535-0231-00L  Medicinal Chemistry II

SemesterSpring Semester 2019
LecturersJ. Hall
Periodicityyearly recurring course
Language of instructionEnglish

AbstractThe lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples.
ObjectiveBasic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties.
ContentMolecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions.
Lecture notesWill be provided electronically in parts before each individual lecture.
Literature- G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press (2013)
- D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005)
- J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002)
- A. Gringauz, "How Drugs Act and Why", Wiley (1997)
- R. Silverman and M. Holladay, "The Organic Chemistry of Drug Design and Drug Action" 3rd Edition, Academic Press, (2014)
Prerequisites / NoticeRequirements: Knowledge of physical and organic chemistry, biochemistry and biology; Medicinal Chemistry I.