535-0310-00L  Glycobiology in Drug Development

Lehrveranstaltungen

Katalogdaten

Kurzbeschreibung	Protein-based drugs constitute around 25% of new approvals and most of them are glycoproteins. Using selected examples of prominent glycoprotein drugs, the course aims at providing insight into glycosylation-activity relationships and into biotechnological production and analytics.
Lernziel	Students gain basic knowledge in "pharmaceutical glycobiology". This implies knowing and understanding: - major mechanisms underlying the roles of glycosylation for the biological/therapeutic actions of glycoproteins (glycosylation-function relationships) using prominent examples of glycoprotein drugs. - the major types of protein-linked glycans and the biosynthetic pathways for their formation - how glycoprotein drugs are produced (including the most important expression systems used), glycoengineered and analysed (quality control). Students are able to apply this knowledge in solving simple problems in glycoprotein drug development (on paper). Students gain the ability to reflect on roles of glycosylation in various biological contexts.
Inhalt	lecture plan: 1. Glycans - information carriers in biology and pharmacotherapy 2. Glucocerebrosidase and the biosynthesis of N-glycans 3. Improving the therapeutic profile of monoclonal antibodies by glycoengineering 4. Mucin-type O-glycans and sialylation as gCQA of glycoprotein hormone drugs 5. production and gCQA analysis of Glucocerebrosidase, monoclonal antibodies, glycoprotein hormone drugs - Glycoanalytics 6. EPO "the same but different"
Skript	The slides used for the lectures will be provided online
Literatur	- Essentials of Glycobiology 3rd edition, A. Varki, R.D. Cummings et al., Cold Spring Harbor Laboratory Press, New York 2017. - recent publications as cited/proposed on the lecture slides
Voraussetzungen / Besonderes	Requirements: Basic knowledge in immunology, molecular biology, protein and carbohydrate chemistry, analytical techniques. Basic knowledge in pharmacology.
Kompetenzen	Fachspezifische Kompetenzen Konzepte und Theorien geprüft Verfahren und Technologien geprüft Methodenspezifische Kompetenzen Analytische Kompetenzen geprüft Problemlösung geprüft Soziale Kompetenzen Kommunikation geprüft Persönliche Kompetenzen Kreatives Denken geprüft Kritisches Denken geprüft

Leistungskontrolle

Information zur Leistungskontrolle (gültig bis die Lerneinheit neu gelesen wird)
Leistungskontrolle als Semesterkurs
ECTS Kreditpunkte	1 KP
Prüfende	V. I. Otto
Form	benotete Semesterleistung
Prüfungssprache	Englisch
Repetition	Repetition ohne erneute Belegung der Lerneinheit möglich.
Zulassungsbedingung	Regular attendance of the lessons and answering the take home questions related to each lesson is highly recommended. The lecture slides are designed to illustrate what is explained and discussed during the lessons.
Zusatzinformation zum Prüfungsmodus	A statement or question regarding the main topics of the course has to be discussed / answered in the form of an essay (700-1000 words written in English, German, French or Italian). The assay will be reviewed and graded. At a later time point to be agreed upon by lecturer and students, the essays and their contents will be discussed.

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Studiengang	Bereich	Typ
Humanmedizin Bachelor	Kompensationsfächer	W
Pharmaceutical Sciences Master	Wahlfächer I	W
Pharmazeutische Wissenschaften Bachelor	Kompensationsfächer	W
Pharmazie Master	Wahlfächer	W