636-0009-00L  Evolutionary Dynamics

SemesterAutumn Semester 2022
LecturersN. Beerenwinkel
Periodicityyearly recurring course
Language of instructionEnglish



Courses

NumberTitleHoursLecturers
636-0009-00 VEvolutionary Dynamics
Attention: lecture starts on Thursday, September 29
Lecture and tutorial will take place via Zoom (flipped classroom) - rooms on campus remain blocked for students.
2 hrs
Thu09:15-11:00BSA E 46 »
09:15-11:00CAB G 52 »
N. Beerenwinkel
636-0009-00 UEvolutionary Dynamics
Lecture and tutorial will take place via Zoom (flipped classroom) - rooms on campus remain blocked for students.
1 hrs
Thu11:15-12:00BSA E 46 »
11:15-12:00CAB G 52 »
N. Beerenwinkel
636-0009-00 AEvolutionary Dynamics
Project Work (compulsory continuous performance assessment), no fixed presence required.
2 hrsN. Beerenwinkel

Catalogue data

AbstractEvolutionary dynamics is concerned with the mathematical principles according to which life has evolved. This course offers an introduction to mathematical modeling of evolution, including deterministic and stochastic models, with an emphasis on tumor evolution.
ObjectiveThe goal of this course is to understand and to appreciate mathematical models and computational methods that provide insight into the evolutionary process in general and tumor evolution in particular. Students should analyze and evaluate models and their application critically and be able to design new models.
ContentEvolution is the one theory that encompasses all of biology. It provides a single, unifying concept to understand the living systems that we observe today. We will introduce several types of mathematical models of evolution to describe gene frequency changes over time in the context of different biological systems, focusing on asexual populations. Viruses and cancer cells provide the most prominent examples of such systems and they are at the same time of great biomedical interest. The course will cover some classical mathematical population genetics and population dynamics, and also introduce several new approaches. This is reflected in a diverse set of mathematical concepts which make their appearance throughout the course, all of which are introduced from scratch. Topics covered include the quasispecies equation, evolution of HIV, evolutionary game theory, evolutionary stability, evolutionary graph theory, tumor evolution, stochastic tunneling, genetic progression of cancer, diffusion theory, fitness landscapes, branching processes, and evolutionary escape.
Lecture notesNo.
Literature- Evolutionary Dynamics. Martin A. Nowak. The Belknap Press of Harvard University Press, 2006.
- Evolutionary Theory: Mathematical and Conceptual Foundations. Sean H. Rice. Sinauer Associates, Inc., 2004.
Prerequisites / NoticePrerequisites: Basic mathematics (linear algebra, calculus, probability)
CompetenciesCompetencies
Subject-specific CompetenciesConcepts and Theoriesassessed
Method-specific CompetenciesAnalytical Competenciesassessed
Problem-solvingassessed
Social CompetenciesCommunicationfostered
Cooperation and Teamworkfostered
Personal CompetenciesCritical Thinkingassessed
Self-direction and Self-management fostered

Performance assessment

Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course
ECTS credits6 credits
ExaminersN. Beerenwinkel
Typesession examination
Language of examinationEnglish
RepetitionThe performance assessment is only offered in the session after the course unit. Repetition only possible after re-enrolling.
Mode of examinationwritten 90 minutes
Additional information on mode of examinationThe final grade is 70% written session examination and 30% project. The practical projects are compulsory continuous performance assessments (60 hours of work, 2 credits) of the course. The project has to be re-run in case of a repetition.
Written aidsNone
This information can be updated until the beginning of the semester; information on the examination timetable is binding.

Learning materials

No public learning materials available.
Only public learning materials are listed.

Groups

No information on groups available.

Restrictions

There are no additional restrictions for the registration.

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