This course builds on the material learned in Organic Chemistry I or Organic Chemistry II for Biology/Pharmacy Students. Topics include advanced concepts and mechanisms of organic reactions and introductions to pericyclic and organometallic reactions. The basics or retro- and forward synthesis are also introduced.
Objective
Goals of this course include a deeper understanding of basic organic reactions and mechanisms as well as advanced transformations. Reactive intermediates including carbenes and nitrenes are covered, along with methods for their generation and use in complex molecule synthesis. Frontier molecular orbital theory (FMO) is introduced and used to rationalize pericyclic reactions including Diels Alder reactions, cycloadditions, and rearrangements (Cope, Claisen). The basic concepts and key reactions of catalytic organometallic chemistry, which are key methods in modern organic synthesis, are introduced, with an emphasis on their catalytic cycles and elementary steps. All of these topics are combined in an overview of strategies for complex molecule synthesis, with specific examples from natural product derived molecules used as medicines.
Content
Redox neutral reactions and rearrangements, advanced transformations of functional groups and reaction mechanisms, carbenes and nitrenes, frontier molecular orbital theory (FMO), cycloadditions and pericyclic reactions, introduction to organometallic chemistry and catalytic cross couplings, protecting groups, retrosynthetic analysis of complex organic molecules, planning and execution of multi-step reactions.
Lecture notes
The lecture notes and additional documents including problem sets are available as PDF files online, without charge. Link: Link
Literature
Clayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012.
Performance assessment
Performance assessment information (valid until the course unit is held again)
Performance assessment as a two-semester course together with 529-0221-00L Organic Chemistry I
For programme regulations
(Examination block)
Bachelor's Degree Programme in Biochemistry - Chemical Biology 2020; Version 28.11.2022 (Examination Block I) Bachelor's Degree Programme in Chemical Engineering 2006; Version 27.03.2018 (Examination Block I) Bachelor's Degree Programme in Chemical Engineering 2018; Version 26.09.2022 (Examination Block I) Bachelor's Degree Programme in Chemistry 2005; Version 27.03.2018 (Examination Block I) Bachelor's Degree Programme in Chemistry 2018; Version 26.09.2022 (Examination Block I) Bachelor's Degree Programme in Interdisciplinary Sciences 2010; Version 27.03.2018 (Examination Block) Bachelor's Degree Programme in Interdisciplinary Sciences 2018; Version 12.07.2022 (Examination Block)
The performance assessment is offered every session. Repetition possible without re-enrolling for the course unit.
Mode of examination
written 60 minutes
Written aids
keine
If the course unit is part of an examination block, the credits are allocated for the successful completion of the whole block. This information can be updated until the beginning of the semester; information on the examination timetable is binding.