551-0434-00L  NMR Spectroscopy in Biology

SemesterSpring Semester 2020
LecturersF. Allain, A. D. Gossert, K. Wüthrich
Periodicityyearly recurring course
Language of instructionEnglish
CommentNumber of participants limited to 6.

The enrolment is done by the D-BIOL study administration.


AbstractIn this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wüthrich and Dr. Gossert. The students will be tutored in their experimental work by experienced postdoc students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as exercises and literature work.
ObjectiveThe course provides first "hands on" insight into applications of NMR spectroscopy in biological sciences. The course should enable the students to understand the potential and limitations of NMR applied to biological problems.
ContentThe topics include studies of proteins, RNA and protein-RNA interactions,

Participation in one of the following projects will be possible:
- NMR of RNA
- NMR of several protein-RNA complexes (hnRNPF, nPTB, SR proteins)
- NMR studies of protein-ligand interactions
- dynamics of protein-RNA complexes
- Segmental isotopic labeling to study multidomain proteins
- NMR Methods Development
Lecture notesNo script
LiteratureLists of individual reading assignments will be handed out.