# 227-0393-10L Bioelectronics and Biosensors

Semester | Autumn Semester 2019 |

Lecturers | J. Vörös, M. F. Yanik, T. Zambelli |

Periodicity | yearly recurring course |

Language of instruction | English |

Abstract | The course introduces the concepts of bioelectricity and biosensing. The sources and use of electrical fields and currents in the context of biological systems and problems are discussed. The fundamental challenges of measuring biological signals are introduced. The most important biosensing techniques and their physical concepts are introduced in a quantitative fashion. |

Objective | During this course the students will: - learn the basic concepts in biosensing and bioelectronics - be able to solve typical problems in biosensing and bioelectronics - learn about the remaining challenges in this field |

Content | L1. Bioelectronics history, its applications and overview of the field - Volta and Galvani dispute - BMI, pacemaker, cochlear implant, retinal implant, limb replacement devices - Fundamentals of biosensing - Glucometer and ELISA L2. Fundamentals of quantum and classical noise in measuring biological signals L3. Biomeasurement techniques with photons L4. Acoustics sensors - Differential equation for quartz crystal resonance - Acoustic sensors and their applications L5. Engineering principles of optical probes for measuring and manipulating molecular and cellular processes L6. Optical biosensors - Differential equation for optical waveguides - Optical sensors and their applications - Plasmonic sensing L7. Basic notions of molecular adsorption and electron transfer - Quantum mechanics: Schrödinger equation energy levels from H atom to crystals, energy bands - Electron transfer: Marcus theory, Gerischer theory L8. Potentiometric sensors - Fundamentals of the electrochemical cell at equilibrium (Nernst equation) - Principles of operation of ion-selective electrodes L9. Amperometric sensors and bioelectric potentials - Fundamentals of the electrochemical cell with an applied overpotential to generate a faraday current - Principles of operation of amperometric sensors - Ion flow through a membrane (Fick equation, Nernst equation, Donnan equilibrium, Goldman equation) L10. Channels, amplification, signal gating, and patch clamp Y4 L11. Action potentials and impulse propagation L12. Functional electric stimulation and recording - MEA and CMOS based recording - Applying potential in liquid - simulation of fields and relevance to electric stimulation L13. Neural networks memory and learning |

Literature | Plonsey and Barr, Bioelectricity: A Quantitative Approach (Third edition) |

Prerequisites / Notice | The course requires an open attitude to the interdisciplinary approach of bioelectronics. In addition, it requires undergraduate entry-level familiarity with electric & magnetic fields/forces, resistors, capacitors, electric circuits, differential equations, calculus, probability calculus, Fourier transformation & frequency domain, lenses / light propagation / refractive index, Michaelis-Menten equation, pressure, diffusion AND basic knowledge of biology and chemistry (e.g. understanding the concepts of concentration, valence, reactants-products, etc.). |