535-0310-00L Glycobiology in Drug Development
| Semester | Autumn Semester 2020 |
| Lecturers | V. I. Otto |
| Periodicity | yearly recurring course |
| Language of instruction | English |
Courses
| Number | Title | Hours | Lecturers | ||||
|---|---|---|---|---|---|---|---|
| 535-0310-00 V | Glycobiology in Drug Development | 1 hrs |
| V. I. Otto |
Catalogue data
| Abstract | Protein-based drugs constitute around 25% of new approvals and most of them are glycoproteins. Using selected examples of prominent glycoprotein drugs, the course aims at providing insight into glycosylation-activity relationships and into biotechnological production and analytics. |
| Learning objective | Students gain basic knowledge in "pharmaceutical glycobiology" This implies knowing and understanding: - major mechanisms underlying the roles of glycosylation for the biological/therapeutic actions of glycoproteins (glycosylation-function relationships) using prominent examples of glycoprotein drugs. - the major types of protein-linked glycans and the biosynthetic pathways for their formation - how glycoprotein drugs are produced (including the most important expression systems used), glycoengineered and analysed (quality control) Students are able to apply this knowledge in solving simple problems in glycoprotein drug development (on paper). Students gain the ability to reflect on roles of glycosylation in various biological contexts. |
| Content | lecture plan: 1. Glycans - information carriers in biology and pharmacotherapy 2. Glucocerebrosidase and the biosynthesis of N-glycans 3. Glyocerebrosidase - production and quality control 4. Improving the therapeutic profile of monoclonal antibodies by glycoengineering 5. Mucin-type O-glycans and sialyltion as gCQA of glycoprotein hormones drugs - production and quality control. 6. EPO "the same but different" The lectures will include some exercises in which students apply their knowledge to solve simple biotechnological problems related to protein glycosylation. |
| Lecture notes | The slides used for the lectures will be provided online |
| Literature | - Essentials of Glycobiology 3rd edition, A. Varki, R.D. Cummings et al., Cold Spring Harbor Laboratory Press, New York 2017. - recent publications as cited/proposed on the lecture slides |
| Prerequisites / Notice | Requirements: Basic knowledge in immunology, molecular biology, protein and carbohydrate chemistry, analytical techniques. Basic knowledge in pharmacology. |
Performance assessment
| Performance assessment information (valid until the course unit is held again) | |
Performance assessment as a semester course | |
| ECTS credits | 1 credit |
| Examiners | V. I. Otto |
| Type | graded semester performance |
| Language of examination | English |
| Repetition | Repetition possible without re-enrolling for the course unit. |
| Admission requirement | Regular attendance of the lessons is highly recommended. The lecture slides are designed to illustrate what is explained and discussed during the lessons. |
| Additional information on mode of examination | A statement or question regarding the main topics of the course has to be discussed / answered in the form of an essay (1-maximally 2 pages A4 written in German, English, French or Italian). The assay will be reviewed and graded. At a later time point to be agreed upon by lecturer and students, the essays and their contents will be discussed. |
Learning materials
| No public learning materials available. | |
| Only public learning materials are listed. |
Groups
| No information on groups available. |
Restrictions
| There are no additional restrictions for the registration. |
Offered in
| Programme | Section | Type | |
|---|---|---|---|
| Human Medicine Bachelor | Compensatory Courses | W |  |
| Pharmaceutical Sciences Master | Electives I | W | |
| Pharmaceutical Sciences Bachelor | Compensatory Courses | W | |
| Pharmacy Master | Electives | W | |