535-0210-00L  Radiopharmaceutical Chemistry

Courses

Catalogue data

Abstract	-Molecular imaging in drug development -Radiopharmaceutical syntheses -Knowledge of the physical principles of radioactivity -Structure and function of radiopharmaceuticals -Examples of application in diagnosis and therapy in humans -Targeted radionuclide therapy
Learning objective	- The students know and are able to describe the different imaging procedures in medicine, especially PET and SPET. - At the end of the lecture, the students are able to explain and describe the physical basics in connection with radioactivity and the different types of radioactive radiation that are relevant in radiopharmacy and nuclear medicine. - The students know how radionuclides can be produced and extracted. - The students can describe the structure and function of radiopharmaceuticals and are able to develop strategies for the design of new radiopharmaceuticals. - The students know selected examples of clinically relevant radiopharmaceuticals and can explain the structure and mechanism of action. - The students can discuss and apply the principles of internal dosimetry of systemically applied radiopharmaceuticals using selected examples.
Content	Introduction to molecular imaging, Radioactive decay, radiation and radionuclides relevant in nuclear medicine. Radionuclide generators Radiopharmaceutical synthesis strategies Heart, brain and tumour diagnostics with radiopharmaceuticals Kinetic modelling with radiopharmaceuticals Tumour therapy with radiopharmaceuticals Dosimetry of radiopharmaceuticals Practical aspect of nuclear medicine and radiopharmacy
Literature	Book Title: Fundamentals of Nuclear Pharmacy Authors Gopal B. Saha DOI https://doi.org/10.1007/978-3-319-57580-3. Book Title: Radiopharmaceuticals Book Subtitle A Guide to PET/CT and PET/MRI Editors Ferdinando Calabria, Orazio Schillaci DOI https://doi.org/10.1007/978-3-030-27779-6. Book Title Radiopharmaceutical Chemistry Editors Jason S. Lewis Albert D. Windhorst, Brian M. Zeglis DOI https://doi.org/10.1007/978-3-319-98947-1. Access via ETH Library
Prerequisites / Notice	Prerequisites: basic knowledge in physics and chemsitry
Competencies	Subject-specific Competencies Concepts and Theories assessed Techniques and Technologies assessed Method-specific Competencies Analytical Competencies assessed Decision-making assessed Media and Digital Technologies fostered Problem-solving assessed Project Management fostered Social Competencies Communication fostered Cooperation and Teamwork fostered Customer Orientation fostered Leadership and Responsibility fostered Self-presentation and Social Influence fostered Sensitivity to Diversity fostered Negotiation fostered Personal Competencies Adaptability and Flexibility fostered Creative Thinking assessed Critical Thinking assessed Integrity and Work Ethics fostered Self-awareness and Self-reflection fostered Self-direction and Self-management fostered

Performance assessment

Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course
ECTS credits	2 credits
Examiners	R. Schibli, L. Mu
Type	session examination
Language of examination	German
Repetition	The performance assessment is offered every session. Repetition possible without re-enrolling for the course unit.
Mode of examination	oral 20 minutes
This information can be updated until the beginning of the semester; information on the examination timetable is binding.

Learning materials

Groups

Restrictions

Offered in

Programme	Section	Type
Pharmaceutical Sciences Bachelor	Third Year Core Subjects	O