Structure Elucidation of Complex Organic Molecules by NMR
Lernziel
Structure elucidation of complex organic molecules (including peptides, oligosaccharides and oligonucleotides) by advanced 1D and 2D NMR spectroscopy: Finding the constitution, rel. configuration and the conformation of an unkown molecule. The emphasis of the course is on the selection of optimal strategies for the solution of a given problem. Discussing and solving these problems by the combined application of various 2D methods form an important part of the course. This also includes the use of state-of-the-art methods for computer assisted structure elucdation (CASE) and chemical shift prediction.
Inhalt
Important experiments for structure elucidation. Finding the optimal strategy for a given problem. Spectral processing for optimal results. Spectral interpretation. Assignment strategies for complex molecules. Common Artefacts. Computer assisted structure elucidation incl. introduction to relevant software and hands-on application. Chemical shift prediction. Discussion of challenging problem sets during class.
Skript
Scripts (in English) are distributed in the course
Literatur
"T.D.W. Claridge, High Resolution NMR Techniques in Organic Chemistryî, Pergamon Press, 1999. (NMR Teil)
Further reading and citations are listed in the script.
Voraussetzungen / Besonderes
The course language is English. Required level: Courses in analytical chemistry of the 2nd year or equivalent.
Kompetenzen
Fachspezifische Kompetenzen
Konzepte und Theorien
geprüft
Verfahren und Technologien
geprüft
Methodenspezifische Kompetenzen
Analytische Kompetenzen
geprüft
Entscheidungsfindung
geprüft
Medien und digitale Technologien
gefördert
Problemlösung
geprüft
Persönliche Kompetenzen
Kreatives Denken
gefördert
Kritisches Denken
gefördert
Leistungskontrolle
Information zur Leistungskontrolle (gültig bis die Lerneinheit neu gelesen wird)
Leistungskontrolle als Semesterkurs