||||
Skript | Beilagen mit zusammenfassenden Texten, Tabellen, Bild- und Grafikdarstellungen werden abgegeben | |||||
Literatur | Literaturliste wird abgegeben. Für NDS-Absolventen empfohlen: Hall EJ; Giacchia A: Radiobiology for the Radiologist, 7th Edition, 2011 | |||||
Voraussetzungen / Besonderes | The former number of this course unit is 465-0951-00L. | |||||
Praktika | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
465-0956-00L | Dosimetrie Findet dieses Semester nicht statt. Nur für MAS in Medizinphysik | W | 4 KP | 6G | ||
Kurzbeschreibung | Dosimetrie in der Strahlentherapie. Planung und Durchführung einer perkutanen Strahlenexposition an einem anthropomorphen Phantom. Überprüfung der resultierenden Dosisverteilungen. | |||||
Lernziel | Praktische Umsetzung der Lerninhalte der Vorlesungen Medizinphysik I & II bezüglich Dosimetrie bei perkutanen Strahlenexpositinen | |||||
Inhalt | Dosimetrie in der Strahlentherapie. Planung und Durchführung einer perkutanen Strahlenexposition an einem anthropomorphen Phantom. Überprüfung der resultierenden Dosisverteilungen. | |||||
Skript | Die Kursunterlagen werden im Blockkurs abgegeben. | |||||
Voraussetzungen / Besonderes | Voraussetzung: Besuch der Vorlesung Medizinische Physik I | |||||
465-0800-00L | Practical Work Nur für MAS in Medizinphysik | W | 4 KP | externe Veranstalter | ||
Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
Wahlfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, P. A. Kaestner | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
Vertiefung Biomechanics | ||||||
Kernfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND https://www1.ethz.ch/lbb/Education/BME | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, P. A. Kaestner | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
376-1651-00L | Clinical and Movement Biomechanics | W | 4 KP | 3G | S. Lorenzetti, R. List, N. Singh | |
Kurzbeschreibung | Measurement and modeling of the human movement during daily activities and in a clinical environment. | |||||
Lernziel | The students are able to analyse the human movement from a technical point of view, to process the data and perform modeling with a focus towards clinical application. | |||||
Inhalt | This course includes study design, measurement techniques, clinical testing, accessing movement data and anysis as well as modeling with regards to human movement. | |||||
376-1985-00L | Trauma Biomechanics | W | 4 KP | 2V + 1U | K.‑U. Schmitt, M. H. Muser | |
Kurzbeschreibung | Trauma-Biomechanik ist ein interdiszipliäres Fach, das sich mit der Biomechanik von Verletzungen sowie Möglichkeiten zur Prävention von Verletzungen beschäftigt. Die Vorlesung stellt die Grundlagen der Trauma-Biomechanik dar. | |||||
Lernziel | Vermittlung von Grundlagen der Trauma-Biomechanik. | |||||
Inhalt | Die Vorlesung beschäftigt sich mit Verletzungen des menschlichen Körpers und den zugrunde liegenden Verletzungsmechanismen. Hierbei bilden Verletzungen, die im Strassenverkehr erlitten werden, den Schwerpunkt. Weitere Vorlesungsthemen sind: Crash-Tests und die dazugehörige Messtechnik (z. B. Dummys), sowie aktuelle Themen der Trauma-Biomechanik wie z.B. Fussgänger-Kollisionen, Kinderrückhaltesysteme und Fahrzeugsitze. | |||||
Skript | Unterlagen werden zur Verfügung gestellt. | |||||
Literatur | Schmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag. | |||||
Praktika | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
465-0800-00L | Practical Work Nur für MAS in Medizinphysik | O | 4 KP | externe Veranstalter | ||
Kurzbeschreibung | The practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution. | |||||
Lernziel | The practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem. | |||||
Wahlfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
151-0255-00L | Energy Conversion and Transport in Biosystems | W | 4 KP | 2V + 1U | D. Poulikakos, A. Ferrari | |
Kurzbeschreibung | Theorie und Anwendung von Thermodynamik und Energieerhaltung in biologischen Systemen mit Schwerpunkt auf Zellebene. | |||||
Lernziel | Theorie und Anwendung von Energieerhaltung auf Zellebene. Verständnis für die grundlegenden Stofftransport-Kreisläufe in menschlichen Zellen und die Mechanismen, welche diese Kreisläufe beeinflussen. Parallelen zu anderen Gebieten im Ingenieurswesen erkennen. Wärme- und Massentransport Prozesse in der Zelle, Kraft Entwicklung der Zelle, und die Verbindung zu modernen biomedizinischen Technologien. | |||||
Inhalt | Massentransportmodelle für den Transport von chemischen Spezies in der menschlichen Zelle. Organisation und Funktion der Zellmembran und des Zytoskeletts. Die Rolle molekularer Motoren in der Kraftentwicklung der Zelle und deren Funktion in der Fortbewegung der Zelle. Beschreibung der Funktionsweise dieser Systeme sowie der experimentellen Analyse und Simulationen um sie besser zu verstehen. Einführung in den Zell-Metabolismus, Zell-Energietransport und die Zelluläre Thermodynamik. | |||||
Skript | Kursmaterial wird in Form von Hand-outs verteilt. | |||||
Literatur | Notizen sowie Referenzen aus der Vorlesung. |
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