376-1620-00L  Skeletal Repair

SemesterSpring Semester 2019
LecturersS. Grad, D. Eglin, F. Moriarty, M. Stoddart
Periodicityyearly recurring course
Language of instructionEnglish
CommentNumber of participants limited to 42.

Only for Health Sciences and Technology MSc and Biomedical Engineering MSc.



Courses

NumberTitleHoursLecturers
376-1620-00 GSkeletal Repair
2 day block course (practical work)
26.-27.04.2019 AO Center Davos Platz
3 hrs
Fri13:15-15:00ML F 38 »
S. Grad, D. Eglin, F. Moriarty, M. Stoddart

Catalogue data

AbstractThe course gives an introduction into traumatic and degenerative pathologies of skeletal tissues. Emphasis is put on bone, cartilage and intervertebral disc. Established and new treatments are described, including cell, gene and molecular therapy, biomaterials, tissue engineering and infection prevention. In vitro/in vivo models are explained.
ObjectiveThe objectives of this course are to acquire a basic understanding of
(1) important pathologies of skeletal tissues and their consequences for the patient and the public health
(2) current surgical approaches for skeletal repair, their advantages and drawbacks
(3) recent advances in biological strategies for skeletal repair, such as (stem) cell therapy, gene therapy, biomaterials and tissue engineering
(4) pathology, prevention and treatment of implant associated infections
(5) in vitro and in vivo models for basic, translational and pre-clinical studies
ContentAccording to the expected background knowledge, the cellular and extracellular composition and the structure of the skeletal tissues, including bone, cartilage, intervertebral disc, ligament and tendon will briefly be recapitulated. The functions of the healthy tissues and the impact of acute injury (e.g. bone fracture) or progressive degenerative failure (e.g. osteoarthritis) will be demonstrated. Physiological self-repair mechanisms, their limitations, and current (surgical) treatment options will be outlined. Particular emphasis will be put on novel approaches for biological repair or regeneration of critical bone defects, damaged hyaline cartilage of major articulating joints, and degenerative intervertebral disc tissues. These new treatment options include autologous cell therapies, stem cell applications, bioactive factors, gene therapy, biomaterials or biopolymers; while tissue engineering / regenerative medicine is considered as a combination of some of these factors. In vitro bioreactor systems and in vivo animal models will be described for preclinical testing of newly developed materials and techniques. Bacterial infection as a major complication of invasive treatment will be explained, covering also established and new methods for its effective inhibition. Finally, the translation of new therapies for skeletal repair from the laboratory to the clinical application will be illustrated by recent developments.
Prerequisites / NoticeBasic knowledge in the cellular and molecular composition, structure and function of healthy skeletal tissues, especially bone, cartilage and intervertebral disc are required; furthermore, basic understanding of biomaterial properties, cell-surface interactions, and bacterial infection are necessary to follow this course.

Performance assessment

Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course
ECTS credits3 credits
ExaminersS. Grad, D. Eglin, F. Moriarty, M. Stoddart
Typegraded semester performance
Language of examinationEnglish
RepetitionRepetition only possible after re-enrolling for the course unit.

Learning materials

No public learning materials available.
Only public learning materials are listed.

Groups

No information on groups available.

Restrictions

Places42 at the most
PriorityRegistration for the course unit is only possible for the primary target group
Primary target groupBiomedical Engineering MSc (238000)
Health Sciences and Technology MSc (380000)
Waiting listuntil 04.03.2019

Offered in

ProgrammeSectionType
Biomedical Engineering MasterRecommended Elective CoursesWInformation
Biomedical Engineering MasterRecommended Elective CoursesWInformation
Health Sciences and Technology MasterElective Courses IIWInformation
Health Sciences and Technology MasterElective Courses IIWInformation