Until further notice, all lectures of this course will take place online, either via ZOOM or as pre-recorded videos. The corresponding links can be found on the Moodle page of the course in the sections for the respective course week.
Introduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
- obtain an overview of global analytical methods - obtain an overview of computational methods in systems biology - understand the concepts of systems biology
Overview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
The course is not taught by a particular book, but some books are suggested for further reading:
- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
Information zur Leistungskontrolle (gültig bis die Lerneinheit neu gelesen wird)