Stem cells are central in tissue regeneration and repair, and hold great potential for therapy. We will discuss the role of stem cells in health and disease, and possibilities to manipulate their behavior for therapeutic application. Basic molecular and cell biology, engineering and novel technologies relevant for stem cell research and therapy will be discussed.
Learning objective
Understanding of current knowledge, and lack thereof, in stem cell biology, regenerative medicine and required technologies. Theoretical preparation for practical laboratory experimentation with stem cells.
Content
We will use different diseases to discuss how to potentially model, diagnose or heal them by stem cell based therapies. This will be used as a guiding framework to discuss relevant concepts and technologies in cell and molecular biology, engineering, imaging, bioinformatics, tissue engineering, that are required to manipulate stem cells for therapeutic application.
Topics will include: - Embryonic and adult stem cells and their niches - Induced stem cells by directed reprogramming - Relevant basic cell biology and developmental biology - Relevant molecular biology - Cell culture systems - Cell fates and their molecular control by transcription factors and signalling pathways - Cell reprogramming - Disease modelling - Tissue engineering - Bioimaging, Bioinformatics - Single cell technologies
Competencies
Subject-specific Competencies
Concepts and Theories
assessed
Techniques and Technologies
assessed
Method-specific Competencies
Analytical Competencies
fostered
Social Competencies
Communication
fostered
Self-presentation and Social Influence
fostered
Personal Competencies
Critical Thinking
fostered
Integrity and Work Ethics
fostered
Performance assessment
Performance assessment information (valid until the course unit is held again)
The performance assessment is only offered in the session after the course unit. Repetition only possible after re-enrolling.
Mode of examination
written 120 minutes
Additional information on mode of examination
Journal club paper presentation (individually or in teams) is a is a compulsory continuous performance assessment of this course, will be graded as pass/fail, and is required to enroll for the examination and to pass this course.
Written aids
None
This information can be updated until the beginning of the semester; information on the examination timetable is binding.
Learning materials
No public learning materials available.
Only public learning materials are listed.
Groups
No information on groups available.
Restrictions
There are no additional restrictions for the registration.