376-1348-00L  Cellular Ageing

SemesterAutumn Semester 2022
LecturersG. Shivashankar
Periodicityyearly recurring course
Language of instructionEnglish


AbstractCells undergo major functional alterations as we age. In this course, we will discuss the basic molecular and cell biological mechanisms of cellular ageing. We will also discuss diseases related to cellular ageing and current rejuvenation and therapeutic strategies for cellular ageing in health and disease.
Objective- Basic molecular and cell biological mechanisms of cellular ageing;
- Diseases related to cellular ageing;
- current rejuvenation and therapeutic strategies for cellular ageing in health and disease.
ContentLecture-1: Hallmarks of cellular ageing
Lecture-2: Cellular microenvironment & extra-cellular matrix
Lecture-3: Cell morphometric changes & cytoskeletal remodeling
Lecture-4: Proteostasis
Lecture-5: Mitochondrial dysfunction
Lecture-6: Endo-membrane signaling
Lecture-7: Nuclear signaling & epigenetic alternations
Lecture-8: Chromatin remodeling & gene expression
Lecture-9: Genomic integrity
Lecture-10: Ageing cell secretome and cellular homeostasis
Lecture-11: Diseases associated with cellular ageing
Lecture-12: Cellular rejuvenation strategies
Lecture-13: Therapeutic interventions to cellular ageing
Lecture-14: Concluding lecture