535-0030-00L Therapeutic Proteins
| Semester | Autumn Semester 2021 |
| Lecturers | C. Halin Winter, D. Neri |
| Periodicity | yearly recurring course |
| Language of instruction | English |
Courses
| Number | Title | Hours | Lecturers | ||||
|---|---|---|---|---|---|---|---|
| 535-0030-00 G | Therapeutic Proteins | 3 hrs |
| C. Halin Winter, D. Neri |
Catalogue data
| Abstract | In this course, various topics related to the development, GMP production and application of therapeutic proteins will be discussed. Furthermore, students will expand their training in pharmaceutical immunology and will be introduced to the basic concepts of pharmaceutical product quality management. |
| Learning objective | Students know and understand: - basic mechanisms and regulation of the immune response - the pathogenic mechanisms of the most important immune-mediated disorders - the most frequently used expression systems for the production of therapeutic proteins - the use of protein engineering tools for modifying different features of therapeutic proteins - the mechanism of action of selected therapeutic proteins and their application - basic concepts in the GMP production of therapeutic proteins |
| Content | The course consists of two parts: In a first part, students will complete their training of pharmaceutical immunology (Chapter 13 - 16 Immunobiology VIII textbook). This part particularly focuses on the pathogenic mechanisms of immune-mediated diseases. Deepened knowledge of immunology will be relevant for understanding the mechanism of action of many therapeutic proteins, as well as for understanding one major concern related to the use of protein-based drugs, namely, immunogenicity. The second part focuses on topics related to the development and application of therapeutic proteins, such as protein expression, protein engineering, reducing immunogenicity, and GMP production of therapeutic proteins. Furthermore, selected examples of approved therapeutic proteins will be discussed. |
| Lecture notes | Handouts to the lectures will be available for downloading under http://www.pharma.ethz.ch/scripts/index |
| Literature | - Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition), Chapters 12-16 - Lecture Handouts - Paper References provided in the Scripts - EMEA Dossier for Humira |
Performance assessment
| Performance assessment information (valid until the course unit is held again) | |
Performance assessment as a semester course | |
| ECTS credits | 3 credits |
| Examiners | C. Halin Winter, D. Neri |
| Type | session examination |
| Language of examination | English |
| Repetition | The performance assessment is offered every session. Repetition possible without re-enrolling for the course unit. |
| Mode of examination | oral 15 minutes |
| This information can be updated until the beginning of the semester; information on the examination timetable is binding. | |
Learning materials
| No public learning materials available. | |
| Only public learning materials are listed. |
Groups
| No information on groups available. |
Restrictions
| There are no additional restrictions for the registration. |
Offered in
| Programme | Section | Type | |
|---|---|---|---|
| DAS Preparation for the Swiss Federal Examination in Pharmacy | Compulsary Courses II | W |  |
| Pharmaceutical Sciences Master | Core Courses I | O | |
| Pharmacy Master | Core Courses I | O | |