529-0615-01L  Biochemical and Polymer Reaction Engineering

SemesterAutumn Semester 2022
LecturersP. Arosio
Periodicityyearly recurring course
Language of instructionEnglish



Courses

NumberTitleHoursLecturers
529-0615-01 GBiochemical and Polymer Reaction Engineering3 hrs
Tue13:45-15:30HCI J 4 »
Wed11:45-12:30HCI J 6 »
P. Arosio

Catalogue data

AbstractPolymerization reactions and processes. Homogeneous and heterogeneous (emulsion) kinetics of free radical polymerization. Post treatment of polymer colloids. Bioprocesses for the production of molecules and therapeutic proteins. Kinetics and design of aggregation processes of macromolecules and proteins.
ObjectiveThe aim of the course is to learn how to design polymerization reactors and bioreactors to produce polymers and proteins with the specific product qualities that are required by different applications in chemical, pharmaceutical and food industry. This activity includes the post-treatment of polymer latexes, the downstream processing of proteins and the analysis of their colloidal behavior.
ContentWe will cover the fundamental processes and the operation units involved in the production of polymeric materials and proteins. In particular, the following topics are discussed: Overview on the different polymerization processes. Kinetics of free-radical polymerization and use of population balance models. Production of polymers with controlled characteristics in terms of molecular weight distribution. Kinetics and control of emulsion polymerization. Surfactants and colloidal stability. Aggregation kinetics and aggregate structure in conditions of diffusion and reaction limited aggregation. Modeling and design of colloid aggregation processes. Physico-chemical characterization of proteins and description of enzymatic reactions. Operation units in bioprocessing: upstream, reactor design and downstream. Industrial production of therapeutic proteins. Characterization and engineering of protein aggregation. Protein aggregation in biology and in biotechnology as functional materials.
Lecture notesScripts are available on the web page of the Arosio-group: Link
Additional handout of slides will be provided during the lectures.
LiteratureR.J. Hunter, Foundations of Colloid Science, Oxford University Press, 2nd edition, 2001
D. Ramkrishna, Population Balances, Academic Press, 2000
H.W. Blanch, D. S. Clark, Biochemical Engineering, CRC Press, 1995

Performance assessment

Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course
ECTS credits6 credits
ExaminersP. Arosio
Typesession examination
Language of examinationEnglish
RepetitionThe performance assessment is offered every session. Repetition possible without re-enrolling for the course unit.
Mode of examinationoral 30 minutes
Additional information on mode of examinationSuccessful accomplishment of at least 80% of the exercises during the course will provide a bonus of +0.25 for the final grade.
This information can be updated until the beginning of the semester; information on the examination timetable is binding.

Learning materials

No public learning materials available.
Only public learning materials are listed.

Groups

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Restrictions

There are no additional restrictions for the registration.

Offered in

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Biomedical Engineering MasterRecommended Elective CoursesWInformation
Chemical and Bioengineering MasterBiochemical EngineeringWInformation
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Doctorate Materials ScienceSustainable & Bioinspired Materials (MaP Doctoral School)WInformation