376-1348-00L Cellular Ageing
| Semester | Autumn Semester 2022 |
| Lecturers | G. Shivashankar |
| Periodicity | yearly recurring course |
| Language of instruction | English |
| Abstract | Cells undergo major functional alterations as we age. In this course, we will discuss the basic molecular and cell biological mechanisms of cellular ageing. We will also discuss diseases related to cellular ageing and current rejuvenation and therapeutic strategies for cellular ageing in health and disease. |
| Learning objective | - Basic molecular and cell biological mechanisms of cellular ageing; - Diseases related to cellular ageing; - current rejuvenation and therapeutic strategies for cellular ageing in health and disease. |
| Content | Lecture-1: Hallmarks of cellular ageing Lecture-2: Cellular microenvironment & extra-cellular matrix Lecture-3: Cell morphometric changes & cytoskeletal remodeling Lecture-4: Proteostasis Lecture-5: Mitochondrial dysfunction Lecture-6: Endo-membrane signaling Lecture-7: Nuclear signaling & epigenetic alternations Lecture-8: Chromatin remodeling & gene expression Lecture-9: Genomic integrity Lecture-10: Ageing cell secretome and cellular homeostasis Lecture-11: Diseases associated with cellular ageing Lecture-12: Cellular rejuvenation strategies Lecture-13: Therapeutic interventions to cellular ageing Lecture-14: Concluding lecture |