376-1721-00L  Bone Biology and Consequences for Human Health

SemesterSpring Semester 2021
LecturersG. A. Kuhn, J. Goldhahn, E. Wehrle
Periodicityyearly recurring course
Language of instructionEnglish


AbstractBone is a complex tissue that continuously adapts to mechanical and metabolic demands. Failure of this remodeling results in reduced mechanic stability ot the skeleton. This course will provide the basic knowledge to understand the biology and pathophysiology of bone necessary for engineering of bone tissue and design of implants.
ObjectiveAfter completing this course, students will be able to understand:
a) the biological and mechanical aspects of normal bone remodeling
b) pathological changes and their consequences for the musculoskeletal system
c) the consequences for implant design, tissue engineering and treatment interventions.
ContentBone adapts continuously to mechanical and metabolic demands by complex remodeling processes. This course will deal with biological processes in bone tissue from cell to tissue level. This lecture will cover mechanisms of bone building (anabolic side), bone resorption (catabolic side), their coupling, and regulation mechanisms. It will also cover pathological changes and typical diseases like osteoporosis. Consequences for musculoskeletal health and their clinical relevance will be discussed. Requirements for tissue engineering as well as implant modification will be presented. Actual examples from research and development will be utilized for illustration.