551-0337-00L Cell Biology of the Nucleus
| Semester | Autumn Semester 2022 |
| Lecturers | R. Kroschewski, Y. Barral, M. Jagannathan, S. Jessberger, K. Weis |
| Periodicity | yearly recurring course |
| Language of instruction | English |
| Comment | Number of participants limited to 18. The enrolment is done by the D-BIOL study administration. |
| Abstract | Introduction to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems. |
| Learning objective | The aim of our course is to introduce the students to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems. Emphasis is given to: • Establishment of nuclear identity and nuclear-cytoplasmic communication • Reorganization of the nucleus in aging • Animal cells during the generation of cell diversity and neuronal differentiation By the end of the course, based on lectures, literature reading and practical lab work, the students will be able to formulate open questions concerning the function of the nucleus. Thus, the students will know about the mechanisms and consequences of nuclear-cytoplasmic compartmentalization, nuclear positioning, DNA clustering in the nucleus and cytoplasm during cell divisions and aging. |
| Content | During this block-course, the students will - learn how organelles establish and maintain identity with a focus on the nucleus - discover the evolutionary and functional plasticity of the nucleus - design, apply, evaluate and compare experimental strategies Students - in groups of 2 or max. 3 - will be integrated into a research project connected to the subject of the course, within one of the participating research groups. Lectures and technical notes will be given and informal discussions held to provide you with the theoretical background. |
| Lecture notes | There will be optional papers to be read before the course start. They serve as framework orientation for the practical parts of this block course and will be made accessible to you shortly before the course starts on the relevant Moodle site. |
| Literature | Documentation and recommended literature (review articles) will be provided during the course. |