535-0230-00L Medizinische Chemie I
| Semester | Herbstsemester 2020 |
| Dozierende | J. Hall |
| Periodizität | jährlich wiederkehrende Veranstaltung |
| Lehrsprache | Englisch |
| Kurzbeschreibung | The lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples. |
| Lernziel | Basic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties. |
| Inhalt | Molecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions |
| Skript | Will be provided in parts before each individual lecture. |
| Literatur | - G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press - D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005) - J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002) - A. Gringauz, "How Drugs Act and Why", Wiley (1997) |
| Voraussetzungen / Besonderes | Requirements: Knowledge of physical and organic chemistry, biochemistry and biology. Attendance of Medicinal Chemistry II in the spring semester. Registration for the course until 15 October. |