535-0230-00L Medicinal Chemistry I

Abstract	The lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples.
Learning objective	Basic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties.
Content	Molecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions
Lecture notes	Will be provided in parts before each individual lecture.
Literature	- G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press - D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005) - J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002) - A. Gringauz, "How Drugs Act and Why", Wiley (1997)
Prerequisites / Notice	Requirements: Knowledge of physical and organic chemistry, biochemistry and biology. Attendance of Medicinal Chemistry II in the spring semester. Registration for the course until 15 October.