542-0002-00L Module II: Radiopharmaceutical Chemistry
| Semester | Spring Semester 2021 |
| Lecturers | R. Schibli |
| Periodicity | two-yearly recurring course |
| Course | Does not take place this semester. |
| Language of instruction | English |
| Comment | Only for CAS in Radiopharmazeutischer Chemie, Radiopharmacy. The enrolment is done by the CAS study administration. |
| Abstract | This postgraduate certificate course consists of three 2-week-modules and enables natural scientists to assume responsibility for the small-batch production and quality control of radiopharmaceuticals. Module II: Radiopharmaceutical Chemistry 6 x 4hours of laboratory practice in different locations (PSI, ETH Hönggerberg) |
| Learning objective | • Introduction to radiopharmacy and physics • Radionuclide production • Generator systems • In vitro- and in vivo-characterization of radiolabelled peptides and antibodies • The chemistry of Tc and Re • Kits and pitfalls • Radiopharmaceutical chemistry with halogen isotopes • 18F- and 11C-radiolabelled pharmaceuticals • Chemistry of radiometals other than Tc and Re • Animal and in vitro models • Practical sessions: • Radiolabelling and quality control of antibodies • Mo/Tc-generator and use of kits including quality control and preclinical application • Ge/Ga-generator and 68Ga-radiolabelling of peptides including quality control/video cell labelling • Insight into the routine manufacturing of clinical PET radiopharmaceuticals • 11C- and 18F- radiolabelling for research • In vitro/preclinical characterization of PET radiopharmaceuticals |