Structure Elucidation of Complex Organic Molecules by NMR
Learning objective
Structure elucidation of complex organic molecules (including peptides, oligosaccharides and oligonucleotides) by advanced 1D and 2D NMR spectroscopy. The emphasis of the course is on the selection of optimal strategies for the solution of a given problem, spectrum interpretation and possible artifacts. Solving and discussing practical case studies/problems demonstrating the individual methods and, in the last third of the course, the combined application of several methods form an important part of the course.
Content
Structure determination by multi-pulse and 2D NMR spectroscopy. Homonuclear and heteronuclear shift correlation through scalar coupling; one and two dimensional methods based on the nuclear Overhauser effect. Choosing the best strategy for a given problem, interpretation and artefacts.
Lecture notes
Scripts (in English) are distributed in the course
Literature
"T.D.W. Claridge, High Resolution NMR Techniques in Organic Chemistryî, Pergamon Press, 1999. (NMR Teil)
Further reading and citations are listed in the script.
Prerequisites / Notice
The course language is English. Required level: Courses in analytical chemistry of the 2nd year or equivalent.
Performance assessment
Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course